Fluconazole capsules and tablets: instructions for use, price, reviews on forums for thrush

pharmachologic effect

The abstract contains information that the drug acts as an antifungal agent, specifically inhibiting the synthesis of fungal sterols. Belongs to the class of triazole compounds.

There is a specific effect on fungal enzymes that depend on cytochrome P450. The active substance demonstrates activity against a variety of strains of Candida spp. (including effective against visceral candidiasis), Cryptococcus neoformans (including effective against intracranial infections), Trichophytum spp, Microsporum spp. The drug is also active against microorganisms that are causative agents of endemic mycoses: Coccidioides immitis, Hystoplasma capsulatum, Blastomyces dermatitidis.

The drug stops the conversion of fungal cells into lanosterol into ergosterol. Under its influence, the permeability of the cell membrane increases, the process of its growth and replication is inhibited. It is highly selective for cytochrome P450 of fungi, but in the human body it almost does not inhibit these enzymes. Does not demonstrate antiandrogenic activity.

Pharmacodynamics

Antifungal agent. A triazole derivative exhibits an antifungal effect by blocking the biosynthesis of ergosterol in the cell membrane of fungi. The “target” for the action of the drug is the enzyme 14-α-demethylase.

14-α-demethylase is part of a group of enzymes known collectively as cytochrome P450. All enzymes of the cytochrome P450 group contain hematinic iron-containing pigment. Fluconazole binds to the iron atom of the hematin group and inactivates 14-α-demethylase, which leads to disruption of ergosterol synthesis and accumulation of lanosterol and other sterols. Their inclusion in the membrane instead of ergosterol significantly disrupts the structure and function of the fungal cell membrane.

Pharmacokinetics and pharmacodynamics

Wikipedia indicates that after oral administration, the drug is actively absorbed into the human gastrointestinal tract. In plasma, the concentration of the active substance is more than 90% of the level that is observed if intravenous administration is practiced. The absorption of the substance is not affected by food intake, so it does not matter how you take it, before or after meals. After taking the medicine orally, the highest concentration in the blood occurs after 0.5–1.5 hours. The half-life from the blood is 30 hours. That is, you can take the product once a day. For vaginal candidiasis, a single dose of the drug is sufficient, for which one tablet or another form of the drug is used.

11–12% of the active substance binds to blood plasma proteins. When the drug begins to work depends on the treatment regimen. If you take the medicine once daily, then a stable concentration of the active component in the human blood is observed on the fourth or fifth day (in 90% of people). If on the first day of treatment the patient is given a double daily dose, then this effect is observed already on the second day of treatment.

Penetrates into all fluids in the body. It is excreted from the body through the kidneys, approximately 80% is excreted unchanged.

Indications for use

The following indications for use of the drug are determined:

infectious diseases caused by candida ( disseminated candidiasis , generalized candidiasis , other forms of invasive candidiasis ;
candidiasis of the mucous membranes (including the pharynx, oral cavity, esophagus);
candiduria;
chronic atrophic and mucocutaneous candidiasis of the oral cavity (develops in people with dentures);
non-invasive bronchopulmonary infections;
genital candidiasis ( vaginal candidiasis in acute form and with relapses);
prevention of recurrent manifestations of vaginal candidiasis (if the disease develops three times a year), candidal balanitis ;
cryptococcal infection, cryptococcal meningitis;
onychomycosis;
dermatomycosis (including mycoses of the body, feet, groin area);
pityriasis versicolor;
endemic mycoses deep;
prevention of the development of fungal infections in people who have undergone cytostatic or radiation therapy.

results

The study included 300 patients aged 22 to 85 years (mean age 53.8 years; 95% CI 52.9-54.2 years). The patients were randomized into two groups of 150 people each. Basic characteristics of the groups are presented in Table. 1. The groups of patients were comparable in terms of demographic characteristics (gender, age, body weight), duration of onychomycosis, number of affected nails, area of affected nails, species composition of onychomycosis pathogens, concomitant diseases and the number of prognostically unfavorable factors. There were no statistically significant differences in these parameters between the groups (χ2, p

>0.05;
t
-Test,
p
>0.05;
Mann-Whitney U
,
p
>0.05).

