Compound
Nurofen for children in the form of a suspension contains ibuprofen , the syrup also contains additional components: glycerol , maltitol syrup, citric acid, sodium saccharinate, sodium citrate, flavoring, sodium chloride, domiphen bromide, xanthan gum, polysorbate 80, water.
Nurofen for children in the form of suppositories contains ibuprofen, as well as additional components: solid fat 1 (vitepsol H15) and solid fat 2.
Release form
The drug is produced in the form of a suspension and rectal suppositories.
Nurofen syrup for children is a whitish syrupy suspension that may have an orange or strawberry flavor. The product is contained in bottles of 100 ml or 150 ml. The kit also includes a special dispenser syringe.
Nurofen in suppositories for children is white, the suppositories are smooth, torpedo-shaped. Aluminum blisters contain 5 pieces each, cardboard boxes contain two such blisters.
Indications for use
Nurofen syrup for children and Nurofen suppositories for children are indicated for use in children aged 3 months to 12 years as an antipyretic drug for diseases that are accompanied by an increase in body temperature. Nurofen for children is prescribed for the following diseases:
- acute respiratory diseases;
- childhood infections;
- flu;
- body reactions after vaccinations.
It is also used as a pain reliever for the following diseases and conditions:
- headache and toothache ;
- migraine;
- neuralgia;
- pain in the throat, ears;
- during teething;
- other types of pain.
Contraindications
Nurofen for children is contraindicated in the following cases:
- with high sensitivity to ibuprofen and drug components;
- for urticaria , bronchial asthma , rhinitis, which appeared after taking acetylsalicylic acid or other NSAIDs;
- with high sensitivity to acetylsalicylic acid or other NSAIDs;
- for erosions or ulcers of the gastrointestinal tract;
- in case of inflammatory bowel diseases;
- with active bleeding from the gastrointestinal tract;
- in case of confirmed hyperkalemia;
- with liver or kidney failure;
- for blood diseases;
- with hearing loss.
Nurofen for children should be taken with caution by those who take other analgesics and by children with liver and kidney diseases. The drug is also carefully prescribed to children who have a history of gastritis, peptic ulcer, bleeding from the gastrointestinal tract, or ulcerative colitis .
Treatment is carried out with caution in the presence of Helicobacter pylori, when the patient is taking antihypertensive drugs, indirect anticoagulants, antiplatelet agents, corticosteroids, diuretics, methotrexate, lithium preparations.
In such cases, before starting treatment, you must consult a doctor who will determine the optimal dosage and frequency of administration.
Nurofen suppositories are not prescribed for proctitis or for children whose body weight is less than 6 kg.
Nurofen 60 mg N10 rectal suppositories for children
Release form
Rectal suppositories (for children).
5 suppositories in an aluminum blister. The inner side of the blister is covered with a layer of polyethylene, the outer side is coated with varnish. Two blisters are placed together with instructions for use in a cardboard box.
Package
10 pieces.
pharmachologic effect
Nurofen for children in suppository format is suitable for the youngest children from 3 months to 2 years *. Fights fever and pain, lasting up to 8 hours.
The mechanism of action of ibuprofen, a propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins, mediators of pain, inflammation and hyperthermic reaction. Indiscriminately blocks cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2), as a result of which it inhibits the synthesis of prostaglandins. In addition, ibuprofen reversibly inhibits platelet aggregation. It has analgesic, antipyretic and anti-inflammatory effects. The analgesic effect is most pronounced for inflammatory pain. The effect of the drug lasts up to 8 hours.
*Depending on the child’s body weight, as specified in the instructions for use of the drug
Indications
Nurofen® rectal suppositories for children are used in children from 3 months to 2 years of age for symptomatic treatment as an antipyretic for acute respiratory diseases (including influenza), childhood infections, other infectious and inflammatory diseases and post-vaccination reactions accompanied by fever bodies.
The drug is used as a symptomatic analgesic for pain of mild or moderate intensity, including toothache, headache, migraine, neuralgia, ear pain, sore throat, sprain pain, muscle pain, rheumatic pain, joint pain and other types of pain.
The drug is recommended for use when taking oral medications (for oral administration) is impossible or in the presence of vomiting.
The drug is intended for symptomatic therapy, reducing pain and inflammation at the time of use, and does not affect the progression of the disease.
Contraindications
- Hypersensitivity to ibuprofen or any of the components included in the drug.
- A history of hypersensitivity reactions (bronchial asthma, bronchospasm, rhinitis, rhinosinusitis, recurrent polyposis of the nose or paranasal sinuses, Quincke's edema, urticaria) in response to the use of acetylsalicylic acid or other NSAIDs.
