Pharmacological properties of the drug Kornam
Terazosin is a selective, long-acting antagonist of postsynaptic α1-adrenergic receptors. α1-Adrenergic receptors are found in the smooth muscles of arterioles and venules. By blocking them, terazosin inhibits vasoconstriction, causes a decrease in blood pressure, and reduces peripheral vascular resistance. Symptoms due to benign prostatic hypertrophy are due in part to bladder neck obstruction. By causing relaxation of smooth muscle by blocking α1-adrenergic receptors in the prostate gland, prostatic capsule and bladder neck, terazosin increases urinary flow and reduces the severity of symptoms of benign prostatic hypertrophy. Its positive effect is noted after 2–4 weeks of treatment. Does not affect bladder contractility. Despite the fact that blockade of α1-adrenergic receptors leads to a decrease in blood pressure in patients with hypertension (arterial hypertension), no clinically significant decrease in blood pressure was detected when treating patients with normal blood pressure. Terazosin has a positive effect on the blood lipid profile: it reduces the level of TG, total cholesterol, LDL, VLDL and increases the level of HDL, as well as the ratio of the HDL level to the level of total cholesterol. It is metabolically neutral, so it can be used in patients with diabetes and gout. Its use is safe for patients with asthma. The drug can be prescribed to patients with peripheral artery disease. When using the drug, a decrease in left ventricular hypertrophy is noted. After oral administration, terazosin is rapidly and completely absorbed. Metabolized in the liver and excreted primarily in bile. The maximum concentration in the blood serum is observed 1 hour after oral administration. The maximum antihypertensive effect occurs 3 hours after taking the drug and persists for 24 hours. The half-life is 12 hours. Food intake does not affect the metabolism of the drug. There were no changes in the pharmacokinetic parameters of terazosin in patients with renal failure, the elderly, or in patients with hypertension (arterial hypertension).
Reviews
Owners
Ekaterina, Khabarovsk:
“My neutered cat has problems urinating. It turned out that the reason was a blockage in the urethra. After catheterization, the veterinarian prescribed several antibiotics and No-shpu. An ultrasound revealed a suspension in the bladder. Then No-shpu was replaced by Kornam. After a few days, improvements were noticeable."
Ivan, St. Petersburg:
“After surgery, the cat had a fibrous tissue blockage. It took about a year for therapy, and Kornam was among the medications prescribed by the veterinarian. Now we are giving this drug to our second cat as a prophylactic against cystitis.”
Veterinarians
Marta, veterinarian, Ekaterinburg:
“I have been using Cornam in my practice for a long time. I recommend using it as a preventative against cystitis and other diseases of the genitourinary system. With the correct dosage, side effects are rare."
Valery, veterinarian, Vladikavkaz:
“The drug is effective. I prescribe it before urethrostomy. Sometimes it is possible to avoid surgical intervention by using this medication in combination with other drugs. The drug costs less than other drugs with similar effects.”
Use of the drug Kornam
AH (arterial hypertension) The dose is selected individually. The initial dose is 1 mg/day at bedtime. The dose is gradually increased until blood pressure stabilizes. The range of daily doses is 1–10 mg 1 time per day. The maximum daily dose is 20 mg. In case of temporary discontinuation of the drug, treatment is resumed according to the same regimen. Terazosin is used for the treatment of hypertension (arterial hypertension) as monotherapy; for the treatment of severe forms of hypertension (arterial hypertension), the drug can be used in combination with other antihypertensive drugs, including diuretics, ACE inhibitors, calcium antagonists and beta-adrenergic receptor blockers. Benign prostatic hypertrophy The initial dose is 1 mg/day at bedtime. Gradually increase the dose to 2, 5.10 mg/day until the optimal effect is achieved. The daily dose is 10 mg. The therapeutic effect is usually observed within 2 weeks from the start of treatment. To achieve a lasting effect, the course of treatment should be 10 mg per day for 4–6 weeks, then maintenance therapy is carried out.
Active ingredient of the drug
The medicine Kornam is available in the form of flat round tablets of yellow or light orange color. On one side there is a notch, thanks to which you can easily divide the dose in half. The tablets are packaged in blisters of 10 pieces. The plates are packed in cardboard boxes of 2 or 3 pieces.
The active ingredient of the drug Cornam is terazosin in the form of hydrochloride dihydrate. Tablets are available in different dosages - 2 or 5 mg. The drug also contains other components:
- lactose monohydrate;
- microcrystalline cellulose;
- corn starch;
- talc;
- magnesium stearate;
- anhydrous silica;
- iron oxide.
The cost of the medicine Kornam depends on the manufacturer and dosage and ranges from 300 to 700 rubles per pack of 20 tablets. This drug should be stored in a dry place at a temperature of +15 to +30 degrees.
