Pharmacological properties of the drug Dalacin c
Pharmacodynamics. The active substance of the drug is clindamycin, a semisynthetic antibiotic that is synthesized from lincomycin by replacing the 7-(R)-hydroxyl group with 7-(S)-chloro. Depending on the sensitivity of the microorganism and the concentration, clindamycin can act bactericidal or bacteriostatic. In vitro active against microorganisms. Aerobic gram-positive cocci, including Staphylococcus aureus; Staphylococcus epidermidis (including strains that produce and do not produce penicillinase). During in vitro , rapid development of drug resistance was noted in some strains resistant to erythromycin; streptococci (except fecal streptococcus), pneumococci; anaerobic gram-negative bacteria, including Bacteroides spp. (including the B. fragilis, B. melaninogenicus ), Fusobacterium spp. ; anaerobic gram-positive non-spore-forming bacteria, including Propionibacterium, Eubacterium, Actinomyces spp. ; anaerobic and microaerophilic gram-positive cocci, including Peptococcus spp., Peptostreptococcus spp. , Microaerophylis streptococci ; Clostridium spp. Clostridia are more resistant to clindamycin than many other anaerobes. Most clostridia, especially Clostridium perfringens, are sensitive to clindamycin, but some species (eg C. sporogenes and C. tertium ) are often resistant to clindamycin. In this regard, it is necessary to test for sensitivity to the antibiotic. In vitro studies have shown that strains of microorganisms such as Bacteroides melaninogenicus, B. disiens, B. bivius, Peptostreptococcus spp., Gardnerella vaginalis, Mobiluncus mulieris, M. curtisii, Mycoplasma hominis . Pharmacokinetics. After oral administration of a dose of 150 mg of clindamycin hydrochloride, rapid and almost complete (90%) absorption of clindamycin occurs. The maximum level of the drug in the blood serum (2.5 μg/ml) is achieved after 45 minutes, after 3 hours the drug concentration is 1.51 μg/ml and after 6 hours - 0.7 μg/ml. After oral administration, almost complete (90%) absorption of clindamycin occurs; simultaneous food intake does not affect the concentration of clindamycin in the blood serum. A study of serum concentrations of the drug with prolonged use of clindamycin hydrochloride (for 14 days) did not reveal the accumulation of the drug or changes in its metabolism. The half-life of clindamycin is slightly increased in patients with significantly impaired renal function. Hemodialysis and peritoneal dialysis are not effective for removing clindamycin from the blood. Clindamycin serum concentrations increase linearly with increasing doses. The serum concentration of the drug already 6 hours after administration at the usual dose exceeds the minimum inhibitory concentration relative to most of the above-mentioned microorganisms. Clindamycin is widely distributed in tissues and body fluids (including bone tissue). The average biological half-life is 2.4 hours. About 10% of the active drug is excreted in the urine, 3.6% in feces, and the rest of the drug in the form of inactive metabolites. Clindamycin 2.0 g for 14 days was well tolerated by healthy volunteers, although an increase in gastrointestinal side effects was noted with increasing doses. In the CSF, even against the background of an inflammatory process, significant concentrations of clindamycin are not achieved. When administered orally, clindamycin hydrochloride was observed to increase the half-life to an average of 4 hours (range 3.4–5.1 hours) in elderly patients compared with 3.2 hours (range 2.1–5.1 hours) in younger patients. 4.2 hours). However, the degree of absorption in different age groups did not differ significantly, so there is no need to adjust the dose of the drug in elderly patients with normal (corresponding to age-related changes) liver and kidney function.
Dalatsin 300 mg No. 16 caps.
Instructions for medical use of the drug DALACIN® DALACIN® C PHOSPHATE Trade name DALACIN® DALACIN® C PHOSPHATE International nonproprietary name Clindamycin Dosage form Capsules of 150 mg and 300 mg Solution for injection 300 mg/2ml, 600 mg/4ml Composition Dalacin® capsules of 150 mg and 300mg: One capsule contains the active substance - clindamycin (in the form of clindamycin hydrochloride) 150 mg and 300 mg, excipients: lactose, magnesium stearate, corn starch, talc, gelatin, titanium dioxide. Dalatsin® C phosphate solution for injection: 1 ml of solution contains the active substance - clindamycin (in the form of clindamycin phosphate) 150 mg, excipients: benzyl alcohol, disodium edetate, water for injection. Description White hard gelatin capsules labeled “Clin 150” and “Pfizer” (for a dosage of 150 mg) or “Clin 300” and “Pfizer” (for a dosage of 300 mg) The contents of the capsules are homogeneous white powder. Dalacin® C phosphate solution for injection: clear, colorless solution. Pharmacotherapeutic group Antibacterial drugs of systemic action. Lincosamides. ATC code J01FF01 Pharmacological properties Pharmacokinetics Absorption After oral administration, almost complete (90%) absorption of clindamycin occurs. In adults, after oral administration of clindamycin at a dose of 150 mg, the maximum level of the drug in the blood serum (2.5 mcg/ml) is reached after 45 minutes. 3 hours after oral administration, the concentration of the drug in the blood serum is 1.5 mcg/ml, and after 6 hours it is 0.7 mcg/ml. After intramuscular administration of 600 mg of clindamycin phosphate, the maximum concentration of the drug in the blood serum (9 μg/ml) is achieved 1-3 hours from the moment of administration. After intravenous infusion of 300 mg of the drug over 10 minutes or 600 mg of the drug over 20 minutes, the maximum concentration of the drug, which is 7 μg/ml and 10 μg/ml, respectively, is achieved at the end of the drug administration. Clindamycin phosphate is prescribed to adults every 8-12 hours, to children - every 6-8 hours, or as a continuous intravenous infusion, which provides clindamycin serum concentrations that exceed the minimum in vitro concentration of the drug necessary to suppress the most sensitive to clindamycin microorganisms. A constant level of the drug in the body is achieved after the third dose. The distribution of 40-90% of the administered drug is bound in the body to blood proteins. After oral administration, accumulation of the drug in the body is not observed. Clindamycin easily penetrates into most tissues and body fluids. The concentration of clindamycin in bone tissue reaches approximately 40% (20-75%) of the drug concentration in the blood serum. In breast milk, the concentration of