Tablets, solution, vaginal gel Metrogyl: instructions for use, price, reviews for acne

Compound

The Metrogyl solution contains the active ingredient metronidazole , as well as: sodium chloride, sodium hydrogen phosphate (anhydrous), citric acid, water.
Metrogyl tablets contain the active ingredient metronidazole , as well as: corn starch, magnesium stearate, colloidal silicon dioxide, hydrogenated castor oil, Opadry II dye, water.

Metrogyl gel includes metronidazole and additional components: propyl parahydroxybenzoate, methyl parahydroxybenzoate, disodium edetate, carbomer 940, sodium hydroxide, propylene glycol, water.

Release form

Currently, Metrogyl solution is produced for intravenous administration, as well as tablets, vaginal gel and gel for external use.

The solution for intravenous administration can be colorless or pale yellow, transparent, packaged in transparent ampoules of 20 ml (100 mg solution) and in polyethylene bottles of 100 ml (500 mg solution). The containers are placed in cardboard packs.
Tablets 200 mg - pink, biconvex, film-coated, round, packaged in blisters of 10 pcs., in cardboard packs of 2 blisters.
Tablets 400 mg - orange, biconvex, film-coated, round, packaged in blisters of 10 pcs., in cardboard packs of 2 blisters.
Metrogyl vaginal gel is homogeneous, colorless or has a yellow tint, contained in tubes of 30 g.

Metrogyl 200 mg 20 pcs. Unique Pharmaceutical Laboratories tablets

pharmachologic effect

Antibacterial, antiprotozoal, trichomonacid.
The nitro group of metronidazole is reduced in anaerobic microorganisms and protozoa, interacts with DNA, inhibits the biosynthesis of nucleic acids and causes the death of bacteria.

Composition and release form Metrogyl 200 mg 20 pcs. Unique Pharmaceutical Laboratories tablets

1 g of gel for external use contains 10 mg of metronidazole, in tubes of 30 g, in a box 1 tube.

Directions for use and doses

Intravaginally, 5 g (one full applicator) of cream 2 times a day (morning and evening). The course of treatment is 5 days.

Indications for use Metrogyl 200 mg 20 pcs. Unique Pharmaceutical Laboratories tablets

trichomoniasis;
giardiasis; amoebic dysentery;
urinary tract infections,
infections of the female genital organs,
prevention of infection during surgical interventions;
chronic alcoholism;
in combination with amoxicillin for gastric and duodenal ulcers and gastritis;
acne treatment;
treatment of long-term non-healing wounds and trophic ulcers.

Contraindications

diseases of the central nervous system;
blood diseases;
hypersensitivity to the drug.

Application of Metrogyl 200 mg 20 pcs. Unique Pharmaceutical Laboratories tablets during pregnancy and lactation

Contraindicated during pregnancy (1st third) and breastfeeding. In the second and third thirds of pregnancy, it is prescribed only for health reasons.

special instructions

Prescribe with caution to patients with severe diseases of the central nervous system, liver and blood.

During treatment, sexual intercourse and alcohol consumption should be avoided.

Side effects Metrogyl 200 mg 20 pcs. Unique Pharmaceutical Laboratories tablets

From the nervous system and sensory organs: dizziness, headache.

From the cardiovascular system and blood (hematopoiesis, hemostasis): leukopenia or leukocytosis.

From the gastrointestinal tract: nausea, constipation or diarrhea, decreased appetite, metallic taste in the mouth.

From the genitourinary system: itching, burning and irritation in the vagina and/or vulva; vulvar swelling, vaginal discharge (non-candidal), increased urination, symptomatic candidal cervicitis, vaginitis.

Other: painful spasm in the abdominal cavity or uterine cavity, allergic skin rash.

Drug interactions

When used simultaneously with warfarin and other indirect anticoagulants, the prothrombin time increases.

pharmachologic effect

The broad-spectrum medicine contains metronidazole , a 5-nitroimidazole derivative.

The drug has antimicrobial and antiprotozoal effects. The mechanism of action is based on the reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids. As a result, the bacteria die.

Metrogyl demonstrates activity against Gardnerella vaginalis, Trichomonas vaginalis, Giardiai ntestinalis, Entamoeba histolytica, Lamblia spp. The drug is also active against obligate anaerobes and a number of gram-positive microorganisms.

If metronidazole is combined with Amoxicillin , activity against Helicobacter pylori is manifested.

Facultative anaerobes and aerobic microorganisms do not show sensitivity to metronidazole, however, in the presence of mixed flora, there is a synergistic effect of metronidazole with antibiotics that are effective against aerobes.

