Furacilin (nitrofural) is a local antimicrobial agent that effectively fights various pathogenic microorganisms. This antiseptic is used to treat inflamed, injured and burned areas of the skin. There are several forms of release of this drug. The most common of these are tablets. A solution for external use is made from tablets, which retains antibacterial properties for only a short time. How and for how long you can store furatsilin in tablets or in the form of a suspension, read this review.
What is Furacilin for?
The drug is prescribed to be taken in order to prevent the start of the decomposition process on the surface of open lesions, for washing the nose, throat and eyes, when cavities become infected with microbes.
Indications include:
- purulent wounds;
- burns;
- bedsores;
- cuts, cracks in the skin;
- inflammatory processes of the outer part of the eye;
- inflammatory reactions in the oral cavity.
Also, each individual form of the drug may have its own indications.
Furacilin (Furacilinum)
5-Nitrofurfural semicarbazone.
Description: Yellow or greenish-yellow fine-crystalline powder with a bitter taste.
Solubility: Very slightly soluble in water, slightly soluble in alcohol, soluble in alkalis.
Authenticity:
Furacilin gives all the reactions characteristic of nitrofuran drugs.
A reaction (non-pharmacopoeial) has been described for furatsilin, which distinguishes it from all other drugs of the nitrofuran series - this is a reaction with resorcinol in a hydrochloric acid environment. When the reaction mixture is heated and subsequently made alkaline, fluorescence is observed, which increases with the addition of isoamyl alcohol.
Quantitation:
Using the reverse iodometry method: a sample of the drug is dissolved in water when heated in a water bath. For better solubility, sodium chloride is added. Then an excess of titrated iodine solution and 0.1 ml of NaOH solution are added to a certain amount of this solution.
Oxidative decomposition of the hydrazine group to nitrogen occurs:
In an alkaline environment, iodine can react with alkali and produce hypoiodides:
I2 + 2NaOH à NaI + NaIO + H2O
When sulfuric acid is added, iodine is released, which, together with the excess titrated solution I2, is titrated with sodium thiosulfate:
NaI + NaIO + H2SO4 à I2 + Na2SO4 + H2O
I2 + 2Na2S2O3à 2NaI + Na2S4O6
Impurities:
GF10 allows: chlorides, sulfates, heavy metals, and arsenic within the standard.
The drug may contain an admixture of semicarbazide, which is determined with Fehling's solution. Since this impurity is unacceptable in the preparation, when adding Fehling’s reagent and heating, a red precipitate of cuprous oxide should not form.
Storage: List B. In well-closed dark glass jars in a cool place, protected from light.
Application: Prescribed externally for the treatment and prevention of purulent-inflammatory processes and internally for the treatment of bacterial dysentery.
Release form: powder; tablets of 0.1 g for oral administration and 0.02 g for - preparation of a solution (for external use), 0.2% ointment.
Furadoninum (Furadonin)
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin.
Description: Yellow or orange-yellow crystalline powder, bitter in taste.
Solubility: Practically insoluble in water and alcohol.
Authenticity:
1. With an alkali solution, a dark red color is observed.
2. When the drug is dissolved in a freshly prepared solution of dimethylformamide, a yellow color appears, which when adding 2 drops of 1 N. alcohol solution, KOH turns brown-yellow.
Quantitation:
According to GF10, it is determined photoelectrocolorimetrically (GF10 p. 322).
Storage: in a dry place, protected from light.
Application: The drug is effective in the treatment of urinary tract infections. Indications: pyelitis, pyelonephritis, cystitis, urethritis. It is also used to prevent infections during urological operations, cystoscopy, catheterization, etc.
Release form: tablets of 0.05 g, tablets of furadonin, soluble in the intestines, 0.1 g of yellow tablets with an orange or greenish tint with a score; tablets, soluble in the intestines, 0.03 g for children.
Furazolidonum (Furazolidone)
N - (5-Nitro-2-furfurylidene) - 3-aminooxazolidone-2.
Description: Yellow or greenish-yellow powder, odorless, slightly bitter taste.
Solubility: Practically insoluble in water, very little in alcohol.
Authenticity:
1. When heated with an alkali solution, a brown color is observed, which is due to the presence of an easily hydrolyzed oxazolidone ring in the furazolidone molecule. Adding an alkali causes the ring to rupture to form a water-soluble colored compound:
2. When the drug is dissolved in the org. solvents and the addition of an alcoholic alkali solution, a violet color appears. When the concentration changes, the color changes.
Quantitation:
GF10 prescribes the use of the photocolorimetry method (GF10 p. 322).
Storage: list B. In a dry place, protected from light.
Application: Effective against gram-positive and gram-negative bacteria. In addition, it has anti-trichomoniacal activity. The drug is also effective for giardiasis. Among the causative agents of intestinal infections, the most sensitive to furazolidone are the causative agents of dysentery, typhoid fever and paratyphoid fever. Relatively weak effect on pathogens of purulent and anaerobic infections. One of the positive features of furazolidone is that resistance of microorganisms to it develops slowly.
Release form: tablets of 0.05 g in a package of 20 pieces.