Table 1. Basic characteristics of the study groups
Of the concomitant diseases in the 1st group of patients, 82 (55%) cases of cardiovascular diseases were identified, of which peripheral circulatory failure was observed in 54 (36%) cases from the total group of patients and in 66% with cardiovascular diseases. Type 2 diabetes mellitus in group 1 was present in 19 (13%) patients, diseases of the hepatobiliary system - in 12 (8%). It should be noted that among patients with pathology of the hepatobiliary system, viral hepatitis C was observed in 5 (3%) cases, and viral hepatitis B - in 7 (5%). 9 (6%) patients in group 1 took immunosuppressive drugs. Of the concomitant diseases in the 2nd group of patients, 84 (56%) cases of cardiovascular diseases were identified, of which peripheral circulatory failure was observed in 56 (37% of the total group, 66% of those with cardiovascular diseases). Type 2 diabetes mellitus in group 2 was present in 21 (14%) patients, diseases of the hepatobiliary system - in 11 (7%). Among patients of group 2 with pathology of the hepatobiliary system, viral hepatitis C was observed in 5 (3%) cases, and viral hepatitis B - in 6 (5%). 8 (5%) patients in group 2 took immunosuppressive drugs. There were no statistically significant differences in comorbidities between groups ( χ

2,
R
>0,05).

297 patients completed the study. Three (1%) patients withdrew from the study due to voluntary refusal to participate in the study. Its results showed that by the 52nd week from the start of treatment, mycological recovery was observed in 161 (54.2%) patients, clinical recovery in 155 (52.2%), complete recovery in 153 (51.5%). The results of treatment in the study groups are presented in table. 2.

Table 2. Study results

As can be seen from the data in table. 2, the effectiveness of combination therapy with fluconazole and amorolfine was higher than fluconazole monotherapy. Combination therapy with fluconazole led to mycological recovery in 61.7% (92 out of 149) of patients, clinical recovery in 60.4 (90 out of 149), and complete recovery in 59.1% (88 out of 149) of observation participants. Monotherapy achieved mycological recovery in 46.6% (69 of 148; χ

2df=1;
p
=0.002) patients.
Clinical recovery after fluconazole monotherapy was observed in 43.9% (65 of 148; χ
2df=1;
p
<0.001) of patients, complete recovery - in 43.9% (65 of 148;
χ
2df=1;
p
<0.001) of patients. Calculation of the odds ratio made it possible to establish that when carrying out combination therapy (fluconazole and amorolfine) for onychomycosis of the feet, the chance of complete recovery is 1.9 times higher (CI 1.2-3.1) than with monotherapy (fluconazole).

During the study, 4 (1.3%) cases of adverse events were recorded. None of the adverse reactions were related to the study drugs (fluconazole or amorolfine). 2 patients developed a hypertensive crisis. There were also 2 cases of acute respiratory infection. Adverse events did not require discontinuation of therapy or exclusion of patients from the study. It should be especially noted that when fluconazole and antidiabetic drugs (sulfonylurea derivatives) were taken together, not a single case of hypoglycemia was reported in patients with diabetes mellitus. We also did not notice an increase in the level of liver enzymes and bilirubin in the blood in patients with pathology of the hepatobiliary system, including in patients with viral hepatitis B and C.

Contraindications

There are the following contraindications for the use of this medicine:

manifestation of high sensitivity to fluconazole or to azole compounds, which are similar in chemical structure to fluconazole;
concurrent use of terfenadine if the patient receives a dose of Fluconazole 400 mg per day or more;
concomitant use of astemizole or any other drugs that increase the QT interval;
age up to 4 years.