It provokes disulfiram-like reactions, under its influence the sensitivity of tumors to radiation increases, and reparative processes are stimulated.

When applied externally, an anti-acne effect is observed, the mechanism of which is not fully known. Metrogyl ointment appears to demonstrate antioxidant activity. Under the influence of this drug, the production of active oxygen, hydrogen peroxide, and hydroxyl radicals by neutrophils is reduced, that is, potential oxidants that contribute to tissue damage in the place where the inflammatory process develops.

The external form of the drug is active against telangiectasia in rosacea .

Metrogyl A gel for external use 0.1%+1% 20g

Pharmacological group:

Acne rash treatment ATC code: D10AX30
Pharmacodynamics:
Adapalene is a retinoid metabolite that acts on the pathological mechanism of development of Acne vulgaris, is a strong modulator of cell differentiation and keratinization and has comedolytic and anti-inflammatory activity. The mechanism of action of adapalene is based on interaction with specific gamma receptors of epidermal skin cells. As a result of the action of adapalene, there is a decrease in the “adhesion” of epithelial cells at the mouth of the pilosebaceous follicle and a decrease in the formation of microcomedones. Adapalene has an anti-inflammatory effect in vivo and in vitro, affecting inflammatory factors by inhibiting the migration of leukocytes at the site of inflammation, inhibits the chemotactic and chemokinetic responses of human polymorphonuclear leukocytes and suppresses the metabolism of arachidonic acid to inflammatory mediators, AP-1 factors and the expression of Toll-like receptors 2 .

Metronidazole is an antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against Trichomonas vaginalis, Entamaeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. and some gram-positive anaerobes (susceptible strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The minimum inhibitory concentration (MIC) for these strains is 0.125-6.25 μg/ml. Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against common aerobes.

Pharmacokinetics:

Adapalene Absorption of adapalene through the skin is very low (about 4% of the applied dose). Excretion from the body occurs mainly through bile.

Metronidazole The maximum concentration of metronidazole in blood plasma when applied externally does not exceed 0.5% of the average maximum concentration of metronidazole in blood plasma after oral administration of 250 mg of metronidazole in tablet form and is achieved after 6-24 hours. When applied externally, the concentration of metronidazole at the site of application of the gel is significantly higher than in blood plasma. The connection with blood proteins is insignificant. The lowest concentration of metronidazole is determined in adipose tissue. It is excreted by the kidneys unchanged and in the form of metabolites.

Pharmacokinetics and pharmacodynamics

After a patient has been administered Metrogyl intravenously, approximately 30-60% of the substance is metabolized through hydroxylation, oxidation and glucuronidation. As a result, a metabolite, 2-oxymetronidazole, is formed, which also produces an antiprotozoal and antimicrobial effect. The half-life is 8 hours (subject to normal liver function), up to 18 hours (if the liver is damaged by alcohol).

Approximately 60-80% of the administered dose is excreted through the kidneys, another 6-15% is excreted through the intestines. Both metronidazole and its metabolites are eliminated from the blood by hemodialysis .

If the antibiotic is taken orally, it is quickly absorbed, and its maximum concentration in the blood is observed after 2 hours. The product has a high ability to penetrate tissues and body fluids. 10-20% bound to plasma proteins. About 60-80% is excreted through the kidneys, while approximately 20% is excreted unchanged. Half-life is 8 hours.

When the product is used externally, a minimal amount is absorbed, so only traces of the active component are detected in the blood. It should be taken into account that the absorbed active substance passes the blood-brain and placental barriers.

Indications for use

The instructions define the following indications for the use of Metrogyl intravenously:

protozoal infections: ( trichomoniasis , extraintestinal and intestinal amebiasis , balantidiasis , giardiasis , cutaneous leishmaniasis , giardiasis , vaginitis and urethritis );
infectious diseases caused by Bacteroides spp.: infections of the abdominal cavity, pelvic organs, skin, soft tissues;
infections caused by Bacteroides spp.: infections of the nervous system, joints, bones, including brain abscess , meningitis , endocarditis , empyema , lung abscess , pneumonia ;
infectious diseases caused by Bacteroides spp., including Clostridium spp., B. Fragilis: sepsis ;
pseudomembranous colitis as a result of treatment with antibiotics;
alcoholism;
gastritis or ulcer as a result of the action of Helicobacter pylori;
prevention of complications after surgery.

