Pharmacy No. 84. Delivery of medicines to your home and office.

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Instructions for use TRICHOPOL

For trichomoniasis

Orally,
adults
are prescribed a single dose of 250 mg 2 times a day in the morning and evening after meals for 10 days. Simultaneous treatment of sexual partners is carried out. Women are simultaneously prescribed vaginal tablets, 1 tablet. (500 mg) in the evening for 10 days.

For amebiasis
adults
are prescribed 250 mg 3 times a day.
The course of treatment is 5-10 days; For children,
the dose is set at the rate of 35-50 mg/kg body weight/day. The daily dose should be divided into 3 doses. The course of treatment is 10 days.

For giardiasis

Orally,
children over 10 years of age
are prescribed 500 mg/day (in 2 doses);
children aged 6-10 years
- 375 mg/day (in 3 doses);
2-5 years
- 250 mg/day (in 2 doses). The course of treatment is 5-10 days. If necessary, treatment can be repeated after 4-6 weeks.

In the treatment of infectious diseases caused by anaerobic bacteria,

Trichopolum can be used in monotherapy or in combination with other antibiotics.
The course of treatment is 7-10 days. For adults and children over 12 years of age,
the drug is prescribed 250-500 mg 3 times a day;
for newborns and children under 12 years of age
- at the rate of 7.5 mg/kg body weight 3 times a day. The drug should be taken during or after meals.

To prevent infections caused by anaerobic bacteria

(before surgical operations on the abdominal cavity, in obstetric and gynecological practice),
adults and children over 12 years of age,
the drug is prescribed at a dose of 1 g, then 250 mg 3 times a day during or after meals until preoperative fasting;
children from 5 to 12 years old
are prescribed 125 mg every 8 hours for 2 days;
newborns and children under 5 years of age
are prescribed at a rate of 5 mg/kg every 8 hours for 2 days.

IV administration of Trichopolum is indicated for severe infection and in the absence of the possibility of taking the drug orally.

The solution for intravenous administration in 100 ml polyethylene bottles is ready for use. The solution that remains after administration is not reused. If there are visible changes in the solution, the drug should not be used.

Adults and children over 12 years old

the drug is prescribed intravenously every 8 hours, 100 ml of a 0.5% solution (500 mg). The infusion is carried out at a rate of 5 ml/min. The maximum daily dose for intravenous administration is 4 g. The course of infusion therapy is individual. In the future, depending on the severity of the infection, they switch to oral forms of Trichopolum.

Children under 12 years of age

The dose for intravenous administration is set at the rate of 7.5 mg/kg body weight every 8 hours. The drug is administered intravenously at a rate of 5 ml/min.

To prevent infections caused by anaerobic bacteria

(before planned surgery on the abdominal cavity and urinary tract),
adults and children over 12 years of age,
the drug is administered as an infusion at a dose of 0.5-1 g on the day of surgery and the next day at a dose of 1500 mg/day (500 mg every 8 hours ). After 1-2 days, they usually switch to oral maintenance therapy.

Patients with severe renal impairment (creatinine clearance less than 30 ml/min) and/or liver

the drug is prescribed in a daily dose of 1 g (in 2 doses).

For nonspecific vaginitis, bacterial vaginosis

the drug is prescribed 1 vaginal tablet per day for 7 days, if necessary in combination with oral metronidazole.

Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

The vaginal tablet should be removed from the contour packaging, moistened with boiled cooled water and inserted deep into the vagina.

Treatment should not be interrupted during menstruation.

Trichopolum

The drug is prescribed orally, during or after meals, the tablets are taken without chewing.

Trichomoniasis

Adults and children over 10 years of age are prescribed 250 mg (1 tablet) 3 times a day or 500 mg (2 tablets) 2 times a day for 7 days. Women must additionally be prescribed metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests.

An alternative treatment regimen is to prescribe 750 mg (3 tablets) in the morning and 1250 mg (5 tablets) in the evening or 2000 mg (8 tablets)/day once. The duration of treatment is 2 days. Treatment is carried out simultaneously for both sexual partners.

Children aged 3 to 7 years are prescribed 125 mg (1/2 tablet) 2 times a day; aged 7 to 10 years - 125 mg (1/2 tablet) 3 times a day. The course of treatment is 7 days.

