TOP 13 analogues of the drug Motilium: list of cheap substitutes for adults and children

Prohibited during pregnancy

Prohibited during breastfeeding

Has restrictions for children

Has restrictions for older people

Has limitations for liver problems

Has limitations for kidney problems

Motilium is an antiemetic, a central blocker of dopamine receptors. Release form: tablets and suspension. Active pharmaceutical substance: domperidone. The antiemetic effect is achieved by activating gastrointestinal motility.

Indications for the use of this drug are as follows:

• vomit;
• convulsive, jerky contractions of the diaphragm;
• nausea;
• intestinal atony;
• inflammation of the gallbladder;
• reflux esophagitis;
• local damage to the inner lining of the stomach;
• necessary acceleration of peristalsis before contrast radiography of the gastrointestinal tract;
• JVP;
• angiocholitis;
• excessive accumulation of gases in the intestines, etc.

Action of Motilium

Motilium has a relatively small list of contraindications, which can be found in the instructions. The presence of contraindications or the high price of it may cause the need to replace the medicine with an analogue. This article will discuss in detail the most common analogues of Motilium.

Compound

Regardless of the form of release, the medicine contains domperidone as an active substance.
Motilium suspension contains the following additional components: sodium saccharinate, sodium carboxymethylcellulose, methyl parahydroxybenzoate, sodium hydroxide, water, MCC, sorbitol , propyl parahydroxybenzoate, polysorbate.

Excipients of lozenges: gelatin, aspartame, poloxamer 188, mannitol, mint essence.

Coated Motilium tablets contain lactose, microcrystalline cellulose, polyvidone, hydrogenated vegetable oil, hypromelose, corn starch, gelatinized potato starch, magnesium stearate, sodium lauryl sulfate.

Motilium

Motilium ®

(lat.
Motilium
®) is a second generation prokinetic agent intended for the treatment of diseases of the upper digestive tract, accompanied by a decrease in motor-evacuation function, as well as an antiemetic drug.
Dosage forms of Motilium:

• lozenges
• film-coated tablets
• suspension for oral administration

Active substance:
domperidone. One lozenge or film-coated tablet contains 10 mg of domperidone. The oral suspension contains 1 mg of domperidone per 1 ml.

Excipients:

• lozenges - gelatin, aspartame, mannitol, mint essence, polyxamer 188
• film-coated tablets - lactose, pre-gelatinized potato starch, corn starch, hydrogenated vegetable oil, microcrystalline cellulose, magnesium stearate, polyvidone, hypromelose, sodium lauryl sulfate
• oral suspension - sodium saccharinate, sorbitol, microcrystalline cellulose, sodium carboxymethylcellulose, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium hydroxide, polysorbate, purified water

Appearance:

• lozenges - white or almost white round tablets
• film-coated tablets - round, biconvex, white to pale cream in color, labeled "Janssen"
• oral suspension - homogeneous white suspension

Pharmacotherapeutic group
- antiemetic, central dopamine receptor blocker. According to the pharmacological index, motilium belongs to the group “Gastrointestinal motility stimulants, including emetics.” For ATC - to the group “Gastrointestinal motility stimulants”, code A03FA03.

Motilium blocks dopamine D2 receptors and thus eliminates dopamine inhibition of the motor activity of the digestive system. Increases the duration of gastric antrum and duodenal peristalsis, prevents slow gastric emptying, and increases the tone of the lower esophageal sphincter.

The antiemetic effect of motilium is due to a combination of gastrokinetic action and blockade of chemoreceptors of the trigger zone of the vomiting center. Motilium prevents the development or reduces the severity of vomiting and nausea.

After oral administration, motilium is quickly absorbed from the gastrointestinal tract. Food or low acidity of gastric juice slows down and reduces absorption. The maximum concentration in the blood is reached after 0.5–1 hour. Motilium is found in small amounts in breast milk. It is subjected to intensive metabolism in the intestinal wall and liver with the formation of hydroxydomperidone and 2,3-dihydro-2-oxo-1-H-benzimidazole-1-propionic acid, respectively. The half-life after a single dose is 7 hours and increases in chronic renal failure. 31% is excreted by the kidneys, of which 1% is excreted unchanged and 66% is excreted by the intestines (10% unchanged). Domperidone may accumulate in patients with liver disease.

Motilium belongs to the second generation prokinetics and, unlike the first generation prokinetics: cerucal, raglan and others (the active substance metoclopramide) does not penetrate the blood-brain barrier (BBB) ​​well. Therefore, Motilium does not cause extrapyramidal disorders: spasms of the facial muscles, trismus, rhythmic protrusion of the tongue, bulbar type of speech, spasms of extraocular muscles, spastic torticollis, opisthotonus, muscle hypertonicity and others. Motilium does not cause parkinsonism: hyperkinesis, muscle rigidity. Motilium less frequently and to a lesser extent than Cerucal and Raglan causes side effects such as drowsiness, fatigue, tiredness, weakness, headaches, increased anxiety, confusion, and tinnitus.

