Oftalmoferon eye drops - detailed instructions for use. For the treatment of viral eye diseases

Diseases of the eyelids and conjunctiva have the largest share (24.2 and 68.1%, respectively) in the structure of inflammatory eye diseases, the number of cases of which is recorded up to 18 million annually [1]. Chronic year-round allergic conjunctivitis, often accompanied by involvement of the eyelids in the pathological process, deserves special attention. In recent years, the prevalence of this pathology exceeds 23% of the total number of allergic eye diseases [2, 3]. The etiological factor of this disease can be any allergen, either independently or as a polyvalent, as well as cross-allergy [2, 4, 5]. Hypersensitivity to pollen, household, epidermal, infectious (chlamydial - Chl

.
psittaci
, bacterial, fungal, etc.) and especially food allergens. It is generally accepted that the development of such processes is based on a delayed type allergic reaction (type IV - cell-mediated immune reactions) [2, 4, 6, 7]. However, polyvalent allergies and cross-allergic reactions additionally include mechanisms of rapid immune response - type I, and the reaction to food allergens, which often accompanies the pathology in question, - immune response type III (damage by immune complexes) [4, 7, 8].

In the diagnosis of chronic year-round allergic conjunctivitis, a carefully collected allergological history is important, which in 70% of cases allows one to correctly assume the etiological allergen. A clarifying diagnosis is made using skin allergy tests, laboratory allergy diagnostics (provocative tests, radioallergosorbent test, enzyme-linked immunosorbent assay, as well as tests using the CAP-system, MAST-CLA-system, etc. are carried out) and, finally, the method of detecting eosinophils in scrapings from conjunctiva (from 4.0 to 90.0%) and in the blood (10.0–12.0%) [4, 8].

The opportunistic Demodex

, which can be found on the eyelashes in 39-88% of patients with blepharoconjunctivitis under 70 years of age and in every patient over 70 years of age [6, 9]. In such cases, a delayed type allergic reaction develops (type IV - cell-mediated immune reactions), predisposing to allergic reactions to other antigens, especially bacterial ones [10]. The relevance of this problem is also associated with the fairly frequent (in relatively healthy individuals) detection of microflora in the conjunctival cavity in such patients [11, 12].

Treatment of patients with allergic blepharoconjunctivitis is based on the systemic and local use of antiallergic drugs (antihistamines, mast cell membrane stabilizers and drugs with a combined effect), many of which can also be used in the treatment of children (Table 1).

Table 1. Main directions of therapy for patients with chronic allergic blepharoconjunctivitis

Of the antihistamines, the most widely used is azelastine, which selectively blocks H1 receptors, stabilizes mast cell membranes, slows down the formation and release of biologically active substances, and also reduces the number of eosinophils and molecular adhesion cells. Cromoglycic acid is most often used as a mast cell membrane stabilizer.

At the same time, combination drugs that simultaneously have an antihistamine and mast cell stabilizing effect are increasingly used in the treatment of patients with this profile. Among them is olopatadine, approved for use in children from 3 years of age.

In addition, a number of drugs from the pharmacological group under consideration contain a combination of several active ingredients. Thus, the combination of diphenhydramine hydrochloride (a first-generation histamine H1 receptor antagonist) with the alpha-adrenergic agonist naphazoline is used in the drugs “Betadrin” and “Polinadim”. The combination of loratadine (a long-acting blocker of H1-histamine receptors that inhibits the release of histamine and leukotriene C4 from mast cells) with human recombinant interferon alpha-2b is presented in the domestic drug “Allergoferon” (gel for local and external use, manufactured by a biotechnology company FIRN M).

The original combination of human recombinant interferon alpha-2b with diphenhydramine hydrochloride (Ophthalmoferon eye drops, FIRN M) turned out to be widely in demand in pediatric ophthalmology [3, 9, 13-16]. The literature provides numerous information proving the immunomodulatory, antiviral, disinfectant, antiproliferative, and anti-inflammatory effects of this drug in both adults and children. It was also noted that the drug additionally has an antihistamine effect and partly has the properties of artificial tears [1-3, 5, 6]. At the same time, the researchers did not note any adverse events of either a local or systemic nature [1, 5, 8, 13, 14].

At the same time, there is little data indicating the possibility of using the drug in question in patients with chronic blepharoconjunctivitis, in the pathogenesis of which allergic reactions are of great importance, and dry eye syndrome is diagnosed more often than in 80.0% of cases [17]. These circumstances were the reason for carrying out this study.

The purpose of the work is to study the possibilities of using the drug “Ophthalmoferon” in the treatment of children with chronic allergic and demodectic blepharoconjunctivitis.

