Linex Forte

How to take Linex and antibiotic correctly

If the patient has been prescribed antibacterial therapy, you should not wait for the first symptoms to appear, which will indicate a microflora disorder. When taking antibiotics, not only pathogenic microorganisms suffer, but also beneficial ones that participate in the digestive process. Therefore, the main rule for simultaneous use of Linex with antibiotics is that the course of Linex should be started on the same day when the first dose of antibacterial medication was taken.

It is better if the patient refers to the instructions for the antibiotic. In it, you need to pay special attention to the section on the half-life of the drug. It is at this interval that it would be wise to drink Lines in order to achieve the best effect.

Linex Forte is a medicine that regulates the balance of intestinal microflora. Contains live lactobacilli, which are representatives of normal saprophytic intestinal microflora. Lactobacilli perform a protective function, reproducing antibacterial substances, producing enzymes, under the influence of which proteins, lipids, fiber, starch are broken down, as well as the connection of bile acids with bilirubin (deconjugation). In addition, lactobacilli take part in the synthesis of ascorbic acid, phylloquinone, B vitamins, non-essential amino acids, and a number of organic acids. Lactobacilli LA-5 and BB-12 suppress the growth and reproduction of pathogenic microorganisms through?

• a shift in the acid-base balance of the intestine towards increasing acidity (the result of the ability of BB-12 to synthesize ethanoic and butanedioic acids and LA-5 - lactic acid);

• formation of metabolites that are toxic to pathogenic microorganisms (for example, hydrogen peroxide);

• formation of specific bacteriocin proteins that suppress the activity of pathogenic bacteria and fungi;

• competitive antagonism with pathogenic microorganisms for nutrient substrate;

• interaction with adhesive cell receptors, resulting in the prevention of colonization of pathogenic bacteria.

Lactobacilli of the drug Linex Forte act directly in the gastrointestinal tract. The drug is not subject to systemic absorption when taken orally, so its pharmacokinetic characteristics have not been studied in a standard form.

LA-5 and BB-12 are resistant to the aggressive environment of gastric juice, which allows these bacteria to overcome the stomach and duodenum with virtually no losses. These bacteria are eliminated through the large intestine and rectum. Linex Forte is indicated for the treatment and prevention of intestinal dysbiosis. This disease is manifested by diarrhea, constipation, increased gas formation, nausea, vomiting, involuntary passage of gases from the esophagus through the mouth, epigastric pain, and in some cases, skin rashes. The optimal time to take Linex Forte is after meals or during meals. It is possible to open the capsule shell and dissolve its contents in a small volume of water (this method of administration is used in children if it is impossible to swallow a whole capsule). Single dose – 1 capsule. Frequency of application – 1-3 times a day (in patients over 12 years old), 1-2 times a day (in patients under 12 years old), 1 time a day (in newborns). The duration of treatment is determined by the etiology of dysbiosis, the severity of the therapeutic response and the individual characteristics of the patient. The medication course can be continued until the clinical signs of dysbiosis completely disappear. Linex Forte is well tolerated by patients and does not cause unwanted side reactions.

How to properly breed Linex for children

For babies, there is a powder form of Linex, which is packaged in sachets. The powder is identical to that contained in the adult capsule shell. Infants are prescribed Linex as a preventive measure for intestinal colic between the ages of 3 weeks and 3 months. The powder can be diluted in an adapted milk formula if the child is bottle-fed. If you are breastfeeding, you can express some breast milk into a bowl to dilute the powder in it. You can give your child the mixture prepared in this way from a teaspoon.

Linux for children: what helps

Babies that are born still have a sterile intestine, which is not inhabited by any bacteria. Having passed through the mother's birth canal, taking the mother's breast into his mouth for the first time, the child receives the first portion of bacteria, which, of course, is not enough to ensure a complete digestion process.

At three weeks of age, newborns experience infantile colic. This is due to the fact that it is difficult for the intestines to process the lactose contained in milk. Hence the flatulence and spasms. To help the child adapt to the environment and teach the intestines to break down lactose, children are given Linex. It populates the gastrointestinal tract with all the necessary types of bacteria, due to which the severity of colic is reduced, the child becomes calmer, sleeps better, and more actively absorbs nutrients from food.

How much to drink Linex for thrush

Thrush is a fungal infection that affects the genitals of both men and women. The causative agent is a fungus - candida, which in itself is not a pathogenic flora. A large percentage of people are carriers of candida, which live in the intestines without causing any negative reactions.

This healthy state of the intestines containing candida fungi is explained by the “armed truce” of the flora. In other words, the intestines maintain a balance in the number of bacteria and fungi, which inhibit the reproduction of each other. As soon as for some reason there are fewer beneficial bacteria than fungi, candidiasis develops.

Linex restores the balance of the flora, as a result of which thrush recedes. To speed up recovery, you can apply antifungal agents topically and supplement therapy with a course of Linex until complete recovery.

