Wobenzym, enteric-coated tablets, 200 pcs.

What is Wobenzym medicine for?

The drug is often prescribed for complex treatment of various diseases. It is accepted in almost all medical fields.

In gynecology:

• inability to bear a child (especially in the 2nd and 3rd trimester);
• endometritis;
• mastopathy;
• chlamydia.

In dermatology:

• skin rash;
• itchy dermatosis.

In neurology:

• angina pectoris;
• myocardial infarction.

In ophthalmology:

• glaucoma;
• uveitis;
• hemophthalmos.

In oncology:

• chemotherapy and radiation therapy (to increase tolerance);
• reducing the likelihood of re-infection.

In pulmonology:

• pneumonia;
• tuberculosis;
• bronchitis.

In urology:

• genital infections;
• cystitis;
• prostatitis.

The medicine is also actively used in pediatrics, surgery, and endocrinology.

Other indications include:

• acclimatization;
• problems with microcirculation;
• negative manifestations after hormonal treatment;
• viral infections and resulting complications.

What are the indications and contraindications for taking Wobenzym?

The clinic has described many pathological conditions in which the use of this drug may be beneficial. Here is their list:

• In angiology: phlebitis, thrombophlebitis, atherosclerosis of the vessels of the lower extremities, postthrombophlebitis disease, endarteritis.
• In cardiology: MI, stable angina pectoris.
• In gynecology: inflammatory diseases of the female genital area, infections (caused by chlamydia, ureaplasma, mycoplasma), gestosis, recurrent miscarriage.
• In dermatovenereology: acne, various dermatoses.
• In gastroenterology: inflammation of the gastrointestinal tract, dysbiosis.
• In neurology: multiple sclerosis.
• In ophthalmology: iritis, uveitis, retinopathy, various forms of glaucoma.
• In ENT: sinusitis, sinusitis, otitis media, laryngitis.
• In pulmonology: tracheitis, bronchitis, pneumonia, tuberculosis.
• In urology: cystitis, prostatitis.
• In oncology: to facilitate the tolerability of antitumor therapy.
• In rheumatology: arthritis, deforming osteoarthritis.
• In surgery and traumatology: postoperative, post-traumatic complications of an inflammatory, edematous or thrombotic nature.

There are also a number of contraindications to the use of Wobenzym:

• Increased risk of hemorrhage and bleeding.
• Carrying out hemodialysis.
• Children under five years of age.
• Individual intolerance to drug components.

How to take Wobenzym

The tablets are intended for oral administration. You should take it 25-30 minutes before meals with a glass of water.

The dose and duration of therapy is determined by the doctor, taking into account the problem and condition of the patient. An adult, depending on his condition, can be prescribed from 3 to 9 tablets. A prerequisite is three times a day. Most often, in the first 3 days of treatment, take 3 tablets 3 times a day. Afterwards, the number of tablets at one time can increase or decrease, but the multiplicity in any case remains the same.

For chronic diseases, treatment may take up to half a year.

For radiation and chemotherapy, it is recommended to use 5 tablets 3 times a day during the entire treatment period. This will have a positive effect on the patient’s condition and prevent possible infectious complications.

In order to prevent various diseases, it is prescribed to take 2 tablets 3 times a day for a month and a half. This course can be repeated no more than 3 times a year.

Compound

Side effects and overdose

Treatment with the drug usually does not lead to adverse reactions. To date, there is no data regarding the occurrence of negative manifestations after taking the medicine. There is also no addiction or withdrawal syndrome, even if the treatment was long-term and large doses were used.

In quite rare cases, urticaria may appear, as well as minor changes in the smell of stool and its consistency.

If, after taking it, the patient discovers undesirable effects, then you need to stop treatment and consult a doctor.

To date, no cases of overdose have been identified.