It should be taken with caution in case of liver failure, also kidney failure, when a rash appears in people suffering from a superficial fungal infection, in potentially pro-arrhythmogenic conditions in people with risk factors (organic heart disease, taking medications that provoke the development of arrhythmia , electrolyte imbalance). How to take Fluconazole in this case, you should definitely ask a specialist.

Side effects

When treated with the drug, the patient may develop the following side effects:

abdominal pain, diarrhea ;
headache;
nausea , flatulence ;
skin rash;
hepatotoxic effects;
anaphylactic reactions.

How to take the medicine when such effects occur, and whether it is worth continuing treatment, should be individually consulted with a doctor.

Can I take Fluconazole while taking antibiotics?

Combinations of antibiotics and antifungal agents are determined only by a doctor. If after treatment with antibiotics the patient develops candidiasis, the use of Fluconazole is possible. But simultaneous use is not always possible due to the fact that the medicine actively interacts with other substances. Some antibiotics, cardiovascular drugs, psychotropic drugs and many others are at risk. Therefore, the patient must be informed about all his concomitant diseases and medications taken.

Instructions for use of Fluconazole (Method and dosage)

The drug is prescribed for oral administration (Fluconazole Stada capsules, Fluconazole Teva, tablets) or for intravenous administration. There are also other forms of medication, the active ingredient of which is fluconazole - suppositories, ointment.

The solution is infused at a rate not exceeding 10 ml per minute.

Fluconazole tablets, instructions for use

The dosage of the drug depends on the disease and its severity.

Patients with disseminated candidiasis and candidemia are prescribed 400 mg on the first day, then the dose should be reduced to 200 mg. For the treatment of generalized candidiasis, are advised to take 6–12 mg per 1 kg of weight per day.

For patients with oropharyngeal candidiasis , 50 mg to 100 mg of Fluconazole is indicated once a day, the treatment period is 1-2 weeks.

People suffering from atrophic candidiasis of the oral mucosa are advised to take 50 mg once a day. Treatment is combined with the use of local products for the treatment of prostheses. When treating other candidiasis infections of the mucous membranes, 50–100 mg per day is prescribed, the period of therapy is from 14 to 30 days.

In order to prevent the development of relapses of oropharyngeal candidiasis in people with AIDS , 150 mg once a week is indicated. If mucosal candidiasis develops in children, the dose should be taken at the rate of 3 mg of drugs per 1 kg of weight per day. On the first day, you can give your child a double dose.

Patients with cryptococcal infections and cryptococcal meningitis are usually prescribed 200–400 mg of drugs once a day. On the first day, 400 mg of the drug is indicated. The duration of treatment can be from 6 to 8 weeks. Children are prescribed a dose of 6–12 mg per 1 kg of weight per day.

People suffering from infectious skin diseases are recommended to prescribe 150 mg once a week or drink 50 mg of the drug once a day. Treatment should be continued for 2-4 weeks. For men and women with mycosis of the feet , longer therapy is sometimes required - up to 6 weeks.

Patients with pityriasis versicolor are recommended to take 300 mg once a week, the treatment period is 2 weeks. Depending on the intensity of your symptoms, your doctor may prescribe another dose of Fluconazole in the third week. It is possible to use another treatment regimen - 50 mg 1 time per day, the treatment period is two to four weeks.

Patients with onychomycosis are prescribed 150 mg once a week. Therapy should continue until a healthy nail grows in place of the diseased nail.

People suffering from deep endemic mycosis sometimes undergo a long course of treatment with the drug, which can last up to two years. The dose per day is 200–400 mg.

Instructions for the use of fluconazole for thrush stipulate that for vaginal candidiasis, a single dose of the drug is taken, its dose is 150 mg.

