Effervescent tablets ACC 100: instructions for use for children, price and reviews

pharmachologic effect

The substance acetylcysteine is a derivative of the amino acid cysteine . There is a mucolytic effect of this substance on the body. Under its influence, the process of sputum discharge is facilitated, since acetylcysteine directly affects sputum, in particular, its rheological properties. As a result, the viscosity of sputum decreases. The drug also provides an antioxidant effect, protecting cells from free radical oxidation that occurs during severe inflammatory reactions. It is active if the patient produces purulent sputum.

of glutathione , which is an important component of chemical detoxification, as well as the antioxidant system, improves

If acetylcysteine is used for the purpose of prevention, then in people suffering from cystic fibrosis and chronic bronchitis, the severity and frequency of exacerbations of bacterial origin are reduced.

Indications for use

The use of ACC 100 is indicated in the following cases:

diseases of the respiratory system in which viscous sputum is formed, which is difficult to separate ( acute, chronic and obstructive bronchitis bronchial asthma, laryngotracheitis , tracheitis , lung abscess , pneumonia, bronchiectasis, bronchiolitis );
cystic fibrosis;
acute and chronic sinusitis
COPD;
otitis media.

Contraindications

ACC 100 is prescribed in the following cases:

hypersensitivity to acetylcysteine or to any other ingredients of the medicine;
hemoptysis;
pulmonary bleeding;
exacerbation of peptic ulcer ;
pregnancy and breastfeeding ;
glucose-galactose malabsorption;
lactase deficiency, lactose intolerance;
child's age up to 2 years.

It is necessary to use ACC 100 carefully if there is a history of duodenal or gastric ulcers, in case of histamine intolerance, bronchial asthma, varicose veins of the esophagus, adrenal disease, obstructive bronchitis kidney failure , arterial hypertension .

ACC Long

Release form

Effervescent tablets. White, round, flat-cylindrical, with a chamfer and a notch on one side, with the smell of blackberries, there may be a slight sulfur smell. The reconstituted solution is colorless, transparent, with a blackberry odor; there may be a slight sulfuric odor.

Compound

Active ingredient: acetylcysteine (600 mg).

Excipients: citric acid, sodium bicarbonate, sodium carbonate, mannitol, lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavor “B”.

Pharmacological group

Secretolytics and stimulants of motor function of the respiratory tract.

Action

Mucolytic agent with expectorant action. Acetylcysteine increases the volume of sputum, facilitates its discharge due to a direct effect on the rheological properties of sputum, and has an anti-inflammatory effect by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue.

Acetylcysteine: description of the substance

Indications

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, tracheitis, laryngotracheitis, bronchiolitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, interstitial lung diseases and atelectasis due to blockage of the bronchi by mucus plug, sinusitis (to facilitate the passage of secretions), cystic fibrosis. Inflammation of the middle ear, acute and chronic sinusitis, rhinosinusitis.

Contraindications and restrictions

Hypersensitivity to components;
hemoptysis, pulmonary hemorrhage;
peptic ulcer of the stomach and duodenum in the acute phase;
pregnancy and lactation;
children up to 14 years of age.

Carefully

history of gastric and duodenal ulcers;
bronchial asthma;
obstructive bronchitis;
liver and/or kidney failure;
histamine intolerance (long-term use should be avoided);
varicose veins of the esophagus;
adrenal gland diseases;
arterial hypertension.

Application and dosage

Inside , after eating.

Adults and children over 14 years of age: 1 effervescent tablet once a day (600 mg).

Effervescent tablets should be dissolved in one glass of water and taken immediately after dissolution; in exceptional cases, the ready-to-use solution can be left for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be taken for a longer period of time to achieve a preventive effect.

special instructions

For patients with diabetes: 1 effervescent tablet corresponds to 0.001 XE.

Storage

In a place protected from light, at a temperature not exceeding 30 °C. Shelf life: 3 years.

Production

Sandoz d. d. (Slovenia),
Salutas Pharma GmbH (Germany),
Hermes Arzneimittel GmbH (Germany).

Package

6, 10 or 20 effervescent tablets in a polypropylene tube in a cardboard box.

Recipe

Available without a prescription.

Side effects

A number of side effects are likely to occur when using this drug:

manifestations of allergies: rash, skin itching , urticaria , exanthema, angioedema , tachycardia , low blood pressure ; in very rare cases - Stevens-Johnson syndrome, anaphylactic manifestations, toxic epidermal necrolysis;
respiratory system: in rare cases – bronchospasm, shortness of breath ;
gastrointestinal system: abdominal pain, heartburn , diarrhea , vomiting, nausea, stomatitis , dyspepsia;
sense organs: tinnitus;
other manifestations: fever , headache ; in isolated cases - bleeding.

Effervescent tablets ACC 100, instructions for use (Method and dosage)

The instructions for use of ACC 100 stipulate that the drug 100 mg should be taken orally after meals.