Furaginum (Furagin)
N-(5-Nitro-2-furyl)-allylideneaminohydantoin.
Description: Yellow or orange-yellow finely crystalline powder, odorless, bitter taste.
Solubility: Practically insoluble in water and alcohol.
Storage: list B. In a dry place, protected from light.
Application: Use internally and topically. It is prescribed orally mainly for diseases of the urinary tract (acute and chronic pyelonephritis, cystitis, urethritis, infections after surgical interventions on the genitourinary system, etc.).
Release form: powder; tablets of 0.05 g in a package of 100 pieces.
How to gargle with Furacilin for a sore throat
The drug has proven itself well for tonsillitis and sore throat. Furacilin is not a replacement for primary treatment, but can significantly improve your well-being. With constant rinsing, harmful organisms and pus will gradually come out. The constituent elements are not absorbed into the blood, so it can be taken at any age and during pregnancy.
To rinse your throat, you need to crush the tablet and fill it with 100 ml of water. To enhance the effect of the solution, add 2 tsp to it. hydrogen peroxide (3%).
You need to gargle for 3 minutes. For one procedure, it will be enough to use ½ cup of solution. Before use, you need to rinse your mouth with baking soda.
FURACILIN. Furacilinum.Synonyms: aldomycin, nefko, furatsin, furalon, furasol, flavazone, hemofuran, nitrofural, nitrofuran, nitrofurazone, nifuran, otofural, vatrocin, etc.
Properties.
Yellow or greenish-yellow finely crystalline powder, bitter in taste, poorly soluble in water (1:4200), slightly soluble in alcohol and well in organic solvents and alkalis (solubility increases when heated). Thermally stable. Aqueous solutions lose their antimicrobial activity during long-term storage.
Release form. Available in powder, tablets of 0.02 and 0.1 g and in the form of an ointment of 0.2% on Vaseline.
Store with caution (list B), in well-sealed dark glass jars, in a cool place. Shelf life: 10 years.
Action and application.
Active against pathogens of anaerobic infection, gram-positive and gram-negative bacteria (staphylococci, streptococci, dysentery bacillus, paratyphoid bacillus). In the presence of pus and blood serum, the activity of furatsilin does not decrease.
The drug is used externally in surgical and ophthalmic practice for the treatment and prevention of purulent-inflammatory processes and internally for the treatment of gastrointestinal diseases.
Furacilin is used in the form of an aqueous 0.02% (1:5000) solution; alcohol solution 0.066% (1:5000), 0.2% ointment.
For the treatment of skin and soft tissue wounds, bedsores, ulcers, cellulitis, mastitis, conjunctivitis, aqueous solutions of furatsilin are used in the form of drops, irrigations, tampons, and bandages. For anaerobic infections and chronic purulent processes, it is advisable to use an alcohol solution of furatsilin. Inflammation of the mucous membranes of the mouth, nose, pharynx and vagina is treated with furatsilin ointment.
To prepare an aqueous solution (1:5000), add 0.1 g of furatsilin to 500 ml of boiled hot water or 1 tablet (0.02 g) to 100 ml of water. To obtain an alcohol solution (1:5000), 0.1 g of furatsilin is added to 150 ml of 70% ethyl alcohol. Furacilin ointment (1:5000) is prepared by adding 100 ml of castor, vaseline oil or fish oil to 0.1 g of furatsilin, then after 10 hours another 40 ml of oil or fish oil is added to this mixture.
For mastitis in cows, milk is first milked from the affected lobe of the udder, and then 25-100 ml of an aqueous solution of furatsilin is injected into the milk tank. This procedure is performed 1-2 times a day until the animal is completely clinically recovered. Along with this, a cow suffering from mastitis is administered intravenously with furatsilin in the form of a solution (1:5000) prepared in an isotonic solution of sodium chloride in an amount of 300-500 ml.
For gastrointestinal diseases of piglets and calves, furatsilin is given orally 2-3 times a day for 3-5 days in a row in doses: piglets - 0.05 g; calves - 0.1 g.
It should be borne in mind that furatsilin is one of the most toxic nitrofuran compounds for birds; ducks and geese are most sensitive to it. For example, in calves, furatsilin at a concentration of 0.011% causes a decrease in weight gain, and a concentration of 0.022% already contributes to the development of severe toxic effects leading to death. For goslings during the first 7-10 days, the toxic concentration of furatsilin is 0.014%. The minimum toxic concentration of furatsilin for adult chickens is 0.034-0.04%. Furacilin does not have cumulative properties.
Is it possible to use Furacilin during pregnancy?
During pregnancy, the medicine can be taken in the form intended for local use, since the constituent components with such use will not be able to penetrate the blood. When gargling, do not allow the product to enter the body. But it still wouldn’t hurt to consult a doctor first.
The drug can be prescribed for bacterial infection of the oral cavity, pharynx, and sinusitis. Also, an aqueous solution will be effective for vaginal candidiasis.
Best before date
How long furatsilin can be stored depends on the form of its release and storage conditions. The packaging with the prepared solution indicates the expiration date of the drug. It is usually stamped on the top side. This information is also present on the bottle label. In liquid form, the medicine can be stored for up to 2 years. But at room temperature, storage time is significantly reduced.
