Aquacitramon instructions for use of the drug

Release form, packaging and composition of the drug Clinical-pharmacological group Pharmaco-therapeutic group Pharmacological action Indications for use Method of administration and doses Side effects Contraindications for use Use in children Special instructions Drug interactions

Registration Certificate Holder:

AGROFITOFARM, LLC (Russia)

ATX Code:

N02BA51

Active substance:

caffeine

Dosage form:

Aquacitramon

pharmachologic effect

Combined drug.

Acetylsalicylic acid

has antipyretic and anti-inflammatory effects, relieves pain, especially caused by the inflammatory process, and also moderately inhibits platelet aggregation and thrombus formation, improves microcirculation at the site of inflammation.

Caffeine

increases reflex excitability of the spinal cord, stimulates the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, fatigue, increases mental and physical performance. In this combination, caffeine in a small dose has virtually no stimulating effect on the central nervous system, but helps normalize cerebral vascular tone and accelerate blood flow.

Paracetamol

has an analgesic, antipyretic and extremely weak anti-inflammatory effect, which is associated with its effect on the thermoregulation center in the hypothalamus and a weak ability to inhibit the synthesis of prostaglandins in peripheral tissues.

Medicinal properties

The medication has anti-inflammatory, antipyretic, and analgesic effects. The medicine prevents the formation of blood clots, reduces the rate of platelet aggregation, and improves microcirculation at the site of inflammation.

Caffeine, which is part of the product, stimulates the vasomotor and respiratory spinal cord at the reflex level, increases the lumen of the renal, cardiac, and cerebral arteries, and enhances both physical and mental performance. Relieves fatigue and drowsiness, inhibits platelet aggregation.

The dosage of caffeine is minimal, capable of improving blood circulation and normalizing vascular tone, but not harming the central nervous system.

Paracetamol also has an anti-inflammatory effect, lowers temperature, and has an analgesic effect. This behavior of the substance is due to inhibition of the production of lipid prostaglandins.

Directions for use and doses

The method of administration and dosage regimen of a particular drug depend on its release form and other factors. The optimal dosage regimen is determined by the doctor. The compliance of the dosage form of a particular drug with the indications for use and dosage regimen should be strictly observed.

Taken orally (during or after meals) every 4 hours. On average, take 3-4 times a day. The maximum frequency of administration is 8 times/day. The course of treatment is no more than 7-10 days.

If kidney or liver function is impaired

the break between doses is at least 6 hours.

The drug should not be taken for more than 5 days when prescribed as an analgesic and more than 3 days when prescribed as an antipyretic. Other doses and regimens of use are determined by the doctor.

Analogs

Citrapar

Verein, RF

Price: 30 rubles

Citrapar is intended for the relief of mild to moderate pain syndromes. Created on the basis of acetylsalicylic acid, caffeine and paracetamol. Available in the form of quick-acting capsules.

Pros:

• Low price
• Convenient release form.

Minuses:

• Difficult to find in pharmacies
• Lots of side effects.

Side effect

From the digestive system:

gastralgia, nausea, vomiting, hepatotoxicity, erosive and ulcerative lesions of the gastrointestinal tract.

From the urinary system:

nephrotoxicity,

Allergic reactions:

skin manifestations, Stevens-Johnson syndrome, Lyell's syndrome, bronchospasm.

From the cardiovascular system:

tachycardia, increased blood pressure,

With long-term use:

dizziness, headache, visual impairment, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, bleeding gums, purpura), kidney damage with papillary necrosis; deafness; Reye's syndrome in children (hyperpyrexia, metabolic acidosis, nervous system and mental disorders, vomiting, liver dysfunction).

Contraindications for use

Hypersensitivity to the components of the drug; erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase); gastrointestinal bleeding; “aspirin” asthma; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; portal hypertension; vitamin deficiency K; renal failure; I and III trimesters of pregnancy; lactation period (breastfeeding); deficiency of glucose-6-phosphate dehydrogenase; severe arterial hypertension; severe course of ischemic heart disease; glaucoma; increased excitability; sleep disorders; surgical interventions accompanied by bleeding; childhood (up to 15 years - the risk of developing Reye's syndrome in children with hyperthermia due to viral diseases).

With caution:

gout, liver disease.

special instructions

Children should not be prescribed medications containing acetylsalicylic acid, since in the case of a viral infection they can increase the risk of Reye's syndrome. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, and liver enlargement. With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary. Since acetylsalicylic acid slows down blood clotting, the patient, if he is undergoing surgery, must notify the doctor in advance about taking the drug. In patients with hypersensitivity or asthmatic reactions to salicylates or their derivatives, acetylsalicylic acid can only be prescribed with special precautions (in emergency settings). Acetylsalicylic acid in low doses reduces the excretion of uric acid. In patients with a corresponding predisposition, this can in some cases provoke an attack of gout. During treatment, you should avoid drinking ethanol (increased risk of gastrointestinal bleeding).