Compared to Coordinax and other prokinetics with the active ingredient cisapride, motilium has a less effective effect on the motility of the digestive tract, but it is completely devoid of the serious cardiac side effects of cisapride - prolongation of the QT interval and ventricular arrhythmias, including ventricular fibrillation.

Since the pituitary gland is located outside the blood-brain barrier, motilium increases the level of prolactin in the blood.

Indications for use of Motilium

In adults, Motilium is indicated for nausea and vomiting, including due to diet disorders, radiation therapy, infections, toxemia, during endoscopic and radiopaque studies of the digestive tract, hiccups, postoperative or other atony of the stomach and intestines;
with a feeling of bloating, fullness in the epigastrium, pain in the upper abdominal cavity, belching, flatulence, heartburn, pharyngolaryngeal reflux (reflux of stomach contents into the pharynx, larynx and oral cavity). In children, Motilium is indicated for regurgitation syndrome, cyclic vomiting, gastroesophageal reflux and other motility disorders of the upper digestive tract. Motilium is used in the treatment of many gastrointestinal diseases, usually in combination with antisecretory and other drugs and much less often as a single drug. It is most often prescribed for:

• gastroesophageal reflux disease
• achalasia cardia
• duodenogastric reflux
• chronic gastritis with decreased motor-evacuation function of the stomach
• gastroptosis
• gastric ulcer with normal and low acidity and weakening of muscle tone and peristalsis
• atony and hypotension of the stomach and duodenum that developed in the postoperative period (gastroparesis)
• hypokinetic type of biliary dyskinesia

Method of application of motilium and dose

• Chronic dyspepsia.
  Adults: 1 tablet or 10 ml of motilium suspension 3 times a day, 15–30 minutes before meals and, if necessary, before bedtime. Per day, a total of no more than 8 tablets or 80 ml of suspension (80 mg of domperidone). Children: 25 ml of suspension per 1 kg of body weight 3 times a day before meals and, if necessary, before bedtime. If necessary, for children over 1 year of age, the indicated dose can be doubled. The maximum daily dose of motilium is 2.4 ml per 1 kg of child’s body weight, but not more than 80 ml.
• Nausea and vomiting.
  Adults: 2 tablets or 20 ml of motilium suspension 3-4 times a day before meals and before bed. Per day, a total of no more than 8 tablets or 80 ml of suspension (80 mg of domperidone). Children: 0.5 ml of suspension per 1 kg of body weight, 3-4 times a day before meals and before bedtime. The maximum daily dose of motilium is 2.4 ml per 1 kg of child’s body weight, but not more than 80 ml (Instructions for use).

For children under 5 years of age
(according to*
, 10 mg film-coated tablets - up to 12 years)
and weighing less than 35 kg, taking Motilium tablets is not recommended. Such children should take motilium in the form of a suspension.

In case of renal failure, it is recommended to reduce the frequency of taking motilium.

At the beginning of 2015, the Russian Ministry of Health* proposed making changes

In the instructions for film-coated tablets, 10 mg: dosage regimen - one tablet 3 times a day, maximum daily dose - 3 tablets (30 mg).

The use of motilium in children suffering from GERD

Among prokinetics, the most effective antireflux drugs currently used in the treatment of children are blockers of dopamine receptors, both central (at the level of the chemoreceptor zone of the brain) and peripheral. These include cerucal and motilium. The pharmacological effect of these drugs is to enhance antropyloric motility, which leads to accelerated evacuation of gastric contents and increased tone of the lower esophageal sphincter. However, when cerucal is prescribed, especially in young children at a dose of 0.1 mg/kg 3-4 times a day, extrapyramidal reactions and, less commonly, allergic reactions in the form of swelling of the tongue and agranulocytosis may be observed. In childhood, treatment with a dopamine receptor antagonist, domperidone (Motilium), is preferable. Motilium has a pronounced antireflux effect. When it is used, there are practically no extrapyramidal reactions in children. Motilium also has a positive effect on constipation in children: it leads to normalization of the bowel movement process. Motilium cannot be combined with antacids, since its absorption requires an acidic environment and with anticholinergic drugs that neutralize the effect of motilium (Khavkin A.I., Privorotsky V.F.).