the drug is 50-100% of the concentration in blood serum, in synovial fluid 50%, in fetal blood 40%, in pus 30%, in pleural fluid 50-90% of the concentration in blood serum. Clindamycin does not cross the blood-brain barrier, even in cases of meningitis. Metabolism The half-life of clindamycin is + 1.5-3.5 hours. In patients with severely impaired liver and/or kidney function, this period may be prolonged. If you have mild or severe kidney or liver disease, the treatment regimen does not need to be changed. Clindamycin is almost completely metabolized. Excretion In the active form, 10-20% of the drug is excreted from the body by the kidneys, 4% - with feces. The remaining amount is excreted as inactive metabolites, mainly in bile and feces. Pharmacodynamics The active substance of the drug is clindamycin, a semi-synthetic substance with antimicrobial activity, which is formed from lincomycin by replacing the 7-(R)-hydroxyl group with 7-(S)-chloro. Depending on the sensitivity of the microorganism and the concentration of the drug, clindamycin can act bactericidal or bacteriostatic. In vitro, clindamycin has an effect on the following isolated forms of microorganisms: 1) Aerobic gram-positive cocci, including: · Staphylococcus aureus · Staphylococcus epidermidis (strains that produce and do not produce penicillinase). During in vitro studies, rapid development of resistance to clindamycin was observed in some staphylococcal strains resistant to erythromycin. · Streptococci (except fecal streptococcus) · Pneumococci 2) Anaerobic gram-negative bacilli, including: · Bacteroides species (including the B.fragilis group and the B.meleninogenicus group) · Fusobacterium species 3) Anaerobic gram-positive bacilli that do not form spores, including: · Propionibacterium · Eubacterium · Actinomyces species 4) Anaerobic and microaerophilic gram-positive cocci, including: · Peptococcus species · Peptostreptococcus species · Microaerophilic streptococci · Clostridia: Clostridia are more resistant to clindamycin than most other anaerobes. Most Clostridium perfringens are sensitive to clindamycin, but other species, such as C. sporogenes and C. tertium, are often resistant to clindamycin. Therefore, it is necessary to conduct sensitivity tests. 5) Various organisms, including Chlamidia trachomatis, Toxoplasma gondii, Plasmodium falciparum and Pneumocystis carinii (in combination with primaquine), Gardnerella vaginalis, Mobiluncus mulieris, Mobiluncus curtisii, Mycoplasma hominis. The following organisms are commonly resistant to clindamycin: Aerobic gram-negative bacilli Streptococcus faecalis Nocardia species Neisseria meningitidis Methicillin-resistant Staphylococcus aureus strains and Haemophilus influenzae strains Cross-resistance exists between lincomycin and clindamycin. There is antagonism between clindamycin and erythromycin. Although clindamycin hydrochloride is active both in vitro and in vivo, clindamycin phosphate and clindamycin palmitate are inactive in vitro. However, both compounds are rapidly hydrolyzed to the active base in vivo. Indications for use Dalatsin® is effective in the treatment of the following infections if they are caused by susceptible anaerobic bacteria or strains of gram-positive aerobic bacteria such as streptococci, staphylococci and pneumococci, as well as clindamycin-sensitive species of Chlamidia trachomatis: - upper respiratory tract infections, including: tonsillitis, pharyngitis, sinusitis, otitis media and scarlet fever - infections of the lower respiratory tract, including: bronchitis, pneumonia, pleural empyema and lung abscess - infectious diseases of the skin and soft tissues, including: acne, boils , cellulite, impetigo, abscesses, infected wounds, specific infectious processes of the skin and soft tissues caused by pathogens sensitive to this drug, such as erysipelas and paronychia (felon) - infectious diseases of bones and joints, including: osteomyelitis and septic arthritis - gynecological infections, including endometritis, tubal and ovarian abscesses, salpingitis and pelvic inflammatory disease, when prescribed in combination with a suitable antibacterial drug active against gram-negative aerobic pathogens. In the case of cervical infections caused by Chlamidia trachomatis, drug therapy exclusively with Dalatsin® has been shown to be effective for complete cure - infectious diseases of the abdominal cavity, including: peritonitis and abdominal abscesses (in combination with other antibacterial drugs that act on gram-negative aerobic bacteria) - septicemia and endocarditis. The effectiveness of the drug Dalacin® has been proven in certain cases of endocarditis: the drug has a bactericidal effect on the infectious agent in vitro when using such concentrations of the drug that are achieved in human blood serum. - oral infections such as periodontal abscess and periodontitis - toxoplasma encephalitis in patients with AIDS. The effectiveness of the drug in combination with pyrimethamine has been proven in patients with intolerance to standard therapy - Pneumocystis pneumonia in patients with AIDS. In patients intolerant or resistant to standard therapy, Dalatsin® can be used in combination with primaquine - malaria, including that caused by multidrug-resistant Plasmodium falciparum, both as monotherapy and in combination with quinine or chloroquine - prevention of endocarditis in patients with hypersensitivity to penicillins - prevention of infections during operations in the head and neck area. Dalacin® C phosphate, diluted in saline solution, is used in surgery to irrigate the surgical wound - early administration of the drug Dalacin® C phosphate in combination with an antibacterial drug from the aminoglycoside group, for example gentamicin or tobramycin, successfully prevents the development of peritonitis or abdominal abscess after perforation intestines or as a result of traumatic infection In vitro studies have shown that the following strains of microorganisms are sensitive to clindamycin: B.melaninogenicus, B.disiens, B.bivius, Peptostreptococcus spp., G.vaginalis, M.mulieris, M.curtisii, Mycoplasma hominis To avoid complications, use strictly as prescribed by your doctor. Method of administration and dosage Adults and children over 12 years of age Dalatsin® C phosphate (intravenously or intramuscularly): For the treatment of infectious diseases of the abdominal cavity, inflammatory diseases of the pelvic organs in women, as well as for other complicated or severe infections, 2400-2700 mg of the drug is usually prescribed per dose. day, divided into 2, 3 or 4 equal doses. In