Pharmacodynamics and pharmacokinetics
The active component of the drug is a high molecular weight carboxyvinyl polymer . Eye gel is designed to moisturize the cornea. It creates a transparent moisturizing and lubricating film. The pH of this product is close to the pH of natural tears. It removes manifestations of irritation, as well as symptoms that arise due to dry eye syndrome ( compensatory lacrimation , burning, itching, visual fatigue , sensation of a foreign body on the eye), and prevents the cornea from drying out.
Penetration into the tissue of the eyeball and accumulation is unlikely. The drug is not absorbed into the gastrointestinal tract and blood.
Pharmacological properties
Pharmacodynamics
The active ingredient of Oftagel is carbomer, which is a high molecular weight carboxyvinyl polymer (polyacrylate). This substance increases the viscosity of tears, forming a protective moisturizing film on the outer surface of the cornea, and also helps to thicken the aqueous and mucin layers of the tear film.
Carbomer eliminates the irritation symptoms that accompany dry eye syndrome. Symptoms of this condition include visual fatigue, compensatory lacrimation, burning, itching, and sensation of a foreign body in the eye. Prolonged contact of the tear film with the cornea has a beneficial effect on the patient's condition in case of insufficient tear production. Oftagel is able to prolong the absorption of other ophthalmic drugs used in combination with it. Its pH is almost identical to that of natural tears.
Pharmacokinetics
When applied topically, the drug is unlikely to penetrate the active component through the cornea and into the systemic circulation due to the relatively large size of the carbomer molecules.
Instructions for use Oftagel (Method and dosage)
For those who decide to use Oftagel eye drops, the instructions for use recommend instilling a drop 1-4 times a day. The exact dosage depends on the symptoms that appear. You need to wash your hands before using them.
The instructions for Oftagel advise tilting your head, pulling back the lower eyelid and dripping the product into the conjunctival sac between the lower eye and the eyelid. In this case, you need to try not to touch the eyelid and eye with the tip of the pipette. After the procedure, you must immediately close the bottle of medicine.
Oftagel
Oftagel is a keratoprotector used to treat diseases accompanied by dry eye syndrome, as well as to accelerate corneal recovery after laser and surgical interventions. Dry eye syndrome is caused by a number of factors, including environmental changes, air conditioning, decreased tear production, slow blinking, side effects of certain medications (oral contraceptives, beta-blockers, antihistamines, sedatives and anticholinergics), rheumatoid arthritis and other systemic diseases, menopause, eye surgery, contact lenses. Characteristic manifestations of dry eye syndrome are excessive blood flow to the conjunctiva, thinning and a decrease in the time of destruction of the tear film. Impaired production of tear fluid cannot be completely cured, it can only be compensated. During treatment, the main attention is paid to the underlying disease, and dry eye syndrome itself is treated with artificial tear preparations, one of which is Oftagel. It contains carbomer, a high-molecular carboxyvinyl polymer that increases tear viscosity and protects the cornea with a moisturizing protective film. Oftagel softens the signs of irritation caused by dry eye syndrome: itching, burning, lacrimation, a feeling of mechanical inclusion in the eye and visual fatigue. Contact of the tear film with the cornea, maintained over a long period of time, has a positive effect in cases of decreased fluid production. When using Oftagel together with other ophthalmic drugs, it may increase the absorption time of the latter. Due to its relatively large size, carbomer molecules practically do not penetrate the cornea. As a rule, Oftagel is well tolerated by patients, only in rare cases causing minor side effects such as mild tingling or irritation of the eye, as well as temporary impairment of visual acuity. These undesirable reactions occur immediately after instillation of the drug and disappear quickly.
Oftagel is available in the form of drops. The drug is instilled 1 drop 1 to 4 times a day, depending on individual tolerance and severity of symptoms. Before instilling oftagel, wash your hands thoroughly. For ease of instillation, you need to tilt your head back, pull down the lower eyelid with your finger and drip the gel into the space between the lower eyelid and the eye. Contact between the pipette and the eye (eyelid) is unacceptable. After using the drug, you should immediately close the bottle tightly. Benzalkonium chloride, which is part of the drug as an excipient, can be absorbed and change the color of contact lenses. In this regard, before using the drug, it is recommended to remove contact lenses and reinstall them half an hour after instillation of the gel. If it is necessary to use other ophthalmic drugs in the form of drops with Oftagel, it should be instilled last with an interval of at least 15 minutes. It should be noted that the bottle of Oftagel is intended for use in only one patient. As mentioned above, the drug may cause a transient decrease in visual acuity. In this regard, before starting work associated with increased concentration (for example, driving a car), it is necessary to wait until vision is completely restored. Storing a bottle of oftagel before and after opening has its own differences. So, in the latter case, it should be stored upside down: this will ensure easier flow of the gel. The shelf life of the drug after opening the bottle will be much shorter - only 1 month. Clinical trials of the drug were carried out, among other things, in the post-Soviet space and covered ophthalmological centers in Russia and Belarus. About 90% of patients rated the drug as very effective and convenient to use (the latter was confirmed by a high degree of adherence to treatment and strict adherence to therapeutic regimens).
Oftagel analogs
Level 4 ATC code matches: Systain Ultra
Systain Gel
Systain Balance
Okoferon
Khilozar-Komod
Hilo-Chest
Visine Pure Tear
Restasis
Catalin
Quinax
Mirtilene Forte
Emoxy optic
Adgelon
Vita-Iodurol
Natural tear
Artificial tear
Optiv
Ophtolic
Balarpan
Taurine
The following analogues of Oftagel can be obtained in pharmacies:
- Vidisk;
- Oftagel Uno;
- Sikalos.
These eye drops are practically no different in price from Oftagel.
