Compound
Each capsule contains the following active ingredients:
- 400 mg lipoid ;
- 300 mg of phospholipids (the main one is phosphatidylcholine, which makes up 73-79% of the total);
- 65 mg sodium glycyrrhizinate.
The following substances are contained in each capsule as auxiliary ingredients:
- “extra” or “luxury” grade ethanol;
- butylated hydroxytoluene;
- sunflower or corn oil.
The capsule shell consists of:
- titanium dioxide;
- dyes: red, black and yellow iron oxides;
- gelatin.
Adverse reaction
Therapeutic measures rarely become a source of development of non-standard responses of the body. Side effects appear:
- allergies - with dermatological rashes, conjunctivitis, cough, difficulty with nasal breathing;
- peripheral swelling, temporary increase in blood pressure;
- dyspepsia with nausea, belching, active gas formation and bloating in the abdomen;
- unpleasant sensations in the gastrointestinal region.
The occurrence of these symptoms requires the patient to immediately stop treatment and visit a doctor for additional consultation. The patient must describe in detail the changes in the condition and receive a new treatment regimen with a different drug.
Release form
The medicine is available in the form of hard gelatin capsules. The body and cap of the capsule are brown. The contents are an oily paste-like mass. The color of this mass ranges between light yellow and orange-brown. Characterized by a weak specific odor.
Capsules are packaged in blister packs of 10 pieces or in plastic containers of 30, 50, 100, 200 or 300 pieces. Cellular packaging is placed in cardboard packs of 2, 3 or 5 pieces. Each container is placed in a separate cardboard box.
How to take
The annotation states the following rules:
- oral capsules are taken with food, with a small amount of liquid;
- children over 12 years old – one unit three times a day;
- adult patients – three times a day, up to 2 pieces per procedure.
The duration of the therapeutic course is determined by the local doctor in accordance with the results of laboratory diagnostics, the results obtained, and indicators of drug tolerability.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Phospholipids, in particular phosphatidylcholine, are structural elements of cell walls and intracellular membranes. Entering the body when taking medication, they promote the restoration of damaged liver cells, inhibit the formation of connective tissue and the replacement of normal tissue with connective tissue elements (prevention of fibrosis ).
Glycyrrhizic acid suppresses inflammatory processes and the ability of viruses to reproduce. This is due to the fact that it stimulates the production of interferons and phagocytosis. Glycyrrhizic acid also has an antioxidant and membrane-stabilizing effect.
Pharmacokinetics
All components of the drug and their active metabolites are very well absorbed in the intestines. through the bloodstream to the organs of the human body, which they actively influence.
Influence of constituent elements
The composition of Phosphogliv Forte is presented:
- phospholipids;
- trisodium salt of glycyrrhizic acid;
- food additive E 321, E171, 172;
- ethyl alcohol;
- sunflower oil;
- gelatin.
Hard capsules with a gelatin base are packaged in packs of 50 units.
The combined medication suppresses the activity of viruses, protects liver cells, and stabilizes the condition of cell membranes. Main Ingredient:
- restores the structure and functionality of membrane elements if they are damaged;
- regulates the secretion of mucus in the stomach;
- increases blood circulation in it and accelerates healing processes;
- stabilizes the metabolism of proteins and lipids;
- prevents loss of nutrients in liver cells;
- restores the basic anti-intoxication function of the liver;
- prevents replacement by connective tissue;
- reduces the risk of formation of fibrosis and cirrhosis.
Due to glycirate, inflammation is stopped and the proliferation of viral infections in the organ is prevented. The process is caused by the production of interferon, accelerating the process of phagocytosis, and increasing the activity of killer cells.
For non-infectious liver pathologies, it reduces the risk of developing allergies and inflammation. In case of skin diseases, it stops the further spread of the lesion and promotes its regression.
Indications for use
The use of Phosphogliv Forte is indicated for:
- acute and chronic forms of viral hepatitis ;
- hepatosis (fatty liver degeneration);
- liver damage caused by medications, alcohol, and other toxins;
- liver cirrhosis;
- intoxications of various origins;
- some skin diseases ( psoriasis , neurodermatitis , eczema ).
For whom is it necessary and prohibited?
