Beloderm cream and ointment: instructions for use, price, reviews, analogues

Compound

Beloderm cream contains the active ingredient betamethasone dipropionate .
As excipients, the product contains sodium dihydrogen phosphate monohydrate, chlorocresol, petroleum jelly, phosphoric acid, cetostearyl alcohol, macrogol cetostearate, sodium hydroxide, mineral oil, water. Beloderm ointment contains the active ingredient betamethasone dipropionate . The preparation also contains petroleum jelly and mineral oil as excipients.

pharmachologic effect

The drug has vasoconstrictor , antiexudative , antiproliferative , antiallergic , antipruritic , anti-inflammatory effects .

After the drug is applied to the skin, it has a pronounced effect at the site of the inflammatory process, reduces the severity of both a number of symptoms and subjective sensations.

The active ingredient betamethasone dipropionate is a synthetically produced adrenocorticosteroid. It has a more pronounced corticosteroid effect, as well as a minor mineralocorticoid effect.

After using the product, there is a decrease in the production and release of histamine, lysosomal enzymes, and prostaglandins.

Also, under the influence of glucocorticosteroids, plasma extravasation decreases and the development of edema stops.

Under the influence of Beloderm, the effect of magrophages and lymphokines of target cells is reduced, and the active access of sensitized macrophages and T-lymphocytes to target cells is prevented. The medicine helps reduce the rate of development of dermatitis of allergic origin .

Description of the drug BELODERM®

GKS. Suppresses the functions of leukocytes and tissue macrophages. Limits the migration of leukocytes to the area of inflammation. It disrupts the ability of macrophages to phagocytose, as well as to form interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of inflammation. Reduces capillary permeability due to the release of histamine. Suppresses fibroblast activity and collagen formation.

Inhibits the activity of phospholipase A2, which leads to suppression of the synthesis of prostaglandins and leukotrienes. Suppresses the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.

Reduces the number of circulating lymphocytes (T- and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed into the lymphoid tissue; suppresses the formation of antibodies.

Betamethasone suppresses the pituitary release of ACTH and β-lipotropin, but does not reduce the level of circulating β-endorphin. Inhibits the secretion of TSH and FSH.

When directly applied to blood vessels, it has a vasoconstrictor effect.

Betamethasone has a pronounced dose-dependent effect on the metabolism of carbohydrates, proteins and fats. Stimulates gluconeogenesis, promotes the uptake of amino acids by the liver and kidneys and increases the activity of gluconeogenesis enzymes. In the liver, betamethasone enhances the deposition of glycogen, stimulating the activity of glycogen synthetase and the synthesis of glucose from protein metabolism products. An increase in blood glucose levels activates the release of insulin.

Betamethasone inhibits the uptake of glucose into fat cells, which leads to activation of lipolysis. However, due to increased insulin secretion, lipogenesis is stimulated, which promotes fat accumulation.

Retains sodium ions and water in the body, stimulates the excretion of potassium ions, reduces calcium absorption from the gastrointestinal tract, washes calcium ions from bones, increases calcium excretion by the kidneys.

It has a catabolic effect in lymphoid and connective tissue, muscles, adipose tissue, skin, bone tissue. Osteoporosis and Itsenko-Cushing syndrome are the main factors limiting long-term GCS therapy. As a result of the catabolic effect, growth suppression in children is possible.

In high doses, betamethasone can increase the excitability of brain tissue and help lower the seizure threshold. Stimulates excess production of hydrochloric acid and pepsin in the stomach, which leads to the development of peptic ulcers.

When used systemically, the therapeutic activity of betamethasone is due to anti-inflammatory, antiallergic, immunosuppressive and antiproliferative effects.

When applied externally and locally, the therapeutic activity of betamethasone is due to its anti-inflammatory, antiallergic and antiexudative (due to the vasoconstrictor effect) effect.

Its anti-inflammatory activity is 30 times higher than hydrocortisone, but does not have mineralocorticoid activity. The presence of a fluorine atom in the molecule enhances the anti-inflammatory activity of betamethasone.

Betamethasone in the form of dipropionate is characterized by long-lasting action.

Indications for use

Hormonal ointment and cream are used for the following diseases and conditions:

a number of types of dermatitis - allergic, atopic, contact; other forms of non-allergic dermatitis;
neurodermatitis;
consequences of insect bites;
different forms of eczema ;
psoriasis;
discoid lupus erythematosus;
bullous dermatoses ;
exudative erythema multiforme ;
manifestations of skin itching ;
lichen planus.

