Quite often there are cases when a person begins to be bothered by such unpleasant symptoms as nausea, causeless vomiting, and abdominal pain. Such signs without proper treatment and immediate response can lead to diseases that will require complex treatment in the future. Therefore, in order to relieve abdominal pain, eliminate nausea and vomiting, the doctor prescribes the modern and effective medicine Motilium, the indications for use of which are described in detail in the instructions. The drug is able to block peripheral and central receptors of the brain, effectively eliminating the symptoms of diseases associated with the gastrointestinal tract, nausea and vomiting.
Pharmacological qualities of the drug
Motilium. Lozenges
Motilium refers to medications that are aimed at stimulating intestinal motility and suppressing the urge to vomit. The main effect of the drug is provided by domperidone, which acts like some antipsychotics and metoclopramide, which are antagonists of dopapine.
This type of medication causes virtually no side effects, since it has poor permeability through the blood-brain barrier. However, sometimes children may experience unwanted side effects of the drug. Thanks to the main, active substance, prolactin is released from the pituitary cells.
The drug copes well with gastric emptying and helps increase the duration of duodenal and antral contractions.
When the medicine is taken orally in an adult, the evacuation of solid and liquid food from the stomach is much easier, while in sick patients, when the evacuation of solid food is slowed down, this process is much faster and better. Taking the medicine in a healthy person normalizes the tone and pressure in the esophageal sphincter area. However, the medicine does not have a negative effect on the secretion of gastric juice.
Analogues of Motilium
Level 4 ATX code matches:
Passazhix
Motinorm
Domrid
Itomed
Metoclopramide
Domperidone
Motilak
Ganaton
Cerucal
The following analogues of Motilium are known:
- Domrid;
- Brulium Lingvatabs;
- Motinol;
- Gastropom-Apo;
- Motinorm;
- Domidon;
- Domperidone Hexal;
- Domperidone Sandoz;
- Domperidone-Credopharm;
- Domperidone-Ostoma;
- Domrid Sr;
- Motilak;
- Motoricum;
- Peridonium;
- Nausilium;
- Motorix;
- Peridon;
- Perilium.
Some analogues are cheaper than Motilium. These include, for example, Nausilium , Motorix , Motinorm , Domrid , Domidon .
Before taking Motilium analogues, you need to carefully study the instructions. Some of them are not suitable for children.
What is better - Motilium or Motilak?
find out which is better Motilium or Motilak only by experience. The active ingredient of both drugs is domperidone . Motilium is available in tablets and suspension form, while Motilak is available only in tablet form. The composition of the auxiliary components of the drugs is different, so if you have an individual intolerance to any of them, only one drug will do.
Both drugs normalize and prolong gastrointestinal motility , relieve vomiting and nausea. In addition, they help eliminate heartburn , flatulence and belching .
The difference between them is also the cost. Motilium costs 2-3 times more than Motilak . People who have taken both drugs claim that there is no qualitative difference between them.
Pharmacokinetic properties of the drug
The medicine is best taken before meals, on an empty stomach. Thus, its rapid absorption from the gastrointestinal tract occurs. After taking Motilium orally, the drug can be detected in the blood plasma after half an hour or an hour. Domperidone has low bioavailability as a result of extensive primary metabolism in the liver and intestinal walls. Although it is noted that if a healthy person takes the medicine after a meal, the bioavailability of the drug increases.
Motilium. Help for the stomach
For a sick person, it is recommended to take the medicine only a few minutes or half an hour before meals. If the acidity of gastric juice is reduced then the absorption of domperidone is reduced. A decrease in the bioavailability of the drug was also observed in the case of prior administration of certain medications such as sodium bicarbonate or cimetinide.
When taking medicine, you need to remember that greater results are achieved if you take it before meals than after meals. Conducted animal studies regarding the binding of domperidone to plasma proteins show that the drug is distributed in high concentrations in the tissues; slightly less of it can be found in the brain.
Studies on rats have shown that the smallest percentage of the drug is able to penetrate the placenta barrier. Motilium is excreted from the body in feces and urine.
Interaction
Anticholinergics may block the action of Motilium. Antifungal drugs of the azole group, HIV protease inhibitors and antibiotics belonging to the macrolide group can inhibit the biotransformation of domperidone and increase its content in the blood plasma , so this combination should be prescribed with caution.
The simultaneous use of Motilium and Ketoconazole in oral form, as well as Erythromycin and strong inhibitors of the CYP3A4 isoenzyme , which cause prolongation of the QT interval .
When is it best to take Motilium?
Many people know what nausea is and what troubles and consequences vomiting brings. This is a constant anxious state of the body, unpleasant abdominal pain, restless and anxious sleep. It is very important to know which medications will best help relieve unpleasant and disturbing symptoms without harming the body. Motilium is an effective and fast-acting remedy that copes well with a complex task. It relieves dyspeptic symptoms that are caused by problems with gastric emptying, esophagitis and gastroesophageal reflux. Basically, the medicine is prescribed when:
Overdose
Overdose symptoms: drowsiness , extrapyramidal reactions , disorientation .
special antidote . In case of overdose, it is advisable to rinse the patient’s stomach and give activated carbon . It is necessary to monitor the patient's condition and carry out supportive measures.
