Compound
One gram of Triacutan cream contains 0.64 mg betamethasone dipropionate , 0.1 mg gentamicin sulfate , 10 mg clotrimazole + propylene glycol, mineral oil, cetostearyl alcohol, sodium hydrogen phosphate, water, methylparaben, disodium edetate, white soft paraffin, cetostearyl ether macrogol 20, sodium dihydrogen phosphate monohydrate, dodecahydrate.
One gram of Triacutan ointment contains the following excipients: phenoxyethanol , mineral oil, octyldodecanol, white soft paraffin. The ratio of active ingredients is the same as that of the cream.
Triacutan
Name: Triacutan Pharmacological action: Triacutan is a combination drug with local action. The effects of Triakutan are associated with its constituent components; it has a local effect on the skin associated with anti-inflammatory, antipruritic, antibacterial, antifungal and vasoconstrictor effects. Clotrimazole, which is part of Triakutan, has an antimycotic effect aimed at disrupting the synthesis of the fungal membrane, which causes its death. Clotrimazole also has an antibacterial effect against staphylococci, streptococci, lamblia, trichomonas, mold fungi, leishmania, corynebacteria.
Gentamicin belongs to the group of aminoglycosides and exhibits antimicrobial properties against many microorganisms, which ensures rapid achievement of bactericidal action when applied locally. The spectrum of antibacterial activity extends to microorganisms that cause secondary infection of the skin. Active against gram (-) bacteria: Aerobacter aerogenes, E. coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella pneumoniae. Gram (+) bacteria: streptococcus (susceptible strains of group A β- and α-hemolytic streptococcus), Staphylococcus aureus (coagulase (+), coagulase (-), some species that produce penicillinase). Betamethasone dipropionate is a representative of GCS. It has an anti-inflammatory effect, affecting all phases of inflammation in the lesion. Has antipruritic and vasoconstrictor effects.
Indications for use: - Dermatoses that are sensitive to GCS treatment; - complicated dermatitis with microorganisms that can be treated with the components of the drug; - fungal skin changes caused by dermatophytes and fungi of the genus Candida (mycoses, pityriasis versicolor, epidermophytosis); - bacterial and infectious skin lesions (acute and chronic process), which are sensitive to the components of the drug.
Directions for use: Triacutane is used as a local remedy for external use. It is recommended to apply a thin layer of cream to affected areas of the skin at intervals of 12 hours. Application should be regular. The duration of therapy depends on the effectiveness and extent of the affected area. If there is low effectiveness within 3-4 weeks, therapy is canceled and modified.
Side effects: Triacutan is well tolerated; undesirable effects are rare, more often when using the drug under occlusive dressings. Local changes in the skin: burning, erythema, decreased pigmentation, skin rash, itching, exudation. Negative reactions associated with the action of gentamicin and clotrimazole: irritation, dry skin, acne, increased hair growth, dermatitis, maceration, folliculitis, atrophic processes of the skin and striae, the appearance of blisters, local edema and urticaria. Local erythema does not require discontinuation of treatment.
Contraindications: - Individual intolerance to the components of the drug; - intolerance to imidazole derivatives; - syphilis, skin manifestations; - psoriasis; - skin tuberculosis; - perioral dermatitis; - acne; - chicken pox; - bacterial skin infections that do not have appropriate etiological treatment; - fungal infections of the skin that do not have appropriate etiological treatment; — post-vaccination skin reactions; - phlebeurysm.
Pregnancy: Triacutane is not used in pregnant women or during lactation.
Interaction with other drugs: Nystatin and natamycin, when applied topically with clotrimazole, reduce their pharmacological activity. Dexamethasone, used in maximum doses, reduces the effect of clotrimazole, and hydroxybenzoic acid enhances the local effect of the latter.
Overdose: Cases of overdose occur with prolonged use of the drug under bandages. As a result of long-term use of gentamicin, susceptibility to antimicrobial agents decreases. With long-term use of GCS, the likelihood of developing secondary adrenal insufficiency increases, as well as the possibility of developing Cushing's syndrome. When permissible doses are exceeded for a short time, overdose symptoms do not develop. When using dressings for no more than 6 hours, it also does not increase the likelihood of developing negative reactions. Symptomatic treatment is used as therapy. In case of prolonged overdose, slow withdrawal of GCS is recommended. Overdose symptoms are reversible.
Release form: Triacutan cream 15.0 No. 1. 1 tube in a cardboard box.
Storage conditions: Temperature no more than 25 degrees Celsius, do not store at low temperatures.
Composition: Betamethasone: 0.64 mg/g; gentamicin sulfate: 1 mg/g; clotrimazole: 10 mg/g; excipients: methylparaben, propylenglykol, disodium edetate, oleum vaselini, white petrolatum, cetostearyl alcohol, disodium phosphate dodecahydrate, Na dihydrogen phosphate monohydrate, purified water, macrogol 20 cetostearyl ether.