As a rule, Fluconazole for thrush is effective after a single dose. But your doctor will tell you more about how to take Fluconazole for thrush after an individual consultation. Before determining how to take any medicine for thrush if you have thrush, the specialist takes into account the causes of the disease and the individual characteristics of its course. For chronic thrush, Fluconazole Teva or other types of the drug are prescribed to prevent relapses at a dose of 150 mg once a month. The product should be used for 4-12 months. For the purpose of prevention, capsules are prescribed in a dose of 50–400 mg once a day, depending on how high the risk of the disease is. For children with thrush, Fluconazole tablets are prescribed at a dose of 3–12 mg of medication per 1 kg of weight per day. How much to drink depends on the severity of the infection.

For balanitis, the treatment regimen for men is as follows: the drug should be taken in a dose of 150 mg once.

Some patients are interested in whether it is possible to take pills or capsules during menstruation. According to experts, you can take Fluconazole at any time, regardless of your monthly cycle. How long it takes for the medicine to help depends on the intensity of the symptoms of the disease.

Can Fluconazole be used during breastfeeding and pregnancy?

The use of the drug during pregnancy should be avoided, with the exception of severe or life-threatening systemic fungal infections, when the expected benefit of therapy for the mother outweighs the possible risk to the fetus.

Women of childbearing age should also use reliable methods of contraception during treatment with Fluconazole and for at least a week after taking the last dose. Since there is information about cases of spontaneous abortion and the appearance of congenital pathologies in children whose mothers received Fluconazole at a dose of 150 mg once or repeatedly in the first trimester of pregnancy.

When pregnant women take increased doses for a long time in the first trimester, the number of defects in infants also increases: curvature of the femurs, impaired formation of the cranial vault, brachycephaly, impaired development of the facial part of the skull, cleft palate, thinning and elongation of the ribs, arthrogryposis and congenital heart defects.

Fluconazole passes into breast milk, so use during breastfeeding is prohibited.

Interaction

Before starting treatment, it is important to know not only what Fluconazole in tablets and other forms helps with, but also about the interaction of drugs with other drugs.

When taking Warfarin , the prothrombin time of fluconazole becomes longer.

With simultaneous administration of hypoglycemic oral agents belonging to the group of sulfonylurea derivatives, the half-life of Fluconazole increases. As a result, there is a possibility of hypoglycemia.

With simultaneous administration of phenytoin, a clinically significant increase in phenytoin concentrations is observed.

With simultaneous repeated use of hydrochlorothiazide, an increase in the concentration of fluconazole in the blood is observed. There is no need to change the dosage.

With simultaneous treatment with Rifampicin, AUC decreases by 25%. The half-life is also reduced by 20%. In some cases, the doctor decides to increase its dose.

When treating with Fluconazole, monitoring the concentration of cyclosporine in the blood is recommended.

If the patient simultaneously receives high doses of Theophylline , it is important to consider the possibility of Theophylline overdose.

It is contraindicated to take a dose of more than 400 mg per day in combination with terfenadine .

When taking cisapride , negative side effects from blood vessels and the heart may occur, in particular, paroxysms of ventricular tachycardia .

If Fluconazole and Zidovudine , the patient should be monitored by a doctor, as the side effects of Zidovudine may increase.

If treatment with Astemizole , cisapride , Tacrolimus , Rifabutin , or any other drug that is metabolized by the cytochrome P450 system is simultaneously prescribed, the concentration of these drugs in the blood may increase.

The absorption of Fluconazole is not affected by simultaneous administration of Cimetidine or antacids.

Using fluconazole: what you need to know before you start taking it

You should not take fluconazole if you are hypersensitive to fluconazole or to any of the excipients of this drug.

Before you start taking fluconazole, you should consult your doctor about any contraindications for you, for example:

problems with the hepatobiliary system (increased liver enzymes ALT (alanine aminotransferase) and AST (aspartate aminotransferase), jaundice, hepatitis, liver failure);
if you are taking medications that, when taken simultaneously with fluconazole, can have a cardiotoxic effect (negative effect on the heart), such as:
terfenadine, astemizole (antiallergic drugs);
amiodarone, quinidine (antiarrhythmic drugs);
cisapride (gastrointestinal motility stimulant);
pimozide (neuroleptic (antipsychotic drug));
erythromycin (a macrolide antibiotic).

