Indocollir eye drops: instructions for use, price, analogues and reviews

Pharmacodynamics and pharmacokinetics

The main mechanism of action of Indocollyr is inhibition of prostaglandin as a key step in the pathogenesis of inflammation and pain by reducing the activity of the cyclooxygenase with indomethacin . Indomethacin is by its nature a non-steroidal anti-inflammatory drug , which, when applied topically, can reduce the intensity of the development of the inflammatory process and the severity of pain, acting by the mechanism of inhibition of the generation and conduction of pain impulses through nerve structures. In addition, indomethacin reduces the synthesis of thromboxane type A, which causes an increase in bleeding time.

Pharmacokinetics

Instillation into the conjunctival sac leads to negligible systemic absorption of indomethacin.

INDOCOLLIR eye drops 0.1% vial - cap. 5 ml

special instructions

Although the systemic absorption of indomethacin when applied topically as eye drops is negligible, the risk of drug interactions with other drugs cannot be completely excluded.
Indirect anticoagulants, other NSAIDs, diflunisal, heparin.

It is known that the use of indomethacin in other dosage forms simultaneously with indirect anticoagulants, other non-steroidal anti-inflammatory drugs in their daily dose of 3 g and above (including salicylic acid derivatives, for example, acetylsalicylic acid, etc.), diflunisal and heparin increases the risk of gastrointestinal tract infections. intestinal tract ulcers and bleeding, and in combination with diflunisal, even fatal.

In turn, diflunisal can increase the concentration of indomethacin in the blood plasma.

Lithium preparations.

Indomethacin may increase the concentration of lithium in the blood to toxic levels due to a decrease in lithium excretion by the kidneys.

Methotrexate (at a dose of 15 mg per week or more).

Due to a decrease in the excretion of methotrexate by the kidneys when taken simultaneously with indomethacin and/or other anti-inflammatory drugs, its hematotoxic effect increases.
Indomethacin is used with caution with methotrexate (at a dose of less than 15 mg/week) -
weekly monitoring of blood counts is necessary in the first weeks of combined use, as well as monitoring for renal dysfunction, especially in the elderly.

Ticlopidine.

Indomethacin enhances the antiplatelet effect of ticlopidine and increases the risk of bleeding.

Indomethacin when used in combination with beta-blockers

may weaken their effect.

Indomethacin may enhance the nephrotoxic effect of cyclosporine

, especially in elderly patients.

NSAIDs may enhance the antidiuretic effect of desmopressin

Use caution when concomitantly using indomethacin with diuretics

and
ACE inhibitors
, since in dehydrated patients there is a risk of acute renal failure (due to decreased glomerular filtration rate by inhibition of vasodilatory prostaglandins after taking NSAIDs) and reduced antihypertensive effect.

In such situations, it is necessary to provide the patient with water and monitor kidney function at the beginning of treatment.

Combined use with pentoxifylline -

increased risk of bleeding from the gastrointestinal tract (use under medical supervision and control the duration of bleeding).

Drugs that affect the gastrointestinal mucosa (salts, oxides and hydroxides of magnesium, aluminum and calcium)

reduce the absorption of indomethacin from the gastrointestinal tract; separate administration with antacids is recommended (if possible, an interval of more than 2 hours).

NSAIDs, including indomethacin, may increase the toxic effects of zidovudine

on reticulocytes with transition to acute anemia 8 days after the start of NSAID therapy.

Combined use with thrombolytics increases the risk of bleeding.

There is an assumption that when using indomethacin there is a possible risk of rupture of the implantable intrauterine device.
When using the drug Indocollir simultaneously with other eye drops, including those containing corticosteroids, to avoid the washout effect (decrease in concentration), the drugs should be administered at intervals of at least 15 minutes.

