Procto-glivenol ointment: description
The drug is produced in the form of ointments and suppositories, which are administered rectally. They contain 2 active ingredients - tribenoside and didocaine in the form of hydrochloride. Auxiliary components are: liquid paraffin, cetyl alcohol, sorbitan in the form of stearate, stearic acid, water and others.
The drug is stored at room temperature up to 25 degrees, in the absence of sunlight. Keep out of reach of children. Candles can only be stored in the refrigerator. Shelf life is 12 months if storage rules are observed. The ointment is packaged in convenient metal tubes weighing 30 g.
Side effects
The drug is safe for health, side effects are extremely rare. They are associated with the following manifestations:
- swelling of the face;
- bronchospasm;
- disruption of the heart;
- anaphylactic reaction;
- hives;
- rashes;
- burning sensation;
- itching
The described symptoms can occur both at the site of application of the ointment and beyond. The reason is that the active components penetrate the bloodstream and have a systemic effect. If side effects occur, stop taking the ointment immediately and consult a doctor. If necessary, symptomatic treatment is indicated.
Procto-ointment for hemorrhoids, 20 g
Topical treatment with corticosteroids may cause local adverse events.
With prolonged topical use or application to large surfaces of the skin, suppression of the function of the adrenal cortex is possible. This is especially common when applying the ointment to children or under occlusive dressings. Protein catabolism can lead to negative nitrogen balance.
Systemic absorption of large amounts of lidocaine following topical application may result in stimulation and/or depression of the central nervous system.
Depending on the amount of GCS and lidocaine absorbed, the following side effects may occur:
infections and invasions: activation of subclinical infections, masking the manifestations of infections, opportunistic infections;
from the immune system: hypersensitivity reactions,
from the endocrine system: suppression of the function of the adrenal cortex, hypercortisolism (as a manifestation of the resorptive effect of prednisolone)
nutritional and metabolic disorders: hypokalemic alkalosis, sodium and fluid retention in the body, hypokalemia
mental disorders: insomnia, mental disorders;
from the central nervous system: convulsions, dizziness, headache, increased intracranial pressure,
from the visual organs: cataract (the likelihood of developing cataracts is greater in children), subcapsular cataract, exophthalmos, glaucoma, papilledema, corneal ulcer;
From the heart: heart failure, cardiac conduction disorders
from the blood vessels: arterial hypertension, peripheral vasodilation
from the digestive tract: gastric bleeding, gastrointestinal bleeding, perforation of the digestive tract, esophagitis, pancreatitis, peptic ulcer;
on the part of the skin and subcutaneous tissues: dermatitis, folliculitis (at the site of application), acne-type rashes (steroid acne), contact dermatitis, dryness, thinning and vulnerability of the skin; erythema, rash, urticaria, hirsutism, hyperhidrosis, diaper rash, itching, skin atrophy, hypopigmentation, skin irritation, formation of striae, telangiectasia, burning skin, purpura
Musculoskeletal and connective tissue disorders: growth retardation, steroid myopathy, osteonecrosis, osteoporosis
general disorders and disorders at the injection site: delayed wound healing;
studies: increased intraocular pressure, negative nitrogen balance, delayed reaction in skin provocative tests.
Procto-glivenol ointment: instructions for use
The ointment is taken externally only. It is applied to the rectal area 1 or 2 times a day - in the morning and in the evening. If regression of acute symptoms is observed, only a single dose is allowed.
The day before, it is important to have a bowel movement (if necessary), as well as perform hygiene of the anal area. If internal hemorrhoids are detected, the ointment is applied using a special nozzle. 1 g of product is applied at a time, so a 30 g tube is enough for 30 applications.
Procto ointment ointment for rectal and external use 20g
Composition: each tube (20 g) contains: active ingredient: bufexamac – 1.0 g, bismuth subgallate – 1.2 g, lidocaine hydrochloride – 0.1 g; excipients: titanium dioxide, lanolin, soft paraffin, yellow, paraffin oil, polyvinylpyrrolidone, isopropyl palmitate, sorbitan sesquioleate, non-crystallizing sorbitol solution, purified water.
Pharmacotherapeutic group: other topical drugs for the treatment of hemorrhoids.
Pharmacological properties Drug for local treatment of diseases of the anorectal region.
Bufexamac is a derivative of arylacetic acid. It has an anti-inflammatory effect due to inhibition of prostaglandin synthesis. Bismuth subgallate and titanium dioxide – have an astringent and drying effect, promote wound healing. Lidocaine is an amide-type local anesthetic.
Indications for use: hemorrhoids of 1st and 2nd degree; – anal fissures; – acute and chronic anal eczema; – inflammatory processes in the rectal area (including proctitis).
Directions for use and doses
For external use, the ointment is applied to the affected area of the anus 2 times a day. Before use, skin should be washed with warm water and a soft cloth (no soap). Squeeze a small amount of ointment (about the size of a pea) onto your finger and lubricate the area around the anus and inside the anal ring. To overcome sphincter resistance, you need to apply the ointment with your fingertip into the rectum 1-2 times a day (if possible after bowel movements). It is recommended to continue using the drug for 8-10 days after the acute effects have subsided.
Side effects
Allergic reactions: burning, itching, redness of the skin of the perianal area, swelling, formation of scales and blisters.
Contraindications – specific inflammatory processes (including syphilis, tuberculosis); - childhood; – pregnancy; – lactation period (breastfeeding); – hypersensitivity to the components of the drug.
special instructions
With the simultaneous use of Procto Ointment and condoms, the strength of condoms may decrease, which reduces their reliability.
