Pharmacodynamics and pharmacokinetics
This oral monophasic combined estrogen-progestogen contraceptive drug can have an inhibitory effect on the pituitary production of gonadotropic hormones .
In this case, the contraceptive effect is associated with several mechanisms. The progestin component progestin includes a 19-nortestosterone derivative known as levonorgestrel . This substance is superior in its activity to the corpus luteum hormone progesterone or its synthetic analogue pregnin , which acts at the receptor level without undergoing metabolism .
The estrogenic component ethinyl estradiol leads to a blockade of the release of releasing hormones by the hypothalamus and inhibition of the production of gonadotropic hormones by the pituitary gland. At the same time, the maturation and release of the egg, ready for fertilization, is inhibited.
It has been established that ethinyl estradiol enhances the contraceptive effect of the drug. The increased viscosity of the cervical mucus remains, which makes it difficult for sperm to penetrate.
Also, regular use of the drug leads to normalization of the menstrual cycle and prevents the development of certain gynecological diseases, for example, tumors.
Inside the body, the drug undergoes rapid absorption. The concentration of Rigevidon depends on the dosage of the drug and the duration of use. In this case, the maximum concentration is usually detected after 2 hours, elimination occurs on average within 16 hours. The drug is excreted in metabolites and unchanged through the intestines and kidneys.
Pharmacological properties of the drug Rigevidon
A monophasic oral contraceptive hormonal drug consisting of two components - a progestogen (levonorgestrel) and estrogen (ethinyl estradiol). Its action is carried out, first of all, by inhibiting ovulation by preventing the release of FSH and LH, as well as by increasing the mobility of the fallopian tubes and increasing the viscosity of the cervical secretion, inhibiting the implantation of the egg into the endometrium and hindering the advancement of sperm. When administered orally, the components of Rigevidon are quickly and almost completely absorbed from the digestive tract. The maximum concentration of levonorgestrel in the blood plasma is reached after 2 hours, and ethinyl estradiol after 1.5 hours. Both components are metabolized in the liver. The half-life of ethinyl estradiol is 2–7 hours. 60% of levonorgestrel is excreted in the urine, 40% in the feces; 40% of ethinyl estradiol is excreted in the urine, 60% in feces. Both components pass into breast milk.
Contraindications
Birth control pills Rigevidon are not prescribed for:
- sensitivity to the drug;
- lactation, pregnancy;
- severe liver diseases;
- congenital hyperbilirubinemia;
- cholecystitis;
- thromboembolism;
- tumor diseases;
- severe forms of arterial hypertension;
- diabetes mellitus and other diseases of the endocrine glands;
- sickle cell anemia ;
- chronic hemolytic anemia;
- hydatidiform mole;
- over 40 years of age;
- migraine;
- otosclerosis.
The drug is also contraindicated for use in cases of bleeding of various origins, idiopathic jaundice, skin itching and herpes in pregnant women.
Rigevidon is prescribed with caution to patients with liver, kidney and gall bladder diseases, epilepsy, depression, ulcerative colitis, uterine fibroids, mastopathy, tuberculosis , diseases of the cardiovascular system, arterial hypertension, renal dysfunction, varicose veins, phlebitis , otosclerosis and multiple sclerosis . Caution is also required when prescribing tablets to adolescent patients.
Side effects of Rigevidon
Usually this drug is well tolerated by patients, but sometimes side effects of Rigevidon occur, which develop transiently and disappear spontaneously. For example, nausea, vomiting, headaches, weight gain and changes in libido , mood, acyclic bleeding, conjunctivitis , vision problems, and so on.
In rare cases, long-term use of the drug causes chloasma, hearing loss, jaundice, generalized itching , convulsions, frequency of epileptic seizures, hypertriglyceridemia , hyperglycemia , increased blood pressure, thrombosis or venous thromboembolism, skin rashes, changes in vaginal secretion, high fatigue, vaginal candidiasis , etc. .
Side effects of the drug Rigevidon
The drug is usually well tolerated. When starting to use Rigevidon, in some cases, digestive disorders, nausea, vomiting, swelling of the mammary glands, headache, mood changes, increased fatigue, skin rash, calf muscle cramps, changes in libido, intermenstrual bleeding, discomfort when using contact lenses, may occur. Subsequently, the severity of these phenomena decreases or they completely disappear. Rigevidone can cause both an increase and a decrease in body weight. When taking the drug, it is necessary to consider the possibility of impaired glucose tolerance. With longer use, chloasma can very rarely occur. Occasionally, an increase in the level of TG in the blood plasma, an increase in blood pressure, thrombosis and thromboembolism of various localizations, hepatitis, gallbladder disease, jaundice, hair loss, changes in vaginal secretion, vaginal mycosis, and diarrhea are noted.
Rigevidon tablets, instructions for use (Method and dosage)
Instructions for use of Rigevidon recommend taking the tablets orally, whole, with water.
