Compound
One tablet of Normoven contains 500 mg of an active compound, which is a flavonoid fraction . The chemical composition of the above-mentioned medicinal substance contains 450 mg. diosmin , and in addition 50 mg of hesperidin .
As auxiliary components, the drug contains compounds such as: microcrystalline cellulose, sodium starch glycolate type A, cyclodextrin, hydroxypropyl methylcellulose, and magnesium stearate.
The film coating of Normoven tablets contains Opadry II Yellow dye, which is a complex compound that includes such elements as: food colors E171 or titanium dioxide, E132 or indigo carmine, E110 or sunset yellow, E104 or quinoline yellow, as well as lactose monohydrate , hydroxypropyl methylcellulose, triacetin and polyethylene glycol.
How it works
The active component Normoven affects the tone of the veins and improves microcirculation of blood and lymph. In particular, the outflow of fluids improves, which determines the medicine’s ability to relieve swelling and discomfort in the lower extremities. The drug also has analgesic and anti-inflammatory properties.
Active substance and release forms
The active component of the drug is the flavonoid fraction, which contains diosmin and hesperidin.
In pharmacies you can buy Normoven in tablet form.
Pharmacodynamics and pharmacokinetics
Thanks to the chemical composition of the drug Normoven, it has venotonic and angioprotective properties, which help increase the tone of the veins , and in addition reduce the risk of developing venostasis and prevent venous stretch marks . In addition, the active medicinal compounds included in the flavonoid fraction have a positive effect on blood microcirculation, enhance lymphatic outflow , thus enhancing lymphatic drainage , and also reduce capillary permeability and increase capillary resistance.
Normoven minimizes the destructive effects of inflammatory mediators that damage the leaflets of venous valves , as well as their walls, by reducing the interaction of the endothelium and leukocytes in post-capillary venules . With regular use of the drug, the feeling of heaviness, tension, fatigue, and, in addition, pain in the legs disappears. In addition, Normoven effectively fights peripheral edema , since the use of the drug increases the tone of the venous walls .
Hesperidin , as well as diosmin , which are part of the flavonoid fraction are extensively metabolized in the human body. of phenolic acids in urine tests of patients taking the drug . After a single oral administration, Normoven is quickly absorbed from the stomach. Active drug compounds reach their maximum concentration in plasma in approximately five hours.
With constant use of the drug, its active components accumulate in the lower extremities, and also settle in small quantities in the lung, liver and kidney tissues . Normoven is excreted from the body after 11 hours through the kidneys and intestines. In addition, some amount of the drug is excreted in the bile .
Normoven tablets p/o No. 10x3
Name
Normoven.
Release forms
Pills.
INN
Diosmin+hesperidin.
FTG
Venotonic and venoprotective agent.
Basic physical and chemical properties
Round tablets with a biconvex surface, film-coated from yellow to brownish-yellow.
Compound
1 tablet contains diosmin 450 mg, hesperidin 50 mg; excipients: sodium starch glycolate (type A), microcrystalline cellulose, hydroxypropyl methylcellulose, cyclodextrin, magnesium stearate; shell: film coating mixture Opadry II Yellow (hydroxypropyl methylcellulose; lactose, monohydrate; polyethylene glycol; triacetin; quinoline yellow (E 104); titanium dioxide (E 171); indigo carmine (E 132); sunset yellow FCF (E 110)).
Pharmacotherapeutic group
Agents that reduce capillary permeability. Bioflavonoids.
Pharmacological properties
Pharmacodynamics. The drug has a venotonic and angioprotective effect, increases venous tone, reduces venous stretching and venostasis, improves microcirculation, reduces capillary permeability and increases their resistance, improves lymphatic drainage, increasing lymphatic outflow. The drug also reduces the interaction of leukocytes and endothelium, the adhesion of leukocytes in post-capillary venules. This reduces the damaging effect of inflammatory mediators on the walls of the veins and the leaflets of the vein valves. The result of the drug is a decrease in peripheral edema, a feeling of heaviness, fatigue, tension and pain in the legs, and an increase in the tone of the venous wall. Pharmacokinetics. The active ingredients of the drug: diosmin and hesperidium, are extensively metabolized in the body, which is confirmed by the presence of phenolic acids in the urine. The half-life is 11 hours. Excretion of the active substance of the drug occurs mainly through the intestines (80%). An average of 14% of the dose taken is excreted through urine.
Indications
— Treatment (as part of complex therapy) of symptoms of venous lymphatic insufficiency (heaviness, swelling and pain in the legs, trophic disorders). — Treatment (as part of complex therapy) of symptoms associated with an acute attack of hemorrhoids.
Contraindications
Hypersensitivity to the active substance or to any of the excipients.
Drug interactions
No interaction studies have been conducted. At the same time, taking into account the extensive post-marketing experience with similar drugs, no drug interactions have been reported. If you are taking any other medications, consult your doctor regarding the use of the drug.
Features of application
Before starting treatment, consult your doctor! For acute attacks of hemorrhoids, taking this drug does not replace special treatment for other diseases of the anorectal area. Treatment should be prescribed in a short course. If symptoms do not go away quickly, it is necessary to conduct a proctological examination and reconsider treatment. For disorders affecting venous circulation, treatment produces maximum effect with a balanced lifestyle. Avoid prolonged exposure to the sun, prolonged standing, and weight gain. Walking improves blood circulation. Patients should strictly follow the additional therapeutic measures prescribed by the doctor, such as wearing compression medical hosiery (socks, stockings), compresses, cool showers on the lower extremities, etc. The drug contains lactose, which should be taken into account in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome. Due to the content of sunset yellow FCF in the drug, allergic reactions are possible. Use in children. Do not use in children.