milder forms of infection and in the presence of a pathogen more sensitive to therapy, the therapeutic effect is achieved by prescribing smaller doses of the drug - 1200-1800 mg/day, divided into 3 or 4 equal doses. Doses of the drug reaching 4800 mg/day have been used with success. It is not recommended to administer intramuscularly a single dose exceeding 600 mg. Dalatsin® capsules (orally): 600-1800 mg/day in 2, 3 or 4 divided doses (equal doses). To avoid irritation of the esophageal mucosa, capsules should be taken with a full glass of water. Children over 1 month Dalatsin® C phosphate (intravenous or intramuscular): 20-40 mg/kg body weight/day, divided into 3 or 4 equal doses. It is administered as an infusion, the solvent is saline solution. Newborns (under 1 month) Dalacin® C phosphate (intravenous or intramuscular): 15-20 mg/kg body weight/day, divided into 3 or 4 equal doses. It is administered as an infusion, the solvent is saline solution. For premature babies, a lower dose of the drug may be sufficient. Selected indications Infections caused by beta-hemolytic streptococcus: doses are indicated above, treatment should be continued for at least 10 days. Pelvic inflammatory diseases: 900 mg of Dalacin® C phosphate IV every 8 hours + IV a suitable antibacterial agent active against gram-negative aerobic pathogens (for example, gentamicin at a dose of 2.0 mg/kg followed by 1.5 mg /kg every 8 hours for patients with normal renal function). Continue IV medications for at least 4 days and then for at least 48 hours after the patient's condition improves. Then take 450-600 mg of Dalacin® orally every 6 hours until the 10-14 day course of therapy is completed. Cervical infections caused by Chlamidia trachomatis: 450-600 mg of Dalatsin® orally 4 times a day for 10-14 days. Toxoplasma encephalitis in patients with AIDS: in patients with intolerance to standard therapy, Dalacin® C phosphate or Dalacin® is used in combination with pyrimethamine according to the following regimen: Dalacin® C phosphate IV or Dalacin® orally at a dose of 600-1200 mg every 6 hours for 2 weeks, and pyrimethamine at a dose of 25-75 mg orally every day. Typically the course of therapy is 8-10 weeks. When using higher doses of pyrimethamine, folinic acid should be prescribed at a dose of 10-20 mg/day. Pneumocystis pneumonia in patients with AIDS: Dalacin® C phosphate IV 600-900 mg every 6 hours or 900 mg IV every 8 hours, or Dalacin® 300-450 mg orally every 6 hours for 21 days and primaquine 15- 30 mg orally once daily for 21 days. Acute streptococcal tonsillitis/pharyngitis: Dalatsin® 300 mg orally 2 times a day for 10 days. Malaria: Dalatsin® capsules 10-20 mg/kg/day for adults and 10 mg/kg/day for children every 12 hours in equal doses for 7 days as monotherapy, or in combination with quinine (12 mg/kg every 12 hours ) or chloroquine (15-25 mg every 24 hours) for 3-5 days. Prevention of endocarditis in patients with hypersensitivity to penicillin: 600 mg capsules orally for adults and 20 mg/kg for children 1 hour before taking penicillin; or Dalacin® C phosphate IV at a dose of 600 mg 1 hour before penicillin administration. Prevention of infections during operations in the neck and head: Dalatsin® C phosphate (900 mg in 1 liter of saline) is used during surgery to irrigate contaminated wounds of the head and neck before closing the wound. Dilution and infusion rate The concentration of clindamycin in the solution for infusion should not exceed 18 mg/ml and the infusion rate should not exceed 30 mg/min. The following infusion rates are typically used: Clindamycin dose Volume of saline Time 300 mg 600 mg 900 mg 1200 mg 50 ml 50 ml 50-100 ml 100 ml 10 min 20 min 30 min 40 min Administration of more than 1200 mg in a single 1-hour infusion is not recommended . Side effects - abdominal pain, nausea, vomiting and diarrhea, and with oral use - esophagitis (in addition to the above reactions) - hypersensitivity reactions. In some cases, maculopapular rash and urticaria are noted. A generalized morbilliform rash of mild to moderate severity is the most common adverse reaction. Rare cases of erythema multiforme resembling Stevens-Johnson syndrome, as well as cases of anaphylactoid reactions. - phenomena of jaundice and liver dysfunction - itching, vaginitis, as well as rare cases of exfoliative and vesicular-bulous dermatitis - neutropenia (leukopenia) and eosinophilia of a passing nature, as well as cases of agranulocytosis and thrombocytopenia, but it was not possible to establish an etiological connection between these phenomena and the therapy with the drug Dalacin® - with too rapid intravenous administration of the drug, cases of respiratory and cardiac arrest, as well as the development of hypotension have been observed - with intramuscular administration of the drug, phenomena such as local irritation, pain and the formation of abscesses in the area of injection may be observed. When administered intravenously, thrombophlebitis sometimes occurred. The incidence of such phenomena decreases when the drug is administered deeply intramuscularly and with the rarest possible use of permanent intravenous catheters. Contraindications - hypersensitivity to clindamycin, lincomycin or any component of the drug Drug interactions The following drugs are physically incompatible with Dalatsin® C phosphate in solution for infusion: ampicillin, phenytoin sodium, barbiturates, aminophylline, calcium gluconate, magnesium sulfate, ceftriaxone sodium, ciprofloxacin. It was found that in vitro antagonism occurs between clindamycin and erythromycin. Because this antagonism may be clinically significant, the two drugs should not be administered simultaneously. Clindamycin has been found to interfere with neuromuscular transmission, so it may enhance the effect of other peripherally acting muscle relaxants. Therefore, it should be used with caution in patients receiving drugs in this group. Special instructions Dalatsin® C phosphate injection solution contains benzyl alcohol. There are reports that benzyl alcohol can cause the development of fatal Gasping Syndrome (respiratory problems manifested by suffocation) in premature newborns. Cases of pseudomembranous colitis of varying severity, even life-threatening, have been observed with the use of almost all antibacterial agents, including Dalatsin®. Therefore, in all cases of diarrhea after taking antibacterial drugs, this diagnosis should be considered. Antibacterial drugs suppress the normal intestinal flora, which can contribute to increased proliferation of clostridia. Toxins produced by Clostridium difficile have