pharmachologic effect
The tablets have a pronounced hypotensive effect. The mechanism of action is based on selective blocking of calcium receptors. Lercanidipine is able to slow down the flow of calcium ions in smooth muscle tissue and cardiomyocytes.
Lerkamen reduces total peripheral vascular resistance and gradually expands the lumen of blood vessels, preventing the development of reflex tachycardia and collapse . The medication does not have a negative inotropic effect.
General information and composition
"Lerkamen", the composition of which can be read in the instructions, is highly effective compared to other drugs in this group.
The main active ingredient is lercanidipine hydrochloride, which belongs to the group of Ca2 ion antagonists. They prevent the absorption of calcium by muscle tissue, as a result of which the blood vessels dilate and blood flow significantly improves, and the pressure gradually normalizes. Today, Lerkamen is one of the most effective and fast-acting drugs compared to other drugs in this group. Thanks to this, it can be used for the prevention and treatment of many diseases of the heart and circulatory system among patients of any age category.
“Lerkamen”, reviews of the drug by cardiologists confirm its high effectiveness, is available only in the form of tablets, the dosage of the active substance in which can be 10 or 20 milligrams.
Pharmacodynamics and pharmacokinetics
The medicine Lerkamen is well absorbed from the digestive system. The maximum plasma concentration is recorded after 1.5-3 hours. Up to 98% of the active substance binds to plasma proteins.
The bioavailability of the drug increases after eating, which is why it is recommended to take the tablets on an empty stomach. As the dose increases, bioavailability increases. Initially, the drug is metabolized in the hepatic system, which explains the low absolute bioavailability of 10%.
The hypotensive effect is observed throughout the day. The active component is excreted through the renal system; the half-life is 10 hours.
Contraindications
- heart failure;
- obstruction of the vessels leaving the left ventricle;
- individual hypersensitivity to lercanidipine ;
- lactase deficiency;
- pregnancy;
- unstable form of angina ;
- acute myocardial infarction ;
- sick sinus syndrome (in patients without a pacemaker);
- lactation;
- age limit – 18 years.
Side effects
Nervous system:
- migraine;
- dizziness;
- sleep and wakefulness disorders.
Digestive tract:
- stool disorders;
- gastralgia;
- dyspepsia (vomiting, nausea);
- increased ALT, AST;
- disruption of food digestion.
The cardiovascular system:
- discomfort behind the sternum;
- increased heart rate;
- increase in angina ;
- drop in blood pressure;
- chest pain.
Allergic responses, frequent urination , development of polyuria , swelling, hyperemia , gum hyperplasia , and muscle pain are also possible.
Side effects of the drug Lerkamen
Those registered during clinical studies are shown in the following table:
From the immune system | Very rare (≤1/10,000) | Hypersensitivity |
Mental disorders | Rare (1/10,000 and ≤1/1000) | Drowsiness |
From the side of the central nervous system | Sometimes (1/1000 and ≤1/100) | Headache, dizziness |
From the side of the heart | Rarely (1/10,000 and ≤1/1000) Sometimes (1/1000 and ≤1/100) | Angina pectoris Tachycardia, increased heart rate |
From the side of blood vessels | Sometimes (1/1000 and ≤1/100) Very rarely (≤1/10,000) | Skin hyperemia Impaired consciousness |
From the gastrointestinal tract | Rare (1/10,000 and ≤1/1000) | Nausea, epigastric pain, diarrhea, dyspeptic disorders, vomiting |
From the skin | Rare (1/10,000 and ≤1/1000) | Rash |
From the musculoskeletal system | Rare (1/10,000 and ≤1/1000) | Myalgia |
From the kidneys and urinary tract | Rare (1/10,000 and ≤1/1000) | Polyuria |
General disorders and local reactions | Rarely (1/10,000 and ≤1/1000) Sometimes (1/1000 and ≤1/100) | Asthenia, increased fatigue. Peripheral edema |
In isolated cases (≤1/10,000), gingival hyperplasia and a reversible increase in the activity of liver transaminases in the blood plasma are detected (no other clinically significant deviations in laboratory tests of liver function were detected). There have been reports of increased urinary frequency. In isolated cases, the use of some dihydropyridines leads to angina attacks. Very rarely, unstable progressive angina may develop, in some cases even leading to the development of myocardial infarction. Lercanidipine does not significantly affect the levels of glucose and lipids in the blood plasma.
