Venter

Pharmacological effect

Gastroprotective agent. By interacting with the proteins of necrotic ulcer tissue, it forms a protective layer that prevents the further destructive effect of pepsin, hydrochloric acid and bile salts. Increases prostaglandin synthesis, reduces pepsin activity and binds bile salts. Inhibits pepsin activity by 30%. It has a weak antacid effect. Being in the stomach and duodenum, it is transformed into a polyanion with many free negative charges, which form strong bonds with positive radicals of protein-like exudate (albumin, fibrinogen) of the mucous membrane. Interaction with unchanged mucous membrane is insignificant.

Pharmacological properties of the drug Venter

A remedy for the treatment of peptic ulcers. Sucralfate protects the gastric mucosa without having a systemic effect and having virtually no effect on the acidity of gastric juice. Sucralfate binds to the proteins of necrotic tissue in the area of ​​the ulcer, forming a protective coating that prevents the action of pepsin, hydrochloric acid of gastric juice and bile salts. Sucralfate reduces pepsin activity by approximately 30%. Accelerates the scarring of peptic ulcers of the stomach and duodenum, prevents their recurrence and the formation of stress ulcers, and also reduces the absorption of phosphates from the digestive tract. After oral administration, ≤5% of sucralfate is absorbed, as a result of which the drug has no systemic side effects. The absorbed part of the drug is excreted by the kidneys.

Interaction with other drugs

When used simultaneously with indirect anticoagulants, their anticoagulant activity (including warfarin) may decrease. With simultaneous use, the absorption of antimicrobial agents of fluoroquinolone derivatives decreases. With simultaneous use, the absorption of amitriptyline decreases, which may lead to a decrease in its clinical effectiveness. It is believed that with simultaneous use may form chelate complexes with sucralfate of amphotericin B, colistin sulfate, tobramycin, which can lead to a decrease in their antimicrobial activity. When used simultaneously with digoxin, a decrease in the absorption of digoxin is possible. It is believed that with simultaneous use, a slight decrease in the absorption of ketoconazole and fluconazole is possible. simultaneous use with levothyroxine significantly reduces the effectiveness of levothyroxine. When used simultaneously with sucralfate, slight changes in the pharmacokinetics of theophylline were observed. It is also believed that a significant reduction in the absorption of theophylline from sustained-release dosage forms is possible. It is believed that with simultaneous use, a decrease in the absorption of tetracycline is possible. With simultaneous use, the absorption of phenytoin and sulpiride is reduced. A case of a decrease in the concentration of quinidine in the blood plasma is described when used simultaneously with sucralfate. With simultaneous use, a slight decrease in the bioavailability of cimetidine, ranitidine, and roxatidine cannot be ruled out.

Venter drug interactions

Antacids can be prescribed during treatment with sucralfate, but they should be taken at least 30 minutes before taking sucralfate or 1.5 hours after taking it. Medicines containing aluminum compounds (for example, some antacids) may cause aluminum to accumulate in the body in patients with kidney failure. Sucralfate may reduce the absorption of certain drugs, such as tetracycline, cimetidine, ranitidine, fluoroquinolones, digoxin, theophylline, warfarin, ketoconazole, levothyroxine, quinidine and phenytoin. These medications should be taken at least 2 hours before taking sucralfate. Sucralfate may bind to some food proteins. For patients being fed by gastric tube, sucralfate should be administered separately from food and other medications.

Directions for use and doses

Orally, without chewing, with a small amount of water, 1 hour before meals and before bedtime. Peptic ulcer of the stomach and duodenum in the acute phase: orally, 1 tablet (1 g) four times a day or 2 tablets (2 g) twice a day. The maximum daily dose is 8 g. The average duration of treatment is 4-6 weeks, if necessary - up to 12 weeks. Prevention of exacerbations of duodenal ulcer: 1 tablet twice a day. Reflux esophagitis: 1 tablet three times a day before each meal and 1 tablet before bed. Hyperphosphatemia: 1 tablet four times a day before meals and before bed. In patients with hyperphosphatemia, when plasma phosphate concentrations decrease, the dose of sucralfate may be reduced. The duration of therapy for reflux esophagitis, hyperphosphatemia, as well as for the purpose of preventing exacerbations of gastric and duodenal ulcers is determined by the clinical condition of the patient and the results of the examination over time, individually by the attending physician. Children over 4 years old: 1/2 - 1 tablet (0.5 -1.0 g) four times a day an hour before meals and at night, i.e. at a dose of 40-80 mg per kg of body weight per day, divided into 4 doses.

