Oflomelid, 1 piece, 50 g, ointment for external use
Oflomelid® is a combination drug that has antimicrobial, anti-inflammatory, local anesthetic, and regenerating effects. The active ingredients are ofloxacin, methyluracil and lidocaine.
Ofloxacin is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. It has a bactericidal effect by blocking DNA gyrase in bacterial cells. DNA gyrase is essential for bacterial DNA replication, transcription, repair, and recombination. Its inhibition leads to unwinding and destabilization of bacterial DNA and, as a result, to the death of the microbial cell.
Microorganisms highly sensitive to ofloxacin (MIC
≤ 0.5 mg/l):
Gram-
aerobes
- Staphylococcus aureus methi-S (methicillin-sensitive strains), Staphylococcus coagulase negative (coagulase-negative staphylococci: Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Staphylococcus occus hominis, etc.);
Gram negative aerobes
– Aeromonas hydrophila, Bordetella spp., Brucella spp., Campylobacter jejuni, Citrobacter spp. (including Citrobacter freundii), Enterobacter spp. (including Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumonia), Moraxella (Brahamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Plesiomonas spp, Proteus spp. (Proteus mirabilis, Proteus vulgaris (indole+ and indole–)), Providencia spp., Salmonella spp., Serratia (including Serratia marcescens), Shigella spp. (including Shigella sonnei), Vibrio spp. (including Vibrio cholerae, Vibrio parahaemolyticus), Yersinia spp. (including Yersinia enterocolitica);
Anaerobes
– Clostridium perfringens, Helicobacter pylori, Propionibacterium acnes;
Other
– Chlamydia trachomatis, Legionella spp., Mycoplasma spp. (including Mycoplasma hominis).
Microorganisms moderately sensitive to ofloxacin:
Acinetobacter spp. (including Acinetobacter calcoaceticus), Bacteroides fragilis, Bacteroides urealyticus, Chlamydia psittaci, Gardnerella vaginalis, Enterococcus faecalis, Mycobacterium tuberculosis, Mycobacterium leprae, anaerobic gram-positive cocci (Peptococcus spp., Peptostreptococcus spp., Pseudomonas spp. (including P seudomonas aeruginosa), Streptococcus spp (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridians) – only penicillin-sensitive strains, Ureaplasma urealyticum.
Microorganisms resistant to ofloxacin (M P K
>
1 mg/l):
Acinetobacter baumannii, most strains of Enterococcus spp., Listeria monocytogenes, Nocardia spp, (including Nocardia asteroids), methicillin-resistant strains of Staphylococcus aureus and Staphylococcus spp. (Staphylococci methi-R), Treponema pallidum.
Methyluracil is a tissue repair stimulator. Has anabolic activity. Accelerates the processes of cellular regeneration in wounds, accelerating the growth and granulation maturation of tissue and epithelization.
Lidocaine has a local anesthetic effect due to the blockade of Na+ channels, which prevents the generation of impulses in the endings of sensory neurons and the conduction of impulses along nerve fibers. When used externally, it dilates blood vessels and does not have a local irritating effect. The water-soluble (hydrophilic) and hyperosmolar base of the ointment is a mixture of polyethylene oxides (polyethylene glycols) with a molecular weight of 400 and 1500 (PEO-400 and PEO-1500 or PEG-400 and PEG-1500), providing a dehydrating (moisture-absorbing) and osmotic effect on tissues, which 20 times stronger than a 10% sodium chloride solution and lasts up to 18-20 hours.
Oflomelid, ointment for external use, 50 g, 1 pc.
Oflomelid® is a combination drug that has antimicrobial, anti-inflammatory, local anesthetic, and regenerating effects. The active ingredients are ofloxacin, methyluracil and lidocaine.
Ofloxacin is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. It has a bactericidal effect by blocking DNA gyrase in bacterial cells. DNA gyrase is essential for bacterial DNA replication, transcription, repair, and recombination. Its inhibition leads to unwinding and destabilization of bacterial DNA and, as a result, to the death of the microbial cell.
Microorganisms highly sensitive to ofloxacin (MIC
≤ 0.5 mg/l):
Gram-
aerobes
- Staphylococcus aureus methi-S (methicillin-sensitive strains), Staphylococcus coagulase negative (coagulase-negative staphylococci: Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Staphylococcus occus hominis, etc.);
Gram negative aerobes
– Aeromonas hydrophila, Bordetella spp., Brucella spp., Campylobacter jejuni, Citrobacter spp. (including Citrobacter freundii), Enterobacter spp. (including Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumonia), Moraxella (Brahamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Plesiomonas spp, Proteus spp. (Proteus mirabilis, Proteus vulgaris (indole+ and indole–)), Providencia spp., Salmonella spp., Serratia (including Serratia marcescens), Shigella spp. (including Shigella sonnei), Vibrio spp. (including Vibrio cholerae, Vibrio parahaemolyticus), Yersinia spp. (including Yersinia enterocolitica);
Anaerobes
– Clostridium perfringens, Helicobacter pylori, Propionibacterium acnes;
Other
– Chlamydia trachomatis, Legionella spp., Mycoplasma spp. (including Mycoplasma hominis).
Microorganisms moderately sensitive to ofloxacin:
Acinetobacter spp. (including Acinetobacter calcoaceticus), Bacteroides fragilis, Bacteroides urealyticus, Chlamydia psittaci, Gardnerella vaginalis, Enterococcus faecalis, Mycobacterium tuberculosis, Mycobacterium leprae, anaerobic gram-positive cocci (Peptococcus spp., Peptostreptococcus spp., Pseudomonas spp. (including P seudomonas aeruginosa), Streptococcus spp (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridians) – only penicillin-sensitive strains, Ureaplasma urealyticum.