Additionally: Triacutane is not used for placement into the conjunctival sac. Long-term therapy with Triakutan can cause disruption of the processes of susceptibility to microbial agents, which increases the risk of developing superinfection. With prolonged use of occlusive dressings, irritation and sensitization to the drug may occur, which requires discontinuation of treatment and symptomatic therapy with a revision of the patient's management plan. When using local corticosteroids, which are part of the product, they increase the risk of developing disorders of the functional state of the adrenal glands, with their subsequent reduction. When using local dressings, when treating large areas of damage, the level of absorption of gentamicin and GCS increases, increasing their systemic effect.
It is recommended not to use gentamicin on damaged skin with cracks or wound surfaces to avoid systemic and undesirable effects of Triacutan. Long-term therapy requires a mandatory step-by-step slow withdrawal of Triacutan, observing all the rules for reducing the frequency of use and dosage of the latter. Gentamicin is not recommended for long-term use in local treatment. There are a small number of cases of cross-allergic manifestations with antibacterial agents of the aminoglycoside group. Local treatment with Triacutan during pregnancy is not recommended, but is justified if there is a high probability of benefit to the mother.
Children's age group. Triacutan is not used in this age group due to the low level of evidence for its use in children. There is no data on the ability of Triakutan to influence the control of transport or complex mechanisms.
Attention! The description of the drug " Triacutan " on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
Pharmacodynamics and pharmacokinetics
Thanks to the combination of components included in Triakutan, the drug has anti-inflammatory, antipruritic , and vasoconstrictor effects .
Also, due to the clotrimazole in the composition, the product has broad antifungal activity. This component disrupts the synthesis of ergosterol , which is part of the cell membranes of fungal cells. Thanks to clotrimazole, the drug is active against Trichophyton rubrum, Epidermophyton floccosum, Candida albicans, Pityrosporum obiculare, Trichophyton mentagrophytes, Microsporum canis.
Gentamicin is broad-spectrum antibiotic aminoglycosides . Provides highly effective local treatment of primary and secondary bacterial skin infections. Shows activity against Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Aerobacter aerogenes, Proteus vulgaris.
The pharmacokinetics of the drug have not been studied.
Pharmacological properties of the drug Triakutan
Pharmacodynamics . Anti-inflammatory, antiallergic, antibacterial, antifungal agent. Betamethasone has anti-inflammatory, antiallergic and antipruritic effects. Inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators at the site of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema. Clotrimazole has an antifungal effect as a result of disruption of the synthesis of ergosterol, which is an integral part of the cell membrane of fungi. Active against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare) . Gentamicin is a broad-spectrum antibiotic of the aminoglycoside group that has a bactericidal effect against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive bacteria: Streptococcus spp., Staphylococcus aureus . Pharmacokinetics . When the drug is used externally in therapeutic doses, transdermal absorption of the active substances into the blood is very low. The use of occlusive dressings significantly increases the transdermal absorption of betamethasone and gentamicin, which may lead to an increased risk of systemic side effects.
Contraindications
The drug is not prescribed:
- if allergic to any of the components of the drug, especially imidazole ;
- patients with skin tuberculosis , syphilis ;
- in the presence of allergic reactions on the skin after vaccination ;
- persons suffering from varicose veins , psoriasis , rosacea ;
- patients with chickenpox ;
- for the treatment of infections caused by microorganisms that are not sensitive to the ointment.
Side effects
During therapy with the drug, adverse reactions rarely occur.
Skin pigmentation disorders, erythema , hypochromia and itching at the application site are sometimes observed.
Also possible:
- burning sensation, peeling of the skin , urticaria , swelling ;
- swelling, itching , general irritation of the skin, hypertrichosis ;
- development of secondary flora resistant to the action of the cream;
- prickly heat , stretch marks , skin atrophy (when applying occlusive dressings ).
Side effects of the drug Triacutan
The drug is usually well tolerated; When used correctly, side effects rarely occur, but burning sensation, irritation, hyperemia, erythema, itching, dryness, flaking, pigmentation disorders, maceration, skin atrophy, stretch marks, hypertrichosis, folliculitis, miliaria, urticaria, acne, perioral dermatitis are possible. When using occlusive dressings, skin maceration, stretch marks and prickly heat are most likely to occur. With long-term use, systemic side effects are possible (suppression of adrenal function).
Instructions for Triakutan (Method and dosage)
Before using the product, it is recommended to consult a doctor and test for the sensitivity of microorganisms to the active components of Triacutan.
The dosage form and duration of treatment are determined by the doctor.
Triacutan cream, instructions for use
The drug is applied to the affected areas and nearby skin, 2 times a day, regularly.
The cream is prescribed, as a rule, for acute forms of the disease.
