Biologically active food supplement “Indinol” (capsules 300 mg) No. 60
Product description
Dietary supplement Not a medicine.
Dosage form
Capsules.
Purpose
For women.
Compound
1 capsule contains 90 mg indole-3-carbinol.
pharmachologic effect
Indinol is a biologically active food supplement that is a universal hyperplastic corrector of pathological processes in the organs and tissues of the female reproductive system (breast, endometrium, myometrium, cervix, ovaries). Normalizes the balance of estrogen in the body and suppresses their negative stimulating effect, and also blocks other (hormone-independent) mechanisms that activate pathological cellular growth in the tissues of the mammary gland and uterus. It has the ability to cause selective death of transformed cells with abnormally high proliferative activity.
Indications
Indinol is recommended as a dietary supplement to food - an additional source of indole-3-carbinol. It is recommended to use: for the prevention of fibrocystic mastopathy and as part of its complex treatment, as well as for the correction of the functional states of the mammary glands caused by this pathology; in combination with the dietary supplement Epigallat in the complex therapeutic treatment of endometriosis, adenomyosis, uterine fibroids and endometrial hyperplasia without atypia, as well as for the prevention of relapse of these diseases after surgical treatment; in the complex treatment of genital diseases in women associated with the human papillomavirus: cervical dysplasia (cervical intraepithelial neoplasia), anogenital condylomatosis.
Contraindications
Individual intolerance to the components of the drug. Not recommended for people taking medications that reduce gastric acidity, as well as for pregnant and lactating women. Consult your healthcare practitioner before use.
How to take, course of administration and dosage
For fibrocystic mastopathy, Indinol is recommended to be taken orally, 1 capsule per day with meals for 2-3 weeks. As part of combination therapy (endometrial hyperplasia without atypia, endometriosis, adenomyosis, uterine fibroids), Indinol is recommended to be taken orally in combination with the dietary supplement Epigallat (1 capsule + 1 capsule) with meals for 2-3 weeks. Longer use is possible on the recommendation of a doctor. For genital diseases associated with the human papillomavirus, take 1 capsule orally once a day in combination with immunomodulator drugs used as standard treatment for these diseases. In this case, both sexual partners must undergo treatment.
Storage conditions
Store in a dry place at room temperature.
Best before date
2 years.
Conditions for dispensing from pharmacies
Over the counter.
Buy Indinol caps. 300 mg No. 60 in the pharmacy
Price for Indinol caps. 300 mg No. 60
Instructions for use for Indinol caps. 300 mg No. 60
Indinol Forto
Indinol Forto (indolecarbinol) is a selective estrogen receptor modulator. Indicated for specific conditions of the mammary glands, which manifest as discomfort and are characterized by pain of varying severity. Prevents hyperplasia of mammary gland tissue. It is an estrogen antagonist. Suppresses excessive proliferation of mammary gland tissue, because causes loss of viability of cells with pathologically high proliferative activity. Potentiates the reaction of the addition of a hydroxyl radical to the estrogen molecule in the 2nd position. The resulting metabolic product blocks the activation of estrogen receptors. As a result, the expression of estrogen-dependent genes is suppressed, which leads to a decrease in stimulation of cells and tissues by estrogen. The use of the drug as part of a full medication course allows you to reduce the intensity and/or completely relieve pain in the mammary gland. Using this medicine does not cause weight gain. The drug has virtually no toxicity. A single dose of Indinol Forto is 200 mg, the frequency of administration is twice a day. The duration of the course of pharmacotherapy is six months. The drug has a favorable safety profile and is well tolerated by women. Possible side effects: lengthening or shortening of the menstrual cycle, epigastric pain, weight loss. In clinical studies, the incidence of side effects in the experimental group was only 6% higher than in the control group (placebo group).
All observed side effects were mild and went away on their own or with minor therapeutic intervention. Indinol Forto is contraindicated in case of individual intolerance to the drug, during pregnancy and breastfeeding. The drug is not used in pediatric practice. Indinol Forto does not affect the ability to drive a car and work with potentially dangerous mechanisms that require increased attention and concentration. Signs of drug overdose: vomiting, diarrhea. Treatment is symptomatic. The active component of the drug indolecarbinol affects the activity of the CYP2C19 and CYP3A4 isoenzymes, which are responsible for the metabolism of foreign organic compounds and drugs, so care must be taken when combining Indinol Forto with drugs in the metabolism of which these isoenzymes are involved: indirect anticoagulants (dicoumarin, warfarin, syncumar ), glucocorticosteroids (beclamethasone, budesonide, hydrocortisone, dexamethasone), tableted antidiabetic drugs (metformin, glibenclamide), antiarrhythmic drugs (amiodarone, sotalol), antiepileptic drugs (carbamazepine, valproic acid), digitalis preparations (digoxin).
Side effects
All side effects are mild and can be relieved independently or with symptomatic therapy. The following side effects have been reported from individual body systems:
Reproductive system
Irregularities in the menstrual cycle, for example, lengthening or shortening the cycle.
Digestive organs
Epigastric pain.