Microorganisms resistant to ofloxacin (M P K
>
1 mg/l):
Acinetobacter baumannii, most strains of Enterococcus spp., Listeria monocytogenes, Nocardia spp, (including Nocardia asteroids), methicillin-resistant strains of Staphylococcus aureus and Staphylococcus spp. (Staphylococci methi-R), Treponema pallidum.
Methyluracil is a tissue repair stimulator. Has anabolic activity. Accelerates the processes of cellular regeneration in wounds, accelerating the growth and granulation maturation of tissue and epithelization.
Lidocaine has a local anesthetic effect due to the blockade of Na+ channels, which prevents the generation of impulses in the endings of sensory neurons and the conduction of impulses along nerve fibers. When used externally, it dilates blood vessels and does not have a local irritating effect. The water-soluble (hydrophilic) and hyperosmolar base of the ointment is a mixture of polyethylene oxides (polyethylene glycols) with a molecular weight of 400 and 1500 (PEO-400 and PEO-1500 or PEG-400 and PEG-1500), providing a dehydrating (moisture-absorbing) and osmotic effect on tissues, which 20 times stronger than a 10% sodium chloride solution and lasts up to 18-20 hours.
Oflomelid, 1 piece, 100 g, ointment for external use
Oflomelid® is a combination drug that has antimicrobial, anti-inflammatory, local anesthetic, and regenerating effects. The active ingredients are ofloxacin, methyluracil and lidocaine.
Ofloxacin is a broad-spectrum antimicrobial agent from the group of fluoroquinolones. It has a bactericidal effect by blocking DNA gyrase in bacterial cells. DNA gyrase is essential for bacterial DNA replication, transcription, repair, and recombination. Its inhibition leads to unwinding and destabilization of bacterial DNA and, as a result, to the death of the microbial cell.
Microorganisms highly sensitive to ofloxacin (MIC
≤ 0.5 mg/l):
Gram-
aerobes
- Staphylococcus aureus methi-S (methicillin-sensitive strains), Staphylococcus coagulase negative (coagulase-negative staphylococci: Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Staphylococcus occus hominis, etc.);
Gram negative aerobes
– Aeromonas hydrophila, Bordetella spp., Brucella spp., Campylobacter jejuni, Citrobacter spp. (including Citrobacter freundii), Enterobacter spp. (including Enterobacter cloacae, Enterobacter aerogenes, Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp. (including Klebsiella pneumonia), Moraxella (Brahamella) catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitides, Plesiomonas spp, Proteus spp. (Proteus mirabilis, Proteus vulgaris (indole+ and indole–)), Providencia spp., Salmonella spp., Serratia (including Serratia marcescens), Shigella spp. (including Shigella sonnei), Vibrio spp. (including Vibrio cholerae, Vibrio parahaemolyticus), Yersinia spp. (including Yersinia enterocolitica);
Anaerobes
– Clostridium perfringens, Helicobacter pylori, Propionibacterium acnes;
Other
– Chlamydia trachomatis, Legionella spp., Mycoplasma spp. (including Mycoplasma hominis).
Microorganisms moderately sensitive to ofloxacin:
Acinetobacter spp. (including Acinetobacter calcoaceticus), Bacteroides fragilis, Bacteroides urealyticus, Chlamydia psittaci, Gardnerella vaginalis, Enterococcus faecalis, Mycobacterium tuberculosis, Mycobacterium leprae, anaerobic gram-positive cocci (Peptococcus spp., Peptostreptococcus spp., Pseudomonas spp. (including P seudomonas aeruginosa), Streptococcus spp (including Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus viridians) – only penicillin-sensitive strains, Ureaplasma urealyticum.
Microorganisms resistant to ofloxacin (M P K
>
1 mg/l):
Acinetobacter baumannii, most strains of Enterococcus spp., Listeria monocytogenes, Nocardia spp, (including Nocardia asteroids), methicillin-resistant strains of Staphylococcus aureus and Staphylococcus spp. (Staphylococci methi-R), Treponema pallidum.
Methyluracil is a tissue repair stimulator. Has anabolic activity. Accelerates the processes of cellular regeneration in wounds, accelerating the growth and granulation maturation of tissue and epithelization.
Lidocaine has a local anesthetic effect due to the blockade of Na+ channels, which prevents the generation of impulses in the endings of sensory neurons and the conduction of impulses along nerve fibers. When used externally, it dilates blood vessels and does not have a local irritating effect. The water-soluble (hydrophilic) and hyperosmolar base of the ointment is a mixture of polyethylene oxides (polyethylene glycols) with a molecular weight of 400 and 1500 (PEO-400 and PEO-1500 or PEG-400 and PEG-1500), providing a dehydrating (moisture-absorbing) and osmotic effect on tissues, which 20 times stronger than a 10% sodium chloride solution and lasts up to 18-20 hours.
Description and composition of Oflomelid
Oflomelid for hemorrhoids is a combination remedy. It is an ointment that is white or close to it.
The active composition of the drug is represented by three components at once - methyluracil (dioxomethyltetrahydropyrimidine (4 g)), lidocaine hydrochloride monohydrate (3 g), ofloxacin (1 g). The remaining components are auxiliary.
Methyluracil stimulates cellular regeneration and increases the body's resistance to infection. This effect is ensured by epithelization and acceleration of growth and granulation maturation of tissues. The substance has anti-inflammatory properties.
Lidocaine provides the anesthetic properties of the drug, and ofloxacin has an antimicrobial effect. Pain relief is provided by blockade of sodium channels. Lidocaine also has vasodilating properties, but there is no local irritating effect. Ofloxacin has a wide spectrum of action and belongs to the group of fluoroquinolones (antibiotics).