- A history of bleeding or perforation of a gastrointestinal ulcer caused by the use of NSAIDs.
- Erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding).
— Severe liver failure or active liver disease.
— Severe renal failure (creatinine clearance <30 ml/min), progressive kidney disease, confirmed hyperkalemia.
— Decompensated heart failure, the period after coronary artery bypass surgery.
— Blood clotting disorders (including hemophilia, prolongation of bleeding time, tendency to bleed, hemorrhagic diathesis).
— Pregnancy (III trimester).
— Child’s body weight is up to 6 kg.
- Proctitis.
- Intracranial hemorrhage.
Precautions for use
If you have the conditions listed in this section, you should consult your doctor before using the drug.
Concomitant use of other NSAIDs, a history of a single episode of gastric ulcer or ulcerative bleeding of the gastrointestinal tract, gastritis, enteritis, colitis, the presence of Helicobacter pylori infection, ulcerative colitis; bronchial asthma or allergic diseases in the acute stage or in history - bronchospasm may develop; severe somatic diseases, systemic lupus erythematosus or mixed connective tissue disease (Sharpe's syndrome) - increased risk of aseptic meningitis; renal failure, including dehydration (creatinine clearance 30-60 ml/min), fluid retention and edema, liver failure, arterial hypertension and/or heart failure, cerebrovascular diseases, dyslipidemia/hyperlipidemia, diabetes mellitus, peripheral arterial diseases, blood diseases of unknown etiology (leukopenia, anemia); simultaneous use of other medications that may increase the risk of ulcers or bleeding, in particular, oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine , paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel); pregnancy (I-II trimester), breastfeeding period, old age.
Use during pregnancy and breastfeeding
The use of the drug is contraindicated in the third trimester of pregnancy. If possible, the use of ibuprofen should be avoided in the first and second trimesters of pregnancy. There is evidence that ibuprofen can pass into breast milk in small quantities without any adverse effects on the health of the nursing infant.
special instructions
It is recommended to take the drug for the shortest possible course and in the minimum effective dose necessary to eliminate symptoms.
During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a complete blood count (hemoglobin determination), and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms
Patients who experience dizziness, drowsiness, lethargy, or blurred vision while taking ibuprofen should avoid driving or operating machinery.
Compound
One suppository contains the active ingredient ibuprofen 60 mg and excipients: solid fat 1 (Vitepsol N 15), solid fat 2 (Vitepsol W 45).
Directions for use and doses
Nurofen® for children are suppositories specially designed for children. For rectal use. For short term use only.
Read the instructions carefully before using the drug.
Fever (fever) and pain
The dosage for children depends on the age and body weight of the child.
The maximum daily dose should not exceed 30 mg/kg of the child’s body weight with intervals between doses of the drug of 6-8 hours.
Children aged 3-9 months (6.0 kg - 8.0 kg): 1 suppository (60 mg) up to 3 times within 24 hours, no more than 180 mg per day.
Children aged 9 months - 2 years (8.0 kg - 12.0 kg): 1 suppository (60 mg) up to 4 times within 24 hours, not more than 240 mg per day.
The duration of treatment is no more than 3 days. Do not exceed the indicated dose.
If symptoms persist or worsen after taking the drug within 24 hours (in children aged 3-5 months) or within 3 days (in children aged 6 months and older), you should stop treatment and consult a doctor.
Post-immunization fever
1 suppository for children under 1 year of age; if necessary, 1 more suppository after 6 hours. Do not use more than 2 suppositories (120 mg) within 24 hours.
Side effects
The risk of side effects can be minimized if the drug is taken in a short course, at the minimum effective dose required to eliminate symptoms.
Side effects are predominantly dose-dependent. The following adverse reactions were observed with short-term use of ibuprofen in doses not exceeding 1200 mg/day. When treating chronic conditions and with long-term use, other adverse reactions may occur.
The frequency of adverse reactions was assessed based on the following criteria: very common (>= 1/10), common (>= 1/100 to < 1/10), uncommon (>= 1/1000 to < 1/100) , rare (>= 1/10,000 to < 1/1000), very rare (< 1/10,000), frequency unknown (no frequency estimates available).
Blood and lymphatic system disorders
Very rare: hematopoietic disorders (anemia, leukopenia, aplastic anemia, hemolytic anemia, thrombocytopenia, pancytopenia, agranulocytosis). The first symptoms of such disorders are fever, sore throat, superficial oral ulcers, flu-like symptoms, severe weakness, nosebleeds and subcutaneous hemorrhages, bleeding and bruising of unknown etiology.