Patients over 14 years old - 2 tablets. 2-3 times a day.

Children and adolescents from 6 to 14 years old are recommended to take 1 tablet. 3 times a day or 2 tablets. 2 times a day.

The instructions for ACC 100 for children from 2 to 6 years old include taking 1 tablet. 2-3 times a day.

For patients with cystic fibrosis whose weight is more than 30 kg, if necessary, the dose is increased to 800 mg of acetylcysteine per day.

100 mg tablets are dissolved in 1 glass of liquid; the solution should be taken immediately.

ACC effervescent tablets

Release form

Effervescent tablets . Round, flat-cylindrical, white, with a notch on one side, with the smell of blackberries. Reconstituted solution: colorless, transparent, with the smell of blackberries. There may be a faint gray odor.

Compound

Active ingredient: acetylcysteine (100 mg or 200 mg).

Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium citrate, sodium saccharinate, blackberry flavoring “B”.

Pharmacological group

Secretolytics and stimulants of motor function of the respiratory tract.

Action

Acetylcysteine: description of the substance

Indications

Respiratory diseases and conditions accompanied by the formation of viscous and mucopurulent sputum: acute and chronic bronchitis, brochiolitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, interstitial lung diseases and atelectasis due to blockage of the bronchi by mucus plug, cystic fibrosis.
Otitis media, sinusitis, acute and chronic sinusitis and rhinosinusitis (to facilitate the passage of secretions).

Contraindications and restrictions

Peptic ulcer of the stomach and duodenum in the acute phase,
hemoptysis, pulmonary hemorrhage,
pregnancy and lactation (breastfeeding),
children under 2 years of age,
lactase deficiency, lactose intolerance, glucose-galactose malabsorption,
hypersensitivity to acetylcysteine and other components of the drug.

Carefully

History of gastric and duodenal ulcers;
bronchial asthma;
obstructive bronchitis;
liver and/or kidney failure;
histamine intolerance (long-term use should be avoided);
varicose veins of the esophagus;
adrenal gland diseases;
arterial hypertension.

Application and dosage

Orally after meals immediately after dissolution, with additional fluid intake. In exceptional cases, the ready-to-use solution can be left for 2 hours.

ACC 100

Adults and children over 14 years of age : 2 effervescent tablets 2 - 3 times a day (400 - 600 mg each);
children from 6 to 14 years old : 1 effervescent tablet 3 times a day, or 2 effervescent tablets 2 times a day (300 - 400 mg);
children from 2 to 6 years : 1 effervescent tablet 2 - 3 times a day (200 - 300 mg).

For cystic fibrosis:

Children from 2 to 6 years : 1 effervescent tablet 4 times a day (400 mg);
children over 6 years old : 2 effervescent tablets 3 times a day (600 mg).

ACC 200

Adults and children over 14 years of age: 1 effervescent tablet 2-3 times a day (400 – 600 mg);
children from 6 to 14 years old: 1 effervescent tablet 2 times a day (400 mg);
children from 2 to 6 years: 1/2 effervescent tablet 2-3 times a day (200 – 300 mg).

For cystic fibrosis:

Children from 2 to 6 years: 1/2 effervescent tablet 4 times a day (400 mg);
children over 6 years of age: 1 effervescent tablet 3 times a day (600 mg).

The duration of the course is assessed individually. For acute diseases, the course of treatment is from 5 to 10 days, for the treatment of chronic diseases - several months (as recommended by a doctor).

special instructions

When working with the drug, you must use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (it is recommended to take the drug before 18.00).

Storage

In a place protected from light, at a temperature not exceeding 25 °C.

Shelf life - 2 years (in plastic tubes) or 3 years (in aluminum tubes, strips).

Production

Sandoz d.d. (Slovenia).
Salutas Pharma GmbH (Germany).
Hermes Arzneimittel GmbH (Germany).
Hermes Pharma Ges. M. b. H. (Germany).

Package

1 tube of 20 effervescent tablets or 2 or 4 plastic tubes of 25 effervescent tablets in a cardboard box.
4 effervescent tablets in strips made of three-layer material, 15 strips in a cardboard box.

Recipe

Available without a prescription.

Interaction

If ACC 100 is taken with other cough suppressants, mucus stagnation may develop due to suppression of the cough reflex. This combination of drugs should be used with caution.

Acetylcysteine enhances the vasodilatory effect of nitroglycerin when these drugs are taken simultaneously.

Acetylcysteine is not pharmaceutically compatible with antibiotics ( cephalosporins , penicillins , amphotericin B , Tetracycline , Erythromycin ) and proteolytic enzymes .

With simultaneous use, acetylcysteine reduces the absorption of cephalosporins, tetracycline, and penicillins. It is necessary to maintain an interval of at least two hours between taking these medications.