When hormonal contraception was not used during the previous menstrual cycle, it should be started on the 1st day of menstruation. Then you need to take one tablet every day for 21 days, preferably at a certain time of day.
After this, a break of 7 days is taken, during which menstrual-like bleeding occurs. For the next 21 days, the tablets are taken from a new package, that is, already on the 8th day, regardless of whether the bleeding has stopped or not.
The transition to these contraceptive pills from another contraceptive is carried out according to the same scheme. You can take the drug as long as you need it.
Taking the drug after an abortion can be started immediately on the day of surgery or the next day. After childbirth, the contraceptive is allowed for use by women who are not breastfeeding. You should start taking it from the first day of menstruation .
When skipping pills, it is important to know how to take Rigevidon in such cases. According to the instructions, the missed pill must be taken within the next 12 hours. If more than 36 hours pass after taking the drug, then contraception will be unreliable, so you need to take care of additional contraceptives .
The use of the drug for medicinal purposes requires individual selection of dosage and therapeutic regimen.
Instructions for use RIGEVIDON 21+7 (RIGEVIDON 21+7)
Before prescribing oral contraceptives or resuming their use, a thorough medical history (including family history) should be obtained, as well as a physical examination to identify contraindications and risk factors. This procedure should be carried out at least once a year during the entire period of use of oral contraceptives. It is also important to conduct periodic medical evaluation due to the possibility of contraindications (eg, transient cerebral ischemia) or risk factors (eg, hereditary venous or arterial thrombotic disorders) while taking oral contraceptives. The frequency and nature of such assessments depend on the woman’s condition, but especially blood pressure, the condition of the mammary glands, abdominal and pelvic organs, incl. carry out cytological examination of the cervix and relevant laboratory tests.
Women should be reminded that oral contraceptives do not protect against HIV infection (AIDS) or other sexually transmitted infections. If there is a risk of HIV infection/AIDS, correct and consistent use of condoms should be recommended, incl. in combination with other methods of contraception.
When using oral contraceptives, smoking increases the risk of serious cardiovascular side effects. The risk increases with age depending on the number of cigars smoked, especially in women smokers over 35 years of age. All women taking oral contraceptives should be strongly advised to refrain from smoking. For women over 35 years of age who smoke, the use of other methods of contraception should be considered.
If a woman has any of the risk factors listed below, the benefits of using combined oral contraceptives should be carefully weighed against the potential risks on a case-by-case basis and discussed with the woman before starting combined oral contraceptives. If any of these symptoms or risk factors worsen, worsen, or appear, the woman should be advised to consult a doctor who will decide whether to stop taking oral contraceptives.
Circulatory disorders
Epidemiological studies have shown an association between the use of oral contraceptives and an increased risk of arterial and venous thrombosis and thromboembolic disorders such as myocardial infarction, stroke, deep vein thrombosis and pulmonary embolic disorders.
The drug should be stopped if symptoms appear that indicate the inevitable development of complications:
- severe abnormal headaches, visual disturbances, increased blood pressure, clinical signs of deep vein thrombosis or pulmonary embolic disorders.
Venous thromboembolism (VTE), which manifests itself as deep vein thrombosis and/or pulmonary embolic disorders, can occur during the use of any oral contraceptives. The incidence of VTE in women using low-estrogen oral contraceptives (less than 50 mcg ethinyl estradiol) is approximately 4 cases per 10,000 women per year, compared with 0.5 cases per 10,000 women not using oral contraceptives per year. However, the likelihood of VTE from using oral contraceptives is much lower than from pregnancy (6 cases per 10,000 women per year).
Cases of thrombosis of other blood vessels have been reported extremely rarely, and damage to the hepatic, mesenteric, renal or retinal veins and arteries may occur among women taking oral contraceptives. There is no consensus as to whether these lesions are related to the use of contraceptives.
The risk of developing thromboembolism (venous and/or arterial) increases:
- with age;
- when smoking (women over 35 years of age are advised to stop smoking if they want to take oral contraceptives);
- with a hereditary predisposition, for example, the presence of venous or arterial thromboembolism in siblings or parents at a relatively young age (if a hereditary predisposition is suspected, the woman should be referred to a specialist before she decides to take oral contraceptives);
- for obesity (body mass index above 30 kg/m2);
- with dyslipoproteinemia;
- with arterial hypertension;
- for diseases of the heart valves;
- with atrial fibrillation;
- with prolonged immobilization, major surgery, leg surgery, or serious injury. In such cases, it is recommended to interrupt the use of oral contraceptives (in the case of planned surgery, at least 4 weeks before the operation) and not to resume use until 2 weeks have passed after the complete restoration of an active lifestyle.
There is no consensus regarding the possible influence of varicose veins and superficial thrombophlebitis on venous thromboembolism.
The increased risk of thromboembolism during childbirth should be taken into account.
Other conditions that may be associated with circulatory problems include diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis), and sickle cell anemia.