It is advisable to prescribe tablets in the following cases:

to prevent the development of postoperative complications (in particular gynecological);
for protozoal infections ( giardiasis , trichomoniasis , amoebic dysentery , amebiasis etc.);
anaerobic infections (those that were provoked by Bac.fragilis, as well as clostridia , fusobacteria , anaerobic cocci , eubacteria );
period after operations;
infectious diseases of the respiratory tract;
gas gangrene ;
septicemia;
osteomyelitis;
meningitis , brain abscess ;
tetanus.

Metrogyl cream is prescribed for the following diseases and conditions:

acne vulgar;
rosacea;
seborrheic dermatitis , oily seborrhea;
trophic ulcers that appear on the lower extremities as a result of varicose veins , diabetes mellitus ;
bedsores;
wounds that heal poorly;
anal fissures , hemorrhoids .

Metrogyl vaginal gel is indicated for the treatment of vaginitis , which is caused by metronidazole-sensitive microflora, as well as for the treatment of urogenital trichomoniasis .

Buy Metrogyl solution for infusion 5mg/ml 100ml in pharmacies

Instructions for use Metrogyl solution for inf. 5mg/ml 100ml Dosage forms solution for injection 5mg/ml 100ml Synonyms Batsimex Klion Metronidazole Metronidazole Nycomed Metronidazole-AKOS Metronidazole-Ros Metronidazole-Rusfar Metronidazole-Teva Metronidazole-UBF Metronidazole tablets Rosamet Rosex Trichopex Trichopol Flagyl Efloran Group Means for treatment of trichomoniasis, amoebiasis and other protozoal infections International nonproprietary name Metronidazole Composition Active substance - metronidazole. Manufacturers Unique Pharmaceutical Laboratories (India), Unique Pharmaceutical Laboratories (a department of the company J.B. Chemicals and Pharmaceuticals) (India) Pharmacological action Antibacterial, antiprotozoal (trichomoniacidal), antiulcer, antialcohol. The nitro group of the molecule, which is an electron acceptor, is integrated into the respiratory chain of protozoa and anaerobes, which disrupts the respiratory processes and causes cell death. In addition, in some species of anaerobes it has the ability to suppress DNA synthesis and cause its degradation. After oral administration, it is quickly and completely absorbed from the gastrointestinal tract. The maximum concentration is reached after 1-2 hours. Penetrates well into tissues and body fluids, creating bactericidal concentrations in saliva, seminal fluid, and vaginal secretions; penetrates the BBB and placental barriers and is secreted into breast milk. With repeated doses it accumulates. Subject to biotransformation in the liver. Excreted by the kidneys and intestines, about 20% unchanged. The spectrum of action includes protozoa: Trichomonas vaginalis, Entamoeba histolytica; anaerobic gram-negative microorganisms: bacteroids, including the Bacteroides fragilis group (B. fragilis, B. caccae, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus); fusobacteria Prevotella (P. bivia, P. buccae, P. disiens); anaerobic gram-positive rods: Clostridium, Eubacterium; anaerobic gram-positive cocci: Peptococcus, Peptostreptococcus; Trichomonacid effect is observed at a drug concentration of 2.5 μg/ml for 24 hours. Shows activity against Helicobacter pylori. Side effects Headache, dizziness, syncope, ataxia, disturbances of consciousness, epileptic seizures, neutropenia (leukopenia), nausea, vomiting, abdominal pain, diarrhea, unpleasant metallic taste, erythematous rashes, skin itching, dark urine discoloration, allergic reactions, thrombophlebitis (after intravenous administration). Indications for use Amebiasis, trichomoniasis, giardiasis, giardiasis, intra-abdominal infections (peritonitis, abscess), anaerobic infections of bones and joints, skin and soft tissues, female genital organs (endometritis, tubo-ovarian abscess), central nervous system (meningitis, brain abscess), lower respiratory pathways (pneumonia, empyema, lung abscess), endocarditis, pseudomembranous colitis, Helicobacter pylori eradication, chronic alcoholism, prevention of postoperative anaerobic infection. For external and local use: rosacea and vulgar acne, bacterial vaginosis, long-term non-healing wounds, trophic ulcers. Contraindications Hypersensitivity (including to other nitroimidazole derivatives), pregnancy, lactation, childhood (excluding cases of amoebiasis). Method of administration and dosage Parenteral (intravenous drip) for adults 500 mg in 100 ml of solvent, for children - at the rate of 7.5 mg/kg in the same amount of solvent. Infusion is carried out at a rate of 5 ml/min at intervals of 8 hours. Overdose Symptoms: nausea, vomiting, ataxia, in severe cases - peripheral neuropathy and epileptic seizures. Treatment: symptomatic; There are no specific antidotes. Interaction Enhances the effects of indirect anticoagulants and lithium salts. Phenytoin and phenobarbital reduce the effect (due to activation of the liver microsomal system and accelerate metabolism and excretion), and cimetidine increases (inhibits the enzymatic systems of the liver and, as a result, slows down biotransformation). Incompatible with alcohol (when taken together, an Antabuse-like syndrome develops). Special instructions When treating with metronidazole, excessive development of fungal flora of the vagina (candidiasis) is sometimes observed, which requires the use of antifungal drugs. Storage conditions: In a cool, dry place, protected from light. List B.