Triacutan ointment, instructions for use
This dosage form is well suited for the treatment of chronic skin lesions.
The ointment is applied in a thin layer twice a day. Preferably in the morning and before going to bed, at regular intervals.
If after a month of therapy with the drug there are no positive changes, it is recommended to reconsider the diagnosis and treatment regimen.
Use of the drug Triakutan
The cream is applied topically. The dose of the drug is set individually, as it depends on the area of the affected area. The cream must be applied to the affected areas of the skin in a thin layer 2 times a day (morning and evening), gently rubbing into the skin; after achieving clinical improvement, the frequency of use of the drug can be reduced to 1 time per day. To increase the effectiveness of treatment, it is possible to use occlusive dressings. The duration of treatment is determined by the relief of the inflammatory process and negative data from bacterial and/or mycological analysis, cessation of itching, and cleansing of the skin; the duration of the course of treatment depends on the type and severity of the disease, the effectiveness and sensitivity to therapy, is determined by the doctor and usually does not exceed 2–4 weeks; Between repeated courses a break of at least 20 days is required. The course of treatment in children and patients with facial lesions should be no more than 5 days. For children aged 7–16 years, the drug is prescribed only according to strict indications and under the supervision of a physician. In children, it is not recommended to use the drug on large areas of the body, as well as the use of occlusive dressings.
Overdose
With a one-time excess dosage of ointment or cream, no adverse reactions were observed, even when a 6-hour occlusive dressing .
Frequent use of large doses of the drug can lead to the growth of strains of of the antibiotic . The following may also develop: depression of pituitary-adrenal function , secondary adrenal insufficiency , hypercortisolism , Cushing's syndrome .
Treatment includes correction of electrolyte balance , symptomatic therapy, and discontinuation of the drug.
If you accidentally swallow a large amount of cream, you must rinse your stomach and take enterosorbents , and take measures to eliminate unpleasant symptoms.
Triacutan drug overdose, symptoms and treatment
Excessive and prolonged use of the drug on large areas of the skin surface can lead to the manifestation of systemic effects characteristic of GCS, in particular to inhibition of the hypothalamic-pituitary-adrenal system with the development of secondary adrenal insufficiency and the appearance of symptoms of hypercortisolism (weight gain, edema formation, hypertension (arterial hypertension), glucosuria, hypokalemia), including Itsenko-Cushing syndrome (especially in children). In children with an overdose, it is also possible to reduce the formation of growth hormone and increase intracranial pressure. Treatment: symptomatic therapy, if necessary, correction of electrolyte balance. Gradual withdrawal of the drug is recommended.
special instructions
Cases of cross-allergy with aminoglycosides .
Do not allow the product to come into contact with the eyes.
hypersensitivity reactions to the drug occur during treatment , you should select another medicine and take appropriate measures.
To avoid systemic absorption of glucocorticosteroids, it is recommended to avoid applying the drug to open wounds, damaged skin areas, and the use of occlusive dressings .
If, with prolonged use of the medicine, a microflora resistant to its action or severe irritation has developed on the surface of the skin, then the medicine must be replaced and appropriate therapy prescribed.
Special instructions for the use of the drug Triacutan
Do not allow the drug to come into contact with the eyes, damaged skin or open wound areas. Do not apply the cream to the skin around the eyes. In order to increase the effectiveness of therapy, it is possible to use occlusive dressings, however, it must be borne in mind that this increases the transdermal absorption of betamethasone and gentamicin, which increases the risk of developing systemic side effects. Systemic absorption of betamethasone increases when the cream is used for a long time, when applied to large surfaces of the body, and also in children. If resistant bacterial or fungal microflora appears, use of the drug should be discontinued and appropriate therapy should be prescribed. The development of cross-resistance with aminoglycoside antibiotics is possible.
Analogues of Triakutan
Level 4 ATX code matches:
Rederm
Losterine
Akriderm SK
Akriderm
Akriderm GK
Akriderm Genta
Elokom S
Diprosalik
Belosalik
Triderm
Kanizon Plus
Betasalik
Momat-S
The closest analogues of the product: Kremgen, Belogent, Betazon Plus, Celederm, Candiderm, Betaderm, Fusiderm-B, Momat-S, Molexin S, Ekolom - S, Dermokas , Diprosalik, Belosalik.
Triakutan price
It is difficult to purchase the product in the Russian Federation, except in online pharmacies.
The price of Triakutan cream is about 60 hryvnia per 15 grams.
The price of Triacutan ointment is practically no different from the cream.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
LuxPharma* special offer
- Triacutan cream tube 15g
RUB 1,680 order
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Pharmacy24
- Triakutan 15 g ointment PAT "Kievmedpreparat", Ukraine
97 UAH. order - Triakutan 15 g cream PAT "Kievmedpreparat", Ukraine
96 UAH order