Compound

1 ml of Oftalmoferon eye drops contains 10,000 IU of human recombinant interferon alpha-2b , as well as an additional active compound – 1 mg of diphenhydramine hydrochloride ( diphenhydramine ).
Auxiliary are: 3.1 mg of boric acid, 0.4 mg of disodium edetate, 2.2 mg of sodium chloride, 7 mg of sodium acetate, 3 mg of hypromellose, 5 mg of povidone 8000, 50 mg of macrogol 4000 and approximately 1 ml of purified water.

Ciprofloxacin-Optic

Ciprofloxacin-Optic drops are an inexpensive broad-spectrum antibiotic that copes well with purulent conjunctivitis. These eye drops are odorless and come in a glass bottle. Dosing the drug is very convenient thanks to the narrow spout-tip. Literally a day after using Ciprofloxacin, pus stops coming out of the eyes, and after three days of treatment, conjunctivitis completely disappears. Eye drops do not “harm” the eyes, and patients note a rapid recovery: swelling of the eyelids, inflammation and burning in the eyes disappear. If you want to quickly cure conjunctivitis, use Ciprofloxacin drops, strictly following the instructions.

Ciprofloxacin-Optic

OJSC Pharmstandard-Leksredstva, Russia

Treatment of corneal ulcers and infections of the anterior segment of the eyeball and its appendages caused by bacteria sensitive to ciprofloxacin in adults, newborns (from 0 to 27 days), infants and infants (from 28 to 23 months), children (from 2 to 11 years) and teenagers (from 12 to 18 years old).
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Pharmacodynamics and pharmacokinetics

Ophthalmoferon is a combined drug containing an antiviral immunomodulatory antiproliferative substance - human recombinant interferon α-2b , which is supplemented with an active antihistamine - diphenhydramine .

Diphenhydramine acts by blocking H1-histamine receptors, which has an antiallergic effect, reducing swelling and itching in the human conjunctiva.

Pharmacokinetic properties

If you follow the instructions and apply eye drops topically, then systemic absorption does not occur - the concentration of the active substances of the drug in the blood is achieved significantly less than the standard detection limit (for example, for interferon α-2b - approximately 1-2 IU in 1 ml), which does not allows you to identify clinically significant reactions.

Pharmacology

Oftalmoferon is a drug of combined action. The composition contains immunomodulatory interferon. Its effects are increased by the presence of diphenhydramine. With the simultaneous influence of these two components, allergic processes manifested in the form of swelling and redness of the conjunctival membrane begin to gradually disappear.

These drops are intended for local use. They are absorbed into the blood in minimal quantities; their presence is even difficult to detect. The active substances cannot cause serious medical consequences.

Indications for use

• conjunctivitis of various types, including adenoviral , hemorrhagic ( enteroviral ), herpetic ;
• keratitis - adenoviral , herpetic (card-shaped, vesicular, dotted or tree-like);
• herpetic keratitis with stroma, which may be accompanied by corneal ulceration;
• or herpetic keratoconjunctivitis ;
• herpetic uveitis or keratouveitis (ulceration is possible);
• with dry keratoconjunctivitis (dry eye syndrome);
• prophylactic for graft disease , to prevent relapses of herpetic keratitis after keratoplasty ;
• prevention or treatment of complications after excimer laser refractive surgery on the cornea.

Types of conjunctivitis

There are two main forms

conjunctivitis: infectious and allergic.

1. Infectious conjunctivitis
   (viral, bacterial, fungal or chlamydial).
2. Allergic conjunctivitis
   (develops as an allergic reaction to various types of irritants).

In addition, conjunctivitis can be acute and chronic.

Causes of conjunctivitis

Photos from open sources

Cause of bacterial conjunctivitis

usually become streptococcal and staphylococcal bacteria. With this type of conjunctivitis, pus is released from the eyes.

Viral conjunctivitis

develop due to adenoviruses, herpes virus, etc. With viral conjunctivitis, the mucous membrane of the eye is irritated, there is redness, and lacrimation. Often a person has a fever, general weakness, headache, cough, runny nose.

Allergic conjunctivitis

occur due to contact with an allergen (plant, house dust, animal hair, certain products, household chemicals, cosmetics, etc.). In addition to the above symptoms, allergic conjunctivitis is accompanied by severe itching of the eyes.

Oftalmoferon eye drops, instructions for use (Method and dosage)

The drug is used conjunctivally until symptoms disappear completely for various eye lesions or for prevention.

For viral diseases

Adults and children in the acute stage are prescribed 1-2 drops to be instilled approximately 6-8 times during the day. When positive dynamics appear and the inflammatory process is stopped, instillation can be reduced to 2-3 times.