Bacterial vaginosis

Adults are prescribed 500 mg (2 tablets) 2 times/day for 7 days or 2000 mg (8 tablets)/day once. Simultaneous treatment of the sexual partner is not required.

Amoebiasis

For invasive forms of intestinal amebiasis in susceptible patients (including amoebic dysentery), adults and children over 10 years of age are prescribed 750 mg (3 tablets) 3 times a day. Children aged 3 to 7 years - 250 mg (1 tablet) 4 times a day; at the age of 7 to 10 years - 375 mg (1.5 tablets) 3 times a day. The course of treatment is usually 5 days.

For intestinal amebiasis in less susceptible patients and for chronic amoebic hepatitis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of the course of treatment is 5-10 days.

For amoebic liver abscess and other forms of extraintestinal amebiasis, adults and children over 10 years of age are prescribed 375 mg (1.5 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The course of treatment is 5 days.

For asymptomatic carriage of cysts, adults and children over 10 years of age are prescribed 375-750 mg (1.5-3 tablets) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 4 times a day; at the age of 7 to 10 years - 250 mg (1 tablet) 3 times a day. The duration of the course of treatment is 5-10 days.

Giardiasis

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 2 times a day for 5-7 days; or 2000 mg (8 tablets) 1 time/day for 3 days.

Children aged 3 to 7 years - 250-375 mg (1-1.5 tablets) 1 time / day for 5 days, or 500-750 mg (2-3 tablets) 1 time / day for 3 days. Children aged 7 to 10 years - 250 mg (1 tablet) 2 times/day for 5 days, or 1000 mg (4 tablets) 1 time/day for 3 days.

Periodontal infections

For acute ulcerative gingivitis, adults and children over 10 years of age are prescribed 250 mg (1 tablet) 3 times a day. Children aged 3 to 7 years - 125 mg (1/2 tablet) 2 times a day; at the age of 7 to 10 years - 125 mg (1 tablet) 3 times a day. The duration of treatment is 3 days.

For acute odontogenic infections, adults and children over 10 years of age are prescribed 250 mg (1 tablet) 3 times a day for 3-7 days.

Infections caused by anaerobic bacteria

Treatment of anaerobic infections usually begins with IV infusions. As soon as possible, treatment should be continued with metronidazole tablets.

Adults and children over 10 years of age are prescribed 500 mg (2 tablets) 3-4 times a day. The duration of treatment should not exceed 7 days.

For children under 10 years of age, the use of metronidazole in the form of infusion solutions is recommended for the treatment of anaerobic infections.

Helicobacter pylori eradication

Prescribe 500 mg (2 tablets) 3 times/day for 7 days (as part of combination therapy, for example, with amoxicillin 2.25 g/day).

Prevention of infections caused by anaerobic bacteria (before abdominal surgery, in gynecology and obstetrics)

Adults and children over 12 years of age are prescribed 250-500 mg (1-2 tablets) 3 times a day 3-4 days before surgery. 1-2 days after surgery (when oral administration is already allowed), 250 mg (1 tablet) is prescribed 3 times a day for 7 days.

In case of severe renal failure (creatinine clearance less than 10 ml/min), the daily dose of Trichopolum should be reduced by 2 times.

Overdose

Symptoms: increased side effects, mainly nausea, vomiting and dizziness; in more severe cases, ataxia, paresthesia and convulsions are possible. The lethal dose for humans is unknown.

Treatment: symptomatic and supportive therapy. There is no specific antidote.

Trichopolum 500 mg 10 pcs. vaginal tablets polpharma

pharmachologic effect

A drug with antiprotozoal and antibacterial effects for topical use in gynecology.

Composition and release form Trichopolum 500 mg 10 pcs. vaginal tablets polpharma

Vaginal tablets - 1 tablet:

Active ingredients: metronidazole - 500 mg;
Excipients: microcrystalline cellulose, povidone, crospovidone, colloidal silicon dioxide, stearic acid.

10 pieces. - blisters (1) - cardboard packs.

Description of the dosage form

Vaginal tablets are white with a yellowish tint, oblong, biconvex.

Directions for use and doses

For trichomonas vaginitis, the drug is prescribed 1 vaginal tablet per day for 7-10 days in combination with taking metronidazole tablets.

For nonspecific vaginitis and bacterial vaginosis, the drug is prescribed 1 vaginal tablet per day for 7 days, if necessary in combination with taking metronidazole tablets.