Contraindications

IV Metrogyl is contraindicated for use in the following conditions and diseases:

organic lesions of the nervous system ( epilepsy , etc.);
blood diseases;
liver failure (large doses cannot be taken);
blood diseases;
lactation and pregnancy (first trimester);
nitroimidazole derivatives .

Intravenous injections are given with caution to people suffering from renal failure.

Metrogyl tablets should not be taken in the following cases:

with organic lesions of the nervous system, in particular epilepsy ;
for blood diseases;
for liver failure (large doses of tablets);
under the age of 12;
during pregnancy (first trimester);
high sensitivity to the active substance, to other nitroimidazole .

Prescribed with caution to people with liver and kidney diseases.

Vaginal gel is not prescribed for the following diseases and conditions:

impaired coordination of movements;
leukopenia (also in history);
lesions of the nervous system of an organic nature, including epilepsy ;
pregnancy (first trimester);
liver failure;
high sensitivity, also sensitivity to nitroimidazole derivatives.

Metrogyl Denta during pregnancy and lactation -

In the previous version of the instructions for Metrogyl-Dent gel, it was contraindicated for use, but only during the 1st trimester of pregnancy. In the current version of the instructions, it is only “not recommended for use,” but throughout pregnancy (pregnancy is not a complete contraindication for the use of the drug). Thus, Metrogyl denta can still be used during pregnancy, but only in consultation with your doctor.

Regarding breastfeeding, it is best to temporarily stop breastfeeding while using this drug. An interesting point is that if you compare this information with the recommendations of the FDA (U.S. Drug Administration), then according to their recommendations, metronidazole can be taken by pregnant women and is also quite safe when breastfeeding.

Alternatives during pregnancy and breastfeeding - an alternative can be the drug Cholisal, which, in accordance with the manufacturer’s instructions, can be taken throughout pregnancy and the breastfeeding period, but also “with caution.” The term “with caution” means that you should not take the drug unsupervised - it should be prescribed by your dentist, and you should also inform your obstetrician-gynecologist about its prescription.

Contraindications to the use of Metrogyl Denta gel:

children under 18 years of age,
allergic reactions to the components of the gel,
blood diseases,
diseases of the nervous system.

Side effects

When using the drug intravenously and orally, the following side effects may develop:

Gastrointestinal tract: loss of appetite, diarrhea , nausea , intestinal colic, vomiting , constipation , dryness or metallic taste in the mouth, glossitis , pancreatitis , stomatitis ;
nervous system: impaired coordination, dizziness , impaired consciousness, ataxia , severe excitability, irritability, insomnia , weakness, headache , hallucinations , convulsions ;
allergies: rash, hyperemia , urticaria , fever , nasal congestion, arthralgia ;
urinary system : cystitis , dysuria , urinary incontinence , polyuria , candidiasis , change in urine color to red-brown;
local manifestations: thrombophlebitis , development of pain, swelling, redness at the site of drug administration;
other manifestations: leukopenia , neutropenia .

When using Metrogyl gel for topical use, a small amount of the active component is absorbed into the blood, so systemic side effects are unlikely. Rarely, the development of allergic manifestations, lacrimation, dryness and burning of the skin is possible.

Metrogyl®

Gastrointestinal disorders: epigastric pain, nausea, vomiting, diarrhea, glossitis, stomatitis, metallic taste in the mouth, decreased appetite, anorexia, pseudomembranous colitis, dry oral mucosa, constipation, pancreatitis (reversible cases) , change in tongue color / “coated tongue” (due to the growth of fungal microflora).

Immune system disorders: angioedema, anaphylactic shock.

Nervous system disorders: peripheral sensory neuropathy, headache, convulsions, dizziness, encephalopathy and subacute cerebellar syndrome (impaired coordination and synergism of movements, ataxia, dysarthria, gait disturbance, nystagmus, tremor) have been reported, which are reversible after discontinuation of metronidazole , aseptic meningitis.