been shown to be a major cause of antibiotic-associated colitis. After making a diagnosis of pseudomembranous colitis, the following measures must be taken: in mild cases, it is usually sufficient to discontinue the antibacterial agent; In moderate to severe cases, consideration should be given to fluid, electrolyte, protein, and an antibacterial drug effective against Clostridium difficile. Dalacin® should not be prescribed for the treatment of meningitis, since clindamycin does not penetrate the blood-brain barrier well. If treatment is carried out over a long period of time, liver and kidney function tests should be carried out regularly. When using antibacterial agents, including Dalatsin®, excessive growth of microorganisms that are insensitive to this drug, especially yeast-like fungi, is possible. Dalacin® C phosphate should not be administered intravenously and at the same time. Infusion must be carried out for at least 10-60 minutes. There are no recommendations for reducing the dose of Dalacin® in patients with impaired liver and kidney function. Pregnancy and breastfeeding clindamycin penetrates through the placenta. After the introduction of several doses of the drug, the concentration in amniotic fluid was approximately 30% of the concentration in the blood of the mother. Dalacin® should be used in pregnant women only according to absolute indications, i.e. When the potential benefits of therapy with the drug surpasses potential risk. It was reported that clindamycin is found in breast milk at a concentration of 0.7-3.8 μg/ml. Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms were not studied. Overdose symptoms: strengthening side effects. Treatment: symptomatic and supportive. The form of release and packaging Dalacin® Capsules: · Blisters of 8 capsules · 2 blisters and instructions for use are packed in a cardboard pack. Dalacin® C phosphate injection solution: · ampoules made of transparent glass of 2 ml, 4 ml; · 1 ampoule and instructions for use are packed in a cardboard pack. Storage conditions are stored at a temperature of not higher than +25 ° C. Keep out of the reach of children! The shelf life of the capsule is 5 years in injection - 2 years cannot be used after expiration of the shelf life. Conditions of pharmacies according to the recipe manufacturer capsule: Pfizer PGM Zone Industrielle-29 Route des Industries 37530 POCE-SUR-CISSE FRANCE A solution for injections: PFIZER MFG Belgium N.V. Rijksweg 12, 2870 Puurs Belgium
Indications for use of the drug Dalacin c
Dalatsin C and Dalatsin S Phosphate is an effective remedy in the treatment of infections caused by pathogens sensitive to it:
- infections of the ENT organs, including pharyngitis, sinusitis, otitis media, scarlet fever;
- lower respiratory tract infections, including bronchitis, pneumonia, lung abscess, pleural empyema;
- infections of the skin and soft tissues, including acne, furunculosis, cellulitis, impetigo, abscesses, infected wounds, specific infectious processes of the skin and soft tissues caused by pathogens sensitive to this drug, such as erysipelas and paronychia/felon;
- infections of bones and joints, including osteomyelitis and purulent arthritis;
- gynecological infections, including endometritis, phlegmon, colpitis, tubo-ovarian abscesses, salpingitis and pelvic inflammatory diseases, if the drug is prescribed in combination with an appropriate antibiotic active against gram-negative pathogens. For cervical infections caused by Chlamydia trachomatis , clindamycin monotherapy is effective in eradicating this organism;
- intra-abdominal infections, including peritonitis and abscesses of the abdominal organs (in combination with antibiotics acting on gram-negative aerobes);
- septicemia and endocarditis. The effectiveness of clindamycin has been proven in certain cases of endocarditis: the drug has a bactericidal effect on the infectious agent in vitro when using such concentrations of the drug that are achieved in human blood serum;
- oral infections, including periodontal abscess and periodontitis;
- toxoplasmic encephalitis in patients with AIDS (the effectiveness of clindamycin in combination with pyrimethamine has been proven in patients intolerant to standard therapy);
- Pneumocystis pneumonia in patients with AIDS (in patients who cannot tolerate or are resistant to standard therapy, clindamycin can be used in combination with primaquine);
- malaria, including cases caused by multidrug-resistant Plasmodium falciparum (as monotherapy or in combination with quinine or chloroquine);
- prevention of endocarditis in patients with hypersensitivity to penicillins;
- prevention of wound infection during surgical interventions in the head and neck area;
- prevention of peritonitis and intra-abdominal abscesses after perforation and post-traumatic contamination when used simultaneously with aminoglycoside antibiotics (gentamicin or tobramycin).
Dermatotropic products Dalatsin gel (Pfizer) - reviews
Almeka
https://pryschotzyv.ru/dalacin-gel/
I give the gel an excellent rating, although before purchasing and starting to use I had some concerns about the composition. Still, galacin is considered a type of antibiotic for external use.
And everything that is considered antibiotics makes me wary. In particular, no one has canceled the addiction, as well as the effect of reducing the effectiveness of other acne care products.
But I had no choice, I had to quickly solve the problem, so I decided to use heavy artillery in the form of this gel.
The release form is standard, in the form of a small hygienic tube with a volume of 30 g, a very good cap. Unscrews easily. The texture is pleasant, light and airy, inside the tube there is literally a transparent gel. The gel literally melts on the skin and turns into water.
It does not dry out immediately, but there is no feeling of tightness on the skin. I usually smear the skin at night, the next morning all the pustules that were turned into small red spots. So I'm very, very pleased with the result. The only negative is that a lasting effect can only be achieved by long-term use, at least 2 months.
RitkaMargoritka
https://pryschotzyv.ru/dalacin-gel/
I have been using the gel for a very long time, usually in courses of 3-4 days in a row, although some people talk about constant use. It is difficult for me to imagine this, since the gel is very strong in composition. Kills all microbes that are in the upper layers of the skin. But not only them, the gel also actively eliminates excess natural secretions of the sebaceous glands, which, of course, is undesirable for skin over 30.