Indications for use

It is used to inhibit miosis during surgical interventions on the anterior chamber of the eye, including cataracts , and also as a prophylactic agent for cystoid macular edema in the postoperative period.
Other surgical interventions on the eyeball - prevention and treatment of various etiologies of inflammatory processes.
In the treatment of non-infectious conjunctivitis .
In the presence of pain after photorefractive keratectomy .
In combination with local antimicrobial therapy, it is used for the treatment or prevention of post-traumatic inflammatory processes resulting from wounds of the eyeball, including penetrating ones.

Contraindications

Hypersensitivity to the constituent components of the drug Indocollyra, as well as to acetylsalicylic acid or other NSAIDs. As a result, attacks of bronchial asthma , the development of urticaria or acute rhinitis .
Should not be used from 6 months. pregnancy or breastfeeding.
Eye drops are contraindicated in patients with peptic ulcers or impaired functioning of the kidneys and liver.
The drug is not used in pediatrics.

Indocollir is prescribed with caution if the patient:

epithelial herpetic keratitis ;
hemophilia , prolonged bleeding time is observed, or other diseases associated with blood clotting disorders are diagnosed.

INDOCOLLIR (drops)

, which has an analgesic effect (what I needed).
The box contains detailed information about the composition and amount of the active substance. Production abroad, as indicated by the barcode. Hence the not the most affordable price (about 350). I'm sure you can find analogues at a more attractive price. I, as an obedient patient, strictly adhered to the recommendations of my attending physician.

"Indocollir" has a fairly wide range of indications - from the treatment of conjunctivitis to the prevention of inflammatory processes after operations. At the same time, it has many contraindications and side effects. For example, it is not recommended during breastfeeding. Unfortunately, I cannot post complete instructions for use, as moderators will delete them. You can find this information on the Internet, fortunately it is there.

Please note that the expiration date is only 15 days after opening. For this reason, more than half of the drops became unusable. Not very economical.

The drops themselves are in a small bottle made of transparent plastic. The walls of the bottle are tight and dense, so it will take some effort to squeeze out a drop. At first I couldn’t get used to the dosage, but over time I adjusted.

The spout through which the medicine is delivered is narrow, and the dispenser is small in diameter. This allows you to avoid spilling the contents in case of a fall.

What are these drops? This is a translucent ivory-colored liquid with a specific (hospital) odor. During storage, a barely noticeable sediment forms at the bottom of the bottle.

And now about my treatment. I had a chalazion on the lower eyelid (inside) of my right eye. It is worth noting that it was small in size, so it was invisible to others. And everything would be fine, but it caused me discomfort. I repeat, the treatment given at the beginning of my review did not produce any particular results. “Indocollir” I dripped 4 times a day into the conjunctival sac, as prescribed by the ophthalmologist. When instilled, the drops did not cause burning or tingling, only a temporary loss of clarity of vision, which passed within a minute. In the first days, the drug helped me a lot. It eliminated pain perfectly, and the unpleasant “nodule” on the eyelid became smaller in size. However, on days 6-7 the positive dynamics went away. Either my body got used to the medicine, or something else, but I never managed to get rid of the sore completely. From time to time the eye hurt, but the lump did not go away. From all of the above, I conclude that the drops eliminate the symptoms of chalazion. More serious measures are required for complete recovery. Physiotherapy is excellent, and sunbathing also helps. Don’t forget about immunity, because it is a failure in this system that provokes all sorts of troubles, so strengthen your immunity.

To summarize, let me remind you about the pros and cons of Indocollir eye drops.

Pros:

+ indicated for many eye diseases; + does not burn the mucous membrane and does not cause side effects (individually); + helped me alleviate the condition (relieved pain and inflammation).

Minuses:

- high price; - short shelf life; - in my case it did not cure completely.

Despite my not very successful experience with this drug, I will recommend it, but for the treatment of other diseases indicated in the instructions.

Thank you for your attention. Good health and good mood to you!

Indocollir eye drops, instructions for use (Method and dosage)

Indocollir for inhibition of intraoperative miosis should be instilled 1 drop. into the conjunctival sac before surgery 4 times within 2 hours, that is, the interval is at least 30 minutes.

As a prophylactic for cystoid macular edema, 1 drop should be instilled. 3-4 times a day for 1 month after the operation.