For keratoconjunctivitis sicca (dry eye syndrome)

Recommended daily use - 1-2 drops twice a day for 25-30 days.

Instructions for the use of Oftalmoferon for preventive purposes

• Complications after excimer laser refractive surgery on the cornea of ​​the eye: drops should be used daily from the first day of surgery according to the scheme: 1-2 drops. 2 times a day, course – at least 10 days.
• Graft disease or prevention of recurrence of herpetic keratitis that occurs after keratoplasty: the drug should be used daily according to the regimen: 1-2 drops. into the operated eye 3-4 times a day, the course is at least 14 days, starting from the first day after surgery.

Attention! When using contact lenses , drops can be used only after removing the lenses; they can be put on only 15–20 minutes after the instillation procedure.

Similar drugs

The drug has several analogues, which, despite similar effects, differ in composition and may have different performance indicators:

1. Alfarona . Immunomodulatory antiviral agent of the interferon group. Typically, pathogens quickly develop immunity to drugs of this class, so long-term treatment using these drops is useless. The drops have the maximum effect only in the first 3-4 days of treatment for keratitis, conjunctivitis and keratouveitis.
2. Albucid. The drug works best in the treatment of bacterial conjunctivitis, penetrating into the deep tissues of the eyeball and stopping the proliferation of pathogenic microflora by destroying its cells.
3. Reaferon-EC . Such drops are prescribed for viral lesions of the external part of the organs of vision.
4. Poludan . In terms of the speed of penetration into the membrane and tissues of the eye, this drug is comparable to ophthalmoferon, but polyriboadenylic acid is indicated as its base. This is not an active substance that acts directly on pathogens, but a powerful stimulant that makes the immune system work, and the body itself begins to fight the pathogens. After the components of poludanum are mixed with the eye fluid and have a stimulating effect, they are also quickly eliminated from the body.
5. Aktipol . An immunomodulatory antiviral drug with antioxidant properties that actively affects the regeneration of the cornea. In addition, the drops help relieve swelling and heal ulcerations and wounds resulting from the negative effects of pathogenic microorganisms. It is permissible to use drops as a healing agent after injuries to the organs of vision.
6. Altevir . Antiviral drops that stimulate the body's immune system, resulting in the mobilization of all resources and their direction to fight viral pathogens of ophthalmic diseases.

Newborns

Since Ophthalmoferon contains interferon and has an immunomodulatory and antiviral effect, it is more preferable for newborns. In addition, it has an antipruritic effect and restores damaged eye tissue, stopping the inflammatory process.

The drug is not contraindicated for newborns, however, before use, the mother should consult an ophthalmologist who, depending on the child’s age and the course of the disease, will determine the dosage and treatment regimen individually.

How to treat conjunctivitis.

August 17, 2022
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Content

• Symptoms of conjunctivitis
• Types of conjunctivitis
• How to treat conjunctivitis
• The most effective drops for conjunctivitis
• Ciprofloxacin-Optic
• Montevisin
• Levomycetin
• Opatanol
• Oftalmoferon
• Aktipol
• Drops for conjunctivitis for children
• Tsiprolet
• Diclofenac
• Vitabact
• Visine Classic

Conjunctivitis

is a common eye disease in which the mucous membrane of the eyeball, the inside of the eyelids and the sclera (the “white” of the eye) become inflamed.

Conjunctivitis usually does not pose a health risk and can go away on its own without treatment, but there are forms of conjunctivitis that cause complications or are contagious.

Oftalmoferon's analogues

Level 4 ATC code matches:
Florenal

Oksolin

Oxolinic ointment

Zirgan

Oftan I'm coming

Poludan

There are known analogues of eye drops that also have antiviral or immunostimulating effects:

• Aktipol
• Poludan
• Oftan-Idu

Montevisin

Eye drops for conjunctivitis "Montevisin" are excellent value for money. This is a kind of “first aid” for conjunctivitis, when you need to quickly get rid of symptoms. Drops instantly relieve eye fatigue, pain, pain, swelling and redness. A few minutes after instillation, the vascular network is no longer so visible, the view becomes clearer. But Montevisin has a number of contraindications associated with high blood pressure and heart disease, so be sure to consult your doctor. Thanks to the convenient pipette, it is very convenient to use Montevisin eye drops.

Montevisin

Swelling of the conjunctiva, secondary hyperemia in allergic eye diseases, irritation of the conjunctiva;
- hyperemia and/or swelling of the conjunctiva caused by various nonspecific causes (condition after tonometry, dust, cigarette smoke, smog, swimming, reading, driving). from 132

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Reviews about Oftalmoferon

Today, Oftalmoferon eye drops are quite popular and in demand, reviews and discussions of which can be found on various Internet resources and forums. Most often, the comments are positive, because they can be used both in children and in elderly patients suffering from eye problems - various etiologies of conjunctivitis, “dry eye”, as well as for prevention purposes.

