Phosphogliv: what kind of medicine and when is it used?

How does Phosphogliv work?

Phosphogliv is considered the only drug in the country that is capable of restoring and treating one of the most important human organs - the liver.

The drug can be taken not only for existing liver diseases, but also for preventive purposes. The liver is regularly subjected to heavy loads: unhealthy food, alcoholic drinks, stressful situations, lack of an active lifestyle. All this together affects the functioning of the human body.

When taking the medicine orally, it is well absorbed in the intestines. The maximum content of the active substance in the blood plasma occurs after 8-22 hours. Excreted in urine and bile.

When administered intravenously, the drug immediately appears in the blood, and the maximum concentration occurs much faster. It is also excreted in urine and bile.

PHOSPHOGLIVE FORTE (capsules)

But here the contents have an oily paste-like consistency of yellow or light brown color.
The smell is also specific, but weaker. However, we do not see or feel this content))) If we compare the composition per capsule, we will see that phospholipids in Phosphogliv forte are 300 mg (in Phosphogliv 65 mg), and sodium glycyrrhizinate is 65 mg (35 mg). In addition, Phosphogliv Forte also contains Lipoid PPL-400 - 400 mg. Actually, I didn't understand a little here? After all, the lipoid PPL-400 is nothing more than Phospholipides phospholipids (this is its international name). Phosphogliv also contains Lipoid only 80. In any case, there are 4.5 times more phospholipids in Forte, and twice as much sodium glycyrrhizinate.

Since the chemical structure of phospholipids is identical to natural ones, they are easily integrated into the membranes of liver cells, thereby restoring and stabilizing its work.

Phosphogliv therapy gives us:

1) normalization of the state of the liver cell membrane; 2) activation of membrane enzymes (necessary for the normal metabolic process); 3) the conversion of fats during the synthesis of lipoproteins in the liver improves; 5) increase in glycogen concentration in the liver; 6) enhancing the liver’s ability to neutralize toxins; 7) increasing the conversion of cholesterol into various compounds, which are then easily excreted from the body; reducing the level of fatty degeneration; 9) reducing the rate of formation of cirrhosis and fibrosis of the liver; 10) normalization of bile properties; 11) treatment of skin diseases; 12) stimulation of the immune system.

The list of diseases is not long, but quite serious:

- acute and chronic viral hepatitis; — fatty liver degeneration (hepatosis); - liver damage of drug, alcohol or toxic origin; cirrhosis of the liver; — treatment of conditions after removal of the gallbladder (cholecystectomy); - intoxication; - psoriasis; — neurodermatitis; - eczema.

Phosphogliv is contraindicated for children under 12 years of age, as well as for pregnant and lactating women.

Phosphogliv is taken with food. 1-2 capsules three times a day. Skin diseases are treated within a month. It is recommended to take a diuretic at the same time (I wrote in a previous review why).

The medicine is not cheap. A package of 50 capsules costs 800 rubles. Even if you take one capsule three times a day, a full course (30 days) will require 90 capsules. I tried to find a package of 100 pieces on sale (to make it cheaper), but for some reason there were only 50 pieces everywhere.

Since the main active ingredient of the drug is phospholipids, of which 73–79% is phosphatidylcholine, and this is nothing more than lecithin. After a little “rummaging” on the Internet, I found natural granulated lecithin. The price for a 250 gram jar is about 300 rubles. Tastes similar to dried egg yolk.

Now this wonderful supplement is used in our family constantly. But I’ll tell you why it’s so wonderful in another review)))

special instructions

The shelf life of capsules is 36 months, ampoules – 24 months from the date of production.

The drug should be kept in a dry place, out of reach of children and away from sunlight. The temperature should not exceed 20 degrees.

People with arterial or portal hypertension should take it with special caution. If your blood pressure increases after using the medicine, you should immediately stop treatment and inform your doctor.

The product in the form of an injection solution is strictly prohibited from being combined with other drugs for intravenous administration.

Phosphogliv Urso

Take orally. Children over 12 years of age and adults weighing more than 47 kg swallow the capsule whole. The drug must be taken regularly.

For convenience, dosage regimens for different indications are presented in terms of ursodeoxycholic acid.

Non-alcoholic steatohepatitis:

The average daily dose is 10-15 mg/kg in 2-3 doses. The duration of therapy ranges from 6-12 months or more.

Alcoholic liver disease:

The average daily dose is 10-15 mg/kg in 2-3 doses. The duration of therapy ranges from 6-12 months or more.

Symptomatic treatment of chronic hepatitis of various origins:

The average daily dose is 10-15 mg/kg in 2-3 doses. Duration of therapy is 6-12 months or more.

Biliary reflux gastritis:

1 capsule of the drug daily in the evening before bed. The course of treatment is from 10-14 days to 6 months, if necessary - up to 2 years.

Biliary dyskinesia:

The average daily dose is 10 mg/kg in 2 divided doses for 2 weeks to 2 months. If necessary, it is recommended to repeat the course of treatment.