If migraine attacks become more frequent or more severe (which may precede cerebrovascular events), the patient should immediately stop taking oral contraceptives.
Biochemical factors characterizing hereditary or acquired predisposition to venous or arterial thrombosis include resistance to activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, the presence of antiphospholipid antibodies (anticardiolipin antibodies, lupus anticoagulant).
Tumors
Some epidemiological studies have reported an increased risk of cervical cancer with long-term use of oral contraceptives, but there is no evidence to what extent this is influenced by sexual behavior and other factors such as human papillomavirus (HPV).
A meta-analysis of 54 epidemiological studies found that the relative risk (RR) of diagnosed breast cancer is only slightly greater (RR=1.24) in women taking combined oral contraceptives. This rate gradually decreases over the next 10 years after stopping oral contraceptives. Because breast cancer is quite rare among women under 40 years of age, the increase in breast cancer diagnoses among women who are current or former users of oral contraceptives is small compared with the lifetime risk of breast cancer.
These studies do not provide evidence of causation. The observed pattern of increased risk may be due to earlier diagnosis of breast cancer among women taking oral contraceptives, biological effects of oral contraceptive use, or a combination of both. Diagnosed cases of breast cancer among women taking oral contraceptives tend to be clinically less advanced compared with diagnosed cases of breast cancer among women not taking oral contraceptives.
The occurrence of benign and malignant liver tumors has been reported among women taking combined oral contraceptives. These tumors in some cases led to life-threatening intra-abdominal bleeding. As a differential diagnosis, the possibility of a liver tumor should be considered if women complain of severe upper abdominal pain or signs of intra-abdominal bleeding in women taking oral contraceptives.
Other pathological conditions
Women with hypertriglyceridemia or a family history of hypertriglyceridemia may have an increased risk of pancreatitis when taking oral contraceptives.
In acute or chronic liver dysfunction, the drug should be discontinued until laboratory liver function tests return to normal. Steroid hormones may be poorly absorbed by patients with impaired liver function.
Women with hyperlipidemia require careful monitoring when using oral contraceptives.
Although slight increases in blood pressure have been reported in many women taking oral contraceptives, clinically significant increases in blood pressure are rare. If persistent arterial hypertension develops as a result of the use of this drug, then use should be stopped and treatment of arterial hypertension should be started. The use of oral contraception can be resumed, if necessary, as soon as normal blood pressure levels are achieved with antihypertensive therapy.
The following conditions may appear or worsen, both during pregnancy and during the use of oral contraceptives, but there is no convincing evidence of a relationship with the use of oral contraceptives:
- jaundice and/or itching associated with bile stagnation;
- formation of gallstones;
- porphyria;
- systemic lupus erythematosus;
- hemolytic-uremic syndrome;
- chorea;
- herpes during pregnancy;
- hearing loss due to otosclerosis.
Oral contraceptives may affect peripheral insulin resistance and glucose tolerance. Therefore, patients with diabetes require careful monitoring while using oral contraceptives.
Rigevidon 21+7 contains lactose and sucrose. Patients with rare hereditary conditions such as galactose intolerance, lactase intolerance, glucose-galactose malabsorption or fructose intolerance should not take this medicine.
An association has been reported between the development of Crohn's disease and ulcerative colitis and the use of combined oral contraceptives.
Chloasma may occasionally develop, especially in women with a history of chloasma during pregnancy. Women predisposed to chloasma should avoid direct sunlight or ultraviolet radiation while taking oral contraceptives.
There are reports of cases of retinal thrombosis while taking oral contraceptives. Taking oral contraceptives should be stopped if there is unexplained partial or complete loss of vision, the onset of proptosis or diplopia, swelling of the optic nerve, or pathological changes in the retinal vessels.
If depression develops while using oral contraceptives, you should stop taking them; in such cases, it is recommended to use alternative methods of contraception until it is determined whether the development of depression is associated with taking oral contraceptives. Women with a history of depression require careful clinical monitoring. If symptoms of depression return, you should stop taking oral contraceptives.
Medicines containing St. John's wort (Hypericum perforatum) should not be used while taking Rigevidon 21+7 due to the possibility of reducing the concentration of active substances in plasma and reducing the clinical effectiveness of Rigevidon 21+7.
The effectiveness of oral contraceptives may be reduced by missing tablets, vomiting, or concomitant use of another drug.
When taking any oral contraceptives, irregular bleeding (spotting or spotting) is possible, especially during the first months. Therefore, bleeding irregularity should be assessed after an adaptation period, which lasts approximately 3 cycles.
If bleeding remains irregular or becomes irregular after a previously stable cycle, non-hormonal causes should be considered and appropriate evaluation undertaken to rule out malignancy or pregnancy. If non-hormonal causes are excluded, the use of hormonal-rich oral contraceptives may need to be considered.
Sometimes, during a break from taking pills, bleeding may not occur. When using the drug in accordance with the dosage regimen, pregnancy is unlikely. However, if the dosage regimen is violated, the possibility of pregnancy should be excluded before continuing the use of oral contraceptives.