Note!

The above drugs, when taken simultaneously with fluconazole at a dosage of over 400 mg, worsen the heart rhythm in the form of negative changes in the ECG (electrocardiogram), such as prolongation of the QT interval, resulting in an increase in heart rate at rest from 90 beats per minute (tachycardia ).

Pregnant women should use fluconazole only after consulting a doctor to determine the balance of benefit for the mother and risk to the fetus. Breastfeeding is allowed if you take a single dose of 200 mg fluconazole, but since it still passes into breast milk, subsequent use should be prescribed by a doctor, if necessary.

Fluconazole should be used strictly as prescribed by a doctor and in accordance with the specified instructions, since improper use and non-compliance with the course of treatment can lead to frequent relapses of fungal infections.

special instructions

If liver dysfunction is observed during treatment, constant monitoring by a physician is important. If signs of liver damage are observed, the medication should be discontinued.

When using the medicine topically for men and women, it should be taken into account that people with AIDS are more likely to develop a variety of skin reactions.

It is necessary to take into account not only how long it takes for Fluconazole to act, but also the fact that if treatment is stopped prematurely, relapses may develop. Therefore, it is important to completely complete the prescribed treatment regimen. It is important to take this into account when using Fluconazole for nail fungus, since reviews for nail fungus indicate that if treatment is stopped prematurely, a relapse of the disease may occur.

Many patients have a question about whether Fluconazole is an antibiotic or not? Please note that this is an antifungal agent, not an antibiotic.

Whether men can take this drug depends on the diagnosis. Fluconazole for men is prescribed for fungal infections; it must be taken exactly as prescribed.

Material and methods

The study was carried out as part of L.P.’s dissertation work. Kotrekhova for the degree of Doctor of Medical Sciences from 2008 to 2013. The study protocol was approved at a meeting of the Local Ethics Committee of the St. Petersburg Medical Academy of Postgraduate Education in January 2008.

The design of the study was single-center, prospective, randomized, open and comparative.

The location of the study was the Department of Dermatovenereology, the Mycological Clinic and the Research Institute of Medical Mycology named after. P.N. Kashkin Northwestern State Medical University named after. I.I. Mechnikov.

Inclusion criteria for the study were:

— availability of informed consent;

— age of patients from 18 years and older;

— onychomycosis of the feet, caused by dermatomycetes and confirmed by positive results of mycological studies (direct microscopy using a 10% KOH solution and culture on Sabouraud’s medium);

- damage to more than two nail plates of the feet;

— affected area is more than 50%;

- one or more unfavorable prognostic factors: damage to the nail matrix, the presence of dermatophytes, onycholysis of more than 25% of the nail area, nail thickness more than 2 mm, nail growth less than 1 mm within 8 weeks.

Exclusion criteria from the study were lack of informed consent, patient age less than 18 years; lack of laboratory confirmation of onychomycosis; pregnancy and lactation; alcohol and drug addiction; mild onychomycosis that does not require systemic antifungal therapy; impaired liver and kidney function; intolerance to the components of the study drugs (terbinafine, itraconazole, fluconazole, amorolfine).

After calculating the required volume of study groups (at least 130 patients in each) with a study power of 90%, the level of statistical significance p

=0.05 and a standardized difference of 0.4, 150 patients with onychomycosis of the feet (300 people in total) were randomized into the study groups.

Combination therapy included hardware nail cleaning with the removal of all affected areas of the nail plate using a milling cutter (at the beginning of treatment, then once every 1.5 months); prescribing fluconazole ( Diflucan

) at a dose of 150 mg per week for a period of 26 weeks (6 months) and the use of varnish with amorolfine (Loceryl) 2 times every 7 days for 26 weeks.
Monotherapy consisted of fluconazole ( Diflucan
) at a dose of 150 mg per week for 26 weeks (6 months).