Use during pregnancy or breastfeeding
In numerous studies, no teratogenic effect was found and there were no reports of adverse events in humans. Due to the lack of data on the excretion of the drug into breast milk, breastfeeding should be avoided during treatment.
The ability to influence the reaction rate when driving vehicles or other mechanisms
The drug does not affect the ability to drive vehicles or perform work that requires a high speed of psychomotor reactions.
Directions for use and doses
Treatment of symptoms of venous insufficiency: 2 tablets per day (1 tablet at noon and 1 tablet in the evening) with meals. Acute hemorrhoids: First 4 days: 6 tablets per day (3 tablets in the morning and 3 tablets in the evening). The next 3 days: 4 tablets per day (2 tablets in the morning and 2 tablets in the evening). Use with meals.
Overdose
There have been no reports of overdose.
Side effects
From the nervous system: dizziness, headache, malaise. From the digestive system: diarrhea, dyspepsia, nausea, vomiting; colitis. From the skin and subcutaneous tissue: rash, itching, urticaria; isolated swelling of the face, lips, eyelids; in exceptional cases – angioedema. If any unwanted reactions occur, you should consult your doctor!
Best before date
2 years. The drug should not be used after the expiration date indicated on the package.
Storage conditions
Store in original packaging at a temperature not exceeding 25 °C. Keep out of the reach of children.
Package
10 tablets in a blister made of colored opaque polyvinyl chloride film and printed varnished aluminum foil. 3 or 6 blisters together with an insert are placed in a pack of cardboard for consumer packaging.
Vacation rules
Over the counter.
Buy Normoven tablets p/o No. 10x3 in the pharmacy
Price for Normoven tablets p/o No. 10x3
Instructions for use for Normoven tablets p/o No. 10x3
Side effects
As a rule, patients do not experience side effects when using Normoven. However, in some cases, the following ailments from the autonomic or gastrointestinal system may appear:
- vomit;
- dispersion;
- nausea;
- diarrhea;
- dizziness or headaches.
The above side effects occur extremely rarely and do not entail discontinuation of the previously prescribed drug. of allergic reactions occur, patients should stop taking the medication and consult a doctor.
Note!
The description of the drug Normoven on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Normoven tablets, instructions for use (Method and dosage)
Instructions for use of Normoven prescribe taking the drug orally. The dosage, as well as the duration of treatment, depends primarily on the type and severity of the disease. For example, for chronic venolymphatic insufficiency associated with leg pain, swelling, trophic ulcers, cramps and lymphedema, the drug is taken 2 tablets twice a day with meals.
After a week has passed after starting to use the drug, you can change the dosage of the medication and take Normoven two tablets once a day with food. When treating chronic hemorrhoids, the drug is also taken 2 tablets in two doses and with meals. After a week of using the medicine, you can take two tablets once a day.
When treating acute forms of hemorrhoids, use a dosage equal to 6 Normoven tablets per day for the first four days, and then take 4 tablets over the next three days. The drug is also taken with meals for an average of three months.
On sale you can find an analogue of the tablet form of the drug Normoven , which is also used for the treatment and prevention of edema. Fatigue and feeling of heaviness in the legs.
Special instructions for the use of the drug Normoven
The use of the drug in the treatment of acute hemorrhoids does not replace basic therapy. If there is no rapid decrease in the severity of symptoms of acute hemorrhoids, it is necessary to conduct an additional proctological examination and adjust the treatment. Children. There are no data regarding the use of the drug in children, therefore this drug is not used in children. During pregnancy and breastfeeding. Experimental and clinical studies have not revealed the teratogenic effect of the drug. Clinical studies involving women in the third trimester of pregnancy have proven the effectiveness of the drug and have not revealed any risk to the fetus. Breastfeeding is not recommended while using the drug (due to the lack of sufficient data regarding the entry of the drug into breast milk). Impact on the ability to drive vehicles and operate precision machinery. The drug does not affect the ability to drive vehicles or operate machinery. If signs of a side effect of the drug appear (see SIDE EFFECTS), caution must be exercised.
Normoven's analogs
The most common analogues of Normoven include the following drugs:
- Venosmin;
- Venorin;
- Detralex;
- Dioflan;
- Juantal;
- Nostalex;
- Antistax;
- Ascorutin;
- Vasocket;
- Venorutinol;
- Venoruton;
- Venosmil;
- Ginkor Fort;
- Immunovit C;
- Indovazin;
- Indovenol;
- Troxevasin;
- Troxevenol;
- Troxegel;
- Troxerutin;
- Phlebodia;
- Phleboton.
Normoven price, where to buy
The cost of the medicine varies by region, for example, the average price of Normoven in Kharkov is 100 UAH per package containing 30 tablets, and in Kyiv for 150 UAH. You can purchase twice the amount of the drug.
- Online pharmacies in UkraineUkraine
Pharmacy24
- Normoven No. 30 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
108 UAH. order - Normoven No. 60 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
182 UAH order