Indications for use
Oftagel is a drug intended for the treatment of diseases accompanied by dry eye syndrome, manifested by compensatory lacrimation, sensation of a foreign body in the eye, burning, itching:
- Eye irritation due to computer work (“office eye syndrome”), exposure to smoke or dust, etc.;
- Dry keratoconjunctivitis;
- Stevens-Johnson syndrome;
- Diseases of the eyelids, in which there is insufficient contact of the cornea with the tear;
- Sjögren's disease;
- Insufficient tear production.
Oftagel is also used for rehabilitation therapy after surgical or laser interventions on the cornea.
Oftagel price, where to buy
You can often find Oftagel eye drops in pharmacies; their price is considered quite affordable among analogues. Their cost in Ukraine is about 50 hryvnia. The price of Oftagel in Russia is approximately 200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Oftagel ophthalmic gel 2.5 mg/g 10 gUrsapharm Arzneimittel GmbH
RUR 357 order
Pharmacy Dialogue
- Oftagel ophthalmic gel (vial 2.5 mg/g 10 g with pipette) Ursapharm
RUB 354 order
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Pharmacy24
- Oftagel 2.5 mg/g 10 g gel Santen AT, Finland/Ursafarm Arzneimittel GmbH, Nimechtina
88 UAH.order
PaniPharmacy
- Oftagel gel Oftagel eye gel 10g Finland, Santen
97 UAH order
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Oftagel eye gel 2.5 mg/g 10 g No. 1
Name
Oftagel.
Release forms
Gel.
INN
Carbomer.
FTG
Keratoprotector.
Description
Colorless or slightly opalescent gel.
Compound
Per 1 g Active substance: Carbomer 974R 2.5 mg. Excipients: benzalkonium chloride, sorbitol, lysine monohydrate, sodium acetate, polyvinyl alcohol, water for injection.
Pharmacological group
Other ophthalmic products. Artificial tears and other indifferent drugs. ATX code: S01XA20.
Pharmacological properties
Pharmacodynamics The most important properties of eye drops intended to reduce the symptoms of dry eye are long contact time of the tear film with the cornea and good moisturizing properties. For this purpose, Oftagel® eye gel contains carbomer. Carbomer, a high molecular weight carboxyvinyl polymer, increases tear viscosity and is commonly used in eye drops intended to treat dry eye. These drops form a protective and moisturizing film on the surface of the cornea. Pharmacokinetics The beneficial effect of carbomer in relation to prolongation of contact time was revealed in a clinical trial, phase I. Contact time on the cornea ranged from 12.5 to 45 minutes. Due to the high molecular weight and cross-linked structure of carbomer, it is unlikely to penetrate into or accumulate in the eye. Not a single study revealed reactions caused by this drug, and good local and systemic tolerability was noted.
Indications for use
Keratoconjunctivitis sicca and other diseases accompanied by dry eye syndrome.
Contraindications
Hypersensitivity to one of the components of the drug.
Pregnancy and lactation
There have been no adequate controlled trials of the drug in pregnant women. Use of the drug during pregnancy and lactation only as prescribed by a doctor.
Directions for use and doses
1 drop of Oftagel® 1–4 times a day, depending on the severity of symptoms. Wash your hands before instilling the drug. Tilt your head back. Pull back the lower eyelid and place one drop of gel into the conjunctival sac between the lower eyelid and the eye. Do not touch the eye or eyelid with the tip of the pipette. Close the bottle. Please remember that the bottle of eye gel is for use on one person only. Oftagel® eye gel contains benzalkonium chloride as a preservative, which can deposit on contact lenses. Contact lenses must be removed before instillation and reinserted at least 30 minutes after instillation.
Overdose
There have been no cases of drug overdose reported.
Side effect
Immediately after instillation, transient blurred vision, a short-term burning sensation and local irritation of the eyes are possible.
Interaction with other drugs
Drug interactions of Oftagel® with other drugs have not been studied.
special instructions
Benzalkonium chloride may be absorbed and discolor contact lenses. Before instilling the drug, they should be removed and reinstalled 30 minutes after instillation of the drug. When prescribing more than one type of drops, Oftagel® should be instilled last, with an interval of at least 15 minutes.
Impact on professional activities
Oftagel® eye gel may cause temporary blurred vision. Before driving a car or operating mechanical devices, you should wait until your visual acuity is fully restored.
Release form
Eye gel 2.5 mg/g. 10 g in a transparent bottle with a capacity of 10 ml, made of low-density polyethylene. The bottle is sealed with a pipette, with a screw cap and a ring to control the opening of the bottle. The bottle with instructions is placed in a cardboard box.
Storage conditions
In a place protected from light, at a temperature of 15 to 25 ° C. Between instillations, the bottle should be stored upside down in a cardboard box to facilitate the flow of the gel. Keep out of the reach of children.
Best before date
30 months. Use within 1 month after opening the bottle. Do not use the drug after the expiration date indicated on the package.
Conditions for dispensing from pharmacies
Over the counter.
Buy Oftagel eye gel 2.5 mg/g 10 g No. 1 in the pharmacy
Price for Oftagel eye gel 2.5 mg/g 10g No. 1
Instructions for use for Oftagel eye gel 2.5 mg/g 10g No. 1
special instructions
One bottle is intended to treat only one person.
Do not touch the tip of the pipette to the eye, eyelid or other surfaces.
After instillation, you must immediately close the bottle.
The benzalkonium chloride contained in Oftagel can be absorbed by contact lenses and discolor them, so they must be removed before instillation and then installed no earlier than 30 minutes later.
When other ophthalmic drugs are prescribed simultaneously, Oftagel should be instilled last with a minimum interval of 15 minutes.
Since the eye gel may cause a short-term decrease in visual acuity, immediately after instillation you should not drive a car or perform potentially dangerous types of work that require clear visual perception.