Taking hormonal contraceptives may affect the results of laboratory parameters, incl. for biochemical indicators of liver function, thyroid gland, functional tests of the adrenal glands and kidneys; on plasma concentrations of transport proteins, for example, corticosteroid binding globulin and lipid/lipoprotein fractions; on the parameters of carbohydrate metabolism and parameters of coagulation and fibrinolysis. As a rule, changes remain within normal limits.
Impact on the ability to drive vehicles and operate machinery
Rigevidon 21+7 does not affect or has virtually no effect on the ability to drive vehicles or other mechanisms with an increased risk of injury.
Experimental results
The acute toxicity of ethinyl estradiol and levonorgestrel is low. Because of the observed variations, preclinical results have limited predictive value in human estrogen use. In experimental animals, estrogens have shown an embryo-lethal effect even in relatively small doses; Malformations of the genitourinary tract and feminization of male embryos were observed. Levonorgestrel had a virilizing effect on female embryos. Reproductive toxicology studies in rats, mice and rabbits did not reveal a teratogenic effect, regardless of gender differentiation.
Preclinical data based on generally accepted repeated dose toxicity, genotoxicity, and carcinogenic potential studies have not revealed any risks to humans other than those described elsewhere in the instructions.
Interaction
Combination with barbiturates, antiepileptic drugs, for example, Carbamazepine and Phenytoin , as well as sulfonamides, pyrazolone derivatives, can lead to increased metabolism of steroid hormones included in the drug.
The combined use of Rigevidon and certain antimicrobial drugs can reduce the contraceptive effect: Ampicillin, Rifampicin, Chloramphenicol, Neomycin, Polymyxin B , sulfonamides and Tetracycline , as they change the composition of microflora .
This drug can increase the bioavailability and toxicity of tricyclic antidepressants, beta-blockers and Maprotiline , and reduce the effectiveness of Bromocriptine .
Combined use with hypoglycemic drugs and insulin often requires changing their dosage. When taken with the drug Dantrolene, it is possible that its hepatotoxicity may increase, mainly in women over 35 years of age.
Interactions of the drug Rigevidon
Rigevidone should be used with caution in combination with ampicillin, rifampicin, chloramphenicol, neomycin, phenoxymethylpenicillin, sulfonamides, tetracyclines, dihydroergotamine, tranquilizers, phenylbutazone (these drugs may reduce the contraceptive effect, so it is recommended to use another non-hormonal method of contraception), with anticoagulants, coumarin derivatives or indindione (it may be necessary to determine the prothrombin time and adjust the dose of the anticoagulant), tricyclic antidepressants, maprotiline, β-adrenergic receptor blockers (bioavailability and toxicity may increase), with oral hypoglycemic drugs, insulin (dosage adjustment may be necessary), bromocriptine (decreased effectiveness), hepatotoxic drugs, primarily dantrolene (risk of increased hepatotoxicity, especially in women over 35 years of age).
special instructions
Before starting to take contraceptive pills, and every six months when using them, it is necessary to undergo a general medical and gynecological examination. It usually includes a cytological analysis, examination of the mammary glands, assessment of blood glucose, cholesterol , liver function, pressure and urine composition.
For patients who have suffered viral hepatitis and their liver functions have normalized, the drug is prescribed no earlier than 6 months from the moment of recovery.
If sharp abdominal pain, hepatomegaly and signs of intra-abdominal bleeding , this may indicate a liver tumor. If necessary, the drug is immediately discontinued.
The appearance of intermenstrual bleeding does not require discontinuation of the contraceptive, since it usually stops on its own. When this does not happen, consultation with a gynecologist is necessary.
As is known, women who smoke when taking hormonal contraceptives can develop vascular diseases with serious consequences - myocardial infarction and stroke.
Rigevidon's analogs
Level 4 ATC code matches:
Ovidon
Non-Ovlon
Mercilon
Yarina Plus
Yarina
Miniziston 20 fem
Novinet
Microgynon
Janine
Lindineth
Cyclo-Proginova
Regulon
Logest
Midiana
Belara
Femoden
Jess Plus
Jess
Zoely
Main analogues: Yarina, Regulon and Janine.
Rigevidon or Regulon – which is better?
To understand which of these drugs is better, you just need to compare Rigevidon and Regulon. Their main difference lies in the gestagen component - in Regulon it is desogestrel, which also does not have an antiandrogenic effect. Moreover, before taking these pills, it is difficult to understand how suitable they are and how they will be tolerated by patients.
There are many reviews of women taking one of these drugs for a long time. This did not lead to the development of undesirable effects, such as changes in libido or weight gain. Moreover, immediately after discontinuation of these contraceptives, pregnancy occurred almost immediately. Therefore, the selection of such drugs must be carried out taking into account individual characteristics after consultation with a gynecologist.