Motilium therapy taking into account electrogastrographic studies

When studying the motor-evacuation function of the stomach using electrogastrography, 5 main types of impaired motility of the stomach and duodenum are determined (Rachkova N.S., Khavkin A.I.):

• irritable stomach (type 1) - characterized by normal or reduced electrical activity of the stomach on an empty stomach with a subsequent increase in its electrical activity after eating by more than 1.5-2 times
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• lazy stomach
  (type 2) - characterized by normal electrical activity of the stomach on an empty stomach and a decrease in it after eating
• asthenic stomach
  (type 3) - characterized by a high level of electrical activity of the stomach on an empty stomach and a decrease in it after eating
• duodenal hypertension, option I
  (type 4) - characterized by an increased level of electrical activity of the duodenum on an empty stomach and after meals
• duodenal hypertension, variant II
  (type 5) - characterized by an increase in the electrical activity of the duodenum on an empty stomach and normalizing after eating.

The figure on the right (Rachkova N.S., Khavkin A.I.) shows the electrical activity of the stomach before and after treatment with Motilium for the listed 3 types of gastric motility disorders. Motilium is also recommended for type 5 disorders (duodenal hypertension, II). At the same time, in type 4 disorders (duodenal hypertension, I), treatment with motilium has no effect and the use of antispasmodics is recommended.

Professional medical publications addressing the effects of motilium on the gastrointestinal tract

• Erdes S.I., Mukhametova E.M., Petukhova E.V., Matsukatova B.O. Differentiated approach to the treatment of children with motor and secretory disorders of the upper digestive tract // RMZh. Mother and Child. – 2010. – T. 18. – No. 10.
• Rachkova N.S., Khavkin A.I. Assessment and principles of differential treatment of gastric and duodenal motility disorders in patients with functional dyspepsia // Bulletin of pediatric pharmacology and nutrition. – 2007. – T. 4. – No. 5. – p. 25–29.
• Rebrov V.G., Loginov A.F., Kalinin A.V. Changes in the electrical activity of the stomach and intestines under the influence of motilium / Russian Journal of Gastroenterology, Hepatology, Coloproctology. –1997. – No. 4. - With. 42–45.
• Khavkin A.I., Privorotsky V.F. Gastroesophageal reflux disease. In the book. Acid-dependent conditions in children / Ed. acad. RAMS V.A. Tabolina. – M. – 1999. – 112 p.

On the website in the literature catalog there is a section “Prokinetics”, containing articles on the use of prokinetics in the treatment of diseases of the gastrointestinal tract.

Contraindications for the use of motilium

Hypersensitivity to motilium, bleeding in the stomach or intestines, perforation of the stomach or intestines, intestinal obstruction, hyperprolactinemia, prolactinoma, epilepsy, glaucoma, breast cancer, pheochromocytoma, pregnancy (first trimester - see below
), simultaneous use of oral forms of ketoconazole.

Part of the active substance of motilium, domperidone, penetrates into mother's milk, so motilium is not recommended during breastfeeding.

At the beginning of 2015, the Russian Ministry of Health* proposed changes

In the instructions for film-coated tablets, 10 mg, in particular, a list of contraindications for use has been added: moderate and severe liver failure, pregnancy, breastfeeding, children under 12 years of age or body weight up to 35 kg, simultaneous use of medications increasing the QT interval and inhibitors of the CYP34A isoenzyme.

Side effects of Motilium

• digestive system
  : rarely - gastrointestinal disorders, very rarely - transient intestinal spasms
• nervous system
  : very rarely - extrapyramidal phenomena (spasms of the facial muscles, trismus, rhythmic protrusion of the tongue, bulbar type of speech, spasms of extraocular muscles, spastic torticollis, opisthotonus, muscle hypertonicity) and disappear after stopping Motilium.
• immune system:
  very rarely - allergic reactions
• endocrine system
  : hyperprolactinemia; very rarely - galactorrhea, gynecomastia and amenorrhea
• integumentary system:
  urticaria, itching

At the beginning of 2015, the Russian Ministry of Health* proposed changes
to the instructions for film-coated tablets, 10 mg, in particular, the list of side effects was added: very rarely - urticaria, anaphylactic shock, angioedema shock, convulsions, increased excitability and irritability, drowsiness, headache pain, changes in liver function tests; frequency unknown - ventricular tachycardia of the “pirouette” type, sudden coronary death.

Motilium overdose

Overdose is manifested by drowsiness, disorientation and extrapyramidal reactions, especially in children. In case of overdose, it is recommended to take activated charcoal and careful monitoring, as well as anticholinergic drugs used to treat parkinsonism and antihistamines.