In case of extrapyramidal reactions, anticholinergic and antihistamine drugs may be effective
Doses of the drug for adults and children
It is preferable to take the medicine before meals. This will help achieve greater effectiveness in treating the symptoms of the disease. You can take the drug in any form without a doctor's prescription for no more than 28 days.
For adult patients and adolescents whose body weight exceeds 35 kilograms, a single dose of the drug is up to 20 ml. Take the drug 4 times a day. For children, infants and those under 12 years of age, the single dose depends on body weight. So, per kilogram of body weight falls from 0.25 to 0.5 ml of the drug in the form of a suspension. Take four times a day. The daily dose should not exceed 80 ml.
It is better for infants and small children to take a suspension as treatment; tablets are recommended only if their body weight is more than 35 kilograms. Doctors often prescribe the suspension to children from the first days of life, however, until they are one year old, they carefully monitor the progress of treatment. This is due to the fact that sometimes children experienced disturbances in the central nervous system as a result of taking the suspension. Before prescribing a medicine, the attending physician must correctly calculate the single dose. Give the suspension three to four times a day, but not more than 80 ml per day.
The medicine should not be given simultaneously with other drugs, so as not to reduce the effect of the main substance.
Motilium should not be given to children whose bodies cannot tolerate lactose and the substances included in the medicine, if they suffer from stomach bleeding or have kidney or liver diseases. The drug is contraindicated for children in whom it causes side effects in the form of spasms, intestinal dysfunction, or when they experience nervous disorders after taking it.
Contraindications
The medicine has the following contraindications:
- bleeding in the gastrointestinal tract, perforation , mechanical obstruction ;
- prolactinoma;
- negative reaction of the body to the components of the drug;
- severe or moderate liver dysfunction
The drug should be taken with caution in case of kidney dysfunction , as well as cardiac and disorders .
It is advisable to consult a specialist about possible contraindications to the use of the medicine.
Side effects caused by taking Motilium. Contraindications
Motilium. Release form - tablets
It is very rare to find medications that do not cause side effects. Even drugs that have a natural base are not suitable for everyone. Therefore, Motilium is no exception. Side effects can be severe or moderate, sometimes even unnoticed. The most common side effects are:
- in the endocrine system. In this case, gynecomastia, galactorrhea, and hyperprolactinemia develop;
- in the central nervous system. In this case, extrapyramidal disorders are observed, which disappear as soon as you stop taking the suspension or tablets;
- in the digestive system. In this case, a disorder of the gastrointestinal tract is very rarely observed, and spasmodic contraction of the intestine is very rarely observed.
After examining the patient and child, the doctor will tell you whether Motilium can be taken as a remedy. Thus, in case of perforation of the stomach or intestines or its obstruction as a result of a mechanical disorder, it is better to replace the drug with another more suitable medicine. It is also contraindicated for people who suffer from prolactinoma. If they have gastrointestinal bleeding, their body cannot tolerate one of the components of this drug.
Compound
Regardless of the form of release, the medicine contains domperidone as an active substance.
Motilium suspension contains the following additional components: sodium saccharinate, sodium carboxymethylcellulose, methyl parahydroxybenzoate, sodium hydroxide, water, MCC, sorbitol , propyl parahydroxybenzoate, polysorbate.
Excipients of lozenges: gelatin, aspartame, poloxamer 188, mannitol, mint essence.
Coated Motilium tablets contain lactose, microcrystalline cellulose, polyvidone, hydrogenated vegetable oil, hypromelose, corn starch, gelatinized potato starch, magnesium stearate, sodium lauryl sulfate.
Reviews about Motilium
Reviews of Motilium characterize the drug as a highly effective, fast-acting remedy. It is very popular among consumers. Reviews of Motilium for children are also mostly positive. This remedy is often recommended by pediatricians, but not for infants. In the latter case, the effect of the drug has not been studied. In addition, the medicine is rarely used by nursing mothers, since its harm to lactation has not been studied.
Among the negative aspects, those who took Motilium note only a slightly inflated cost.
During pregnancy (and lactation)
data on the effect of the drug during pregnancy . There is no information about the risk to the fetus. However, it is advisable to allow the drug during pregnancy only if the benefit of treatment is greater than the potential threat to the fetus.
When breastfeeding, the concentration of the active substance of the drug is 10-50% of its level in the blood . It is not known whether the drug has negative effects on newborns. Taking the drug is also possible only if the benefit to the mother is greater than the possible risk to the baby.
Which drug is better
Motilak and Motilium are analogues. They have the same indications. Side effects and contraindications differ, so you need to carefully read the instructions for each drug. Both drugs can be prescribed for the shortest possible course.
Motilium is more suitable for children, as is the case for women during pregnancy. The suspension can even be used to treat infants.
Motilak costs almost twice as much, as it is produced in Russia. Motilium is a Belgian drug.
When you need to quickly relieve nausea, you can use Motilak dissolving tablets. If the symptoms of dyspepsia are constant, you need to be examined by a doctor who will select the most effective and safe medications for your particular case.
Motilium price, where to buy
The price of Motilium suspension is on average 540 rubles. This form of release is mainly used for children. The average price of Motilium in lozenges is 530 rubles. You can buy the product in this form of release in many pharmacies; as a rule, it is purchased for adults. In addition, coated tablets are popular. The price of Motilium in this form of release is 620 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Motilium Susp.
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