So I determined a comfortable usage schedule for myself. Only when necessary. The gel was recommended to me by a cosmetologist.
In terms of its effect on the skin, the gel can be compared to an acid peel. After several applications, the skin becomes very red, and a reaction is evident. So after application I have to make a soothing mask to relieve the itching.
But all the pimples and dark spots go away without a trace, I don’t make any special efforts. And one more thing, Dalacin is simply an ideal care option during the warm, sunny season, when harsh exfoliation and retinoid-based creams/gels are not recommended.
Evgeniya
https://www.imho24.ru/recommendation/29275/
Ever since I was a teenager, I was terribly bothered by acne; it broke out not only on my face, but also on my shoulders. It’s a pity, then I couldn’t have this gel... and their number decreased by the age of 18, as one would expect. But there was a lot of breakout on my face, and it’s been 26 years. This gel was recommended to me - it helps wonderfully! It helps quickly and effectively, does not leave an oily sheen on the face - it removes everything, pimples soon disappear, and, most importantly, cleanses the pores. Completely restores the skin. Easy to use - transparent, non-sticky, has no unpleasant odor and can even be used under powder or foundation, if necessary)). Absorbs quickly, lasts a long time, can be applied at night, does not leave marks on the pillow).
An excellent method of combating acne, I am very grateful to this wonderful gel, which simply saved my face from a terrible deficiency.
Karina
https://www.imho24.ru/recommendation/29275/
I often suffer from inflammation on my face. I tried a lot of things. Some are better, some are worse. I decided to buy this cream and did not regret it! I applied it directly to pimples, several times a day. It relieves inflammation very well and dries out acne. It contains zinc in its composition, which is why it has such a positive effect.
The next day after use, the result is already noticeable, and after 5 days there is no trace of acne left. A huge advantage of this product is that it does not contain hormones, which means you can use it 2-3 times a day. For me, it is a good remedy in the fight against skin imperfections. Now my face is fresh, without blemishes on the skin. The only negative is that the cream is not cheap.
Marina Nikel
https://otzovik.com/review_2152186.html
Advantages:
There is a result.
Flaws:
Price
Dalacid was recommended to me by a cosmetologist; I can’t say, of course, that my face was heavily covered, but nevertheless there were small pimples in the forehead area. I used it exactly according to the instructions. I didn’t use any other funds. After two weeks, my face became completely clear. What can I say about the gel itself: it doesn’t dry out, it’s quickly absorbed, it has a pleasant aroma, and the consumption is low. Of course, I can’t say that the price is normal. Of course it’s expensive for me, but I took it and of course I’m glad that it helped. As for the combination with antibiotics, I read this in the reviews. Honestly, I don’t know, but I think it’s probably combined with chloramphenicol alcohol, externally. Because if you drink it internally, it will have to restore the microflora. My cosmetologist always says that rashes on the face are intestinal or gynecological diseases.
masha-msk
https://otzovik.com/review_2406825.html
Advantages:
transparent, easy to apply, moderate in price
Flaws:
No
The child (as luck would have it, 2 weeks before September 1st, we are first-graders) first developed rashes on his head, then across his face. Initially, I actually thought it was lichen ((they ran to the KVD, took a scraping. FUUUU... it turned out not to be lichen. As a result, the nearest KVD didn’t tell me anything intelligible - they immediately started prescribing antibiotics. But no... I said and started looking for a good dermatologist. Hurray I found it in the Central Clinical Hospital of Moscow))) It turned out to be a streptococcal infection. I was prescribed to treat it with 5% levomycetine. alcohol, and then dalocin. And no antibiotics))) The very next day, the rashes stopped and everything began to dry out faster. So on September 1st we went beautiful.
beautyreviews
https://irecommend.ru/content/zrya-otkladyvala-lechenie-etim-antibiotikom-davno-uzhe-vylechila-kozhu-esli-znala-chto-pomoz
A little background on my sad skin:
From the age of 14 to 24, I suffered from periodic rashes, I tried baziron, effezel, and many other remedies, all as it should be in long courses, of course, before that I underwent a full examination and made sure that the problem with these rashes was not internal problems.
And now, after 10 years of various experiments in attempts to cure my skin, I was completely desperate and decided to buy an antibiotic, postponing it until the last moment, because... I convinced myself that it was very harmful to the skin (I read too much on the internet). At one point, my patience ran out and I decided to take Dalatsin, because I no longer had the strength to look at the bumpy, pimply skin, and all other drugs had already been tried without any positive dynamics.
Day X and the campaign for Dalatsin arrived.
Price 650 rubles.
Tube volume 30 ml.
Gel texture.
At this point, my skin was between mild to moderate acne. There were a couple of subcutaneous pimples and closed, inflamed comedones. There were also open ones, but I clean them immediately when special ones appear. tool. All this was based on the cheeks and along the jaw line.
Already on the first day, all redness and inflammation subsided and became flesh-colored, like healthy skin. The magical power of an antibiotic) Subcutaneous acne went away within the first week. The only thing that remained were the hard pimples and closed comedones, but they couldn’t be removed with antibiotics. The second stage of treatment removed them with Azelik.
It turns out that the maximum result from Dalatsin was achieved in exactly a month, just before the New Year, for me this is the best and long-awaited gift.
I continued to use Dalacin because... According to the instructions, the full course of treatment is 6-8 weeks.
During the first month of treatment, I noticed that it did not dry out or irritate the skin at all, unlike the above-mentioned vigorous medicinal products such as Effezel. Not greasy and dries quickly. I applied it in the morning and at night, no unpleasant sensations or reactions were noticed. I was afraid that because of the antibiotic, the skin’s immunity would decrease and any infection would begin to stick, but this did not happen. In a month it took me exactly half a tube, so one tube is enough for exactly a full course of 2 months.