Interaction of motilium with other drugs

Anticholinergic drugs may counteract the effects of motilium.
The oral bioavailability of motilium is reduced after previous administration of cimetidine or sodium bicarbonate. Antacids and antisecretory drugs, when taken simultaneously with motilium, reduce its bioavailability. Antifungal drugs of the azole group, antibiotics of the macrolide group, HIV protease inhibitors can block the metabolism of domperidone and increase its level in plasma, so their combined use with motilium requires caution. Motilium may also be combined with:

• paracetamol
• digoxin
• neuroleptics, the effect of which it does not enhance
• agonists of dopaminergic receptors: bromocriptine, levodopa, the undesirable effects of which are indigestion, vomiting, nausea, without affecting their basic qualities, it suppresses

Special instructions for Motilium therapy

When using motilium with antacid or antisecretory drugs, the latter are not recommended to be taken simultaneously with motilium.
In this case, antacids or antisecretory drugs are taken after meals. The drug should be given to infants, as well as to patients of any age with liver disease, very carefully and under medical supervision.

In severe renal failure, the elimination time of the active substance of motilium, domperidone, increased by approximately 3.5 times, but drug concentrations in plasma were lower than in healthy volunteers. There is no need to adjust a single dose in patients with renal failure, however, when re-administered, the frequency of administration should be reduced to once or twice a day, depending on the severity of the failure, and it may also be necessary to reduce the dose. During long-term therapy, such patients should be under medical supervision.

Manufacturers of Motilium

• lozenges - Cardinal Health UK 416 (UK)
• film-coated tablets - Janssen-Cilag (France)
• suspension for oral administration – Janssen Pharmaceutica (Belgium)

general information

Motilium does not affect the ability to drive a car or use other mechanisms ( according to* when taking 10 mg film-coated tablets, caution must be exercised when driving vehicles and similar activities
).
Motilium is an over-the-counter product
(
letter* suggests converting 10 mg film-coated tablets to prescription status
).

Trade names of other drugs containing active ingredients

Domperidone
: Damelium, Domet, Domperidone, Domperidone Hexal, Domstal, Motilak, Motinorm, Motonium, Passazhix.
* Letter from the Director of the Department of State Regulation of Medicines of the Ministry of Health of the Russian Federation A.G. Tsyndymeev No. 20-3/162 dated 03/05/2015

Motilium has contraindications, side effects and application features; consultation with a specialist is necessary.

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Pharmacodynamics and pharmacokinetics

The medicine inhibits dopamine receptors . This property, in combination with the gastrokinetic effect, determines the antiemetic effect of the drug.

When used internally, Motilium increases the pressure of the lower esophageal sphincter , accelerates gastric emptying and helps improve antroduodenal motility .

After taking on an empty stomach, the active substance of the drug is absorbed from the gastrointestinal tract in a short time. The degree of absorption of domperidone is reduced due to a decrease in the acidity of gastric juice. plasma concentration is observed after approximately 0.5-1 hour. In people with moderate liver dysfunction it can be 1.5 times higher than in healthy people.

Absolute bioavailability is about 15%. When using the medicine after meals, the maximum concentration is reached later. In healthy people, bioavailability increases when taken after meals. If you have problems with the gastrointestinal tract, you should use the drug 15-30 minutes before meals.

The degree of binding of the active substance to plasma proteins is 91-93%. Once in the body, it undergoes rapid and active biotransformation in the liver through hydroxylation and N-dealkylation.

The drug is excreted 31% in urine and 66% in feces. About 11% of the active substance is excreted unchanged.

The plasma half-life after a single dose is 7-9 hours. In people with severe renal impairment, the half-life increases to 20.8 hours and plasma concentrations decrease. Only about 1% is excreted unchanged through the kidneys. In people with impaired liver function, the half-life is 15-23 hours.

Therapeutic effect

Motilium has the ability to eliminate nausea, stop vomiting, and gently activate intestinal motility. The active component of the drug, domperidone, exhibits some properties of an antipsychotic, suppressing sensitivity to dopamine. Unlike other inhibitors, it is more neutral: it does not cause dystonia, tremor, or nervous tics.

The drug increases the tone of muscle fibers and enhances contractions of the esophageal sphincter in its lower part. Thanks to this, the evacuation function of the stomach is normalized, signs of dyspepsia, indigestion, and other motility disorders and diseases of the gastrointestinal tract are eliminated.

The drug is absorbed by the mucous membranes within a few minutes and actively binds to blood proteins. Transformed by liver cells. It is excreted from the body by the kidneys and with intestinal contents within 0.5–1 days after administration.

Domperidone stimulates the release of prolactin. The secretion of gastric juice and its acidity are not affected. When consumed during or immediately after a meal, the effect of Motilium may slow down somewhat.

Indications for use of Motilium

Indications for the use of Motilium: vomiting, hiccups, nausea, atony and hypotension , cholecystitis , reflux esophagitis , peptic ulcers , the need to accelerate peristalsis before X-ray studies of the gastrointestinal tract, biliary dyskinesia cholangitis , flatulence .