The expiration date of furatsilin tablets can be seen on the packaging and on each blister. For this form of release it is 5 years.
Furacilin should be stored after opening the package under the conditions specified by the manufacturer. If the storage rules are followed, the drug will not lose quality even after opening during the entire shelf life.
Long-term storage may affect the structure of the drug. The tablets become more friable, and a precipitate forms in the solution. When you shake the bottle it dissolves.
Using expired product is not recommended. It will be ineffective in terms of antibacterial and antimicrobial action. This may make the situation worse instead of a positive action. Therefore, before using an antiseptic, always check its expiration date and conduct a visual inspection.
The drug in tablet form has a yellow color with a greenish tint and a dense, uniform structure. The solution is bright yellow, transparent, without impurities and suspension.
Storage conditions
Home storage conditions for furatsilin must comply with the manufacturer's recommendations. The tablets can be kept in a dark, dry place where the temperature does not exceed +25°C.
The bottle with the solution should be placed in a cool place, taking into account that its storage temperature is in the range of +5°C - +15°C. Storing furatsilin solution in the refrigerator is the best option, but it is advisable to keep the container on the door, where the temperature is higher than on the shelves.
This product should not be frozen or overheated (left in a sunny place). Humid air is also contraindicated for him.
Furacilin solution for external use 0.2 mg/ml 1000 ml No. 1
Name
Furacilin solution for nar. approx. 0.2 mg/ml in polymer container 1000 ml in pack No. 1
Description
The drug is a clear yellow solution
Main active ingredient
Nitrofural
Release form
solution for external use
Dosage
0.02% 1 l
Indications for use
purulent infected wounds, bedsores, ulcers; infected second and third degree burns; preparation of the granulating surface for skin grafting; osteomyelitis; pleural empyema; boil of the external auditory canal; empyema of the paranasal sinuses; conjunctivitis.
Directions for use and doses
For purulent wounds, bedsores, ulcers, II and III degree burns, to prepare the granulating surface for skin grafts and for the secondary suture, irrigate the wound with an aqueous solution of furatsilin and apply wet bandages. In case of osteomyelitis, after surgery the cavity is washed with an aqueous solution of furatsilin and a wet bandage is applied. In case of pleural empyema, the pus is sucked out, the pleural cavity is washed, followed by the introduction of 20-100 ml of an aqueous solution of furatsilin into the cavity. When treating boils of the external auditory canal and empyema of the paranasal sinuses, the damaged areas are washed 2-4-6 times a day (depending on the severity of the damage). When treating conjunctivitis, instill an aqueous solution into the conjunctival sac, 2-3 drops 3-4 times a day. The duration of treatment is determined by the doctor, taking into account the characteristics of the disease, tolerability of the drug and the achieved effect.
Use during pregnancy and lactation
When prescribing to pregnant women, women during lactation and children, it is recommended to take into account the possible risk-benefit ratio of using this drug.
Precautionary measures
Due to the fact that there is insufficient data on the safety of use, the drug is not recommended for use in children and adolescents under the age of 18 years. When using the drug, so-called cross-sensitization is possible. To avoid sensitization, it is recommended to use the drug for no more than 5 days. If, while using the drug, the symptoms of the disease persist or the condition worsens, you must stop using the drug and consult a doctor.
Interaction with other drugs
Incompatible with epinephrine (adrenaline), tetracaine, procaine (novocaine), resorcinol (resorcinol) and other reducing agents, as it decomposes to form pinkish or brownish-colored products. Incompatible with potassium permanganate, hydrogen peroxide and other oxidizing agents due to oxidation of the drug.
Contraindications
severe renal dysfunction; allergic dermatoses; hypersensitivity to nitrofuran derivatives.
Compound
Active ingredients: Nitrofural (furacilin) 0.2 g Excipients: 9.0 g to 1000 ml Sodium chloride Water for injection
Overdose
If the recommended methods of use are followed, cases of overdose are not known. If accidentally ingested, nausea, vomiting, loss of appetite, dizziness, and neuritis may develop.
Side effect
When used externally, furatsilin is usually well tolerated. In some cases, dermatitis is possible, requiring a temporary break or cessation of taking the drug. Bleeding. If any adverse reactions occur, including those not listed in this instruction, you should stop using the drug and consult a doctor.
Storage conditions
Store in a place protected from light at a temperature not exceeding 25 °C. Keep out of the reach of children.
Buy Furacilin solution for external use 0.2 mg/ml 1000 ml No. 1 in the pharmacy
Price for Furacilin solution for external use 0.2 mg/ml 1000 ml No. 1
Instructions for use for Furacilin solution for external use 0.2 mg/ml 1000 ml No. 1
Storage of furatsilin tablets
Furacilin tablets should be stored in a dark place, out of reach of children, at temperatures up to +25°C. You should not keep the drug in the bathroom, on the balcony or in the kitchen. Too humid air and sudden temperature changes will quickly render the medicine unusable. The shelf life of furatsilin tablets is 5 years.
Furacilin tablets can be stored in the refrigerator, but they must first be sealed.