Reviews about Rigevidon
Many women of reproductive age take various contraceptive medications. Therefore, you can find reviews about Rigevidon on forums where women actively discuss such products.
Of course, the attitude towards them is completely different. Some believe that birth control pills have only benefits and willingly take them. Others, on the contrary, are afraid of using any hormonal drugs and therefore use other methods of contraception, which are not always effective. There are also reports when users do not know what the pills are for or why they are taking them.
Women who have tested this drug on themselves also express completely different opinions. Some patients report that while taking it they experienced constant nausea, mood swings and gained significant weight. However, many women say that they have been taking Rigevidon 21+7 for several years and during all this time they have not felt any unwanted effects. At the same time, the drug provides them with reliable protection from unwanted pregnancy.
The reviews of doctors who use different drugs in their practice deserve special attention. They once again note that the choice of such funds should not be done independently. If the need for contraception arises, you can always consult a gynecologist to conduct a full examination, determine your hormonal status, discuss pregnancy plans and choose the appropriate method of protection against unwanted conception.
Contraceptives Gedeon Richter Rigevidon - reviews
Ambroziya
https://nashiotzyvy.com/krasota-i-zdorove/59758-kontraceptivy-gedeon-richter-rigevidon.html
Pros: Reliable contraceptive effect, low price, no PMS, smooth cycle
Cons: Noticeably reduces libido, may make you feel sick, old drug
Contraceptive pills Rigevidon were recommended to me by a gynecologist. I was worried about my periods being too heavy. There was no pain, just a lot of flooding. She underwent an examination and an ultrasound showed endometrial hyperplasia and chronic adnexitis on the left. At first I was prescribed to drink a herbal mixture that has hemostatic and anti-inflammatory properties, but I was tired of brewing it every day. Then Rigevidon was prescribed.
I took these pills several years ago. They were then sold in convenient packaging designed for three cycles.
Started taking pills. I didn't have any side effects from them. They were well tolerated. I didn’t feel sick, I didn’t have a headache, I didn’t gain weight. I drank them consistently for three years.
My periods began to tick by like clockwork in a pharmacy. Most importantly, the amount of discharge has been adjusted. I was no longer flooded. The contraceptive effect was also stable. But, probably, there was still one side effect - a weak sexual desire.
I decided to take a break from taking it. I think maybe it’s harmful to take hormones for so long? I haven't had them for a while. The symptoms that bothered me before returned. Here’s the treatment: as long as you drink, everything is fine, you just stopped, you’re wearing it... Again you had to stock up on a ton of pads. I decided to return to taking Rigevidon.
As usual, on the 5th day of the cycle, I take a pill in the evening, after a few hours nausea appears. The same is true for all subsequent days of admission. I can’t tolerate this side effect for a long time - I stopped the drug. In general, it didn’t suit me a second time.
By the way, Rigevidon is not such a modern contraceptive. If a gynecologist prescribes it for therapeutic purposes, try it. But, if you drink only for contraception, there are more gentle drugs, with less hormones. And there are many possible side effects on the list, and quite a few contraindications.
Maria Sinitsyna
https://xlebez.ru/kontraceptivy-gedeon-richter-rigevidon/
Advantages: reliable contraceptive effect, lost weight, smooth cycle
Disadvantages: noticeably reduces libido
Sorry for such a frivolous review, but I’ve been wanting to write for 4 months! Finally the day has come. I’ve been taking OK for five years intermittently, before I only drank Regulon - no side effects, skin is fine, weight too (I even lost a little weight, but not much). In the fall of 2012, I had to undergo a complex operation, and a month before it I stopped taking the pills. The operation was completed, after 5 months the need for contraception arose again, since my husband and I had not yet planned children, and my health does not yet allow me to get pregnant….alas…. So I resumed taking Regulon......HORROR! Within a week, so many pimples, blackheads and other nasty things appeared on my face that were not observed during adolescence! Not a single remedy helped get rid of them! In addition to everything, 3 extra pounds! Choking on tears, I drank the entire package and lo and behold, during the week of the break my face cleared up a little and the weight went off on the second day!......hmmm......I didn’t expect such a setup from Regulon)
Since the need for contraception remained, I went to a gynecologist I knew, who advised me to start taking Rigevidon, saying that the dosage was lower and the side effects were less frequent. I bought it and started taking it with caution. A week passed, every morning I looked at my face and body in the mirror like crazy every morning for unpleasant side effects, but everything was fine. I was happy early, gentlemen))) in the second week my libido began to leave me... Before that, our intimate life was more than eventful, desire arose from the slightest touch, and sometimes from the unequivocal glance of my husband))) And then the trouble…. Imagine that you simply lost your desire! at all! it does not arise under any circumstances! I never thought before that such a problem could arise, and this is really a PROBLEM!!! When there is not a single emotion from... Hm…. making love…. And here I had to learn to imitate incredible pleasure, it’s difficult, but you can’t do anything for your loved one))) I think many girls will understand me)))
6 months of taking it have passed, there are still no side effects, except for those described above, I have lost 4 kg, which is good news. And the libido quietly dozes until the onset of the 7-day break))
This is a side effect of many OCs. In general, I am satisfied with Rigevidon. Recently I was examined at the antenatal clinic - everything is fine, ugh ugh ugh.