Immune system disorders
Uncommon: hypersensitivity reactions - nonspecific allergic reactions and anaphylactic reactions, reactions from the respiratory tract (bronchial asthma, including its exacerbation, bronchospasm, shortness of breath, dyspnea), skin reactions (itching, urticaria, purpura, Quincke's edema, exfoliative and bullous dermatoses, including toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme), allergic rhinitis, eosinophilia.
Very rare: severe hypersensitivity reactions, including swelling of the face, tongue and larynx, shortness of breath, tachycardia, hypotension (anaphylaxis, Quincke's edema or severe anaphylactic shock).
Gastrointestinal disorders
Uncommon: abdominal pain, nausea, dyspepsia.
Rare: diarrhea, flatulence, constipation, vomiting.
Very rare: peptic ulcer, perforation or gastrointestinal bleeding, melena, hematemesis, ulcerative stomatitis, gastritis.
Frequency unknown: exacerbation of ulcerative colitis and Crohn's disease.
Urinary system and liver disorders
Very rare: acute renal failure, especially with long-term use, in combination with an increase in urea levels in the blood plasma and the appearance of edema, papillary necrosis, liver dysfunction, hepatitis.
Nervous system disorders
Uncommon: headache.
Very rare: aseptic meningitis (in patients with autoimmune diseases).
Cardiovascular disorders
Frequency unknown: heart failure, peripheral edema, with long-term use there is an increased risk of thrombotic complications (for example, myocardial infarction, stroke), increased blood pressure.
Disorders of the respiratory system and mediastinal organs
Frequency unknown: bronchial asthma, bronchospasm, shortness of breath.
Others
Very rare: edema, including peripheral edema.
Laboratory indicators
- hematocrit or hemoglobin (may decrease)
- bleeding time (may increase)
- plasma glucose concentration (may decrease)
- creatinine clearance (may decrease)
- plasma creatinine concentration (may increase)
- activity of “liver” transaminases (may increase)
If side effects occur, you should stop taking the drug and consult a doctor.
Drug interactions
The simultaneous use of ibuprofen with the following drugs should be avoided:
Acetylsalicylic acid: with the exception of low doses of acetylsalicylic acid (no more than 75 mg per day) prescribed by a doctor, since combined use may increase the risk of side effects. With simultaneous use, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (an increase in the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent is possible after starting ibuprofen).
Other NSAIDs, including selective COX-2 inhibitors: The simultaneous use of two or more drugs from the NSAID group should be avoided due to a possible increased risk of side effects.
Use with caution simultaneously with the following medications:
Anticoagulants and thrombolytic drugs: NSAIDs may enhance the effect of anticoagulants, in particular warfarin and thrombolytic drugs.
Antihypertensives (ACE inhibitors and angiotensin II antagonists) and diuretics: NSAIDs may reduce the effectiveness of drugs in these groups. Diuretics and ACE inhibitors may increase the nephrotoxicity of NSAIDs.
Corticosteroids: Increased risk of gastrointestinal ulceration and gastrointestinal bleeding.
Antiplatelet agents and selective serotonin reuptake inhibitors: increased risk of gastrointestinal bleeding.
Cardiac glycosides: simultaneous administration of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.
Lithium preparations: there is evidence of the likelihood of an increase in the concentration of lithium in the blood plasma during the use of NSAIDs.
Methotrexate: there is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.
Cyclosporine: increased risk of nephrotoxicity when NSAIDs are administered concomitantly with cyclosporine.
Mifepristone: NSAIDs should be started no earlier than 8 to 12 days after taking mifepristone, as NSAIDs may reduce the effectiveness of mifepristone.
Tacrolimus: When NSAIDs and tacrolimus are coadministered, the risk of nephrotoxicity may increase.
Zidovudine: Concomitant use of NSAIDs and zidovudine may result in increased hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received concomitant treatment with zidovudine and ibuprofen. Quinolone antibiotics: In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may be increased.
Overdose
In children, overdose symptoms may occur after taking a dose of the drug exceeding 200 mg/kg of the child’s body weight.
Symptoms:
nausea, vomiting, epigastric pain or, less commonly, diarrhea, tinnitus, headache and gastrointestinal bleeding. In more severe cases, manifestations from the central nervous system are observed: drowsiness, rarely - agitation, convulsions, disorientation, coma. In cases of severe poisoning, metabolic acidosis and increased prothrombin time, renal failure, liver tissue damage, decreased blood pressure, respiratory depression and cyanosis may develop. In patients with bronchial asthma, exacerbation of this disease is possible.