The study protocol required six scheduled patient visits. At the 1st visit (screening), the patient signed informed consent and then underwent a physical examination, verification of compliance with inclusion and exclusion criteria, blood and urine collection for laboratory tests, and collection of nail plates for mycological studies. All patients underwent tests at the 1st visit: general urine analysis, clinical and biochemical (alanine aminotransferase, aspartate aminotransferase, bilirubin, creatinine) blood test.

2 weeks after the 1st visit (after receiving the results of mycological studies, blood and urine tests), a 2nd visit was scheduled. The patient's compliance with the criteria for inclusion or exclusion from the study and the effectiveness of treatment of onychomycosis with the combined method were re-checked. After this, a randomization procedure was carried out using a random number generator program (Statistica for Windows version 5.5, license No. AXXR402C29502 3FA) and the patient was assigned to one of the study groups. Patients of group 1 received combination therapy with fluconazole and 5% varnish with amorolfine. Patients of group 2 received therapy only with fluconazole. Before prescribing antifungal therapy at the 2nd visit, patients of group 1 underwent hardware treatment of the affected nail plates. At this visit, all patients were given observation diaries, where they had to note taking the drug, applying varnish, and adverse events if they developed undesirably.

The 3rd visit took place 6 weeks after the start of treatment. At this visit, patients underwent control blood tests (clinical and biochemical), urine (general), the diary was checked (compliance) and adverse events were noted. If they developed, the possibility of continuing systemic therapy was assessed. If it was impossible to continue taking a systemic antimycotic, the patient was excluded from the study.

12 weeks from the start of therapy there was a 4th visit, at which patients underwent control blood tests (clinical and biochemical), urine, the diary was checked (compliance) and adverse events were noted.

At the 5th visit (26 weeks from the start of therapy), nail plates were collected for mycological examination and diaries were checked to record adverse events when using varnish with amorolfine (Loceryl). One week before the last visit at week 25, patients stopped using the antifungal varnish. Based on the results of the mycological study, an intermediate assessment of the effectiveness of treatment was carried out: mycological, clinical and complete.

At the final 6th visit (52 weeks from the start of treatment), nail plates were collected and mycological examination was performed. Based on the results of the mycological study, the final assessment of the effectiveness of treatment was determined: mycological, clinical and complete.

During the study, the following methods of statistical analysis were used: determination of numerical characteristics of variables; assessment of compliance with the law of normal distribution using the Kolmogorov-Smirnov criterion; comparison of frequency characteristics of qualitative indicators using nonparametric methods Pearson Chi-square (χ2), in case of instability, a two-sided Fisher exact test was used. Comparison of quantitative parameters in the study groups was carried out using the Mann-Whitney tests. The difference in values was considered significant at the significance level p

<0,05.

Fluconazole analogs

Level 4 ATC code matches:
Medoflucon

Vfend

Itracon

Mikosist

Irunin

Mikomax

Orungal

Mycoflucan

Sporagal

Orungamin

Flucostat

Difluzol

Rumicosis

Futsis

Vero-Fluconazole

Kandizol

Kanditral

Itraconazole

Diflazon

Fluconazole analogues are products with a similar active ingredient. The price of analogues depends on the manufacturer and the form of release of the drug. There are a number of analogues of this drug:

Diflazon
Diflucan
Vero-Fluconazole
Mikomax
Flucostat

Which is better: Fluconazole or Diflucan?

Often patients compare two drugs with antifungal action - Fluconazole and Diflucan . What is the difference between these medicines? Both drugs are based on the active substance fluconazole. Diflucan is available in tablets of 50 mg, 100 mg, 150 mg, and other forms. But the price of Diflucan is much higher.

Flucostat or Fluconazole - which is better?