The abstract indicates the following groups of patients for whom the medication is intended:
- with fatty liver degeneration – fatty hepatosis;
- damage to the organ due to alcoholic, toxic, and medicinal factors.
The drug is contraindicated:
- women during lactation and during pregnancy;
- minors under 12 years of age;
- people prone to spontaneous allergic reactions;
- patients with confirmed individual intolerance to the components of the capsules.
The drug is not prescribed for antiphospholipid antibody syndrome - autoimmune hypercoagulation.
Analogues of Phosphogliv Forte
Level 4 ATC code matches:
Hepatosan
Sirepar
Hepatomax
Phosphogliv
Thiotriazolin
Karsil Forte
Darsil
Silibor
Karsil
Erbisol
Silimar
Methionine
Remaxol
Enerliv
Laennec
Progepar
Antral
Potassium orotate
Legalon
Hepa-Merz
Drug analogues:
- Antral;
- Apkosul;
- Bonjigar;
- Vimliv;
- Hepa-Merz;
- Gepabene;
- Hepalex;
- Heparete;
- Heparsil;
- Hepatofalk;
- Hepafil;
- Hepaforte;
- Hypoglisil;
- Glutargin;
- Glutarsol;
- Darsil;
- Karsil;
- Levasil;
- Legalon;
- Lecithin;
- Livenziale;
- Livolact;
- Ornitox;
- Remaxol;
- Silibor;
- Triliv.
Manufacturer's instructions
During scientific and clinical studies, no effect of the drug on the reaction rate was noted. During treatment, patients can drive a car and work with complex moving mechanisms.
Therapy is carried out only on the recommendation of a local doctor and under his constant supervision. Self-medication with Phosphogliv Forte is unacceptable due to the risk of non-standard body responses if the dosage is incorrectly selected.
The appearance of any non-standard symptoms requires contacting a specialist and deciding whether to replace the medication or reduce the initial dosage.
The medication is not intended for children under 12 years of age, nursing or pregnant women. The consequences of such treatment are unpredictable.
Price Phosphogliv Forte, where to buy
The price of Phosphogliv Forte in Russian pharmacies is 800-950 rubles for 50 capsules. The cost in Ukrainian pharmacies is 700-900 hryvnia for a similar package.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Phosphogliv Forte capsules 300 mg + 65 mg 50 pcs. Pharmstandard-Leksredstva OJSC
1000 rub. order
Pharmacy Dialogue
- Phosphogliv forte (caps. No. 50) FS.-Leksredstva
RUB 1,036 order
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Treatment of overdose
Accidental or intentional increase in prescribed doses leads to general intoxication of the body and manifests itself:
- swelling of tissues and increased blood pressure due to fluid retention in tissues;
- a drop in sodium ions in the bloodstream.
Therapy depends on the severity of the clinical picture of poisoning. In most cases, it is limited to reducing the initial dose and prescribing spironolactone from 50 to 100 mg per day.
Reviews
Patients who have already used the medicine leave positive reviews and confirm its effectiveness. After taking it, the condition of the liver noticeably improves, and troubling problems disappear. The drug allows you to eliminate the signs of the disease, and your overall health and test results noticeably improve. The same reviews are left by patients with more severe pathologies, such as hepatitis C. After use, there is also a noticeable improvement in the condition of the skin.
Another undeniable advantage is the reasonable price.
Doctors also speak positively about the drug. They prescribe it for the treatment of liver diseases of various origins.
special instructions
The shelf life of capsules is 36 months, ampoules – 24 months from the date of production.
The drug should be kept in a dry place, out of reach of children and away from sunlight. The temperature should not exceed 20 degrees.
People with arterial or portal hypertension should take it with special caution. If your blood pressure increases after using the medicine, you should immediately stop treatment and inform your doctor.
The product in the form of an injection solution is strictly prohibited from being combined with other drugs for intravenous administration.
Phosphogliv forte 50 pcs. capsules
pharmachologic effect
Hepatoprotective agent.