As a component of complex treatment, the drug is taken for exacerbation of gastric and duodenal ulcers .

Indications for the use of Motilium for children: gastroesophageal reflux , cyclic vomiting, regurgitation syndrome .

The cheapest analogues

When it is necessary to replace Motilium, its inexpensive, but usually no less effective analogues are often chosen. Let's look at the most popular of them in more detail.

Domidon

This is a popular remedy from the group of peristalsis stimulants. Its action is aimed at relieving the symptoms of disorders of the digestive system. At the same time, there is a general improvement in their motor skills and functional activity.

The medicine is used to relieve attacks of vomiting for various digestive problems. It is prescribed exclusively for adults and adolescents over 12 years of age.

Domidon is not used if there are such contraindications:

• individual intolerance to components;
• prolongation of the cardiac conduction interval and other heart pathologies;
• presence of prolactinoma;
• severe liver or kidney pathologies.

The drug is also not prescribed when stimulation of gastric motility can lead to dangerous consequences - bleeding, perforation. As a rule, Domidon is well tolerated by patients, but in some cases side effects may occur. The most dangerous of them are cardiac dysfunction, mental and neurological disorders, and anaphylactic reactions.

The tablets should be taken orally half an hour before meals. The dosage regimen depends on the age and body weight of the person. It is used only to treat those patients whose body weight is above 35 kg. The daily dose should not exceed 30 mg (that is, 3 tablets). In this case, the medicine should be divided into 2 or 3 doses. It is permissible to take it for 2 days without consulting a doctor. In some cases, the appointment can be extended for a week.

Mechanism of action

This product is a complete analogue of Motilium. Their only difference is the manufacturer.

Metoclopramide

This medicine belongs to the group of peristalsis stimulants. It contains an active component - metoclopramide, which is a dopamine antagonist and also has cholinergic activity. The drug has 2 main properties - antiemetic and increased peristalsis.

The drug is used to eliminate nausea and gag reflex during radiation or chemotherapy. It is also prescribed as an additional remedy for relieving nausea and vomiting during migraine. In this case, first-line medications are oral analgesics.

The following conditions are contraindications:

• intolerance to components;
• bleeding from the digestive organs or their perforation;
• mechanical intestinal obstruction;
• signs of dyskinesia while taking antipsychotics;
• epileptic disease;
• parkinsonism;

  Parkinsonism

• prolactinoma;
• tendency to seizures;
• combination with levodopa or other dopamine antagonists.

Side effects are usually associated with extrapyramidal disorders. This is due to the effect of metoclopramide on dopamine receptors in the central nervous system.

Drink the tablets whole with liquid half an hour before meals. Dosage is determined by age and body weight:

1. Adults take 10 mg three times a day. This dose is the maximum. The course of treatment is no more than 5 days.
2. Children are prescribed a daily dose depending on their weight (from 1 to 10 mg three times a day).

Elderly patients or those with kidney or liver problems require a reduced dosage.

The main difference between this medicine and Motilium is its composition. They also have slightly different indications and contraindications. Metoclopramide can also be used to treat children from 1 year of age.

Motinorm

Indian remedy based on domperidone. Refers to peristalsis stimulants. It has an antiemetic effect and has the ability to improve the functioning of the digestive system, stimulating the motility of its organs.

The drug is prescribed to relieve the symptoms of digestive disorders (nausea, abdominal pain, vomiting). It should not be used in case of hypersensitivity to the constituent components, the presence of prolactinoma, cardiac anomalies, perforation or bleeding from the organs of the digestive system, as well as against the background of liver failure.

Available in the form of tablets for oral administration, each containing 10 mg of domperidone. They are taken orally before meals, swallowed whole and washed down with water. Prescribed only to adults and children over 12 years of age and weighing more than 35 kg. The daily dose is 30 mg, which should be divided into 3 doses. The duration of treatment should not exceed 7 days.

Has many side effects. When taking high doses, symptoms of overdose may be observed - extrapyramidal disorders, agitation, drowsiness, convulsions.

The drug is a structural analogue of Motilium, therefore it has the same indications, limitations and side effects. It differs only in the manufacturer and, accordingly, in the quality of raw materials.

Motorix

Another structural analogue of Motilium, which costs much less. Refers to stimulants of motility of the gastrointestinal tract. The drug is indicated to eliminate nausea in digestive disorders. It is not prescribed for hypersensitivity to the constituent components, liver failure, prolongation of the cardiac conduction interval, intestinal and gastric bleeding, and the presence of prolactinoma.