Mental disorders: psychotic disorders, including disturbances and confusion, hallucinations; depression, insomnia, irritability, increased excitability.

Visual disturbances: transient visual disturbances, such as diplopia, myopia, blurred contours of objects, decreased visual acuity, impaired color perception; neuropathy/optic neuritis.

Blood and lymphatic system disorders: agranulocytosis, leukopenia, neutropenia, thrombocytopenia.

Disorders of the liver and biliary tract: increased activity of liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), development of cholestatic or mixed hepatitis and hepatocellular liver damage, sometimes accompanied by jaundice; In patients treated with metronidazole in combination with other antibacterial agents, cases of liver failure requiring liver transplantation have been observed.

Skin and subcutaneous tissue disorders: rash, itching, skin flushing, urticaria, pustular skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis.

Renal and urinary tract disorders: brownish-reddish coloration of urine due to the presence of a water-soluble metabolite of metronidazole in the urine, dysuria, polyuria, cystitis, urinary incontinence, candidiasis.

General disorders: fever, nasal congestion, arthralgia, weakness.

Laboratory and instrumental data: flattening of the T wave on the electrocardiogram.

Instructions for use of Metrogyl (Method and dosage)

Metrogyl solution, instructions for use

A Metrogil dropper is indicated in cases of severe infectious diseases, as well as in cases where the patient is unable to take the medicine orally.

Adolescents over 12 years of age and children receive the drug intravenously (duration of administration is about 40 minutes), the initial dose is 0.5-1 g. Then 500 mg should be administered every 8 hours (rate 5 ml/min.). If a person tolerates the injection normally, then after 2-3 infusions the drug can be administered in a stream. The injections must be taken for 7 days.

If necessary, a longer administration of the medicine is practiced. The permissible dose per day is 4 g. If indicated, maintenance doses can be used - 400 mg three times a day.

A similar regimen of use is practiced for children under 12 years of age, a single dose is 7.5 mg/kg.

To treat purulent-septic diseases, one course of therapy is sufficient.

For prevention, adolescents over 12 years of age and adults are given 0.5-1 g of medication intravenously before surgery, and 1.5 g per day on the day after surgery, that is, 500 mg every 8 hours. After 1-2 days, the patient can be transferred to maintenance oral medication.

If liver and kidney function are impaired, you should not take more than 1 g of medication per day; the dose should be divided into 2 doses.

Metrogyl tablets, instructions for use

You can take the tablets both during and after meals; they do not need to be chewed.

The dose for adults and adolescents over 15 years of age is 200-400 mg two to three times a day. per day

Both the dosage and duration of the course depend on the infection.

For trichomoniasis, you need to drink 200 mg 3 times for 7 days, while women take additional vaginal products with metronidazole. You can increase the dose or repeat the course of therapy if necessary.

For amebiasis , adults receive 400 mg 3 times a day. per day, children - 30-40 mg per 1 kg/day, the dose is divided into three doses. You need to take Metrogyl for up to 10 days.

For amoebic liver abscess, adults receive 400 mg or 800 mg three times a day, the drug is combined with tetracyclines. Children - 30-35 mg per 1 kg/day, the dose is divided into three doses. Therapy lasts up to 10 days.

For anaerobic bacterial infections, adults receive 200-400 mg 2-3 times. per day, children should receive 7 mg per 1 kg of weight every 8 hours. Therapy lasts up to 10 days.

For the purpose of prevention before operations, you need to take 1000 mg once, then 200 mg three times a day.

If Metrogyl is combined with amoxicillin, the dose of metronidazole per day should be 1.5 g, divided into three doses.

Vaginal gel Metrogyl, instructions for use

The ointment is applied intravaginally, once in a dose of 2 g or 500 mg twice a day, 10 days. During this time, sexual activity is not allowed.

Metrogyl gel for thrush is used as prescribed by a doctor.

The gel is applied externally to cleansed skin twice a day, treatment lasts from 3 to 9 weeks, it is possible to use the product for a longer time - up to 4 months. An occlusive dressing can be applied if necessary.

Metrogyl for acne

Often those who use Metrogyl gel on their face give positive reviews for acne. Despite the fact that the official instructions do not provide detailed information about the use of this medicine for the face, Metrogyl gel for acne is still used very often, since metronidazole has a bactericidal and bacteriostatic effect. Accordingly, it helps to get rid of dermatological problems. If the patient has single pimples, it is enough to apply the ointment several times.