Instructions for use LINEX® (LINEX®)

A drug of biological origin that regulates the balance of intestinal microflora. Normalizes intestinal microflora. Maintains and regulates the physiological balance of intestinal microflora (microbiocenosis), ensures its physiological functions in the intestine.

Bacteria in the composition of Linex® restore the disturbed balance of intestinal microflora due to dysbacteriosis.

Live lactic acid lyophilized bacteria that are part of the drug are an integral part of the normal intestinal microflora, maintain and regulate the physiological balance of microbiocenosis in all parts of the intestine, and have pronounced antagonistic properties against pathogenic and conditionally pathogenic flora. They participate in the synthesis of vitamins B1, B2, B6, B12 (in nature they are synthesized only by microorganisms), PP, K and E, folic and ascorbic acids, provide the body with biotin, and have immunostimulating properties. By producing lactic acid and reducing the pH of the intestinal contents, the microorganisms used create favorable conditions for the absorption of iron, calcium, and vitamin D. Lactic acid bacteria carry out the enzymatic breakdown of proteins, fats and complex carbohydrates (including in lactase deficiency in children) that are not absorbed into the body. In the small intestine, carbohydrates and proteins undergo deeper breakdown in the large intestine by anaerobes (including bifidobacteria). The bacteria included in the drug facilitate the digestion of proteins in infants (phosphoprotein phosphatase of bifidobacteria is involved in the metabolism of milk casein); participate in the metabolism of bile acids (formation of stercobilin, coprosterol, deoxycholic and lithocholic acids; promote the reabsorption of bile acids).

Taking into account the peculiarities of the distribution of microflora throughout the human gastrointestinal tract - the predominance of lactobacilli and lactic acid streptococcus in the small intestine, and bifidobacteria in the large intestine, Linex® ensures the supply of “medicinal” microflora in quantitatively and qualitatively balanced proportions.

The antagonistic properties of Linex® are associated with the ability of its constituent microorganisms to produce lactic and, to a lesser extent, acetic and propionic acids. The created acidic environment (pH of the intestinal contents approaches 4-5.8) is unfavorable for the development of pathogenic and opportunistic microorganisms.

Linex® forte capsules contain Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12). Both strains of lactic acid bacteria are normal representatives of the human intestinal microflora. There are several potent mechanisms by which strains LA-5 and BB-12 exert their characteristic protective and therapeutic effects.

They inhibit the growth of pathogenic bacteria by:

decrease in pH in the gastrointestinal tract (as a result of the ability of LA-5 to produce lactic acid, and BB-12, in addition to lactic acid, also produce acetic and succinic acids);
production of metabolites toxic to pathogenic bacteria (H2O2 production);
production of antibacterial substances, bacterions (LA-5 produces acidocin, which is a broad-spectrum bacteriocin that inhibits the growth of bacteria and fungi);
competition with pathogenic bacteria for nutrients;
blocking adhesive receptors, which prevents the colonization of other, potentially pathogenic microorganisms.

They also stimulate specific and non-specific parts of the immune system.

Disturbances in the balance of the intestinal microflora (for example, with viral and bacterial gastrointestinal infections, with the use of broad-spectrum antibiotics and chemotherapy, irradiation of the abdominal and pelvic organs, during long-distance travel) or a delay in the development of permanent flora in infants can cause digestive disorders (such such as flatulence, diarrhea and constipation).

Regular intake of LA-5 and BB-12 effectively reduces the frequency and severity of mild to moderate symptoms of digestive disorders (mainly diarrhea) associated with an imbalance of intestinal microflora, and also normalizes the functioning of the gastrointestinal tract.

How many days should you take Linex?

Regardless of what reason provoked the imbalance of beneficial microorganisms in the intestines, Linex will help to cope with it. The duration of treatment directly depends on the symptoms and condition of the patient. As a rule, a 7-day course is enough to restore the functioning of the gastrointestinal tract. But in cases where the patient was prescribed antibacterial therapy lasting 10 days, taking Linex becomes longer. First of all, you should take the supplement throughout your course of antibiotics. After which it is better to continue drinking Linex for another week to help the body fully recover.

Linex Forte, capsules 14 pcs.

Manufacturer

Lek d.d., Slovenia

Compound

1 capsule contains:
Active ingredient:

Probio-tec AB Blend 64 powder (Probio-tec® AB Blend 64) – 60,000 mg (powder contains active ingredients: Lactobacillus acidophilus (LA-5) – 13.8 mg and Bifidobacterium animalis subsp. lactis (BB-12) – 4 .2 mg;

auxiliary components:

dextrose anhydrous – 29.1 mg,

microcrystalline cellulose – 6 mg,

potato starch 6 – mg,

magnesium stearate – 0.9 mg).