The drug is available in the form of tablets for oral administration. One tablet contains 10 mg of the active ingredient. This remedy is prescribed only to adults and children over 12 years of age. Drink the tablets whole with water. The daily dose is 30 mg, which should be divided into 3 doses. The duration of treatment is no more than 5 days.

The use of the medicine may be accompanied by side effects. In this case, various allergic reactions, digestive disorders, cardiac abnormalities, mental disorders and neurological disorders occur.

Motorix is ​​structurally and functionally no different from Motilium.

Tseruglan

This medicine is classified as an antiemetic. The main component is metoclopramide, a centrally acting dopamine antagonist. Its action is directed:

• to increase the motor activity of the esophagus and the tone of its lower section;
• speeding up the passage of food through the small intestine.

At the same time, the drug does not provoke the appearance of diarrhea. Indications for use are:

• relief of symptoms of digestive disorders (nausea, hiccups, vomiting);
• elimination of the gag reflex while taking certain medications (cytostatics) or radiation therapy;
• postoperative disturbance of intestinal motility;
• biliary dyskinesia;
• diagnostics of the digestive organs (when increased peristalsis is required);
• peptic ulcer (as part of complex treatment).

  Peptic ulcer

It has many contraindications and restrictions for use. Among them:

• intolerance to the constituent components;
• mechanical intestinal obstruction;
• bleeding from the gastrointestinal tract or perforation;
• extrapyramidal disorders;
• the presence of pheochromocytoma or prolactinoma;
• epilepsy;
• tendency to seizures;
• parkinsonism;
• high blood pressure;
• bronchial asthma;
• kidney or liver failure.

It is also not used to treat pregnant women, nursing mothers, and children under 6 years of age.

Take the drug orally half an hour before meals. The dosage regimen depends on the patient’s age:

• adults take 5 or 10 mg three times a day (no more than 20 mg at a time and a maximum of 60 mg per day);
• Children over 6 years old should take 5 mg 1 or 4 times a day.

The most commonly observed side effects are those associated with digestive disorders, neurological or mental disorders. Sometimes, while taking this drug, parkinsonism, depressive states, and dyskinesia may develop.

It differs from Motilium in composition, some indications and contraindications. This medicine can also be prescribed to children.

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Contraindications

The medicine has the following contraindications:

• bleeding in the gastrointestinal tract, perforation , mechanical obstruction ;
• prolactinoma;
• negative reaction of the body to the components of the drug;
• severe or moderate liver dysfunction

The drug should be taken with caution in case of kidney dysfunction , as well as cardiac and disorders .

It is advisable to consult a specialist about possible contraindications to the use of the medicine.

Motilium or Domperidone – which is better?

Manufacturer: Alsi Pharma, Ozon, Russia
Release form: tablets

Active ingredient: domperidone

Domperidone and Motilium - drugs with the same composition, are synonymous. They have the same indications, contraindications, and side effects.

A significant disadvantage of the domestic analogue of Domperidone is the low quality of raw materials (from India or China) and the frequent occurrence of side effects. The cost of the substitute is several times lower.

Another difference between Domperidone and Motilium is the release form. Pharmacies stock only regular tablets; the imported analogue is presented in display cases as dispersible tablets and syrup for children.

Side effects

The following side effects are possible when taking this medicine:

• endocrine system: amenorrhea , hyperprolactinemia (in rare cases can cause galactorrhea ), gynecomastia ;
• Gastrointestinal tract: spasms in the intestines;
• allergies : urticaria , rash;
• nervous system: extrapyramidal disorders .

Negative effects are observed only in extremely rare cases.

Instructions for use of Motilium (Method and dosage)

The instructions for use of Motilium indicate that the dosage regimen may vary depending on whether the tablets or suspension are used in each specific case.

In case of chronic dyspepsia, adults need to take the medicine 10 mg (1 tablet) on an empty stomach 3 times a day. If necessary, you can use the drug before bedtime. For those who use Motilium suspension and tablets, the instructions for use do not recommend exceeding the daily dosage of 80 mg.

Children are given syrup in a dosage of 2.5 ml of medicine per 10 kg of weight. This should be done 3 times a day on an empty stomach. If necessary, take the medicine before bedtime.

Instructions for use of Motilium for children over 1 year of age also indicate that, if necessary, the dose can be increased by 2 times. The maximum dosage per day is 2.4 mg/kg, but not more than 80 mg.

In case of nausea and vomiting, take syrup in a dosage of 20 ml or 2 tablets. This should be done 3-4 times a day on an empty stomach and before bedtime. Daily dosage – no more than 80 mg.

Suspension for children is given at the rate of 5 ml of product per 10 kg of weight. The medicine is taken 3-4 times a day on an empty stomach and before bedtime. The maximum daily dosage is 2.4 mg/kg, but not more than 80 mg.