In the case of acne, treatment may take longer. However, after the first use, the severity of negative symptoms decreases. Metrogyl is used as the main remedy for the treatment of acne, and in combination with other drugs. Apply the gel twice a day to areas affected by acne.

Metrogyl and Differin

Differin , which is a synthetic retinoid, contains the active component adapalene. This drug has a beneficial effect on the skin; when used with Metrogyl, users note a more pronounced effect.

Metrogyl – powder, solution, suspension, tablets

Orally and parenterally.

Orally, during or after meals (or with milk), without chewing.

For trichomoniasis - 250 mg 2 times a day for 10 days or 400 mg 2 times a day for 5-8 days. Women must additionally be prescribed metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g/day. Between courses you should take a break of 3-4 weeks with repeated control laboratory tests. An alternative treatment regimen is to prescribe 2 g once to the patient and his sexual partner.

Children 2-5 years old - 250 mg/day; 5-10 years - 250-375 mg/day, over 10 years - 500 mg/day. The daily dose should be divided into 2 doses. The course of treatment is 10 days.

For giardiasis - 500 mg 2 times a day for 5-7 days.

Children under 1 year old - 125 mg/day, 2-4 years old - 250 mg/day, 5-8 years old - 375 mg/day, over 8 years old - 500 mg/day (in 2 doses). The course of treatment is 5 days.

For giardiasis - 15 mg/kg/day in 3 divided doses for 5 days.

Adults: for asymptomatic amebiasis (if a cyst is detected), the daily dose is 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.

For chronic amebiasis, the daily dose is 1.5 g in 3 divided doses for 5-10 days, for acute amoebic dysentery - 2.25 g in 3 divided doses until the symptoms stop.

For liver abscess, the maximum daily dose is 2.5 g in 1 or 2-3 doses, for 3-5 days, in combination with antibiotics (tetracyclines) and other methods of therapy.

Children 1-3 years old - 1/4 adult dose, 3-7 years old - 1/3 adult dose, 7-10 years old - 1/2 adult dose.

For balantidiasis - 750 mg 3 times a day for 5-6 days.

For ulcerative stomatitis, adults are prescribed 500 mg 2 times a day for 3-5 days; In this case, the drug is not indicated for children.

For pseudomembranous colitis - 500 mg 3-4 times a day.

For eradication of Helicobacter pylori - 500 mg 3 times a day for 7 days (as part of combination therapy, for example in combination with amoxicillin 2.25 g/day).

When treating anaerobic infection, the maximum daily dose is 1.5-2 g.

In the treatment of chronic alcoholism, 500 mg/day is prescribed for a period of up to 6 (not more than) months.

To prevent infectious complications - 750-1500 mg/day in 3 doses 3-4 days before surgery or 1 g once on the first day after surgery. 1-2 days after surgery (when oral administration is already allowed) - 750 mg/day for 7 days.

In case of severe renal dysfunction (creatinine clearance less than 10 ml/min), the daily dose should be reduced by 2 times.

Suspension for oral administration. Anaerobic bacterial infections: children - 7 mg/kg every 8 hours, course of treatment - 7-10 days; Giardiasis: children 2-5 years old - 200 mg/day, 5-10 years old - 300 mg/day, 10-15 years old - 400 mg/day. The duration of treatment for giardiasis is 5 days. The course of treatment can be repeated after 10-15 days

Parenterally. For adults and children over 12 years of age, an initial dose of 0.5-1 g IV drip (infusion duration is 30-40 minutes), and then every 8 hours, 500 mg at a rate of 5 ml/min. If well tolerated, after the first 2-3 infusions they switch to jet administration. The course of treatment is 7 days. If necessary, intravenous administration is continued for a longer time. The maximum daily dose is 4 g. According to indications, switch to maintenance oral administration at a dose of 400 mg 3 times a day. Children under 12 years of age are prescribed according to the same regimen in a single dose of 7.5 mg/kg.

For purulent-septic diseases, 1 course of treatment is usually carried out.

For preventive purposes, adults and children over 12 years of age are prescribed 0.5-1 g intravenously on the eve of surgery, on the day of surgery and the next day - 1.5 g / day (500 mg every 8 hours). After 1-2 days, they switch to maintenance therapy orally. For patients with chronic renal failure and creatinine clearance less than 30 ml/min and/or liver failure, the maximum daily dose is no more than 1 g, the frequency of administration is 2 times a day.