Nosological classification (ICD-10)

L13.9 Bullous changes, unspecified
L20 Atopic dermatitis
L23 Allergic contact dermatitis
L24 Simple irritant contact dermatitis
L25 Contact dermatitis, unspecified
L29 Itching
L30.9 Dermatitis, unspecified
L40 Psoriasis
L43 Lichen ruber flatus
L51 Erythema multiforme
L56.2 Photocontact dermatitis
L56.3 Solar urticaria
L58 Radiation radiation dermatitis
L93 Lupus erythematosus
W57 Bite or sting by non-venomous insects and other non-venomous arthropods

Contraindications

Beloderm should not be used for the following diseases and conditions:

intolerance to the active ingredient and additional components;
phlebeurysm;
tuberculosis of the skin;
perioral dermatitis;
rosacea;
the presence of a pronounced reaction after vaccination;
other infectious skin diseases associated with exposure to bacteria and fungi.

The cream should absolutely not be applied to the periorbital area.

A number of relative contraindications for the use of the drug are also determined. In particular, Beloderm cream should not be applied to the face if there are lesions for more than one week. In case of liver failure, only small doses of the drug can be used for a short period of time, and a bandage should not be used. Care should be taken to apply the product to areas where there are body folds and natural occlusion , as the risk of systemic influence increases.

It is used very carefully for the treatment of children due to the increased absorption of betamethasone in children. Under no circumstances should cream be used under diapers.

Side effects

In the process of using a product with the active substance betamethasone externally, a reduction in collagen, as well as a number of other changes in the skin, is possible. skin atrophy , stretch marks , folliculitis , telangiectasia , hypertrichosis , and ecchymosis may appear .

Patients who practice long-term treatment should note that with long-term use of Beloderm, hyperpigmentation , skin depigmentation , itching and skin rash .

With prolonged use of Beloderm, the functions of the sweat glands may decrease. Secondary skin infection may occur as a consequence of immunosuppression. If a standard treatment regimen is followed, side effects are unlikely. The risk of their occurrence increases if treatment is carried out over a long period of time and in large doses. If reactions are observed on the skin, use of Beloderm should be stopped immediately.

Beloderm ointment for external use 0.05% 40 g tube 1 pc. in Kirov

Pharmacological action: Interacts with specific receptors in the cytoplasm of the cell, the resulting complex penetrates the cell nucleus, binds to DNA and stimulates the synthesis of mRNA, inducing the formation of proteins, incl. lipocortin, mediating cellular effects. In some cells (for example, in lymphocytes) it causes suppression of mRNA. Lipocortin inhibits phospholipase A2, blocks the liberation of arachidonic acid and the biosynthesis of endoperoxides, PGs, and leukotrienes (which contribute to the development of inflammation, allergies and other pathological processes).

Affects all phases of inflammation. The anti-inflammatory effect is due to many factors. One of the leading ones is inhibition of phospholipase A2 with subsequent inhibition of the formation of pro-inflammatory mediators - PG and leukotrienes. In addition, it stabilizes cell membranes, incl. membranes of lysosomes, prevents the release of lysosomal enzymes and reduces their concentration at the site of inflammation. Inhibits the migration of neutrophils and macrophages to the site of inflammation and their phagocytic activity. Improves microcirculation, reduces vascular permeability, causes vasoconstriction of capillaries, and reduces fluid exudation.

The antiallergic effect develops as a result of a decrease in the synthesis and secretion of allergy mediators, inhibition of the release of histamine and other biologically active substances from sensitized mast cells and basophils, a decrease in the number of circulating basophils, suppression of the proliferation of lymphoid and connective tissue, a decrease in the number of T- and B-lymphocytes, mast cells , reducing the sensitivity of effector cells to allergy mediators, suppressing antibody formation, changing the body’s immune response.

The immunosuppressive effect is associated with suppression of the activity of T- and B-lymphocytes, as well as inhibition of the release of cytokines (interleukin-1, interleukin-2, interferon-gamma) from leukocytes and macrophages.

Antishock and antitoxic effects are associated with an increase in blood pressure (due to an increase in the amount of circulating catecholamines, restoration of the sensitivity of adrenergic receptors to catecholamines and vasoconstriction), activation of liver enzymes involved in the metabolism of endo- and xenobiotics.