Bottom line: for me this remedy turned out to be a real magic wand. Ideal to use, and the result is achieved in a very short time.
The only thing left after complete treatment is to remove acne spots, but I have already learned how to deal with them with acidic agents.
As proof, I am attaching a photo before Dalatsin and after a month of treatment with it, without filters. Perhaps someone will say that pf this is not problem skin at all, but in real life, under different lighting, all these bumps and pimples are much more visible and brighter, not to mention the fact that they were felt to the touch and periodically became inflamed and turned into red spots, and no tonal one lay flat on these places. Now the skin is clean, smooth and healthier.
LSGrec
https://irecommend.ru/content/obyazatelen-k-pokupke-vsem-obladatelnitsam-podkozhnykh-pryshchei-foto-do-i-posle-na-primere
Hi all.
The review will be dedicated to the drug that literally “saved” my skin from subcutaneous acne. I have been looking for a spot treatment for acne for a very long time, and also built an entire skin care system to reduce sebum production and reduce the number of pimples, blackheads, tighten pores, etc.
We will talk about dalacin. I’ll make a disclaimer right away: I use it in tandem with Effezel, so I can’t attribute all the changes to it alone, but the fact that it/they work is for sure.
Packaging: tube 30 g.
Application:
Externally. A thin layer of gel is applied to the affected area of clean, dry skin 2 times a day.
To obtain the first positive results, it should be used for 6-8 weeks, and if necessary, can be continued for up to 6 months.
If after using the drug for several months the effectiveness of Dalatsin decreases, you should take a break from treatment for 4 weeks.
Now about my skin. In order not to be unfounded, I will simply show you what happened and how my skin changed after using this gel and Effezel:
I’ll say right away: the difference between the photos is 5 days. I didn’t take intermediate photos, because... these creams make my skin flaky wildly (at least for me), it becomes hypersensitive that it stings even from the moisturizing and nourishing pharmacy cream from La Roche Posay. During these five days, I wildly hated my skin, I couldn’t put on makeup properly, even applying powder was a problem for me - all the peeling immediately became visible, the skin peeled off like a snake’s in pieces, in those places where I had previously applied these gels.
But this torment was worth it, because look what the skin has become! Even if there are traces of acne, this is a second matter, they also need to be dealt with separately, but how quickly the subcutaneous tissues “deflated”! This is simply incredible!
For the price: I bought it for 700 rubles at the Ozerki pharmacy (St. Petersburg).
The consumption is very economical, since it must be applied in a thin layer locally to the affected areas, so even if you really want to, you won’t quickly use it up.
To summarize all of the above: I strongly recommend it to anyone who periodically has such subcutaneous acne.
Thank you for your attention and clear skin for you!
Use of the drug Dalacin c
The dose and method of administration of the drug depend on the severity of the disease, the patient’s condition and the sensitivity of the infectious agent to the antibiotic. The course of treatment lasts on average 7–10 days. Adults Dose of Dalacin C in capsule form for oral use: 600–1800 mg per day, divided into 2, 3 or 4 equal doses. In order to prevent possible irritation of the esophagus, Dalacin C capsules should be taken with a full glass of water. Capsules should not be opened. Children over 6 years of age The dose of Dalacin C is 8-25 mg/kg per day in 3-4 doses. To avoid irritation of the esophageal mucosa, capsules should be taken with a full glass of water. Elderly patients No dosage adjustment is required in elderly patients with normal liver and kidney function. Patients with renal failure Patients with renal failure do not require dose adjustment. Patients with liver failure Patients with liver failure do not require dose adjustment.
Dalatsin
Dalacin (the pharmacologically active substance in its composition is clindamycin) is a semisynthetic antibiotic from the lincosamide group, obtained from lincomycin. The drug is effective against infections caused by a wide range of anaerobes and gram-positive aerobes. Gram-negative aerobic bacteria (for example, enterobacteria) are resistant to this antibiotic. Dalacin realizes its antimicrobial effect through binding to the 50S ribosomal subunit of the bacterial cell, which makes it possible to suppress the synthesis of the protein necessary for the growth and reproduction of the microorganism even in the early stages.
Dalacin is available in four dosage forms: capsules, vaginal suppositories and cream, as well as a gel for external use. Capsules, as a systemic dosage form acting on the body as a whole, are used for many different infections of a wide variety of etiologies and localizations: infections of the upper and lower respiratory tract, ENT organs (ear/nose/throat), skin and soft tissues, bones and joints , genitourinary tract, oral cavity, etc. Vaginal suppositories and cream have a narrow specialization and are intended for the treatment of bacterial vaginosis, or, as it is also called, vulvovaginitis. Gel for external use is also a highly targeted remedy and is used to combat acne vulgaris.
The use of capsules is not complicated: adults - 600-1800 mg, children - 8-25 mg per 1 kg of weight in equal doses for 2, 3 or 4 doses per day, washed down with a full glass of water to avoid damage to the mucous membrane of the esophagus. The specific dose, frequency and duration of taking dalacin is determined by the doctor, based on the information collected during the interview, examination and diagnostic studies. Suppositories should be administered before bedtime for 3 days. For ease of administration, the packaging with the dosage form is equipped with a reusable plastic applicator (however, you need to wash it after each use using warm water and regular soap). The cream should be administered before going to bed for 3-7 days (the specific period of use is determined by the attending physician). The instructions for use included in the package contain the rules for introducing the cream into the vagina, where this entire jewelry process is described very clearly and with illustrations. As for the gel, it should be applied in a thin layer to the surface of the skin affected by acne (it should be dry and clean) twice a day for 6-8 weeks. If necessary, it is possible to increase the therapeutic course to 6 months.