As a radiosensitizing drug, it is administered intravenously at a rate of 160 mg/kg or 4-6 g/sq.m of body surface 0.5-1 hour before the start of irradiation. Apply before each irradiation session for 1-2 weeks. During the remaining period of radiation treatment, metronidazole is not used. The maximum single dose should not exceed 10 g, course dose - 60 g. To relieve intoxication caused by radiation, drip administration of a 5% dextrose solution, Hemodez or 0.9% NaCl solution is used.

For cervical and uterine cancer, skin cancer, it is used in the form of local applications (3 g dissolved in a 10% DMSO solution), tampons are moistened with the drug and applied topically, 1.5-2 hours before irradiation). In case of poor tumor regression, applications are carried out throughout the entire course of radiation therapy. If there is a positive dynamics of tumor clearance from necrosis - during the first 2 weeks of treatment.

Interaction

The dropper with Metrogyl should not contain other medications - it is not recommended to mix the product with other drugs.

Metronidazole activates the effect of indirect anticoagulants, resulting in an increase in the time of prothrombin .

Causes ethanol . When used simultaneously with Disulfiram, a variety of neurological symptoms may develop. It is important to keep the interval between taking these medications at least 2 weeks.

When taking Cimetidine , the metabolism of metronidazole is suppressed, so the concentration of the latter may increase, which leads to the development of side effects.

With the simultaneous use of Phenobarbital , phenytoin , that is, drugs that stimulate microsomal oxidation enzymes in the liver, it is possible to accelerate the elimination of metronidazole. As a result, its plasma concentration decreases.

If metronidazole is taken simultaneously with lithium preparations, the concentration of the latter in plasma may increase. In this case, signs of intoxication of the body may appear.

You should not combine Metrogyl with non-depolarizing muscle relaxants .

The antimicrobial effect of metronidazole is enhanced by sulfonamides .

When the gel is applied topically, there is no significant interaction with other drugs, but it should be used with caution with Warfarin and other indirect anticoagulants, since an increase in prothrombin time is possible.

special instructions

It is not recommended to combine Metrogyl with amoxicillin in patients under 18 years of age.

Long-term therapy requires constant monitoring of the blood picture.

If the patient develops leukopenia , continuation of therapy depends on whether there is a risk of an infectious process.

Therapy should be discontinued if the patient develops dizziness , ataxia and other symptoms indicating a deterioration in neurological status.

Under the influence of the drug, immobilization of treponema may occur, which leads to a false-positive Nelson test.

During treatment, the urine turns dark.

During the treatment of trichomonas vaginitis and urethritis, you should abstain from sexual intercourse. It is important that both sexual partners undergo therapy at the same time. During menstruation, treatment is not stopped.

Do not allow the gel to get into your eyes. If this happens, you need to rinse your eyes with warm water.

The Metrogyl dropper in gynecology is used only as prescribed by the attending physician.

In cosmetology, Metrogyl gel for the face is used to treat acne and other skin lesions. You can use it on your face only on the recommendation of a specialist.

Analogs

Level 4 ATC code matches:
Oflokain

Furasol

Chlorophyllipt

Oflomelid

Rozamet

Currently, numerous analogues of Metrogyl gel, tablets and solution are produced. These are the drugs Deflamon , Batsimex , Klion , Metrovagin , Metrolacare , Metron , Orvagil , Trichobrol , Trichopol , Siptrogil , Rosex , etc. Suppositories with the active substance metronidazole .

Reviews about Metrogil

In most reviews about the drug, users write that all forms of the drug are quite effective. Women who have used Metrogyl vaginal gel leave reviews that the medicine is convenient to use and at the same time it helps to quickly and quite effectively cope with the treatment of infectious diseases. Many women write that vaginal gel helped cure thrush .

There are also often opinions that Metrogyl ointment is an excellent remedy for treating acne . Reading reviews about Metrogyl for acne, we can conclude that this medicine significantly improves the situation after a course of use. Patients consider severe dryness of the skin when using the cream to be a negative point. However, it is often used to combat acne; women also use external remedy Metrogyl under the supervision of a doctor during pregnancy.

Metrogil price, where to buy

The price of Metrogil in tablets is about 80 rubles per pack; suppositories with metronidazole can be bought at a price of 100 rubles.

You can buy Metrogyl facial gel for 160 – 180 rubles.

The price of ampoules depends on the volume; an IV solution in 5 ml ampoules costs 30 rubles. for 1 ampoule. The cost of 100 ml ampoules (for a dropper) is about 80 rubles.