Speaking about how Flucostat from Fluconazole, it should be noted that both drugs contain the same active substance. Flucostat is a more expensive medicine. What is the difference between these medications, and which one is best prescribed in a particular case, is determined by a specialist. As a rule, Fluconazole is more often prescribed when prophylaxis is necessary for cancer patients after radiation and chemotherapy.

Fluconazole or Nystatin - which is better?

Nystatin is an antifungal drug, an antibiotic, active against candida bacteria. Under the influence of Nystatin, the permeability of the membrane of fungal cells is disrupted, which contributes to disruption of their growth and reproduction. Which drug is preferred in a particular case depends on the diagnosis and the doctor’s prescription.

conclusions

1. Efficiency (mycological, clinical, complete) of combination therapy, including hardware cleaning of nails, taking the systemic antimycotic fluconazole ( Diflucan

), applying varnish with amorolfine (Loceryl) is higher than monotherapy with the systemic antimycotic fluconazole (
Diflucan
) in patients with onychomycosis of the feet, which occurs with prognostically unfavorable clinical manifestations.

2. The high safety profile of fluconazole allows it to be prescribed for the treatment of onychomycosis of the feet in patients with a high risk of developing adverse events.

Reviews about Fluconazole

Due to the high fungicidal activity of this drug, patient reviews and doctors' reviews of Fluconazole are mostly positive. Patients, leaving reviews about Fluconazole Teva, as well as reviews about Fluconazole Stada on the forums, write that the drug helps to quickly and effectively eliminate the symptoms of fungal diseases. Users mention that the tablets are relatively inexpensive, but at the same time they allow you to completely get rid of nail fungus and other unpleasant diseases. In some cases, it is enough to take Fluconazole 150 mg once to completely overcome the symptoms of the disease.

Very often, women write positive reviews about Fluconazole for thrush . It is noted that the medicine not only relieves thrush, but also helps prevent relapses of the disease.

How to take Fluconazole for thrush?

With this pathology, patients can purchase medicine without a prescription and on the advice of a pharmacist. If you visit a doctor, he will confidently prescribe Fluconazole even before receiving test results for pathogens. Later, if the examination results are available, the doctor will only need to adjust the treatment regimen, or continue the chosen tactics. Fluconazole capsules help very quickly.

When taken orally, the level of bioavailability of the drug is as high as when administered intravenously, so it is enough to take one 150 mg capsule once with water. To prevent symptoms from returning, it is possible to take the drug every three days, with a total of 3 doses - on days 1, 4 and 7.

Fluconazole can begin to work within a day. In particular, the manufacturer of the original drug Pfizer (Diflucan) specifically reports that relief occurs within 24 hours. However, it is necessary to consult a doctor in order to exclude the presence of other pathogenic agents.

Fluconazole 150 mg

Thrush itself is not a sexually transmitted infection. Candidiasis develops against a background of reduced immunity, for example, after using antibiotics, when wearing synthetic underwear, during periods of very hot weather and even under stress. During a visit to the doctor, patients must be informed about the presence of a sexual partner so that preventive or therapeutic measures can be prescribed.

Women often ask the question: can cystitis appear from thrush? In this case, only the doctor can give an objective answer. The development of cystitis against the background of thrush is a very real scenario if the patient ignores visiting a specialist. Yeast-like fungi travel from the urethra to the bladder and cause inflammation there. Symptoms of vaginal candidiasis and cystitis may be similar. In the future, the infection from the bladder can reach the kidneys and there lead to acute renal failure. Therefore, therapy must be started on time. Sometimes women do not have candidiasis, but it develops after treating cystitis with antibiotics. A doctor will help correct the unpleasant effect.

Fluconazole price, where to buy

The price of Fluconazole tablets depends on the packaging and manufacturer. You can buy Fluconazole in Moscow at prices ranging from 40 to 140 rubles. Capsules 150 mg (1 piece in a package) can be purchased for 140 rubles. Capsules 50 mg can be purchased for 60 rubles (pack of 7 pieces)

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

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