Special instructions for the use of Dalacina C
for selected indications Treatment of infections caused by β-hemolytic streptococcus. For infections caused by β-hemolytic streptococcus, treatment must be continued for at least 10 days. Treatment of acute streptococcal tonsillitis/pharyngitis. The dose of Dalacin C in capsules for oral use is 300 mg 2 times a day for 10 days. Treatment of inflammatory diseases of the pelvic organs. After parenteral administration of the drug for 6 days, clindamycin hydrochloride should be continued orally at a dose of 450–600 mg every 6 hours until completion of the 10–14 day therapy cycle. Cervical infections caused by Chlamydia trachomatis 450–600 mg Dalacin C orally 4 times a day for 10–14 days. Toxoplasmosis encephalitis in patients with AIDS. Dalacin C orally at a dose of 600–1200 mg every 6 hours for 2 weeks, then 300–600 mg orally every 6 hours. The course of therapy is usually 8–10 weeks. The dose of pyrimethamine is 25–75 mg orally daily for 8–10 weeks. When using pyrimethamine in higher doses, folinic acid should be prescribed at a dose of 10–20 mg/day. Pneumocystis pneumonia in patients with AIDS. Dalacin C 300–450 mg orally every 6 hours for 21 days and primaquine 15–30 mg orally once a day for 21 days. Treatment of malaria. Adults are prescribed at a dose of 10–20 mg/kg per day, children - 10 mg/kg per day in equal doses 2 times a day for 7 days as monotherapy or in combination with quinine (12 mg/kg 2 times a day) or chloroquine (15–25 mg once daily) for 3–5 days. Prevention of endocarditis in patients with hypersensitivity to penicillin. Adults are prescribed 600 mg 1 hour before surgery or a therapeutic and diagnostic procedure (for example, tonsillectomy, adenoidectomy, bronchoscopy with a rigid bronchoscope, dilation of esophageal stricture, retrograde cholangiopancreatography, cystoscopy, etc.); children - 20 mg/kg 1 hour before surgery or diagnostic and treatment procedures.
DALACIN (cream)
specific key cells - already at your own expense?
We have some kind of half-hearted diagnostic system in domestic gynecology. The gynecologist suggested taking paid tests either at the antenatal clinic itself or in private laboratories. I chose the second and did not regret it - “Hemotest” turned out to be both cheaper and more convenient. Moreover, private clinics send results by email, and I did not have to go to get them.
4 tests (ureaplasma urealyticum comes together with parvum, the results are simply recorded separately) cost 1,590 rubles. It was lucky that the deviant element was immediately identified, otherwise it would have been fun to sort through all the remaining options.
Based on the test results, treatment was prescribed:
1) Orally - Tiberal tablets, 2 times a day for 5 days. 2) Vaginally - “Dalacin” cream for 7 days. 3) After treatment, Vagilak capsules to restore microflora, 2 times a day for 14 days.
I was treated according to this course, so now I turn to the very object of the review - the Dalatsin vaginal cream.
The first thing I want to talk about is, of course, the price. Because one of the worst things about treatment is its cost.
For 7 days I needed to buy a 40 gram pack of cream, or 2 packs of 20 grams each. BUT! A 20 gram package of “Dalacin” contains only 3 applicators, which means that 1 applicator would not be enough for me. Looking ahead, I’ll say that the applicators come in such a form that they can be easily reused, so don’t worry, like I did, looking for a package with 7 applicators, but feel free to take 2 packages of 20 grams each. But keep in mind that 2 packages will cost you much more than 1 large one. In St. Petersburg, prices for 20 grams now fluctuate around 800 rubles!
I was very lucky in my search, because at the Nevis pharmacy I found a 40 gram package with a very good discount, and it was there that I bought it for 755 rubles:
Thanks to the Nevis pharmacy for not hiding prices on the website, as some pharmacy chains do.
Now let's move on to the product itself:
On some sellers' websites the manufacturer is indicated as such - "Pharmacia and Upjohn Company". As you can see, this is indeed “.
The active ingredient of the drug is 2% clindamycin:
More precisely, clindamycin phosphate. For me, the most important thing was that this phosphate turned out to be completely non-irritating and did not give me any unpleasant sensations in the vagina. Although, perhaps something else in the composition contributed to this. True, it is better to ask chemist-biologists.
But then things get interesting. Inside the box is a whole set:
Long instructions, a soft tube of cream and a small tube with applicators.
The tube of cream is of very high quality: soft, comfortable and very easy to roll up when you need to squeeze the cream out of it:
The information about the batch and expiration date matches that on the box.
But then comes a not entirely pleasant thing: the neck is not sealed with aluminum foil:
This has happened in many medicines and cosmetics lately. I wonder what the reason is?
But the tube with applicators has the inscription on the lid: “twist and pull”:
Rough translation: “twist and pull” or “twist and pull”. Twist the applicator and pull out the cream. But in fact, this is an incorrect inscription, because it is impossible to pull out the cream with the applicator. So it’s much more logical to write “wind and squeeze.”
And here is the drum itself with applicators:
They are quite long - almost 12 cm:
And when extended it is almost 20 cm:
Two different ends. One - internal - for screwing onto the neck of the tube:
It's probably not very visible, but there is a plastic track inside for screwing onto the thread.
And it is this end that needs to be inserted into the vagina. And at first it seemed like it would be painful:
But, in fact, it turned out to be quite normal! This blunt end does not cause any discomfort or pain. However, this also depends on the injection technique, but I will talk about this below.
The second end - the outer one - has a different shape and is convenient for placing a finger:
We got acquainted, now we read what the manufacturer wrote in the instructions:
Remove the cap from the tube and screw the applicator onto the neck:
Until the applicator fits tightly to the tube itself:
And then start squeezing the cream into the applicator, slowly twisting the tube from the end:
The cream is filled quite slowly, pushing the internal piston out until it hits the place where the piston stops:
Now you can unscrew the applicator from the tube and go to the bathroom or other place where it is convenient to lie down.
And the manufacturer advises administering the cream by pulling your knees to your chest:
For me this turned out to be a torture position, so I chose a different method of insertion. True, I don’t know how correct this is from a medical point of view, but it turned out to be much more convenient for me to insert the applicator and medicine in the “birch tree” position with legs bent and apart. This is the only optimal way to insert vaginal cream completely into the vagina without subjecting the tissue to physical stress and without losing half of the cream due to its rapid leakage.