It has a pronounced effect on all types of exchange. Stimulates gluconeogenesis in the liver, increases blood glucose levels (glucosuria is possible). Accelerates protein catabolism, especially in muscle tissue. Causes a redistribution of fat: increases lipolysis in the tissues of the extremities, promotes the accumulation of fat mainly in the face (moon face), neck, and shoulder girdle. Retains Na+ and water, stimulates the excretion of K+, increases the excretion of Ca+.

With long-term use, it suppresses the function of the hypothalamus-pituitary-adrenal system.

After parenteral (i.m.) and enteral administration, it is rapidly absorbed - the maximum effect (when taken orally) develops after 1–2 hours.

When using a combination of salts in one preparation, betamethasone disodium phosphate is well absorbed from the injection site and has a rapid effect; betamethasone dipropionate has a slower absorption, but provides a long-lasting effect.

When instilled into the conjunctival sac, it penetrates into the intraocular fluid, cornea, iris, choroid, ciliary body, and retina. Systemic absorption may be significant only when used in high doses or with prolonged use in children.

When applied locally to the skin, the intensity of absorption depends on a number of factors: the solvent (polypropylene components improve diffusion), the state of the epidermal barrier (inflammation and skin diseases increase absorption).

Binds to plasma proteins. Easily passes histohematic barriers, including placental ones. Partially excreted in breast milk. Biotransformed mainly in the liver, the resulting metabolites are inactive. Excreted by the kidneys.

Carcinogenicity, mutagenicity, effect on fertility

Long-term animal studies have not been conducted to evaluate the potential carcinogenicity or effects on fertility of topical betamethasone. Betamethasone was genotoxic in vitro

in the chromosomal aberration test on human lymphocytes (with metabolic activation) and
in vivo
in the micronucleus test on mouse bone marrow.

Instructions for use Beloderm (Method and dosage)

If Beloderm cream or ointment is prescribed, the instructions for use by the patient must be carefully followed.

The instructions for the cream provide for external use only. The ointment or cream should be easily rubbed into dry, cleansed skin. This procedure should be carried out up to 3 times daily, but in most cases, for effective treatment it is enough to treat the affected areas 1-2 times a day. Apply the cream in a thin layer to the area being treated. If the patient missed applying the cream, then it should be applied as soon as the person remembers. In this case, the usual dose of the drug is used.

When using occlusive dressings, the systemic effect of the drug is enhanced, so they are not recommended for use. Treatment lasts no more than 4 weeks. If it is necessary to ensure the prevention of relapses in chronic diseases, the application of ointment or cream should continue after the disappearance of severe symptoms.

During treatment, it is important to carefully monitor the functioning of the hypothalamic-pituitary-adrenal system. If signs of inhibition of this system appear, Beloderm should be discontinued. It is important to avoid getting the product into your eyes.

The cream is advisable to use for the treatment of skin lesions that have an acute course. The ointment is applied to dry, flaky skin for the treatment of subacute and chronic dermatoses when occlusive action is required.

Directions for use and doses

Externally, apply a thin layer to the affected area of the skin, lightly rubbing, 2 times a day. On areas with thicker skin (elbows, palms, feet), as well as places from which the drug is easily washed off, it can be applied more often. The duration of a continuous course of treatment is usually no more than 4 weeks. To prevent relapses in the treatment of chronic diseases, treatment should be continued for some time after all symptoms disappear. Therapy may be repeated several times throughout the year.

In the form of a cream, the drug is intended for the treatment of acute, incl. weeping, skin lesions. The ointment is used for the treatment of subacute and chronic dermatoses, incl. dry, lichenified and scaly lesions or in cases where an occlusive action is necessary.

Overdose

Systemic overdose may occur if the drug is applied in large quantities over a large area of skin, while occlusive coatings are used. Cases of chronic overdose have been recorded when using the product for more than three weeks. Symptoms of overdose are inhibition of the functions of the hypothalamus-pituitary-adrenal system .

As a result, children experience growth retardation and intracranial hypertension ( headaches , swelling and pulsation of the crown), Cushing's syndrome, and impaired glucose metabolism. If such signs occur, you should immediately stop treatment with the drug and ensure the restoration of water-salt balance. Next, symptomatic treatment is practiced.