When acetylcysteine comes into contact with metals, rubber, etc., sulfides are formed.

special instructions

It is important to use glass containers when diluting the drug to avoid contact with rubber, flammable substances, and metals.

In very rare cases, severe allergic reactions have been reported when taking acetylcysteine. If changes in the skin and mucous membranes are noted, you should definitely consult a doctor and immediately stop taking it.

ACC 100 should be taken with caution by people who suffer from obstructive bronchitis and bronchial asthma , and it is important to constantly monitor bronchial patency.

It is not recommended to take ACC 100 before bed; it is advisable to take it before 18:00.

It does not affect a person’s ability to work with dangerous mechanisms or drive vehicles.

Pharmacokinetics and pharmacodynamics

Once in the body, it is absorbed quickly. Metabolism occurs in the liver, resulting in the formation of a pharmacologically active metabolite - cysteine , also cystine , diacetylcysteine , mixed disulfides.

When taken orally, the level of bioavailability is 10% (as there is a pronounced first-pass effect). The highest level of concentration in the blood is determined after 1–3 hours. 50% bound to plasma proteins. Excreted from the body through the kidneys. The half-life is approximately 1 hour; if liver function is impaired, the half-life is 8 hours. Penetrates through the placental barrier. There is no evidence of penetration through the BBB.

Analogs

Level 4 ATX code matches:
Mukolik

Abrol

Ambrosan

Bronchorus

ACC 200

ACC Long

ACC

Mukolwan

Lazolvan

Bromhexine 8

Bromhexine 8 Berlin-Chemie

Bromhexine

Bronchobos

Carbocisteine

Erdomed

Pulmozyme

Pectolvan C

Halixol

Ambrobene

Acetylcysteine

Analog drugs of ACC 100 - ACC Long , Fluimucil , Acetylcysteine , Acetal , Acestad , Acestin etc. Only a specialist should choose the optimal drug.

ACC Long price, where to buy

The price of 600 mg tablets is from 350 rubles for 10 pieces. Packaging of the drug 20 pcs. can be purchased at a price of 650 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

ZdravCity

Acc Long tablets spike.
600 mg 20 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH 450 rub. order
Acc Long tablets spike. 600 mg 10 pcs. Hermes Arzneimittel GmbH/Salutas Pharma, GmbH
RUR 384 order

Pharmacy Dialogue

ACC long (tab. spike 600 mg No. 10) Hermes
155 rub. order
ACC long (tab.spike.600mg No.20)Hermes
RUR 431 order
ACC long (tab. spike 600 mg No. 10) Hermes
RUB 305 order
ACC long (tab.spike.600mg No.20)Hermes
RUB 692 order
ACC long (spike tab. 600 mg No. 20) Salutas Pharma GmbH
610 rub. order

Pharmacy24

ACC Long 600 mg No. 10 effervescent tablets Salutas Pharma GmbH.,Nimechchina/Hermes Artsnaimittel Gmb.H.Nimechchina
146 UAH.order
ACC Long Lemon 600 mg N6 tablets Salutas Pharma GmbH, Nimechchina
130 UAH order

Price ACC 100, where to buy

The price of ACC 100 is on average 250 rubles for 20 pieces.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

Pharmacy Dialogue

ACC 100 (spike tab. 100 mg No. 20 for children) Hermes
RUB 233 order

Pharmacy24

ACC 100 mg No. 20 powder Salutas Pharma GmbH, Nimechchina / Lindopharm GmbH, / Zambon Switzerland Ltd, Switzerland
121 UAH. order
ACC 100 No. 20 tablets Salutas Pharma GmbH., Nimechchina/Hermes Pharma Ges.m.b.H., Austria/Hermes Arznaimittel Gmb.H.Nimechchina
116 UAH order

How to take ACC

The dosage regimen and dosage of the drug depend on the patient’s age. ACC is taken orally and always after meals.

Syrup:

adults and adolescents over 14 years of age - 10 ml twice or thrice a day;
children 6-14 years old - 5 ml 3-4 times or 10 ml twice a day;
children 2-6 years old - 5 ml twice or thrice a day.

ACC 100 mg (one tablet or one sachet):

adults and adolescents over 14 years of age – 2 tablets/2 sachets twice or thrice a day;
children 6-14 years old – 1 tablet/1 sachet three times a day or 2 tablets/2 sachets twice a day;
children 2-6 years old - 1 tablet/1 sachet twice or thrice a day.

ACC Long adults and adolescents from 14 years of age take one effervescent tablet once a day.

Patients with cystic fibrosis are allowed to increase the dose of acetylcysteine to 800 mg per day.

Effervescent tablets must be dissolved in 200 ml of water; the solution should be drunk immediately after preparation. The powder is dissolved in non-hot tea, water or juice.

During therapy, it is advisable to drink more fluid to better thin the mucus.

The duration of treatment for coughing against the background of ARVI is no more than a week.

Chronic bronchitis and cystic fibrosis are indications for longer courses.