Composition and release form Phosphogliv forte 50 pcs. capsules
Capsules - 1 capsule:
- Active ingredients: Phospholipids (Lipoid PPL-400) 400.0 mg [calculated as 100% substance (the main component is phosphatidylcholine 73-79%)] 300.0 mg, sodium glycyrrhizinate (trisodium salt of glycyrrhizic acid) 65.0 mg;
- excipients: butylated hydroxytoluene 0.1 mg, ethyl alcohol “lux” or “extra” (ethanol) 12 mg, sunflower oil or corn oil 22.9 mg;
- Composition of the capsule shell: titanium dioxide, red iron oxide dye, black iron oxide dye, yellow iron oxide dye, gelatin.
30, 50, 100, 200 or 300 capsules in plastic containers with lids made of high-density polyethylene or propylene or polymer jars, sealed with tamper-evident lids with a moisture-absorbing insert.
10 capsules per blister pack made of polyvinyl chloride film and aluminum foil.
1 container or 2, 3, 5 strip packaging along with instructions for use are placed in a cardboard pack.
Description of the dosage form
Hard gelatin capsules No. 0; The body and cap of the capsule are brown.
The contents of the capsule are an oily paste-like mass from light yellow to orange-brown in color with a weak specific odor.
Directions for use and doses
Take orally, during meals, with a small amount of liquid.
Adults take 1-2 capsules 3 times a day, children over 12 years old - 1 capsule 3 times a day.
Pharmacodynamics
Combined remedy. It has membrane-stabilizing, hepatoprotective and antiviral effects.
Phosphatidylcholine (the main component of phospholipids) is the main structural element of cellular and intracellular membranes, capable of restoring their structure and function when damaged, providing a cytoprotective effect.
Normalizes protein and lipid metabolism, prevents the loss of enzymes and other active substances by hepatocytes, restores the detoxification function of the liver, inhibits the formation of connective tissue, reducing the risk of fibrosis and cirrhosis of the liver.
Glycyrate (glycyrrhizic acid and salts) has an anti-inflammatory effect, suppresses the reproduction of viruses in the liver and other organs by stimulating the production of interferons, increasing phagocytosis, and increasing the activity of natural killer cells. It has a hepatoprotective effect due to its antioxidant and membrane-stabilizing activity. Potentiates the effect of endogenous glucocorticosteroids, providing anti-inflammatory and antiallergic effects in non-infectious liver lesions.
In case of skin lesions, due to the membrane-stabilizing and anti-inflammatory effects of the components, it limits the spread of the process and promotes regression of the disease.
Pharmacokinetics
The components of the drug are well absorbed in the intestine, both in the form of the whole molecule and the bioactive products of their hydrolysis (unsaturated fatty acids, choline, glycyrrhetic acid), which, after absorption through the intestinal walls, easily penetrate the liver, lungs, skin and other organs.
Indications for use: Phosphogliv forte 50 pcs. capsules
Viral hepatitis (acute and chronic), fatty liver degeneration (hepatosis), other liver damage (drug, alcohol, toxic), liver cirrhosis, intoxication, psoriasis, neurodermatitis, eczema.
Contraindications
Hypersensitivity to the components of the drug, pregnancy, lactation, children under 12 years of age.
Overdose
Not marked.
Side effects Phosphogliv forte 50 pcs. capsules
With increased individual sensitivity, a skin rash may appear, which disappears after discontinuation of the drug.
Rarely, when daily doses are exceeded, the following may occur: sodium and fluid retention, which is manifested by peripheral edema and increased blood pressure, hypokalemia. If these symptoms appear, depending on their severity, it is necessary to reduce the dose of the drug and/or prescribe spironolactone 50-100 mg per day.
Drug interactions
Not described.
How does Phosphogliv work?
Phosphogliv is considered the only drug in the country that is capable of restoring and treating one of the most important human organs - the liver.
The drug can be taken not only for existing liver diseases, but also for preventive purposes. The liver is regularly subjected to heavy loads: unhealthy food, alcoholic drinks, stressful situations, lack of an active lifestyle. All this together affects the functioning of the human body.
When taking the medicine orally, it is well absorbed in the intestines. The maximum content of the active substance in the blood plasma occurs after 8-22 hours. Excreted in urine and bile.
When administered intravenously, the drug immediately appears in the blood, and the maximum concentration occurs much faster. It is also excreted in urine and bile.