The patient should be warned that if there is no effect or any adverse reactions occur, it is necessary to stop using the drug and consult a doctor.
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Information about the appearance, color of the product, delivery set and technical characteristics is for reference only and is based on the latest information available at the time of publication
Overdose and special instructions
According to the instructions, cases of overdose have not been described to date. If the drug is accidentally ingested, gastric lavage is indicated. If necessary, seek medical help and carry out symptomatic treatment.
If you do not feel better within a few days and/or new unusual symptoms appear, you should stop taking the drug and consult a doctor for advice.
During treatment, it is important to constantly maintain hygiene in the anal area and avoid too much strain while sitting. If necessary, you need to replace the chair or chair with a softer one.
The drug does not contain substances that affect psychomotor reactions. Therefore, it can be used by drivers, operators of machine tools and other potentially dangerous mechanisms.
Cases of drug interactions have not been described. The product can be combined with various medications. But in the case of using ointments or rectal suppositories, they must be administered separately at intervals of several hours.
During pregnancy (2nd, 3rd trimesters) and during breastfeeding, the product can be used with caution, with prior agreement with your doctor. The drug may be used only in cases where the expected benefit clearly outweighs the risks to the health of the mother and child.
Procto ointment for rectal and external use 20g No. 1
Name
Procto ointment drect. and nar.prim. in tubes 20g in pack No. 1
Description
Yellow ointment of uniform consistency.
Release form
ointment for rectal and external use
Dosage
20 g
Pharmacological properties
Pharmacodynamics
A special combination of active ingredients in the ointment provides a significant reduction in pain in a short time. The local anesthetic lidocaine quickly relieves painful symptoms such as burning and itching. Lidocaine has a medium potency, medium duration, and rapid onset of action compared to other local anesthetics. Bismuth has an astringent effect, which reduces the tendency to bleed. Damaged tissues are protected from further irritation, the surface remains dry. The inflammation inhibitor bufexamac promotes healing and restoration of healthy mucosa. The ointment provides rapid reduction of hemorrhoidal pain, reduction and attenuation of hemorrhoid symptoms. Stool occurs easier and less painful. Titanium dioxide potentiates the therapeutic effect of bismuth subgallate and bufexamac. The ointment base of the drug protects the surface of the wound and facilitates emptying.
Pharmacokinetics
When 5 g of 5% bufexamac ointment base was applied to the skin, the metabolic concentration was below the limit determined by gas chromatography. Lidocaine is rapidly absorbed from the gastrointestinal tract through mucous membranes or damaged skin.
Indications for use
Hemorrhoids of 1st and 2nd degrees, anal fissures (acute anal fissures), acute and chronic eczema of the anus, inflammatory processes in the anus and rectum (proctitis).
Directions for use and doses
a) External use: the ointment is applied twice a day to the affected area of the anus and lightly massaged. Before use, skin should be washed with warm water (without soap) and dried with a soft cloth. b) Insertion into the anus or intestine: by squeezing a small amount of ointment (about the size of a pea) onto your finger, you need to lubricate the area around the anus and inside the anal ring. For deeper insertion into the rectum, place the applicator on the tube of ointment, make sure that it is inserted deep enough into the rectum and then, gently pressing the tube from the lower end, gradually remove the applicator. The ointment is used twice a day (if possible after bowel movement). The ointment should be used until acute symptoms subside. After the acute inflammation has reduced, it is recommended to continue therapy to consolidate the treatment results. Treatment with the drug should last no more than 7 days. For longer-term treatment, medications that do not contain local anesthetics are used.
Use during pregnancy and lactation
There is no clinical experience with the use of the drug Procto Ointment during pregnancy and breastfeeding, so it is not used during these periods.
Precautionary measures
With the simultaneous use of Procto Ointment and condoms, the strength of condoms may decrease, which reduces their reliability. The patient should be warned that if there is no effect or any adverse reactions occur, it is necessary to stop using the drug and consult a doctor.
Interaction with other drugs
Interaction with other drugs has not been described.
Contraindications
Hypersensitivity to any of the components of the drug, specific skin processes in the area of application (syphilis, tuberculosis); contact allergic reactions and atopic dermatitis in the medical history.
Compound
One tube (20 g) contains: active ingredients: bufexamac – 1.0 g, bismuth subgallate – 1.0 g, titanium dioxide E 171 – 1.0 g, lidocaine hydrochloride – 0.1 g; excipients: lanolin, soft yellow paraffin, petroleum jelly, povidone K-17, isopropyl palmitate, sorbitan sesquioleate, sorbitol non-crystallizing solution, purified water.
Overdose
Data on drug overdose are unknown and unlikely if the drug is used as directed (i.e. topically in limited areas).
Side effect
Rare: As a result of hypersensitivity to any component of the drug, skin reactions may occur, such as swelling of the skin followed by the formation of blisters, discharge and peeling. Also, these reactions may involve areas of skin that were not treated. In rare cases, these symptoms may be clearly visible. Very rare: large areas of skin may be affected due to hypersensitivity to the components of the drug. Hypersensitivity to any of the components of the drug usually manifests itself in the form of local irritation (erythema, redness, itching). If hypersensitivity reactions occur, as well as a sharp deterioration in skin condition, you should immediately stop using the drug.
Storage conditions
At a temperature not higher than 25? C. Keep out of the reach of children.