Laboratory indicators
An increase in the concentration of thyroid-stimulating hormone and follicle-stimulating hormone , as well as prolactin , estradiol .
Decreased creatinine , development of eosinophilia (increased number of eosinophils).
Among others
Weight loss.
Indinol Forto price, where to buy
You can buy Indinol Forto in capsules 200 mg, package No. 60, for an average of 2,500 rubles in Moscow, Novosibirsk, Saratov, and other cities.
The price of Indinol Forto at the Ozerki pharmacy in St. Petersburg is approximately 2,650 rubles.
Packs of 120 capsules are not sold.
- Online pharmacies in RussiaRussia
ZdravCity
- Indinol Forto capsules 200 mg 60 pcs. JSC MiraxBioPharma
RUB 2,582 order
Pharmacodynamics and pharmacokinetics
Indinol Forto is a universal hyperplastic corrector of various pathological processes in the organs and tissues of the woman’s reproductive system, including: mammary glands, ovaries, endometrium, myometrium, cervix.
The drug has a normalizing effect on the balance of estrogen in the female body, suppresses the negative stimulating effect of the latter, and blocks other hormone-independent mechanisms that activate the pathological growth of cells in the mammary glands and uterus. It has selective stimulation of the death of transformed cells with unusually high proliferative activity.
Interaction
with indirect anticoagulants , glucocorticosteroids , oral hypoglycemic agents, antiarrhythmics , antiepileptics , and digitalis drugs, since cytochrome P 450 isoenzymes , the activity of which is influenced by indole carbinol . Dose adjustment may be necessary.
Indinol Forto caps 200 mg pack cards x60
ATX code: G03XC (Selective estrogen receptor modulators) Dosage form INDINOL® FORTO caps. 200 mg: 60, 90 or 120 pcs. reg. No.: LP-002010 dated 02/20/2013 - Valid Release form, composition and packaging Hard, gelatin capsules, size No. 0, with a white body and an orange cap. Capsule contents: white to light yellow or light brown powder.
1 caps. indolecarbinol 0.2 g
Excipients: lactose monohydrate (milk sugar) - 0.14 g, modified corn starch - 0.095 g, microcrystalline cellulose - 0.064 g, magnesium stearate - 0.001 g.
20 pcs. — contour cellular packaging (aluminum/PVC) (3) — cardboard packs. 20 pcs. — contour cellular packaging (aluminum/PVC) (6) — cardboard packs. 60 pcs. — polymer jars (1) — cardboard packs. 90 pcs. — polymer jars (1) — cardboard packs. 120 pcs. — polymer jars (1) — cardboard packs.
Clinical-pharmacological group: Selective estrogen receptor modulator Pharmaco-therapeutic group: Metabolic agent
Indications: treatment of cyclic mastalgia (mastodynia), incl. against the background of benign mammary hyperplasia.
ICD-10 codes ICD-10 code Indication N64.4 Mastodynia
Dosage regimen: Orally, 2 times/day, 200 mg.
The daily dose of the drug is 400 mg. Capsules are taken before meals.
The duration of treatment is 6 months.
Side effects From the reproductive system: menstrual cycle disorders in the form of lengthening or shortening.
From the digestive system: epigastric pain.
Laboratory indicators: increased concentrations of thyroid-stimulating and follicle-stimulating hormones, prolactin and estradiol, decreased concentrations of creatinine, eosinophilia.
Other: weight loss.
According to clinical studies, the number of patients with adverse events did not have significant differences between the groups of patients receiving Indinol® Forto (26.9%) and placebo (20.0%). All identified adverse reactions were mild and resolved independently or by prescribing symptomatic therapy.
If any of the side effects indicated in the instructions get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Contraindications for use: hypersensitivity to the components of the drug,
- hereditary galactose intolerance,
- lactase deficiency,
- glucose-galactose malabsorption,
- pregnancy,
- breast-feeding,
- children and adolescents up to 18 years of age.
Use during pregnancy and lactation The use of Indinol® Forto during pregnancy and lactation is contraindicated. Use in children Contraindication: children and adolescents under 18 years of age. Special instructions Impact on the ability to drive vehicles and operate machinery
Based on the pharmacodynamics and the profile of undesirable effects, it is unlikely that Indinol® Forto affects the ability to drive vehicles and operate equipment.
Overdose Symptoms: possible nausea, vomiting, diarrhea.
Treatment: specific antidote is unknown. If an overdose of Indinol Forto is suspected, symptomatic therapy is recommended.
Drug interactions Considering the effect of indole carbinol on the activity of cytochrome P450 isoenzymes, caution should be exercised when combined with drugs whose metabolism involves cytochrome P450 isoenzymes (indirect anticoagulants, glucocorticosteroids, oral hypoglycemic agents, antiarrhythmics, antiepileptics, digitalis preparations, sex hormone preparations), because their dose may require adjustment.
Conditions for dispensing from pharmacies The drug is dispensed with a prescription. Conditions and periods of storage The drug should be stored in a dry place, protected from light and out of reach of children, at a temperature not exceeding 25°C. Shelf life: 2 years. Do not use after the expiration date stated on the package.