Treatment with metronidazole should not last more than 10 days and be repeated more than 2-3 times a year.

The vaginal tablet should be removed from the contour packaging, moistened with boiled cooled water and inserted deep into the vagina.

Pharmacodynamics

Antiprotozoal drug with antibacterial activity for topical use in gynecology. Refers to nitro-5-imidazoles. The mechanism of action of metronidazole is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is an effective antimicrobial and antiprotozoal agent with a broad spectrum of action. Shows high activity against Trichomonas vaginalis, Gardnerella vaginalis, Giardia intestinalis, Entamoeba histolytica, Lamblia spp., as well as against obligate anaerobes - Bacteroides spp. (Bacteroides fragilis, Bacteroides ovatus, Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Clostridium spp., Peptostreptococcus spp., Peptococcuc spp., Eubacterium spp., Mobiluncus spp.).

Pharmacokinetics

Metronidazole is well absorbed when administered intravaginally. Biotransformed in the liver. It is excreted 40-70% (about 20% in unchanged form) by the kidneys.

Indications for use Trichopolum 500 mg 10 pcs. vaginal tablets polpharma

For local treatment:

nonspecific vaginitis;
bacterial vaginosis;
trichomonas vaginitis.

Contraindications

blood diseases;
leukopenia (including history);
impaired coordination of movements;
organic lesions of the central nervous system (including epilepsy);
liver failure (for use in high doses);
pregnancy (first trimester);
lactation (breastfeeding);
hypersensitivity to metronidazole or other nitroimidazole derivatives.

Application Trichopolum 500 mg 10 pcs. Polpharma vaginal tablets during pregnancy and breastfeeding

Metronidazole passes through the placenta, so the drug should not be prescribed in the first trimester of pregnancy. In the future, the drug should be used only if the potential benefit to the mother outweighs the possible risk to the fetus.

Metronidazole is excreted in breast milk. Breastfeeding should be discontinued during the period of use of the drug. Breastfeeding should be resumed no earlier than 48 hours after stopping the drug.

special instructions

It is recommended that the sexual partner be treated simultaneously with metronidazole, regardless of whether he or she has any manifestations of the disease.

During treatment with the drug, it is recommended to abstain from sexual intercourse.

If there are indications in the anamnesis of changes in the composition of peripheral blood, as well as when using the drug in high doses and/or during long-term treatment, monitoring of a general blood test is necessary.

Metronidazole may cause immobilization of treponemes, resulting in false-positive Nelson test results (TPI).

Impact on the ability to drive vehicles and operate machinery

The possibility of dizziness should be taken into account when prescribing the drug to patients engaged in potentially hazardous activities (especially vehicle drivers).

Overdose

Data on overdose of the drug Trichopolum are not provided.

Side effects Trichopolum 500 mg 10 pcs. vaginal tablets polpharma

Local reactions: itching, burning, pain and irritation in the vagina; thick, white, mucous vaginal discharge (odorless or with a slight odor), frequent urination; after discontinuation of the drug - development of vaginal candidiasis.

From the digestive system: nausea, changes in taste, metallic taste in the mouth, dry mouth, decreased appetite, abdominal cramps, nausea, vomiting, constipation or diarrhea.

From the side of the central nervous system: headache, dizziness.

From the hematopoietic system: leukopenia or leukocytosis.

Allergic reactions: urticaria, skin itching, rash.

Other: rarely - red-brown coloring of urine due to the presence of a water-soluble pigment formed as a result of the metabolism of metronidazole; a burning sensation or irritation of the penis in a sexual partner.

Drug interactions

The drug is compatible with sulfonamides and antibiotics.

Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.

You should not combine metronidazole with disulfiram, since the interaction of these drugs may cause depression of consciousness and the development of mental disorders.

When used simultaneously with indirect anticoagulants (including warfarin), metronidazole enhances their effect, which leads to an increase in prothrombin time.

It is not recommended to use metronidazole in combination with non-depolarizing muscle relaxants (vecuronium bromide).

Under the influence of barbiturates, the effectiveness of metronidazole may decrease due to acceleration of its metabolism in the liver.

Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood plasma and an increased risk of adverse reactions.

When taken simultaneously with lithium preparations, it is possible to increase its concentration in the blood plasma.