Treatment:
symptomatic, with mandatory maintenance of airway patency, monitoring of ECG and vital signs until the patient’s condition is normalized. Frequent or prolonged seizures should be treated with intravenous diazepam or lorazepam. If bronchial asthma worsens, the use of bronchodilators is recommended.
Storage conditions
At a temperature not higher than 25°C. In a dry place.
Best before date
2 years.
Do not use a drug that has expired.
Side effects
When taking Nurofen suspension and Nurofen Suppositories for children, side effects are observed only in rare cases. The following negative manifestations may develop:
- Gastrointestinal tract : pain or discomfort in the epigastrium, vomiting, nausea, diarrhea , ulcers and erosions of the gastrointestinal tract, bleeding from the gastrointestinal tract;
- nervous system : headache, insomnia , agitation;
- allergic manifestations : itching , rash, urticaria, angioedema, bronchospasm, anaphylactic shock , exacerbation of bronchial asthma, fever, toxic epidermal necrolysis, erythema multiforme;
- cardiovascular system : increased blood pressure, tachycardia ;
- hematopoiesis: thrombocytopenia, anemia, leukopenia, agranulocytosis;
- urinary system : cystitis , renal dysfunction.
Overdose
The use of a dose of 200 mg/kg body weight in children may cause intoxication.
Symptoms
Symptoms of overdose may include the following: nausea, vomiting, epigastric pain, or less commonly, diarrhea. Nystagmus, blurred vision, tinnitus, headache, and gastrointestinal bleeding may also occur. With more severe poisoning, toxic damage to the central nervous system is possible in the form of vertigo, dizziness, drowsiness, and sometimes agitation and disorientation or coma. Sometimes patients develop seizures. In severe poisoning, hyperkalemia and metabolic acidosis may occur, as well as an increase in PT/INR (probably due to interaction with coagulation factors circulating in the bloodstream). Acute renal failure, liver damage, hypotension, respiratory depression and cyanosis may occur. In patients with bronchial asthma, exacerbation of asthma is possible.
Treatment
There is no specific antidote. Treatment should be symptomatic and supportive and include airway management and monitoring of cardiac function and vital signs until the patient's condition returns to normal.
Children's Nurofen, instructions for use (Method and dosage)
Suspension and suppositories are forms of Nurofen that were developed specifically for children. Tablets, capsules - forms developed for adult patients.
Instructions for Nurofen syrup for children
The dosage of the suspension is calculated taking into account the child’s body weight. The drug must be taken orally. The dose is calculated at the rate of 5-10 mg of the drug per 1 kg of child’s body weight. The daily dose should not exceed 30 mg per 1 kg of patient body weight.
If a child under 1 year of age develops a fever after immunization, he is prescribed a suspension at a dose of 50 mg (2.5 ml). For children over 1 year of age, if necessary, the drug is given again in the same dose after 6 hours. More than 5 ml of medication should not be used during the day.
Nurofen syrup should not be used as an antipyretic drug for more than three days, or as an analgesic for more than 5 days. If the patient's fever persists, a doctor should be consulted
Shake the suspension thoroughly before use. It should be taken into account that 5 ml of suspension contains 100 mg of ibuprofen, and use a measuring syringe to dose the medication.
Nurofen suppositories for children, instructions for use
Suppositories are used rectally. For children who have fever and pain, the dose is determined depending on the age and weight of the baby. A single dose is from 5-10 mg per 1 kg of weight, depending on the disease and age, the drug should be administered 3-4 times a day. The maximum permissible daily dose is 30 mg per 1 kg of weight.
Children from 3 to 9 months should receive 1 sup. three times a day, with an interval of 6-8 hours.
Children from 9 months to 2 years old receive 1 supp. Four times a day, with an interval of 6 hours.
In case of fever after immunization, children under 1 year of age are prescribed 1 supp., children over 1 year of age receive 1 supp., if necessary, 1 supp. can be administered after six hours. again.
Treatment with the drug as an antipyretic drug lasts no more than 3 days, and as an analgesic the drug is used for no more than 5 days. If symptoms persist, you should definitely consult a specialist.
How long it takes for it to take effect depends on the child’s condition. However, the dosage of Nurofen syrup for children and suppositories should not be exceeded.