Wobenzym intestinal tablets No. 40

Compound

Active ingredients: Pancreatin 345 prot. Eur.Pharm.-Units, papain 90 FIP-Units, rutoside 3 H2O 50.00 mg, bromelain 225 FIP-Units, trypsin 360 FIP-Units. lipase 34 FIP-Units. amylase 50 FIP-Units. , chymotrypsin 300 FIP-Units. Excipients: Lactose, corn starch, magnesium stearate, stearic acid, purified water, colloidal silicon dioxide, talc. Sucrose, talc, methacrylic acid-methyl methacrylate copolymer, shellac, titanium dioxide, white clay, yellow-orange dye S (E110), crimson dye 4R (E124), povidone, macrogol 6000, triethyl citrate, vanillin, bleached wax, carnauba wax.

Pharmacokinetics

Combined drug. It is a combination of highly active enzymes of plant and animal origin. It has immunomodulatory, anti-inflammatory, fibrinolytic, decongestant, antiplatelet and secondary analgesic effects.

Wobenzym has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, and has a positive effect on the body’s immunological reactivity. Stimulates and regulates the functional activity of monocytes-macrophages, natural killers, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.

Under the influence of Wobenzym, the number of circulating immune complexes decreases and membrane deposits of immune complexes are removed from tissues.

Wobenzym reduces the infiltration of the interstitium by plasma cells. Increases the elimination of protein detritus and fibrin deposits in the area of ​​inflammation, accelerates the lysis of toxic metabolic products and dying tissues, improves the resorption of hematomas and edema, and normalizes the permeability of vascular walls.

Wobenzym reduces the concentration of thromboxane and platelet aggregation. Regulates the adhesion of blood cells, increases the ability of red blood cells to change their shape, regulating their plasticity, normalizes the number of normal discocytes (platelets) and reduces the total number of activated forms of platelets, normalizes blood viscosity, reduces the total number of microaggregates, thus improving microcirculation and rheological properties of blood, and also supplying tissues with oxygen and nutrients.

Wobenzym normalizes lipid metabolism, reduces the synthesis of endogenous cholesterol, increases HDL content, reduces the level of atherogenic lipids, and improves the absorption of polyunsaturated fatty acids.

Wobenzym increases the effectiveness of antibiotic therapy by increasing the concentration of antibiotics in the blood plasma and the site of inflammation, and also reduces the side effects of antibiotics (dysbacteriosis).

Wobenzym reduces the severity of side effects associated with taking hormonal drugs (including hypercoagulation).

Wobenzym regulates nonspecific defense mechanisms (production of interferons), thereby exhibiting antiviral and antimicrobial effects.

The secondary analgesic effect of Wobenzym manifests itself through its effect on the causative factors of the acute inflammatory process.

Indications for use

As part of complex therapy:

• thrombophlebitis (including acute thrombophlebitis of the superficial veins), postphlebitis syndrome, obliterating endarteritis and atherosclerosis of the arteries of the lower extremities, lymphatic edema, prevention of recurrent phlebitis,
• cystitis, cystopyelitis, prostatitis,
• sexually transmitted infections
• chronic genital infections, gestosis, mastopathy, adnexitis, to reduce the frequency and severity of side effects of hormone replacement therapy in gynecology,
• angina pectoris, subacute stage of myocardial infarction (to improve the rheological properties of blood),
• sinusitis, bronchitis, pneumonia,
• pancreatitis, hepatitis,
• pyelonephritis, glomerulonephritis,
• diabetic angiopathy, diabetic retinopathy,
• autoimmune thyroiditis,
• rheumatoid arthritis, reactive arthritis, ankylosing spondylitis,
• atopic dermatitis, acne,
• multiple sclerosis,
• uveitis, iridocyclitis, hemophthalmos, use in ophthalmic surgery,
• treatment of postoperative complications (inflammatory processes, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgeries,
• injuries, fractures, distortions, ligamentous injuries, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine.

Prevention:

• microcirculation disorders, post-stress disorders, as well as failure of adaptation mechanisms,
• side effects of hormone replacement therapy, hormonal contraception,
• during surgical interventions to prevent infectious complications and adhesive disease.

Wobenzym is recommended for the prevention of infectious complications and improving the quality of life during chemotherapy or radiation therapy, viral infections and their complications.

Contraindications

Diseases associated with an increased likelihood of bleeding (including hemophilia, thrombocytopenia), hemodialysis, children under 5 years of age, individual intolerance to the drug.

Directions for use and doses

Set individually depending on the severity of the disease.