Beloderm ointment for external use 0.05% 15 g tube 1 pc. in Moscow

With long-term use, it suppresses the function of the hypothalamus-pituitary-adrenal system.

After parenteral (i.m.) and enteral administration, it is rapidly absorbed - the maximum effect (when taken orally) develops after 1–2 hours.

Carcinogenicity, mutagenicity, effect on fertility

Long-term animal studies have not been conducted to evaluate the potential carcinogenicity or effects on fertility of topical betamethasone. Betamethasone was genotoxic in vitro

in the chromosomal aberration test on human lymphocytes (with metabolic activation) and
in vivo
in the micronucleus test on mouse bone marrow.

special instructions

Long-term use is not recommended for the treatment of facial skin lesions due to the likelihood of developing acne , perioral dermatitis , and rosacea .

Do not allow the cream or ointment to come into contact with the mucous membrane of the eyes, as this can provoke the development of glaucoma , cataracts , and fungal eye diseases.

You cannot use the medicine for a long time to treat areas of the body with natural occlusion.

If a bacterial or fungal infection develops, an antibacterial or antifungal drug should be additionally used for treatment.

Does not affect the ability to concentrate and drive.

Analogs

Level 4 ATC code matches:
Gistan-N

Sinalar

Avecourt

Mesoderm

Momederm

Betazon

Silkaren

Elokom

Flucinar

Sinaflan

Celestoderm

Cutivate

Advantan

Betamethasone

Mometasone Furoate

Uniderm

Momat

The following analogues of Beloderm are available: Celestoderm-B , Akriderm , Celeston . These drugs have a similar effect, but they can be used for specific diseases only after permission from a specialist.

Reviews about Beloderm

There are different reviews about Beloderm on the network. Patients use it for various skin diseases. Reviews of ointments and creams often indicate that the product can reduce the severity of symptoms of diseases after just a few applications. It is also noted that Beloderm helps prevent remissions of some chronic diseases. However, this drug should not be used independently and uncontrolled, since its use without a doctor’s prescription often blurs the overall picture of the disease, which makes it difficult to establish a diagnosis and prescribe the correct treatment regimen.

Dermatitis: which cream to choose?

This problem causes discomfort and, in some cases, fear and confusion. Symptoms of dermatitis can affect not only your health, but also your work and personal life. It causes particular concern among young parents, like any illness in the baby.

Dermatitis is usually called any kind of manifestation on the skin that differs from its normal state: redness, peeling, itching, and so on.

If any changes occur, consult a specialist. It is worth noting that 10% of all visits to a dermatologist are related to manifestations of dermatitis. Women apply more often due to greater contact with household chemicals.

Types of Dermatitis

There are two main groups of dermatitis: contact and allergic.

The manifestations of contact dermatitis are:

Acute - the onset is rapid after a single interaction with substances that have a pronounced irritant effect.

Chronic - develops gradually with constant contact with an irritant over several days or even years. In this case, the cause will be mild irritants such as: household chemicals, soap solutions, dry air, dust.

Allergic dermatitis is a manifestation of a malfunction of the body's immune system to one or more irritants, manifested by inflammation.

The most common places of manifestations:

Skin of hands
Face
Neck
Armpits
Scalp
Anogenital area, most often in children.
Ears
Shin
Feet

The manifestations of acute contact and allergic dermatitis are very similar: redness, swelling and rashes in the form of bubbles and blisters and “pimples”. Itching, burning, and soreness of the skin will also be felt. With allergic dermatitis, the manifestations will not be limited to the place of skin contact with the irritant; the reaction goes far beyond its limits. As a result, mandatory consultation with a specialist is necessary to confirm the correct diagnosis and treatment.

In chronic dermatitis, the lesions do not look as bright as in acute dermatitis, but also have swelling, which can be accompanied by: cracks, hyperpigmentation and damage to the integrity of the skin, the desire to scratch and pinch it. Even after eliminating the impact of the irritant, the process can continue for up to several months.

To make an accurate diagnosis, the doctor will need to tell you in detail how, when and after what the skin lesion occurred. Skin tests will also be performed.

Dermatitis is usually called any kind of manifestation on the skin that differs from its normal state.