Instructions for use of Indocollir for other indications: 1 drop. 3-4 times a day for 1-4 weeks. The dosage of treatment and duration may vary depending on the severity of the condition and the course of the disease.

Indocollir (vial-drops 0.1% 5ml eye drops)

A country

Germany, France
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.

Active substance

Indomethacin + Troxerutin

Compound

Active ingredient: indomethacin 1 mg/1 ml.

pharmachologic effect

Indocollyr is a non-steroidal anti-inflammatory drug and has anti-inflammatory and analgesic effects. The main mechanism of action of the drug is inhibition of the synthesis of prostaglandins, which play an important role in the pathogenesis of inflammation and pain. Pharmacokinetics: There is confirmed evidence that the drug penetrates the anterior chamber of the eye. With a single instillation, the active substance of the drug is determined in the moisture of the anterior chamber for several hours. When the drug is applied topically, systemic absorption is low.

Indications for use

Inhibition of miosis during cataract surgery; treatment and prevention of inflammatory processes after surgical interventions on the eyeball; prevention of cystoid macular edema after cataract surgery; treatment of non-infectious conjunctivitis; treatment and prevention of post-traumatic inflammatory process in penetrating and non-penetrating wounds of the eyeball (as addition to local anti-infective therapy).

Mode of application

To inhibit intraoperative miosis, the drug is instilled 1 drop into the conjunctival sac for 2 hours with an interval of 30 minutes (4 times) before surgery. To prevent cystoid macular edema, the drug is instilled 1 drop 3 - 4 times a day for 1 month after surgery. Other indications: 1 drop 3-4 times a day, depending on the severity of the condition. The course of treatment can last from 1 to 4 weeks.

Interaction

The drug may enhance the effect of indirect anticoagulants, lithium. The simultaneous use of this drug with diflunisal (as bleeding from the gastrointestinal tract may develop) and other non-steroidal anti-inflammatory drugs, including acetylsalicylic acid in large doses (3 g or more per day) is not recommended. The simultaneous use of indomethacin with beta-blockers and saluretics may weaken the effect of the latter. If necessary, it can be used simultaneously with other eye drops, including those containing glucocorticosteroids. In this case, the break between applications should be at least 5 minutes to prevent leaching of the active substances with subsequent doses.

Side effect

In rare cases, the following undesirable side effects were noted during the use of the drug: mild or moderate burning and/or temporary loss of clarity of vision immediately after instillation of eye drops; local skin hypersensitivity reactions in the form of itching and redness. With prolonged use of the drug, systemic side effects may develop .

Contraindications

Increased individual sensitivity to the active substance of the drug or to any auxiliary ingredients included in this dosage form of the drug; the drug is contraindicated in patients in whom acetylsalicylic acid or other non-steroidal anti-inflammatory drugs provoke the development of attacks of bronchial asthma, the appearance of urticarial rash, acute rhinitis, etc. .

Overdose

Accidental ingestion does not pose a risk of unwanted side effects.

special instructions

The drug should be used with caution in the following pathologies: epithelial herpetic keratitis (including a history); diseases that cause blood clotting disorders (including hemophilia, prolonged bleeding time, bleeding tendency). Use during pregnancy and/or during breastfeeding. Currently, there are no well-controlled studies in pregnant women confirming the safety of this dosage form of this drug during pregnancy and breastfeeding. However, the drug can be used in the first 5 months of pregnancy if the expected benefit to the mother outweighs the possible risk to the fetus. Starting from the 6th month of pregnancy, the drug should not be used, as this can lead to dysfunction of the vascular system and kidneys in the fetus. The drug passes into breast milk, so you should stop breastfeeding during treatment with the drug or avoid its use during breastfeeding. Patients using contact lenses should use the drug only with the lenses removed and can put them on 15 minutes after instillation of the drug. Patients who temporarily lose clarity of vision after application are not recommended to drive a car or work with complex equipment, machines or any other complex equipment that requires clear vision immediately after instillation of the drug. The bottle must be closed after each use. Do not touch the tip of the pipette to your eye.