Mothers praise Oftalmoferon, noting its safety of use, availability, lack of itching and allergies.

Interaction with other drugs

Attention! Ophthalmoferon does not have any obvious consequences that occur when used simultaneously with other ophthalmic agents.

The drug can be confidently used in combination with drops of the “artificial tear” and “natural tear” groups, as well as with antibacterial, anti-inflammatory and corticosteroid eye drops.

But only the interval between instillations of different solutions should be 5-10 minutes.

Oftalmoferon price, where to buy

Many patients like the easy-to-use and affordable Oftalmoferon eye drops, the price of which does not exceed 350 rubles. for 10 ml. The price of eye drops of a smaller volume - 5 ml is usually up to 200 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Oftalmoferon drops hl.
  10000 IU/ml 10 ml ZAO Firn M 355 rub. order

Pharmacy Dialogue

• Ophthalmoferon (vial 10 ml eye/drop) Firn M

  RUB 310 order

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How to treat conjunctivitis

Treatment of conjunctivitis should be aimed at eliminating the causes that caused it. And the causes of the disease can be determined by an ophthalmologist.

For bacterial

form, you need to wash your eyes with saline solution, plus the doctor prescribes drops for conjunctivitis.
Viral
conjunctivitis is usually not treated (like colds), since there are no special antiviral drugs for this disease - the person recovers on his own.
If necessary, treatment is reduced to symptomatic therapy to reduce negative symptoms (artificial tears, cool compresses). Allergic
conjunctivitis involves eliminating the causes of allergies.

Basic rules of hygiene when treating conjunctivitis:

• If you wear contact lenses, remove them until you recover;
• do not touch your eyes with your hands;
• wash your hands frequently and thoroughly;
• exclude close contact with others;
• during illness you should have your own soap and towel, change pillowcases and bed linen as often as possible;
• with conjunctivitis, women need to give up eye cosmetics;
• Ventilate the room you are in more often.

Side effects

The medicine does not cause unwanted side effects. However, in case of individual intolerance or hypersensitivity to the components of the drug, the following actions may occur:

• increased tearfulness;
• redness, itching of the mucous membrane;
• burning sensation;
• other symptoms of an allergic reaction.

Additional substances included in the composition may cause intolerance reactions. If the symptoms do not go away or get worse, it is advisable to stop using the drops.

In addition to interferon, the drug contains diphenhydramine, which may be poorly tolerated.

Diclofenac

Diclofenac eye drops relieve inflammation in conjunctivitis and are prescribed after injuries and eye surgeries to reduce pain. The active ingredient of the drug is diclofenac sodium, which, due to its rapid absorption into the blood, instantly relieves unpleasant symptoms. Use Diclofenac drops strictly according to the instructions, since the drug has contraindications and side effects (allergies, itching, swelling, nausea and vomiting). An opened bottle of Diclofenac can be stored for a month.

Diclofenac drops

Sintez OJSC, Russia

Has anti-inflammatory and analgesic effects.
In inflammatory processes that occur after operations, it relieves pain and reduces inflammatory swelling at the wound site. from 20

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Precautionary measures

The medicine combines well with other antimicrobial and anti-inflammatory drugs for the eyes. It is not recommended to exceed the prescribed dose.

Before use, you should remove the lenses (if any) from your eyes. You can put them on 20-25 minutes after using the drops.

Immediately after using the drug, blurred vision may be observed, so it is better not to drive a vehicle for half an hour after using the drops, the same applies to driving other dangerous mechanisms.

Release form

Oftalmoferon is an antiviral drug in the form of eye drops, produced by the Russian pharmaceutical plant FIRN M. The bottle capacity is 10 ml. Ease of use is ensured by the existing pipette.

When stored correctly and within the expiration dates, the drug has no color or a slightly yellowish tint without sediment or foreign impurities. If there is a change in color, precipitation, or the appearance of suspensions and impurities, the medicine cannot be used.

Visine Classic

These American-made eye drops are great for patients with allergic conjunctivitis. Literally 5-7 minutes after instillation, the condition of the eyes noticeably improves. The positive effect after Visin Classic lasts 4-8 hours. Visin Classic drops for conjunctivitis relieve inflammation, dry mucous membranes, swelling and redness if they are caused by wearing lenses, a reaction to dust and cosmetics, or chemical irritants. Visin Classic can be used in children from 2 years of age, but only if there are indications for this (inflammation and swelling). Allergic conjunctivitis with proper use of the drug goes away in 3-4 days.

Visine Classic