Instructions for use of Lerkamen (Method and dosage)
The tablets are intended for oral administration. It is not allowed to crush the drug or damage the protective shell. The effectiveness of the drug increases when lercanidipine is taken on an empty stomach. The duration of therapy is determined by the doctor.
1 tablet of 10 mg is taken 1 time every 24 hours. If there is insufficient reduction in blood pressure, after 14 days you can switch to a single dose of 20 mg.
Take the tablets with water on an empty stomach. When the dose of the drug is increased (more than 20 mg per day), an increase in the hypotensive effect is not observed, but an increase in the frequency and severity of undesirable side reactions is recorded.
If the medication is ineffective in the treatment of arterial hypertension, it is recommended to prescribe additional antihypertensive drugs from other pharmacological groups.
Compatibility with other drugs
"Lerkamen", reviews of which by cardiologists note that side effects when taking the drug are very rare, can react with quite a large number of drugs, due to which it is often combined to increase the effectiveness of therapy.
As a rule, it is combined with the following medications:
- In some cases, the drug is prescribed together with diuretics and angiotensin-converting enzyme inhibitors.
- In the treatment of some diseases, Lerkamen is prescribed together with cardiac glycosides, but in this case, treatment is carried out under the strict supervision of a cardiologist.
- Good compatibility of the drug is observed together with Cimetidine. In this case, no significant changes in the blood plasma are observed.
- It is necessary to be extremely careful when taking the drug simultaneously with inhibitors of the CYP3A4 group, since in this case the effectiveness of the drug may be noticeably reduced.
- While taking Lerkamen, it is recommended to avoid drinking grapefruit juice and any alcoholic beverages, as they also reduce the effect of the medicine on the body.
It costs about 5 mg - this is the minimum dosage of the drug; it is not recommended to combine it with any other medications on your own, as this can cause various negative manifestations that can pose a threat to human health and life.
Overdose
There is a drop in blood pressure, drowsiness , ischemic changes in myocardial tissue, nausea, and the development of cardiogenic shock . Induction of vomiting, administration of laxatives and enterosorbents are recommended.
In case of severe intoxication, Dopamine , catecholamines , and diuretics are prescribed. It is possible to administer Atropine bradycardia develops , a drop in blood pressure and loss of consciousness. Treatment is carried out in a hospital. Hemodialysis has not proven effective.
Interaction
Absorption of the drug is enhanced during treatment with midazolam . Inducers of CYP3A4, ethanol, Cyclosporine and grapefruit juice are strictly contraindicated when taking Lerkamen.
Caution is required when taking high doses of cimetidine (more than 800 mg).
The bioavailability of the active substance increases simultaneously with an increase in the negative inotropic effect during therapy with beta-blockers.
A mandatory dose adjustment of Digoxin after starting lercanidipine therapy.
To reduce the risk of negative interactions, it is necessary to maintain a 10-hour window when taking Simvastatin and lercanidipine.
Features of application
As medical practice shows, “Lerkamen”, reviews from cardiologists do not contain negative information about the drug, it can cause deterioration of attention and a decrease in the ability of spatial orientation in patients, therefore, while taking the drug, it is recommended to refrain from driving, since people may experience sometimes dizziness, drowsiness and neuropsychic weakness appear. When drinking grapefruit juice, these manifestations will only intensify.
Ethyl alcohol neutralizes the effect of lercaledilin, therefore the consumption of any alcoholic beverages is strictly prohibited during treatment.