Treatment

The main goal of treatment is to return the person to the previous comfort and condition of the skin. The priority in the treatment of contact dermatitis is to identify the irritating factor and eliminate it. If it is impossible to eliminate contact, for example, due to professional necessity, adequate and reliable skin protection must be selected (overall clothing, gloves, protective creams and ointments). For simple contact dermatitis, the effectiveness of hormonal ointments and creams is not enough. The effectiveness of the use of selective alcineurin inhibitors tacrolimus and pimecrolimus for the types of dermatitis indicated in the article has not been proven in controlled studies.

In case of severe itching, it is possible to use antihistamines - Zodak, Claritin, Xestin, Erius, Suprastinex, Dizal, Alegra, Xyzal, Fenistil.

Local treatment:

Cutivate (fluticasone propionate) cream, ointment for 2 weeks
Triacort, Fluorocort (triamcinolone acetonide) ointment 0.025%, 0.1% for 2 weeks, treatment must begin with a higher dose
Dermovate, Clobetasol, Psoriderm, Dilasen, Powercourt (clobetasol propionate) ointment for 3–4 weeks
Akriderm, Beloderm, Celestoderm (betamethasone valerate) cream, ointment 2 weeks
Uniderm, Elokom, (mometasone furoate) cream, ointment 0.1% 2 weeks

It happens that a bacterial infection can join the course of the underlying dermatitis. In this case, it is worth connecting additional local antibacterial therapy:

Fucidin (fusidic acid) cream, gel 2% for 1–2 weeks
Supirocin, Bactroban (mupirocin) ointment 2% for 2 weeks

If there is no result in the treatment of allergic dermatitis, it is possible to use immunosuppressive drugs cyclosporine, azathioprine. Application of UV-B or PUVA therapy.

Prevention of dermatitis is the understanding that this reaction is lifelong and even short-term contact should be avoided.

Reminder for hand skin care for occupational contact dermatitis:

Be sure to wear gloves
Use soap substitutes. Soap removes the protective fatty layer of the skin and damages the stratum corneum of the skin, which retains water, thereby greatly increasing permeability to any substances. In addition, some soap components themselves are irritating.
Avoid Potentially Irritating Substances
Follow your doctor's recommendations for at least six months
Do not wear rings as they are a place where irritants accumulate, and if a person is still not ready to give up wearing them, then it is necessary to remove them while working and doing household chores.
Also regularly use emollients - these are substances similar in composition to the natural protective fatty film of the skin, affecting the upper layers of the skin. They are: natural, chemical, synthetic.

Available daily care products that can be purchased at any pharmacy: Bepanten, Tipikrem, Emolium, Mustela, Lipobase, La-cree.

For adults only: Lokoid, Dermovate, Sinalar. They should only be applied to clean, dry skin.

One of the new directions is the use of corneoprotectors. These are products that restore the integrity of the stratum corneum directly. Physiogel, Oilatum, Lipikar, Protopic.

By self-medicating, you can cause irreparable harm to your health; be sure to consult a doctor and follow his recommendations.

Literature: Federal clinical guidelines for the management of patients with contact dermatitis, Moscow - 2015

Beloderm price, where to buy

The price of Beloderm ointment (15 g) ranges from 120 to 140 rubles. Cream (30 g) can be bought at a price of 200 to 240 rubles. Beloderm price in Ukraine - from 60 UAH. per pack of cream or ointment 30 g.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

ZdravCity

Beloderm cream 0.05% 30g Belupo
191 rub. order
Beloderm cream 0.05% 15gBelupo
125 rub. order
Beloderm cream 0.05% 40gBELUPO, Medicines and cosmetics d.d.
RUB 278 order
Beloderm ointment 0.05% 30gBelupo
189 rub. order
Beloderm ointment 0.05% 40g BELUPO, Medicines and cosmetics d.d.
RUB 266 order

Pharmacy Dialogue

Beloderm ointment (tube 0.05% 40g)Belupo
260 rub. order
Beloderm cream (tube 0.05% 40g)Belupo
RUB 273 order
Beloderm Express (spray 0.05% 50ml)Belupo
RUB 503 order
Beloderm cream (tube 0.05% 15g)Belupo
130 rub. order
Beloderm ointment (tube 0.05% 30g)Belupo
175 rub. order

Pharmacy24

Beloderm 0.05% 30 g Belupo ointment, liquids and cosmetics d.d., Croatia
103 UAH.order
Beloderm 0.05% 30 g Belupo cream, Liki and cosmetics d.d., Croatia
103 UAH order
Beloderm 0.05% 15g tube cream for external use
79 UAH order