Dissolution of cholesterol gallstones:

The average daily dose of ursodeoxycholic acid is 10 mg/kg per day, which corresponds to:

The drug must be taken in a daily dose once daily in the evening, before bedtime. It usually takes 6-24 months for stones to dissolve. If after 12 months of treatment the size of the stones does not decrease, then treatment should be stopped.

The effectiveness of treatment should be assessed every 6 months with ultrasound or radiography. During the interim examination, it is necessary to assess whether calcification of the stones has occurred during the intervening period. In case of calcification of stones, treatment should be discontinued.

Primary biliary cirrhosis:

The daily dose depends on body weight and ranges from 2 to 6 capsules (approximately 10 to 15 mg of ursodeoxycholic acid per 1 kg of body weight).

In the first 3 months of treatment, the drug should be divided into several doses throughout the day. After improving liver parameters, the daily dose of the drug can be taken once, in the evening. The following mode of application is recommended:

Capsules should be taken regularly, without chewing, with a small amount of water.

The use of Phosphogliv® URSO for the treatment of primary biliary cirrhosis can be continued indefinitely.

In patients with primary biliary cirrhosis, in rare cases, clinical symptoms may worsen at the beginning of treatment, for example, itching may become more frequent. In this case, treatment should be continued, taking one capsule daily, then the dosage should be gradually increased (increasing the daily dose by one capsule weekly) until the recommended dosage regimen is achieved again.

Primary sclerosing cholangitis:

Daily dose 12-15 mg/kg; if necessary, the dose can be increased to 20 mg/kg in 2-3 doses. The duration of therapy ranges from 6 months to several years.

Reviews

Patients who have already used the medicine leave positive reviews and confirm its effectiveness. After taking it, the condition of the liver noticeably improves, and troubling problems disappear. The drug allows you to eliminate the signs of the disease, and your overall health and test results noticeably improve. The same reviews are left by patients with more severe pathologies, such as hepatitis C. After use, there is also a noticeable improvement in the condition of the skin.

Another undeniable advantage is the reasonable price.

Doctors also speak positively about the drug. They prescribe it for the treatment of liver diseases of various origins.

Phosphogliv

Phosphogliv is a domestic hepatoprotector, which is a combination of phospholipids (phosphatidylcholine) and glycyrrhizic acid. In addition to the hepatoprotective properties, the drug has a membrane-stabilizing and antiviral effect. Used in the treatment of viral hepatitis, hepatosis and other liver lesions, as well as skin diseases (psoriasis, eczema, etc.).

Chronic viral hepatitis is a pressing problem, both on a Russian and global scale. Vaccination can prevent acute hepatitis, but in the fight against chronic forms of this disease, it is, unfortunately, not so effective. Classic drug therapy for chronic hepatitis is a rather complex and expensive undertaking, motivating pharmacologists to create new, more effective drugs. One of these promising drugs is the drug phosphogliv, which, according to its creators, has no analogues on the global pharmaceutical market and is an absolute pioneer in many aspects. Thus, this is the only hepatoprotector that has both etiotropic and pathogenetic effects. The uniqueness of phosphogliv also lies in the combination of hepatoprotective and antiviral effects under the “roof” of one dosage form. One of the components of this drug, phosphatidylcholine, is endowed with the ability to structurally restore liver cells, acting like a “membrane sealant” that patches up holes in biological membranes. This pharmacologically active “ingredient” of phosphogliv is its main active principle, normalizing the metabolism of proteins and lipids and preventing the loss of enzymes by liver cells, restoring the detoxifying function of this organ. Phosphatidylcholine suppresses the excessive formation of connective tissue, which reduces the risk of developing hepatic fibrosis and cirrhosis, as well as improving the prognosis and increasing the quality of life of patients.

Another component of the drug is glycyrrhizic acid, a substance with antiviral activity that inhibits the reproduction of viruses in the body by activating the synthesis of interferons, stimulating the formation of phagocytes and the activity of natural killer cells. Being an antioxidant and exhibiting a membrane-stabilizing effect, glycyrrhizic acid potentiates the hepatoprotective effect of phospholipids and has anti-allergic and anti-inflammatory effects. The novelty of phosphogliv also lies in the unparalleled technology for creating a dry powder form of granular soy phospholipids. This made it possible to increase the shelf life of the capsulated dosage form. The original technology for producing a lyophilisate for intravenous administration made it possible to create a stable phospholipid nanosystem consisting of emulsified micelles and liposomes and free of toxic detergents (surfactants). Complex micelles can be stored in an active state for several years, which is of great clinical importance, because the patient in this case receives the active drug, and not the product of metabolic processes of pharmacologically active substances.

Phosphogliv has undergone a number of tests in leading Russian clinics. Its effect was assessed according to many criteria, including improvement in the patient’s general condition, elimination of symptoms of intoxication, disappearance of the yellow color of the skin, the presence/absence of bile in the stool, a decrease in the concentration of bilirubin and the activity of liver enzymes. As a result, all patients receiving phosphogliv showed positive dynamics. Thus, this drug has been demonstrated to be highly effective in treating liver diseases. It significantly improves the synthetic function of this organ and reduces the manifestations of liver failure. The drug is well tolerated and has a favorable safety profile.