Analogues of Lerkamen
Level 4 ATC code matches:
Lacipil
Cordafen
Azomex
Nimodipine
Felodipin
Nifedipine
Farmadipin
Amlotop
Nimotop
Tenox
Nifecard HL
Cordipin
Felodip
Normodipine
Phenigidine
Norvask
Cordaflex
Corinfar
Vero-Amlodipine
Amlodipine
Analogues of Lerkamen, produced and prescribed in Russia and other countries:
- Zanidip-Recordati
- Lercanorm
- Lernikor
- Lerkaton
- Lervask
- Zanikor
Reviews of analogues are positive and indicate the high effectiveness of the drugs in the treatment of hypertension.
Drug price
Every person who has been diagnosed with any disease of the vascular system is interested in the question of how much Lerkamen costs. You can buy this drug in almost every pharmacy, and its average cost is 390 rubles, which is not much in these days. Therefore, given the high effectiveness of the drug, there is absolutely no point in replacing it with similar medications.
Reviews about Lerkamen
Thematic portals and medical forums, where patients share their impressions of taking medications, contain only positive reviews.
The drug is well tolerated and stabilizes blood pressure after 2 weeks of regular use in patients with stage 1 arterial hypertension.
The incidence of adverse reactions is low; the drug is considered highly effective in the treatment of grade 2.3 hypertension in combination with other antihypertensive drugs.
Indications for use
More and more cardiologists are prescribing Lerkamen to their patients.
Indications for use of this drug are as follows:
- arterial hypertension, which is at the initial and progressive stages;
- essential hypertension of the first and second stages.
The drug shows excellent results because, in addition to being highly effective and long-lasting, it causes virtually no side effects regardless of the duration of treatment. To increase the effectiveness of therapy and speed up the patient’s recovery, cardiologists can prescribe Lerkamen together with other antihypertensive drugs.
Lerkamen price, where to buy
The cost varies depending on the region and pharmacy network. The price of Lerkamen 10 mg is about 400 rubles. for 28 tablets. The price of Lerkamen 20 mg is about 700 rubles. for 28 tablets.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Lerkamen 20 tablets p.p.o.
60 pcs. Berlin-Chemie AG/Menarini Group RUR 1,122 order - Lerkamen 10 tablets p.p.o. 28 pcs.Berlin-Chemie AG/Menarini Group
RUB 395 order
- Lerkamen 20 tablets p.p.o. 28 pcs.Berlin-Chemie AG/Menarini Group
RUR 682 order
- Lerkamen Duo tab. p/o captivity. 10mg + 10mg No. 28Recordati Chemical and Pharmaceutical Industry S.p.A.
RUB 511 order
Pharmacy Dialogue
- Lerkamen Duo (tab.p.pl/vol. 10mg+10mg No. 28)Recordati
510 rub. order
- Lerkamen Duo (tab.p.pl/vol.10mg+20mg No. 28)Recordati
608 rub. order
- Lerkamen (tab.p.pl/vol. 10mg No. 60)Berlin-Chemie AG/Menarini
RUR 688 order
- Lerkamen (tab.p.pl/vol. 20mg No. 28)Berlin-Chemie AG/Menarini
RUR 654 order
- Lerkamen (tab.p.pl/vol. 20mg No. 60)Berlin-Chemie AG/Menarini
RUB 1,078 order
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Pharmacy24
- Lerkamen 10 mg No. 28 tablets Berlin Chemi AG, Nimechchina
164 UAH.order - Lerkamen 10 mg N60 tablets Berlin Chemi AG, Nimechchina
297 UAH order
- Lerkamen 20 mg No. 28 tablets Berlin Chemi AG, Nimechchina
263 UAH order
PaniPharmacy
- Lerkamen tablets Lerkamen tablets. p/o 10 mg No. 60 Germany, Berlin-Chemie
343 UAH. order
- Lerkamen tablets Lerkamen tablets. p/o 10 mg No. 28 Germany, Berlin-Chemie
179 UAH. order
- Lerkamen tablets Lerkamen tablets. p/o 20 mg No. 28 Germany, Berlin-Chemie
284 UAH order
- Lerkamen tablets Lerkamen tablets. p/o 20 mg No. 60 Germany, Berlin-Chemie
509 UAH. order
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