Adults, depending on the activity and severity of the disease, are prescribed a dose of 3 to 10 tablets. 3 times/day. In the first 3 days of taking the drug, the recommended dose is 3 tablets. 3 times/day.

With average disease activity, the drug is prescribed in a dose of 5-7 tablets. 3 times/day for 2 weeks. In the future, the dose of the drug should be reduced to 3-5 tablets. 3 times/day. Course - 2 weeks.

If the disease activity is high, the drug is prescribed in a dose of 7-10 tablets. 3 times/day for 2-3 weeks. In the future, the dose should be reduced to 5 tablets. 3 times/day. Course - 2-3 months.

For chronic long-term diseases, Wobenzym can be used according to indications in courses of 3 to 6 months or more.

In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, Wobenzym should be used throughout the entire course of antibiotic therapy at a dose of 5 tablets. 3 times/day. After stopping the course of antibiotic therapy to restore the intestinal microflora, Wobenzym should be prescribed 3 tablets. 3 times/day for 2 weeks.

During radiation and chemotherapy, Wobenzym should be used in a dose of 5 tablets. 3 times a day until completion of the course of radiation and chemotherapy in order to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.

For preventive purposes, Wobenzym is prescribed 3 tablets. 3 times a day for 1.5 months, repeating the course 2-3 times a year.

Children aged 5-12 years are prescribed a daily dose of 1 tablet. per 6 kg body weight. For children over 12 years of age, the drug is prescribed according to the regimen intended for adults. The duration of treatment is determined individually.

The drug should be taken at least 30 minutes before meals, without chewing, with water (200 ml).

Storage conditions

List B. The drug should be stored out of the reach of children, in a dry place at a temperature of 15 to 25C.

Best before date

2.5 years.

special instructions

In the case of infectious processes, WOBENZYM does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and the site of inflammation. It should be borne in mind that at the very beginning of taking the drug, the symptoms of the disease may worsen; in such cases, treatment should not be interrupted, but a temporary reduction in the dose of the drug is recommended. The drug is not a doping and does not have a negative effect on driving a car or performing work that requires a high speed of mental and physical reactions.

Conditions for dispensing from pharmacies

Available without a prescription

Side effects

Wobenzym is generally well tolerated by patients. In most cases, no side effects, withdrawal syndrome, or addiction were observed even with long-term use in high doses.

In some cases: minor changes in the consistency and odor of stool, urticaria (disappears when the dose is reduced or the drug is discontinued).

The patient should be warned that if other adverse reactions occur, it is recommended to stop taking the drug and consult a doctor.

Use during pregnancy and breastfeeding

Wobenzym should be prescribed with caution and under medical supervision during pregnancy and lactation.

Interaction

When Wobenzym is taken simultaneously with other drugs, cases of incompatibility are unknown.

Overdose

No cases of overdose of Wobenzym have been reported.

Is it possible to take Wobenzym with alcohol?

It is worth saying that with any disease and even in a healthy state, drinking alcohol, especially in large quantities, has a negative effect on the human body. When wondering about the possibility of combining the drug with alcohol, you need to keep in mind that it is prescribed not so often and mainly as part of a complex treatment, as a result of which various reactions may appear in the body. If the drug is taken in parallel with antibiotics or antiviral drugs, then drinking alcohol is strictly prohibited.

Pharmacological action, pharmacodynamics and pharmacokinetics

The main effects of Wobenzym:

• anti-inflammatory;
• fibrinolytic
• antiplatelet;
• immunomodulatory;
• decongestant.

The active components of the drug reduce the number of active circulating ICs in the blood, activates immunity directed against tumor cells and phagocytosis, thereby exerting its immunomodulatory effect.

The drug also normalizes the permeability of vascular walls, reduces the infiltration of damaged tissues, thereby reducing swelling and accelerating the time of resorption of bruises and hematomas.

Wobenzym regulates blood viscosity, normalizes the number of formed elements, thereby improving rheological parameters and microcirculation in tissues.

It is absorbed from the small intestine quite quickly, enters the bloodstream, where it interacts with carrier proteins, thanks to which it enters the organs where pathological processes occur.