Of course, taking OK is not the best for our health, but...
Health to everyone!!!
Anonymous
https://xn--b1accz8b1g.xn--j1amh/ru/%D0%BA%D0%BE%D0%BD%D1%82%D1%80%D0%B0%D1%86%D0%B5%D0 %BF%D1%82%D0%B8%D0%B2%D1%8B_gedeon_richter_%D1%80%D0%B8%D0%B3%D0%B5%D0%B2%D0%B8%D0%B4%D0%BE %D0%BD-r259788.html
I have heard for a long time that many women use contraceptives as a way to get pregnant. Many people say that if you take these pills and then suddenly quit, for example in the middle of the pack, pregnancy will occur almost immediately.
I couldn't get pregnant for two years. I went to the doctors and had an ultrasound. Everywhere everyone said that as far as the female part was concerned, I was absolutely healthy. But pregnancy did not occur.
That’s when I decided to try to apply the so-called “oRigevidon effect.” I drank through the first package completely. And from the second I only took about 10 tablets and stopped. And here is the result - after a month the test showed 2 stripes :-)
I would like to note that this is not a call to action, we are all different and our organisms are individual.
I'm just sharing my experience using Rigevidon.
DesertWind
https://www.babyblog.ru/drug/rigevidon/otzyv
After taking rigevidon for a long time, I didn’t have my period for half a year. how. But I drank it for a long time.
Lisa01
https://www.woman.ru/health/medley7/thread/4383567/1/#m44889499
I’ve been taking Regivedon for 10 years, I stopped it only for the period of pregnancy and lactation (four years ago), and I also take a break once a year for a couple of months. Now he’s on it again. Apart from the fact that the breasts hurt and enlarged during the withdrawal period (a month and a half), there were no side effects. At the very beginning, when I consulted with a gynecologist, the doctor advised me to “check” my liver every six months or a year and quit smoking, because. a large load on the heart together with OK. And that’s it... Once every three years I get examined - no problems have been identified. But, as I read the comments about “Rigevidon”, my hair stands on end, and everywhere - what am I taking?!!!)))))) It’s possible that everything is individual, but, I think (as an experienced “user” “Rigevidon”))), that the majority of their obesity, health problems associated with an indecent lifestyle for a person, etc., are attributed to “Rigevidon” - it’s easier for them to justify themselves, to justify their own laziness, hence all the “horrors” about side effects.
Svetlana Evgenievna
https://www.neboleem.net/comments-reviews/rigevidon/66/3046/1/
I can't understand it a bit. So I took 21 tablets. I took a break for 7 days, I already need to drink on the 8th day, but my period has not started yet. What should I do then? Should I take it after 7 days or wait until my period starts and then drink it on the 7th day of my period? Help, I don't understand anything
Nadezhda Doctor
Svetlana Evgenievna, you need to take a break for 7 days, and then start a new package, regardless of whether there was bleeding or not. Gradually the cycle will improve.
Sveta
https://www.medcentre24.ru/medicamenty/rigevidon.html
I took the drug Rigevidon about two years ago to restore the menstrual cycle. The drug adjusted the menstrual cycle after two months. It helped a lot, as I had big problems with my cycle. It happened that there were no periods for several months. As soon as I started drinking Rigevidon, everything improved.
Nina
https://www.sikirina.tsi.ru/forum/kontracepciya-predohranenie-ot-beremennosti/rigevidon-otzivi7.html
Hello Evgenia! Yesterday the Mirena IUD was removed because a submucous node appeared and the IUD was displaced. The doctor prescribed me to take Rigevidon to avoid bleeding because in the near future I am preparing for an operation to remove the uterus. Only I didn’t understand the dosage regimen a little. For now, drink according to one tablet 1 tablet per day, and if menstruation increases, then 1 tablet every 4 hours, the next day 1 tablet less at an equal interval of time, and so on until one tablet? And should I take a break for 7 days or drink without a break before surgery? If possible, please tell me.
Evgeniya34 (consultant):
Nina, you should have asked the doctor again if you didn’t understand the first time)) I don’t know what the doctor meant)) Now start taking Rigevidon 1 t per day. If breakthrough bleeding suddenly begins (this happens in the first three months of taking OCs), then take Rigevidon according to the 4-3-2-1 scheme. But whether to take it this way before surgery or take a seven-day break, that’s up to you to ask your doctor.
Yulia M.
https://www.medcentre.com.ua/medicamenty/rigevidon.html
Even if the drug is so hot, it’s too much of a bark – no problem!
jasmin98437
https://www.babyplan.ru/questions/49466-rigevidon/
I took regevidon. I hardly gained any weight, well, maybe 2 kg. no more. I took it for 3 months. The doctor explained that it shouldn’t cause weight gain. By the way, I also have polycystic disease.