Tablets can only be given to adults and children weighing over 35 kg. If your body weight is less, you need to use the so-called children's Motilium in the form of syrup.

Before use, the bottle of suspension must be shaken well. To open it, you need to press on the plastic cover and turn it. Next, remove the cap containing the Motilium suspension; the instructions for use indicate that it should only be drawn up using a special pipette that comes with the drug.

Release forms and structural analogues

The medicine Motilium is available in several forms. Among them:

1. Tablets for internal use. These are round tablets of white or cream color, each of which contains 10 mg of the active ingredient - domperidone, as well as excipients. They are packaged in cell blisters of 10 pieces. A cardboard box contains 30 tablets.
2. Lozenges (Motilium Express). They are round in shape and white in color. 1 tablet contains 10 mg of domperidone. Packed in 10 pieces in aluminum blisters. In a cardboard package – 10 or 30 tablets.
3. Suspension for oral administration. It looks like a white homogeneous liquid. The content of the active substance is 1 mg per 1 ml. The liquid is in a dark glass bottle with a volume of 100 ml. The kit includes a dosing syringe.

   Scheme for using Motilium

The drug Motilium has a fairly high price (about 550 rubles for a pack of 30 tablets), but pharmacies have its analogues (cheaper). The most popular ones:

1. Domidon.
2. Domrid.
3. Motilak.
4. Motinorm.
5. Motorix.
6. Nausilium.
7. Perilium.

You can also find special forms that are used to treat children. Among them, Perinorm, Passazhix and Domperidone stand out.

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Overdose

Overdose symptoms: drowsiness , extrapyramidal reactions , disorientation .

special antidote . In case of overdose, it is advisable to rinse the patient’s stomach and give activated carbon . It is necessary to monitor the patient's condition and carry out supportive measures.

In case of extrapyramidal reactions, anticholinergic and antihistamine drugs may be effective

Interaction

Anticholinergics may block the action of Motilium. Antifungal drugs of the azole group, HIV protease inhibitors and antibiotics belonging to the macrolide group can inhibit the biotransformation of domperidone and increase its content in the blood plasma , so this combination should be prescribed with caution.

The simultaneous use of Motilium and Ketoconazole in oral form, as well as Erythromycin and strong inhibitors of the CYP3A4 isoenzyme , which cause prolongation of the QT interval .

Motilium or Ganaton - which is better?

Manufacturer: Mylan, Japan
Release form: tablets

Active ingredient: itopride

Synonyms: Itomed, Retch, Itopra

An analogue of Motilium tablets is the Japanese drug Ganaton, often prescribed for GERD, and has positive reviews from doctors and patients. The medicine belongs to the group of stimulants of gastrointestinal motility and stimulators of acetylcholine release. Age limit – up to 16 years. Prescribed for dyspeptic symptoms and gastrointestinal motility disorders (reflux).

Motilium is available in additional forms - soluble tablets and syrup, and is used in pediatrics. It also affects intestinal motility and eliminates dyspeptic disorders.

The choice of medication and form is discussed with the doctor based on the diagnosis, symptoms, concomitant diseases, and restrictions.

Analogues of Motilium

Level 4 ATX code matches:
Passazhix

Motinorm

Domrid

Itomed

Metoclopramide

Domperidone

Motilak

Ganaton

Cerucal

The following analogues of Motilium are known:

• Domrid;
• Brulium Lingvatabs;
• Motinol;
• Gastropom-Apo;
• Motinorm;
• Domidon;
• Domperidone Hexal;
• Domperidone Sandoz;
• Domperidone-Credopharm;
• Domperidone-Ostoma;
• Domrid Sr;
• Motilak;
• Motoricum;
• Peridonium;
• Nausilium;
• Motorix;
• Peridon;
• Perilium.

Some analogues are cheaper than Motilium. These include, for example, Nausilium , Motorix , Motinorm , Domrid , Domidon .

Before taking Motilium analogues, you need to carefully study the instructions. Some of them are not suitable for children.

What is better - Motilium or Motilak?

find out which is better Motilium or Motilak only by experience. The active ingredient of both drugs is domperidone . Motilium is available in tablets and suspension form, while Motilak is available only in tablet form. The composition of the auxiliary components of the drugs is different, so if you have an individual intolerance to any of them, only one drug will do.

Both drugs normalize and prolong gastrointestinal motility , relieve vomiting and nausea. In addition, they help eliminate heartburn , flatulence and belching .

The difference between them is also the cost. Motilium costs 2-3 times more than Motilak . People who have taken both drugs claim that there is no qualitative difference between them.