Side effects of the drug Kornam
When treating hypertension (arterial hypertension), orthostatic hypotension may develop (in approximately 1% of patients) after taking the first dose or first few doses, especially if the patient is simultaneously taking diuretics and beta-blockers. Symptoms reported more frequently with terazosin than with placebo include dizziness, asthenia, nasal congestion, peripheral edema, and somnolence. Rarely - nausea, palpitations and blurred vision. Dizziness and asthenia occur more frequently in patients taking terazosin for the treatment of benign prostatic hypertrophy . Postural hypotension, drowsiness and nasal congestion, headache, shortness of breath, tachycardia, myalgia, arthralgia, allergic reactions, dysuria are rarely noted. Patients who are hypovolemic or sodium deficient are more susceptible to developing orthostatic hypotension. This effect can be expressed during physical activity.
Side effects and contraindications
When treated with this medication, a cat may experience the following negative reactions:
- drowsiness;
- tachycardia;
- allergic manifestations;
- vomit;
- indigestion;
- swelling of the paws.
If allergic reactions occur, use of the drug should be discontinued.
The medication is used together with antibacterial and non-steroidal anti-inflammatory drugs, antihistamines.
Exceeding the dosage may cause fainting and other negative reactions. In this case, you need to immediately seek help from a veterinarian. In case of overdose, symptomatic treatment is necessary.
The drug is contraindicated in the treatment of pregnant and lactating cats, as well as kittens.
Special instructions for the use of the drug Kornam
Terazosin, like other selective α1-adrenergic blockers, may cause orthostatic hypotension and syncope with the first or first few doses. To minimize this effect, the dose of terazosin should be increased slowly and the initial dose should be administered at bedtime. When treated with terazosin, control laboratory tests revealed a decrease in hematocrit, hemoglobin, leukocyte levels, albumin and total protein, which was due to the reaction of the kidneys to the hypotensive effect of the drug. Treatment with terazosin does not affect prostate specific antigen (PSA) levels. After temporary cessation of treatment (if the patient forgot to take the drug), treatment is resumed at the initial dosage regimen. Patients should be warned about the possibility of developing syncope or orthostatic hypotension, especially at the beginning of treatment. In this regard, it is not recommended to drive vehicles or engage in potentially hazardous activities for 12 hours after taking the first dose, after increasing the dose, or when resuming treatment after a temporary break.
Price and analogues
The price of a package of tablets with a dosage of 2 mg (20 pcs.) - from 320 rubles, 20 tablets of 5 mg - from 450 rubles. You can purchase the medicine at any pharmacy with a prescription.
The drug has few analogues among medications used in therapy in cats. There are 2 products with similar characteristics, located in the same price category:
- Setegis. It is used both in monotherapy and in complex treatment of urinary tract diseases. When treating a cat, you must ensure that the animal swallows the tablet whole without chewing. The drug, like Kornam, is not used for pregnant and lactating cats and kittens. Price 30 tablets of 2 mg - from 800 rubles.
- Terazosin. The drug is effective for diseases of the genitourinary system and helps normalize lipid metabolism. It contains the same active ingredient as Kornam. The maximum effect occurs 2-3 hours after taking the product. Therapy with the drug lasts 6-8 weeks. Terazosin is prescribed with caution for kidney and liver diseases. The medication is contraindicated in kittens. The average cost of a package of the drug (20 pieces, 5 mg each) is 330 rubles.
Cornam is used for the treatment and prevention of urinary tract diseases in cats. You should not give the drug to a cat if it has an intolerance to the components of the medication, chronic infectious diseases, or kidney stones. During therapy, it is important to adhere to the dosage prescribed by the veterinarian.
The medication can be combined with other medications, which enhances the therapeutic effect. Before using the drug as a prophylactic agent, you should consult your doctor. In case of overdose and side effects occur, stop taking the drug and contact a veterinarian.
Drug interactions Kornam
Concomitant use with other antihypertensive drugs may potentiate the antihypertensive effect of terazosin. In clinical trials, terazosin was administered to patients who were simultaneously taking painkillers, NSAIDs, antibiotics (erythromycin, trimethoprim, sulfamethoxazole), anticholinergics, sympathomimetic agents, uricosurics, antihistamines, oral hypoglycemic agents, corticosteroids, antacids, sedatives and tranquilizers, diuretics and β blockers -adrenoreceptors. No clinical signs of interaction were observed.
Overdose of the drug Cornam, symptoms and treatment
bradycardia, circulatory shock, electrolyte imbalance and severe renal failure. First of all, the usual supportive measures (gastric lavage) are prescribed, and then constant monitoring and support of basic vital functions, if necessary, in the intensive care unit. Hemodialysis is not an effective way to remove terazosin from the body due to its high degree of protein binding. In case of hypotension, it is necessary first of all to replenish the loss of fluid and salts. If there is no positive effect, IV catecholamines or angiotensin II are prescribed. In the case of reflex bradycardia, a pacemaker is used. It is necessary to monitor the level of electrolytes and serum creatinine.