Venter

Release form: tablets (blister packs) 500 mg

Pharmacological group - gastroprotective agent

pharmachologic effect

• antiulcer
• increasing prostaglandin synthesis
• reducing pepsin activity
• forming a protective film

Ingredients – sucralfate 500 mg

Indications

• Gastritis and duodenitis
• Gastritis, unspecified
• Gastroesophageal reflux
• Gastroesophageal reflux with esophagitis
• Gastrojejunal ulcer
• Gastroduodenitis, unspecified
• Alcoholic gastritis
• Acute hemorrhagic gastritis
• Peptic ulcer of unspecified localization
• Chronic gastritis, unspecified
• Chronic atrophic gastritis
• Chronic superficial gastritis
• Esophagitis
• Other gastritis
• Other diseases of the esophagus
• Other acute gastritis
• Esophageal ulcer
• Duodenal ulcer
• Stomach ulcer

Composition by components

• sucralfate

Pharmacodynamics

It has gastroprotective, antiulcer effects, forming a protective film, increasing the synthesis of prostaglandins, reducing the activity of pepsin. It has a local effect on ulcerative lesions of the mucous membrane of the stomach and duodenum. Dissolves in an acidic environment, most of the drug forms an adhesive polymer paste with basic properties. Being in the stomach and duodenum, it is transformed into a polyanion with many free negative charges, which form strong bonds with positive radicals of mucosal proteins. Thus, it forms a strong barrier that, over a long period, protects the affected areas of the mucous membrane from the influence of aggressive factors (acid, bile and pepsin do not come into contact with the ulcerated surface). It has a cytoprotective effect, promoting the synthesis of prostaglandins in the mucous membrane. The drug moderately inhibits the activity of pepsin.

Pharmacokinetics

It is poorly absorbed from the gastrointestinal tract and therefore does not have a significant systemic effect. The drug is absorbed by 3-5% of the administered dose, more than 90% is excreted unchanged in the feces.

Application

Peptic ulcer of the stomach and duodenum in the acute phase; reflux esophagitis gastritis, gastroduodenitis, heartburn, drug ulcer.

Dosage regimen

Prescribe 1 g 4 times a day (1 hour before meals and before bedtime). It is also possible to take it twice a day: 2 tablets or 2 bags of granules in the morning and evening. The maximum daily dose is 8 g. The tablet can be swallowed whole with a small amount of liquid, or, like granules, mixed in 0.5 glasses of water and drunk. The average duration of treatment for peptic ulcer is 4-6 weeks. If necessary, treatment is continued for up to 12 weeks.

Side effects

When used according to indications and in the recommended dosage, patients usually tolerate the drug well. In rare cases - dyspeptic disorders (constipation, diarrhea, nausea, dry mouth), itching, pain in the lumbar region, insomnia, dizziness. In patients with renal failure, serum aluminum and phosphate concentrations should be monitored.

Contraindications

Pregnancy, children (up to 4 years), severe renal dysfunction, bleeding from the gastrointestinal tract (GIT), hypersensitivity.

Interaction

If it is necessary to prescribe antacids simultaneously, they should be taken 30 minutes before or 30 minutes after taking sucralfate. In case of insufficiency of renal function, monitoring of the concentration of aluminum and phosphates in the blood serum is necessary. Sucralfate reduces the absorption of tetracyclines, cimetidine, ciprofloxacin, norfloxacin, ranitidine, digoxin, warfarin and theophylline. Therefore, the interval between taking sucralfate and the above drugs should be at least 2 hours.

special instructions

There are no known harmful effects of the drug on the fetus or child. However, for pregnant women and breastfeeding women, treatment is recommended only in urgent cases.

special instructions

If simultaneous use of antacids is necessary, they should be taken 30 minutes before or 30 minutes after taking sucralfate. In case of renal failure, monitoring the concentrations of aluminum and phosphates in the serum is necessary. The appearance of drowsiness and convulsions may indicate manifestations of the toxic effect of aluminum. Short-term treatment can lead to complete scarring of the ulcer, but does not change the frequency and severity of relapses of the peptic ulcer after scarring. Administration of sucralfate through a nasogastric tube can lead to the formation of a bezoar (a stone formed in the digestive tract and shaped like a ball) with other drugs or solutions for enteral nutrition, because . sucralfate can bind protein.

Special instructions for the use of the drug Venter

The small amount of aluminum contained in sucralfate is absorbed in the digestive tract and subsequently excreted in the urine. In case of severe renal dysfunction, aluminum may accumulate in the body with the development of its toxic effect. The risk of accumulation increases with simultaneous administration of other drugs containing aluminum (for example, some antacids). The safety and effectiveness of sucralfate in children under 4 years of age have not been sufficiently studied, so it is not recommended to prescribe the drug to children in this age group. The drug can be used during pregnancy only when the expected benefit to the expectant mother outweighs the potential risk to the fetus. There is no evidence that sucralfate passes into breast milk, so it should be used with caution during breastfeeding.

Doctor's review

Alexander Pichugin Doctor of the highest category,

“Venter is suitable for seasonal and regular use; its effect is manifested not only in eliminating allergic symptoms, but also in eliminating the causes. The first cases of using the drug can eliminate tearfulness, swelling, runny nose, relieve nasal congestion, itching on the skin and rashes, attacks of asthmatic cough and shortness of breath. Carrying out a course of therapy with this drug can eliminate allergic reactions at the peak of its exacerbation. Additionally, this remedy can restore metabolic reactions, cleanse the body of poisons and toxins, increase immunity, improve general condition, and increase performance. This drug has participated in clinical-level studies and received the necessary certificates.”