Excipients:

Beneo Synergy 1 (Beneo® Synergy 1) – 171,500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose)); magnesium stearate – 3,500 mg.

Composition of the capsule body:

hypromellose – 33.149 mg, titanium dioxide (E 171) – 0.691 mg. Composition of the capsule cap: hypromellose - 22.080 mg, titanium dioxide dye (E 171) - 0.240 mg, yellow iron oxide dye (E 172) - 0.240 mg.

pharmachologic effect

PHARMACOTHERAPEUTIC GROUP

Eubiotic. ATX code: A07FA51

PHARMACOLOGICAL PROPERTIES

Pharmacodynamics

Linex® Forte normalizes intestinal microflora. One capsule of Linex® Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12)), each capsule contains 109 colony-forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal part of the natural intestinal microflora. The main functions of lactic acid bacteria:

protective: synthesis of substances with antibacterial activity;
enzyme-producing: hydrolysis of fiber, proteins, fats, starch, deconjugation of bile acids
synthetic: synthesis of vitamins B, C, K, amino acids, organic acids, etc. Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:
decreased intestinal pH (a result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);
production of metabolites that have a toxic effect on pathogenic bacteria (formation of H2O2);
formation of antimicrobial substances, bacteriocins (LA-5 secretes acidocin, a broad-spectrum bacteriocin that prevents the growth of bacteria and fungi);
competition with pathogenic bacteria for nutrients;
interaction with adhesion receptors, thus preventing the colonization of other, potentially pathogenic microorganisms.

Pharmacokinetics

Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract; when taken orally, the drug is not subject to systemic absorption. Standard pharmacokinetic studies are therefore not applicable.

The resistance of LA-5 and BB-12 to gastric juice and bile allows the strains to survive in large numbers when passing through the stomach and duodenum. Both strains attach to the intestinal lining. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.

Indications

Treatment and prevention of intestinal dysbiosis.

Intestinal dysbiosis is manifested by the following symptoms: diarrhea (diarrhea), dyspepsia (indigestion), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.

Contraindications

- Hypersensitivity to the components of the drug;

- hereditary fructose intolerance, deficiency of sucrase, isomaltase or glucose-galactose malabsorption.

CAREFULLY

With caution in case of diabetes mellitus (contains simple sugars), immune system deficiency (for example, HIV infection). Diarrhea in children under 6 years of age should be treated under medical supervision.

Side effects

The drug is well tolerated.

There are no reports of adverse effects, but hypersensitivity reactions may occur.

Interaction

No undesirable interactions with other drugs were noted.

When using antibiotics simultaneously, the recommended interval between taking the drug (antibiotic) and Linex® Forte capsules is 3 hours.

How to take, course of administration and dosage

Linex® Forte capsules are recommended to be taken during or after meals with a small amount of liquid.

Adults and adolescents over 12 years of age: 1 capsule 1-3 times a day.

Children from 2 to 12 years: 1 capsule 1-2 times a day.

Newborns and children under 2 years of age: 1 capsule 1 time per day.

Diarrhea in children under 6 years of age should be treated under medical supervision.

When prescribing Linex® Forte to children and patients who cannot swallow a whole capsule, it must be opened, the contents poured into a spoon and mixed with a small amount of liquid.

The duration of treatment depends on the cause of the development of dysbiosis and the individual characteristics of the organism. The drug Linex® Forte can be taken until the symptoms of dysbiosis disappear.

Do not exceed recommended daily doses of the drug.

Overdose

There are no data on overdose symptoms.

Special instructions

Linex® Forte should not be washed down with hot drinks or taken simultaneously with alcohol.

You should consult your doctor before taking the drug if you:

body temperature above 38 °C;
traces of blood or mucus in the stool;
diarrhea lasts more than two days and is accompanied by severe abdominal pain, dehydration and weight loss;
chronic diseases - diabetes, HIV infection.

When treating diarrhea, it is necessary to replace lost fluids and electrolytes.

Release form

Opaque capsules, white body - yellow cap. Capsule contents: light beige powder interspersed with yellow color.

Storage conditions

Store at a temperature not exceeding 25°C, out of the reach of children.

Best before date

2 years.

Active substance

Lactobacillus acidophyllus, Bifidobacterium BB12

Dosage form

capsules

Purpose

For children from birth, For adults

Barcode and weight

Barcode: 3838957068050 Weight: 0.046 kg

How to take Linex for constipation

Constipation is difficulty defecating or no bowel movements for three days in a row. If constipation occurs as a result of poor nutrition, Linex can help restore the formation and movement of stool lumps towards the exit. However, it is important to understand that one dose of Linex will not save you from chronic bowel dysfunction if the patient does not change his attitude towards food. It is important to increase the amount of fluid consumed, as well as fresh fruits and vegetables, which, thanks to their fiber, help facilitate bowel movements and form soft stools.