Prices for the drug and its main analogues, average in Russia

One of the reasons for replacing the drug is its high price.
Information on prices for Motilium and its analogues is given in Table 1. Table 1 - Average prices for Motilium and its analogues

As can be seen from the table, Motilium is the most expensive drug compared to its analogues. There are cheaper antiemetics. Some of them contain the same active ingredient – ​​domperidone. There are also drugs that contain other active ingredients (prinfia bromide, bromopride), but their effect is similar to that of Motilium.

There are also analogues that are not sold in the Russian Federation (Domrid, Nausilium, Bromoprid, Brulium lingvatabs and others). If necessary, such a drug can be ordered online or purchased in another country.

During pregnancy (and lactation)

data on the effect of the drug during pregnancy . There is no information about the risk to the fetus. However, it is advisable to allow the drug during pregnancy only if the benefit of treatment is greater than the potential threat to the fetus.

When breastfeeding, the concentration of the active substance of the drug is 10-50% of its level in the blood . It is not known whether the drug has negative effects on newborns. Taking the drug is also possible only if the benefit to the mother is greater than the possible risk to the baby.

Reviews about Motilium

Reviews of Motilium characterize the drug as a highly effective, fast-acting remedy. It is very popular among consumers. Reviews of Motilium for children are also mostly positive. This remedy is often recommended by pediatricians, but not for infants. In the latter case, the effect of the drug has not been studied. In addition, the medicine is rarely used by nursing mothers, since its harm to lactation has not been studied.

Among the negative aspects, those who took Motilium note only a slightly inflated cost.

Motilium or Trimedat

Manufacturer: Valenta Pharm, Russia
Release form: tablets

Active ingredient: trimebutine

Synonyms: Neobutin, Neobutin retard, Trimedat forte

For GERD, Motilium or Trimedat may be prescribed. The first medicine has an antiemetic effect and regulates gastrointestinal motility. The second drug can replace Motilium for adults. Refers to antispasmodics that normalize intestinal motility.

The analogue of Motilium Trimedat is cheaper and is prescribed for children from 3 years of age. Indications: reflux disease, dyspeptic disorders, impaired intestinal motility (increased or decreased).

The drugs have similar actions, but different composition and mechanism. In each individual case, the choice is made based on the characteristics of the disease.

Motilium analogues are drugs from different pharmacological groups: antispasmodics, gastrointestinal motility regulators, antidiarrheals, sorbents, antacids, enzyme preparations. To make the right choice, consult your doctor for a diagnosis and determine the cause of the condition.

Motilium price, where to buy

The price of Motilium suspension is on average 540 rubles. This form of release is mainly used for children. The average price of Motilium in lozenges is 530 rubles. You can buy the product in this form of release in many pharmacies; as a rule, it is purchased for adults. In addition, coated tablets are popular. The price of Motilium in this form of release is 620 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Motilium Susp.
  for internal approx. 1mg/ml 100mlJanssen Pharmaceuticals N.V. 956 rub. order
• Motilium express tablets for rassas. 10 mg 10 pcs. Catalent UK Swindon Zaidis Limited/Jansen-Cilag S.p.A.

  RUR 521 order

• Motilium tablets p.p.o. 10mg 30 pcs JANSSEN CILAG

  RUR 879 order

Pharmacy Dialogue

• Motilium Express lozenges No. 30Janssen-Cilag

  RUB 849 order

• Motilium Express (table no. 10)Janssen-Cilag

  RUR 565 order

• Motilium bottle 1mg/ml 100mlJanssen Pharmaceutica

  956 rub. order

• Motilium tablets 10 mg No. 30Janssen-Cilag

  RUB 809 order

• Motilium Express lozenges No. 10Janssen-Cilag

  RUR 547 order

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Pharmacy24

• Motilium 10 mg No. 10 tablets Janssen-Cilag S.A., France
  65 UAH. order
• Motilium 10 mg No. 30 tablets Janssen-Cilag S.A., France

  135 UAH order

PaniPharmacy

• Motilium tablets Motilium tablets. 10mg No. 30 France, Janssen-Cilag

  163 UAH order

• Motilium tablets Motilium tablets. 10 mg No. 10 France, Janssen-Cilag

  80 UAH order

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pharmachologic effect

Manufacturer: Catalent/Janssen-Cilag, UK or Italy
Release form: tablets, dispersible tablets, suspension

Active ingredient: domperidone

Synonyms: Motilak, Motonium, Passazhiks, Motizhekt, Motinorm, Motogastrik, etc.

The drug is a dopamine antagonist with antiemetic properties. Contains domperidone, which accelerates intestinal motility, improves the movement of food and prevents stagnation in the stomach.

At the same time, Motilium does not change gastric secretion and does not affect the production of hydrochloric acid, like proton pump inhibitors (Omez, Nolpaza, etc.).