Dispensing conditions in pharmacies

On prescription

Interaction

Indocollir can be used simultaneously with other eye drops, including those containing glucocorticosteroids . However, to prevent washout of indomethacin with subsequent doses, the recommended interval between instillations is at least 5 minutes. In addition, the interaction of various drugs with Indocollir causes the following effects:

anticoagulants , lithium preparations - potentiation of their indirect effects;
diflunisal - can lead to the development of bleeding from the gastrointestinal tract;
saluretics , β-blockers - weakening of their effects.

Indocollyre

Although the systemic absorption of indomethacin when applied topically as eye drops is negligible, the risk of drug interactions with other drugs cannot be completely excluded.

Indirect anticoagulants, other NSAIDs, diflunisal, heparin.

In turn, diflunisal can increase the concentration of indomethacin in the blood plasma.

Lithium preparations.

Indomethacin may increase the concentration of lithium in the blood to toxic levels due to a decrease in lithium excretion by the kidneys.

Methotrexate (at a dose of 15 mg per week or more).

Ticlopidine.

Indomethacin enhances the antiplatelet effect of ticlopidine and increases the risk of bleeding.

Indomethacin when used in combination with beta-blockers

may weaken their effect.

Indomethacin may enhance the nephrotoxic effect of cyclosporine

, especially in elderly patients.

NSAIDs may enhance the antidiuretic effect of desmopressin

Use caution when concomitantly using indomethacin with diuretics

In such situations, it is necessary to provide the patient with water and monitor kidney function at the beginning of treatment.

Combined use with pentoxifylline -

increased risk of bleeding from the gastrointestinal tract (use under medical supervision and control the duration of bleeding).

Drugs that affect the gastrointestinal mucosa (salts, oxides and hydroxides of magnesium, aluminum and calcium)

reduce the absorption of indomethacin from the gastrointestinal tract; Separate administration with antacids is recommended (if possible, an interval of more than 2 hours).

NSAIDs, including indomethacin, may increase the toxic effects of zidovudine

on reticulocytes with transition to acute anemia 8 days after the start of NSAID therapy.

Combined use with thrombolytics increases the risk of bleeding.

There is an assumption that when using indomethacin there is a possible risk of rupture of the implantable intrauterine device.
When using the drug Indocollir simultaneously with other eye drops, including those containing corticosteroids, to avoid the effect of “washing out” (decrease in concentration), the drugs should be administered at intervals of at least 15 minutes.

During pregnancy and lactation

There have been no detailed clinical studies of Indocollir for the safety of use during pregnancy or lactation. However, the use of the drug in the first 5 months is acceptable. pregnancy under the supervision of the attending physician, provided that the potential benefit of treatment for the mother is significantly higher than the possible risk to the fetus. In the future, from the 6th month, eye drops are contraindicated, since the fetus may experience dysfunction of the cardiovascular, respiratory or kidney systems.

The active substance, indomethacin , is excreted in mother's milk, therefore, if necessary, therapy is carried out by stopping breastfeeding.

Analogues of Indocollir

Level 4 ATX code matches:
Nevanak

Analogues and generics of Indocollyr come in different pharmacological forms (suppositories, ointment), their anti-inflammatory and analgesic effect is possible due to the presence of the same chemically active substance in the composition of the drugs - indomethacin. Among them are known:

Indomethacin
Indomethacin-Health
Methindol retard

Among the eye drops of similar action are:

Akuvail
Nevanak
Uniclofen

Indocollier price, where to buy

The average price of Indocollir eye drops is 340 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

Pharmacy Dialogue

Indocollier (vial-drops 0.1% 5ml main drops)Laboratoire Chauvin SA
RUR 484 order

Pharmacy24

Indocollir 0.1% 5 ml drops Laboratory Chauvin / Dr. Gerhard Mann Chem.-Pharm.
Fabrik GmbH, France/Nimechina 114 UAH.order