At least in this position I was able to insert the applicator much deeper than in other positions, and the leakage did not haunt me either. Although I went to bed immediately after the injection, I had to get up periodically, and the leakage of any liquids did not bother me.
I didn’t feel the medicine itself inside. There was no burning, no pain, no heating, no irritation. And there was no feeling that the medicine was absorbed into the vagina, as one of the authors wrote. The cream was gradually squeezed out the next day during visits to the toilet. That is, in order for it to flow out completely, you had to either push or move a lot and actively, because it didn’t flow out much on its own. As for me, this is a very good consistency of vaginal cream. But, again, we remember how I introduced it. It is possible that the “birch” position allowed the cream to be inserted deep enough and well enough for the cream to cover all the walls of the vagina and flow down quite slowly. But I still used daily journals so as not to stain my laundry.
So, I used all 7 applicators, drank “Ornidazole” tablets (the active ingredient of “Tiberal”), drank “Vagilak” and at the end I got the microflora that had returned to normal:
These, by the way, are the first results of bacterial culture (the second results are a long sheet of something that has not grown). Girls from St. Petersburg, I’ll tell you the news in case anyone hasn’t encountered it. It turns out that on Moiseenko 26 in the Central District there is a laboratory complex that accepts referrals for bacterial culture from district antenatal clinics. It’s free, but apparently there is some kind of limit on the number of quotas for such referrals, because my gynecologist didn’t offer it to me, but her replacement during the holidays just did. So ask your doctors! The laboratory on Moiseenko is almost empty, there are no queues, however, it is only open on weekdays and during business hours. But they send the results by email if you leave it to them! So you only have to go once.
Let me summarize.
Of course, I liked Pfizer Dalacin vaginal cream. He completed the main task: he restored the microflora and brought gardnerella to life.
It also fulfilled secondary tasks: - it did not cause any irritation or unpleasant sensations, - it turned out to be convenient and easy to use, - thanks to a successful pharmacy, it did not hit the wallet very hard.
Therefore, on my own behalf, of course, I recommend it, but only if a doctor prescribed it to you. Self-medication in gynecology is the last thing, it does not lead to anything good.
Thank you for your attention, I hope it was useful, I will be glad to see you again!
Side effects of the drug Dalacin c
blood and lymphatic system: transient neutropenia/leukopenia, eosinophilia, agranulocytosis, thrombocytopenia (no clear cause-and-effect relationship with the use of Dalacin C has been established); immune system: anaphylactoid reactions; nervous system: dysgeusia; Gastrointestinal tract: abdominal pain, nausea, vomiting, diarrhea, esophagitis, esophageal ulcer; hepatobiliary disorders: jaundice, changes in liver function tests (including hyperbilirubinemia); skin, subcutaneous tissue and mucous membranes: maculopapular rash, urticaria, mild or moderate generalized rash, erythema multiforme, Stevens-Johnson syndrome, itching, vaginitis, exfoliative and vesiculobullous dermatitis, toxic epidermal necrolysis.
Special instructions for the use of the drug Dalacin c
Treatment with clindamycin, like other antibiotics, may be complicated by the development of pseudomembranous colitis. Therefore, it is important to promptly diagnose this pathology in patients with diarrhea while using antibacterial agents and discontinue the drug. Antibacterial drugs inhibit the functioning of the normal flora of the large intestine, which can cause rapid proliferation of clostridia. The results of the studies indicate that toxins produced by clostridia, especially Clostridium difficile , are the most important and direct cause of the development of colitis. If pseudomembranous colitis develops, appropriate treatment should be prescribed. In mild cases of pseudomembranous colitis, discontinuation of clindamycin may be sufficient. With the development of a moderate and severe form, it is necessary to carry out appropriate therapy, which includes the use of fluids, solutions of electrolytes and protein preparations and the use of drugs that are effective against the pathogen - Clostridium difficile . Clindamycin should not be used to treat meningitis because the drug does not penetrate the CSF well. With long-term treatment with antibacterial drugs, it is necessary to monitor liver and kidney function. As a result of clindamycin therapy, microflora that are insensitive to this drug, especially yeast, may be activated. Cases of diarrhea associated with Clostridium difficile have been reported with the use of almost all antibacterial agents, including clindamycin. The severity of diarrhea can range from moderate to severe fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon, leading to an increase in Clostridium difficile . C. difficile produces exotoxins A and B, which cause Clostridium difficile -associated diarrhea. Toxin-overproducing strains of C. difficile cause increased morbidity and mortality because these infections may be refractory to antibiotic therapy; Sometimes a colectomy may be necessary. In patients who have developed diarrhea syndrome during the use of antibiotics, it is necessary to exclude the possibility of developing Clostridium difficile -associated diarrhea. Careful monitoring and maintenance of the patient's medical records is necessary from the moment of reporting the occurrence of Clostridium difficile -associated diarrhea until 2 months after the use of antibacterial agents. During pregnancy and breastfeeding. Clindamycin is able to cross the placenta. With long-term use, the level of clindamycin in amniotic fluid is about 30% of the drug concentration in the mother's blood. Dalatsin C can be prescribed during pregnancy only in case of urgent need. Clindamycin has been reported to pass into breast milk at concentrations of 0.7–3.8 mcg/ml. It is recommended to stop breastfeeding while using Dalatsin C. Impact on the ability to drive vehicles and work with potentially dangerous mechanisms. There is no data indicating the effect of Dalatsin C on the ability to drive vehicles and operate machinery.
Drug interactions Dalacin c
Cross-resistance exists between clindamycin and lincomycin. also in vitro antagonism between clindamycin and erythromycin. The drug is also incompatible with ampicillin, barbiturates, aminophylline, calcium gluconate, magnesium sulfate. Due to the potential clinical significance of this interaction, these agents should not be coadministered. Concomitant use with antidiarrheal drugs increases the risk of pseudomembranous colitis. Clindamycin has the ability to block neuromuscular transmission and may enhance the effect of other neuromuscular blockers, so the drug should be used with extreme caution in patients prescribed muscle relaxants.