Features of application
Pregnant
Suppression of prostaglandin synthesis may negatively affect pregnancy and/or embryonic/fetal development. Data from epidemiological studies indicate an increased risk of miscarriage, congenital heart defects and gastroschisis after the use of prostaglandin synthesis inhibitors in early pregnancy. Ibuprofen is contraindicated during the third trimester of pregnancy.
Ibuprofen and its metabolites pass into breast milk in low concentrations. To date, there is no evidence of negative effects on the infant, so short-term treatment of pain and fever with recommended doses usually does not require interrupting breastfeeding.
There is some evidence that drugs that inhibit cyclooxygenase/prostaglandin synthesis may impair female fertility by affecting ovulation. This effect is reversible when treatment is discontinued.
Drivers
If used in accordance with the recommended doses and duration of treatment, the drug is not expected to affect the ability to drive vehicles or use other mechanisms.
Interaction
If you take Nurofen for children simultaneously with anticoagulants, the effect on the body of the latter may be enhanced.
When taken simultaneously, children's Nurofen increases the concentration of phenytoin, digoxin , lithium, and methotrexate in the blood.
The simultaneous use of children's Nurofen with antihypertensive drugs and diuretics may lead to a weakening of the effect of the latter. Diuretics can also increase the degree of nephrotoxicity of NSAIDs.
Nurofen for children, when taken simultaneously, may increase the side effects of glucocorticoids and mineralocorticoids.
Concomitant use with GCS increases the patient's risk of developing gastrointestinal bleeding and ulcers.
Taking medications with cardiac glycosides can lead to exacerbation of heart failure, as well as provoke a decrease in glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood.
When using Nurofen for children and drugs from the cyclosporine group, tacrolimus, the degree of nephrotoxicity increases.
The risk of hepatotoxicity increases if simultaneous use with Zidovudine .
The simultaneous use of children's Nurofen and drugs of the quinolone group increases the risk of developing seizures.
If the simultaneous use of Nurofen and Mifepristone , the effectiveness of the latter is reduced, therefore, Nurofen for children can be taken no earlier than 8-12 days after completion of treatment with mifepristone .
Side effects
The most commonly observed adverse reactions were from the gastrointestinal tract. Most adverse reactions are dose dependent. In particular, the risk of gastrointestinal bleeding depends on the dose and duration of treatment. Gastrointestinal ulcers, perforation, or gastrointestinal bleeding may occur, sometimes fatal, especially in elderly patients. Nausea, vomiting, diarrhea, bloating, constipation, dyspepsia, abdominal pain, melena, hematemesis, ulcerative stomatia, exacerbation of colitis and Crohn's disease have been reported after the use of ibuprofen. Gastritis was observed less frequently.
Analogs
Level 4 ATC code matches:
Artrum
Brustan
Ketonal Duo
Nurofen Plus
Nurofen Express
Nurofen Forte
Nurofen Express Lady
Nurofen
Ibuprom
Ibuprofen
Advil
MIG 400
Has
Ketoprofen
Vimovo
Naproxen
Flexen
Nalgesin
Flamax
Novigan
Analogues of the drug are Bofen , Brufen Forte , Ibunorm Baby , Ibufen for children , Orafen . When using any analogue, you should first agree with your doctor.
Which is better: Panadol or Nurofen for children
The drug Panadol contains another active ingredient - paracetamol . But the effect on the body of both drugs is similar.
Panadol is also available in suspension form, making it convenient to give to a child. The final decision on the choice of medication should be made by the doctor.
Note!
Description of the drug Nurofen for children sup. rectal 60mg No. 10 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Children's Nurofen during pregnancy and lactation
During pregnancy , Nurofen for children can be used in the first two trimesters, but only according to strict indications and under the supervision of a doctor. Treatment with the drug in the last months of pregnancy is not allowed, as this may provoke the development of uterine contractions.
When breastfeeding, children's Nurofen is not prescribed. If there is a need for treatment, the specialist selects other pills or advises you to stop breastfeeding.
Price of children's Nurofen, where to buy
When buying Nurofen children's syrup, you can find out the price directly at the pharmacy. On average, a 150 ml bottle costs 200 rubles.
The price of Nurofen for children in suppositories is on average 100-110 rubles per 10 pieces. You can buy suppositories at the pharmacy without a prescription.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Nurofen for children susp.
for internal approx. strawberry 100mg/5ml fl. 200ml Reckitt Benckiser Healthcare International Ltd RUB 214 order
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Pharmacy24
- Nurofen for children 60 mg N10 suppositories Famar S.A., Greece/Famar A.V.E, Greece
55 UAH.order