Vaginal gel Metrogyl, price

You can buy vaginal gel for an average of 170 rubles (30 g ointment). The price of the gel in Ukraine (Kharkov, Kyiv, etc.) is 80 – 90 hryvnia. You can find out how much the gel costs at a specific pharmacy.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Metrogyl Denta dental gel for gums 20g 1pcUnique Pharmaceutical Lab.
RUB 313 order
Metrogyl Plus vaginal gel (tube) 50g + applicator 10 pcs. Unique Pharmaceutical Laboratories
RUB 338 order
Metrogyl gel vaginal. 10mg/g 30gUnique Pharmaceutical Lab.
180 rub. order
Metrogyl gel for external use. approx. 1% 30gUnique Pharmaceutical Lab.
RUB 241 order
Metrogyl Plus vaginal gel tube 50 g + applicator 1 pc. Unique Pharmaceutical Laboratories
RUB 267 order

Pharmacy Dialogue

Metrogyl plus vag.gel (tube 50g + application No. 1)Unique Farm Lab
RUB 249 order
Metrogyl Denta (gel for gums tube 20g)Unique Farm Lab
RUB 313 order
Metrogyl gel (tube 30g)Unique Farm Lab
RUB 225 order
Metrogyl (vial 5mg/ml 100ml)Unique Farm Lab
25 rub. order
Metrogil vag. gel (tube 30g with applique)Unique Farm Lab
RUB 171 order

Pharmacy24

Metrogyl Denta 20 g gel Unik Pharmaceutical Laboratories, India
55 UAH order
Metrogyl 30 g gel Unik Pharmaceutical Laboratories, India
78 UAH order
Metrogyl 30 g gel Unik Pharmaceutical Laboratories, India
85 UAH order
Metrogyl 5 mg/ml 100 ml solution for infusion
20 UAH order

PaniPharmacy

Metrogyl denta gel Metrogyl denta gel 20g India, Unique
61 UAH order
Metrogyl gel Metrogyl gel 30g India, Unique
92 UAH order
Metrogyl gel Metrogyl vag. gel 30g with appl. India, Unique
103 UAH order
Metrogyl infusion Metrogyl solution inf. 100ml India, Unique
24 UAH order

Metrogyl Denta: instructions for use

Next we will tell you how to properly use Metrogyl Denta as part of complex therapy (together with antiseptic rinses). You probably already realized that this drug will not be very effective as monotherapy, especially when it comes to a form of gum inflammation such as periodontitis.

ANTI-INFLAMMATORY THERAPY SCHEME:

For Metrogyl Denta gel, the instructions for use require that you apply the drug to the gums - 2 times a day (morning and evening - for 7-10 days). Morning treatment is carried out after breakfast and oral hygiene, and it is important in this sequence, and not vice versa. Immediately after brushing your teeth, you should take an antiseptic mouthwash and, without spitting, rinse your mouth with it for 1 minute. For rinsing, 10 ml of solution is enough (this is approximately 1 sip). After rinsing, under no circumstances should you rinse your mouth with water.

If you only have gingivitis, a large list of rinses will suit you (you can read about the main rinses for gum inflammation at this link). But if you have periodontitis, then together with Metrogyl denta gel it is better to use combined products - with 0.2% chlorhexidine or 0.1% hexitedine (which will additionally contain anti-inflammatory components, for example, methyl salicylate). In this case, the best option would be the product – PRESIDENT Antibacterial “Powerful protection against bacteria”, and another good option is “Hexoral” in the form of a solution.

How to apply the gel to the gums - immediately after rinsing, the gel is applied to the gums. It is advisable to pre-dry the gums with a dry gauze pad, because... in this case the gel will stick better. The gel is applied directly only to the gingival margin, which is adjacent to the neck of the teeth (and interdental gingival papillae, respectively). The gel should be applied not only to the gums from the front surface of the teeth, but also from the side of the palate/tongue, although the emphasis should be placed on treating the gums from the front surface of the teeth.

You can apply the gel using your finger or a special thin medical spatula. You need to do this in front of a mirror, with your teeth bared well, so that you can visually see where exactly you are applying the gel. First, the gel is applied to the gums around the lower teeth, and then around the upper teeth. During the application of the gel, as well as after, you may actively salivate. You don’t need to save it or spit it out on purpose, you should swallow it - as you usually do during the day. After applying the gel, we do not recommend drinking for 30 minutes, rinsing your mouth or eating for 2-3 hours.

Important: evening treatment is carried out according to the same scheme (meal → oral hygiene → antiseptic mouth rinse → application of Metrogyl Denta gel to the gums). If you have gingivitis, the duration of therapy is usually 7-8 days, and for periodontitis - 10 days.