Anonymous
https://otziv.net/kontratseptivy-gedeon-richter-rigevidon
Greetings to all who stopped by! Our gynecologists like to prescribe this contraceptive along with Regulon. It is affordable and does its job well. Namely: it protects against unwanted pregnancy. It is suitable for women who have given birth under 40 years of age. I had no side effects.
Masha Petrova
https://flap.rf/Medicine/Rigevidon/Reviews/4213581
A normal contraceptive, the only downside is that it is hormonal and is not suitable for everyone. The cost is cheap, since the pack contains three blisters designed for three months. They drink it for 21 days every day at the same time, and from my own experience it has been proven that it does not let me down. But this drug makes some people gain weight, and many people don’t like it.
djessi1985
https://otzovik.com/review_3060145.html
Advantages:
Effective
Flaws:
Lots of side effects
Greetings, my friends and site guests! In today’s review I want to talk about Gedeon Richter “Rigevidon” birth control pills. When I had a question about how to protect myself from an unwanted pregnancy, my gynecologist recommended this drug to me. I bought it at the pharmacy, the convenient packaging is designed for one month, this is what it looks like: You need to take one tablet once a day, preferably at the same time. After three months of taking this drug, I not only did not get pregnant, my menstrual cycle normalized, and my ovarian cyst also resolved. But in addition to the positive effects, the tablets also have significant side effects. In the first month of taking it, there were headaches, disturbed sleep and severe chest pain, but after two months all the negative symptoms disappeared.
abalmasowa1988
https://otzovik.com/review_529408.html
Advantages:
Very reliable device
Flaws:
After it I couldn’t get pregnant for about 2 years
I took these pills for about 3 months, the result was amazing at first, of course I was calm and didn’t worry. They are not as hormonal as others, I haven’t gained an ounce of weight, although I’ve heard everything about how contraceptives make you fatter by leaps and bounds, I haven’t gained anything like that! The main thing is to drink on time and not miss it!
Senia_Ch
https://irecommend.ru/content/otzyv-cheloveka-prinimayushchego-rigevidon-uzhe-5i-god-rasseivayu-mify-i-dayu-sovety-vengers
This is how most modern women are structured, that they are afraid of hormonal drugs. There are a lot of negative reviews on the Internet, everyone is screaming about terrible side effects. I will also write about my experience, which, fortunately, turned out to be positive.
This drug belongs to the group of combined oral contraceptives (COCs). Combined - because it has 2 components (progestagen + estrogen), oral - because it is taken orally, so to speak “per os” - “through the mouth”. As for contraception, this is its main function, but like other drugs in this group, it is often used to treat certain gynecological diseases. That is why it was prescribed to me more than 4 years ago, and the contraceptive effect came as a pleasant addition)
"Rigevidon" is a generic from Hungarian. The original drug is called "Mikroginon" German. The original drug has better quality, more research, and a correspondingly high cost, which is usually justified. However, it is in this case that I believe that the generic is extremely worthy from a company that has proven itself in the market. Therefore, I don’t see any point in overpaying. “Mikrogynon” in pharmacies in my city for 1 cycle (21 tablets) costs around 300-400 rubles, “Rigevidon” for 3 cycles (large package for 3 blisters of 21 tablets) costs, if you look hard enough, about 600 rubles (if you look If it doesn’t work out well – 700-800 rubles).
As for the packaging, it’s quite girly, in the recognizable style of the manufacturing company. In addition to the blisters, the large package (for 3 cycles) includes the following pocket for storing the blister, which is extremely convenient when carried in a bag:
For convenience, on the front side of the blister, each tablet is numbered and indicated by arrows “where to go”, BUT! "Rigevidon" single-phase COC, i.e. All tablets in the blister have the same composition and you can take them in absolutely any order.
Personally, it would be more convenient for me if the blister had not numbers, but days of the week, like on the same Microgynon. Because sometimes you get confused and don’t remember whether you took a pill today or not, you have to remember the date when the first pill was taken and count down the days. Life hack - I write the number on the package so as not to forget when I started it). After taking 21 tablets, a break is taken for 7 days, during the break a menstrual-like reaction occurs, a week later we start a new blister (i.e., for example, we took the 21st tablet on Friday, which means we start the next blister also on Friday, but a week later).
Let's move on to the composition.
Levonorgestrel – 150 mcg (progestogen) + Ethinyl estradiol – 30 mcg (estrogen).
I won’t list the excipients, there are many of them and they are not that important. So, addressing those who have read that Rigevidon contains large doses of active ingredients - do not be afraid and do not cause panic. According to the classification of COCs, it belongs to low-dose drugs, which, of course, is not as kosher as micro-doses, but also not as scary as high-dose drugs, which, by the way, are no longer used.