Citramon Aquacitramon granules for oral solution 3 g x5

MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION

INSTRUCTIONS

on the use of a medicinal product for medical use

AQUACITRAMON

Registration number: Р N003404/01

Trade name: Aquacitramon

Group name

Acetylsalicylic acid + Caffeine + Paracetamol

Dosage form: granules for oral solution

Composition per package:

Active ingredients:

Acetylsalicylic acid , , , , , , , 0.36 g

Paracetamol , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 0.27 g

Caffeine , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , 0.045 g

Excipients: citric acid - 1.34 g, sodium bicarbonate - 0.782 g, sodium benzoate - 0.048 g, orange flavor - 0.04 g, lemon flavor - 0.02 g, sodium saccharinate - 0.015 g, curcumin dye - 0, 08

Description: a mixture of granules and powder, light yellow in color with a faint citrus odor.

Pharmacotherapeutic group: analgesic, non-narcotic drug (non-steroidal anti-inflammatory drug + psychostimulant + non-narcotic analgesic).

ATX code: [N02BA71]. ,

PHARMACOLOGICAL PROPERTIES.

The drug has analgesic, antipyretic and psychostimulating effects.

Acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects, inhibits platelet aggregation. Paracetamol has an antipyretic and analgesic effect. Caffeine reduces drowsiness and fatigue, increases mental and physical performance, increases heart rate, and increases blood pressure.

with hypotension.

Indications for use

Aquacitramon is used in adults for moderate or mild pain syndrome (headache, toothache, neuralgia, myalgia, thoracic radicular syndrome, lumbago, arthralgia, pain during menstruation

etc.), in adults and children over 15 years of age to reduce elevated body temperature, for “colds”

and other infectious and inflammatory diseases.

Contraindications

Increased individual sensitivity to the components of the drug, erosive and ulcerative lesions (in the acute phase) of the gastrointestinal tract, gastrointestinal bleeding, increased tendency

to bleeding, “aspirin asthma”, hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, hypoprothrombinemia, thrombocytopenia, thrombocytopenic purpura), dissecting aortic aneurysm, portal hypertension. Vitamin K deficiency. Glucose-6-phosphate dehydrogenase deficiency. Pregnancy (I and III trimester) and breastfeeding period.

The drug is not prescribed as an analgesic to persons under 18 years of age, and as an antipyretic to children under 15 years of age with acute respiratory diseases caused by viral infections, due to the risk of developing Reye's syndrome (encephalopathy and acute fatty liver degeneration with acute development of liver failure) .

With caution - hyperuricemia, urate nephrolithiasis, gout, peptic ulcer of the stomach and/or duodenum (history), decompensated heart failure.

Directions for use and doses

Dissolve one packet of the drug in 100 ml of water and drink. A slight sediment in the glass is allowed. Use freshly prepared solution.

The drug is taken orally after meals, 1 packet 2-3 times a day. The maximum daily dose is 6 packets. The break between doses of the drug should be at least 4 hours.

If kidney or liver function is impaired, the interval between doses is at least 6 hours.

The drug should not be taken for more than 5 days when prescribed as a pain reliever.

and more than 3 days as an antipyretic. Other dosages and regimens of use are determined by the doctor.

Side effect

Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, liver and/or renal failure, increased blood pressure, tachycardia.

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

With long-term use - dizziness, headache, visual impairment, tinnitus, decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nosebleeds, bleeding gums, purpura

etc.), kidney damage with papillary necrosis, deafness, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), Reye's syndrome in children (hyperpyrexia, metabolic acidosis, nervous system and mental disorders, vomiting, liver dysfunction ).

Overdose

Nausea, vomiting, stomach pain, sweating, pale skin, tachycardia.

With mild intoxication - ringing in the ears, severe intoxication - incoherent thinking, drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding. As intoxication increases, there is progressive respiratory paralysis and uncoupling of oxidative phosphorylation, causing respiratory acidosis.

If you suspect poisoning, you should immediately seek medical help.

Treatment: the victim should undergo gastric lavage and be prescribed adsorbents (activated carbon).

Drug interactions

Strengthens the effect of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic agents. Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-gout drugs that promote the excretion of uric acid.

Increases the side effects of glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

The combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drinks should be avoided (the risk of hepatotoxic effect increases).

Under the influence of paracetamol, the elimination time of chloramphenicol increases 5 times. Caffeine accelerates the absorption of ergotamine.

special instructions

With prolonged use of the drug, monitoring of peripheral blood and the functional state of the liver is necessary. Since acetylsalicylic acid has an antiaggregation effect, the patient, if he is undergoing surgery, must notify the doctor in advance about taking the drug. Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

During treatment, you should avoid drinking alcoholic beverages (increased risk of gastrointestinal bleeding).

Acetylsalicylic acid has a teratogenic effect: when used in the first trimester of pregnancy it leads to a malformation - cleft palate, in the third trimester - inhibition of labor (inhibition of prostaglandin synthesis), closure of the ductus arteriosus in the fetus, which causes pulmonary vascular hyperplasia

and hypertension in the vessels of the pulmonary circulation. Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in the baby due to impaired platelet function.

Release form

3 g of granules in a single-dose cell-free contour packaging (bag) made of paper with a polymer coating,

from a combined material (buflen). ,

5 or 10 packets along with instructions for use are placed in a cardboard pack.

Storage conditions

In a place protected from moisture and light at a temperature of 2 to 25 °C. Keep out of the reach of children.

Best before date

2 years. Do not use after the expiration date stated on the packaging.

Dispensing conditions, , Without a prescription.

, , , 300004, Tula, Torkhovsky proezd, 10.

Organization receiving consumer complaints

LLC "Tula Pharmaceutical Factory", , 300004, Tula, Torkhovsky proezd, 10.