Regarding contraindications - naturally, at the first appointment you should make sure that you are not pregnant. It would be a good idea to take a coagulogram (check blood clotting), since one way or another, the estrogen component increases the risk of thrombosis, especially in women at risk. In addition, if you smoke, then reduce the number of cigarettes you smoke (no more than 10). And if you smoke and are over 35 years old, then it is better to think about contraceptives that do not contain estrogen. Well, or think about your health and quit smoking) Personally, I smoked both before and during taking Rigevidon, I only quit recently. I didn't notice any fluctuations in my condition. It will be absolutely wonderful if, before starting your appointment, you do an ultrasound of the mammary glands (if you are under 35 years old) and a mammogram if you are over 35 years old. And then you will also monitor it once a year. Again, it’s all because of estrogen, as if something unnecessary grew in the chest (or did not grow, if it was there before you started taking it). And of course, if you have liver and kidney diseases, you should not get carried away with pills. None. And yes, Rigevidon too.
And now about migraines. I have them. And this is a contraindication, because when taken they can become stronger. Balancing the risk versus benefit, I still made a choice in favor of Rigevidon. To reduce the severity and frequency of migraines, they often give advice to take pills at night, roughly speaking at 21-22 o’clock, that’s what I do.
The most worrying side effect for all women is weight gain. This is from the category of “I don’t eat anything, but I’m not losing weight,” i.e. a myth that is very convenient to justify yourself with. A SMALL increase in body weight can only be due to water retention by the estrogen component. Some people allegedly experience an increase in appetite. It seems to me that I should see a psychologist about this. From my personal experience - over the course of all 5 years, I either lost weight or gained weight within 10 kg, but this was due solely to the degree of my overeating. The second most discussed and worrying side effect is decreased libido. I don’t know, my performance dropped only because of fatigue. In general, all drugs have side effects, they are studied, and the frequency of occurrence is recorded. And if one of them manifests itself specifically for you, there is no need to panic. You just need to stop taking this drug and try another one. Speaking of stopping, it’s not necessary in the middle of the cycle (unless you find out about pregnancy). You need to take 21 tablets. If you were really impatient and stopped earlier, don’t be afraid of a menstrual-like reaction (withdrawal bleeding).
If you missed 1 tablet, it’s no problem, we drink it as soon as we remember it. The instructions on this matter are described in detail. In 5 years, I only missed an appointment for more than 12 hours once. Pregnancy did not occur.
"Rigevidon" and alcohol. Perfectly compatible, you know) there are only 2 cases when something can go wrong: if, under the influence of alcohol, you forgot to take a pill and if you took a pill, but also drank too much alcohol and you started vomiting. I discussed the first case above, and in the second - if less than 4 hours have passed since taking it - we take another tablet, if more, then it’s okay. In my practice there was only a case when more than 4 hours passed. Pregnancy again did not occur.
The menstrual-like reaction comes like clockwork and is not abundant. The skin has improved, acne only during the withdrawal period. PMS has become much less pronounced.
And yes, for those who are afraid after a seven-day break to remember that it is time to take the first tablet from a new blister, there are 21+7 blister packs. Everything is the same, but they also added 7 inactive “placebo” tablets so that nothing would change in the woman’s daily routine and she would not forget to take the drug.
Perhaps these are the main points that I wanted to talk about. If you have any questions, ask, I will definitely answer. The most important thing to remember is that such drugs should be prescribed by a doctor, not a friend or neighbor.
Addition 8.11.17 - after Rigevidon I switched to Janine due to emerging endometriosis, and then to
Modell Libera
Still, the appearance of endometriosis is my individual feature, not related to Rigevidon, so my positive opinion about it will remain unchanged.
Rigevidon price, where to buy
The price of Rigevidon in pharmacies varies between 200-650 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Rigevidon 21+7 tablets p.p.o.
28 pcs. JSC Gedeon Richter RUR 341 order - Rigevidon tablets p.p.o. 21 pcs. JSC Gedeon Richter
RUB 295 order
- Rigevidon tablets p.p.o. 63 pcs. JSC Gedeon Richter
RUR 724 order
Pharmacy Dialogue
- Rigevidon (tab. No. 21x3)Gedeon-Richter
RUR 701 order
- Rigevidon (tab. No. 21)Gedeon-Richter
RUB 281 order
- Rigevidon tablets No. 21+7Gedeon-Richter
RUB 351 order
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Pharmacy24
- Rigevidon No. 21 tablets VAT "Gedeon Richter", Ugorshchina
153 UAH. order - Rigevidon No. 63 tablets VAT "Gedeon Richter", Ugorshchina
478 UAH. order
PaniPharmacy
- Rigevidon tablets Rigevidon tablets. p/o No. 21 Hungary, Gedeon Richter
168 UAH order
- Rigevidon tablets Rigevidon tablets. p/o No. 63 Hungary, Gedeon Richter
496 UAH. order
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