The pharmaceutical product Rotokan is a natural anti-inflammatory drug, made from extracts of many plants.
Rotocan solution helps well with pathologies caused by damage to the mucous membrane and infection. The instructions included with the medication describe in detail how to use the drug.
Characteristics
The drug contains several active ingredients. They are represented by the following plant extracts:
- Chamomile flowers.
- Yarrow herbs.
- Calendula flowers.
Ethyl alcohol at a concentration of 70% acts as an extractant. This is how the tincture is obtained - a transparent solution of a yellowish-brown hue. It is bottled in dark glass bottles of 30 and 50 ml.
Action
The therapeutic effects of the drug are due to biologically active substances contained in plant extracts: essential oils, saponins, terpenes, resins, flavonoids, organic acids, vitamins, etc. They provide the tincture with the following properties:
- Anti-inflammatory.
- Antimicrobial.
- Regenerative.
- Antispasmodic.
- Hemostatic.
Thanks to this, Diarotokan helps eliminate the pathological process of an infectious-inflammatory nature that affects the mucous membranes. Accordingly, the symptoms provoked by it are alleviated. Natural extracts have a mild but quite pronounced effect.
The complex drug Diarotocan contains plant extracts that have a variety of positive effects.
Distribution in the body
When the tincture is applied locally, the plant components act only on the mucous membrane, without being absorbed internally. And oral administration of the drug is accompanied by systemic absorption of its components. However, pharmacokinetic studies were not carried out due to the impossibility of detecting all biologically active substances.
Composition of the drug, release form
Several varieties of medicinal plants are used in the production of the drug. Externally, the pharmaceutical product is a dark brown liquid and has a specific aroma. Plant extracts are obtained using a solution of alcohol in water.
Plant extracts included in Rotokan:
- 1 part common yarrow
- 2 parts chamomile
- 1 part medicinal calendula
The pharmaceutical product contains:
- tannins
- B vitamins
- quercetin
- chamazulene
Ethyl alcohol contained in the medicinal solution enhances the following effects of herbs:
- anti-inflammatory
- painkiller
- antiseptic
The medicine is marketed in the form of a liquid extract, which can be used orally or topically. The medicine is packaged in glass bottles that are equipped with droppers. For inpatient departments, the solution is released in brown jars of various capacities.
Indications
The drug is most often used in the treatment of oral pathologies: stomatitis, gingivitis, periodontitis. However, it can also be successfully used in patients with ENT diseases, in particular tonsillitis and pharyngitis. In addition, Diarotocan is indicated in the complex treatment of chronic diseases of the digestive tract (gastritis and enterocolitis).
Indications for use
For inflammation of various etiologies, dentists and ENT doctors often prescribe Rotokan to patients. Germs and damage, burns can cause bleeding, pain and swelling.
For stomatitis, the medicine is very effective at the first stage of the pathology. It affects bacterial and fungal infections and quickly destroys them.
Indications for treatment with Rotokan for dental pathologies:
- periodontal disease
- tooth socket disease
- periodontitis
- gingivitis
- various stomatitis
- necrotizing gingivostomatitis
For pathologies of the pharynx and tongue, the drug is used for rinsing.
Treatment with Rotokan helps reduce inflammation with tonsillitis, pharyngitis, and glossitis.
Pathologies of the digestive system when the drug is prescribed orally:
- gastroduodenitis
- enterocolitis
- gastritis with low acidity of gastric contents
- chronic enteritis, inflammation
- functional dyspepsia
Application
Since herbal tincture is considered a medicinal product, it should be used as prescribed by a doctor. Only a specialized specialist can make a correct diagnosis and determine the optimal therapeutic tactics. Under no circumstances should self-medication be allowed.
Method of administration
Diarotocan is intended for topical use and oral administration. In ENT practice and dentistry, it is often used as a rinse. To do this, dilute a teaspoon of tincture in a glass of water. Rinse the mouth and throat for 1–2 minutes. In addition, the solution is applied to the affected areas of the mucosa (exposure time is about 15 minutes). The course of treatment is determined by the doctor individually, but in most cases it does not exceed 5 days.
Side effects
Although the drug is a herbal remedy, it can also cause side effects. Patients with individual intolerance and hypersensitivity may experience allergic reactions to extractive substances - from itching and urticaria to anaphylaxis. No other negative effects were noted during treatment.
The side effects of the drug may include allergies. In such cases, you should always consult a doctor.
Methods and types of use of the product
The drug is recommended to a greater extent at the first stage of therapy. For primary symptoms of sore throat, pharyngitis and acute respiratory infections, it is useful to rinse your mouth with Rotokan:
- soreness
- itching
- pain in the throat area
- hoarseness of voice
Within 24 hours, children over 12 years of age can undergo 2 or 3 treatment sessions; for adults, the number of procedures can be increased to 5.
If an adult patient tolerates external use of the medicine well, then the dose is increased to 3 tablespoons per 200 g of water.
To rinse the gums, the method of preparing the solution is similar to that described above.
The prepared medication is used for diseases of the oral mucosa. A sterile cloth napkin is moistened in the solution and applied to the damaged area for a quarter of an hour.
For periodontal disease and after tooth extraction, Rotokan will also be useful. Small turundas moistened with a medicinal solution are inserted into the hole at the site of the former tooth or into the gum pockets. The procedure can be performed only once per day, the duration of the session should not exceed 20 minutes.
When treating diseases of the digestive tract, the medicine is taken orally. 1 teaspoon of the medicine is dissolved in 200 g of water, the resulting infusion must be drunk in two doses. The therapeutic course can last up to 3 weeks.
For inflammation of the colon, microenemas from Rotokan will help well.
For skin diseases, the drug can be used in its pure form. To do this, dip a cotton swab into the solution and apply it to pimples, abrasions or wounds.
Restrictions
In order for treatment with tincture to have only a positive result, before prescribing it, the doctor takes into account all the limiting factors present in the patient. Identifying contraindications and predicting likely drug-drug interactions are key aspects of therapeutic safety.
Contraindications
Considering the composition of the drug, it contains certain contraindications. Diarotokan's instructions contain mention of the following conditions in which you should refrain from taking the drug:
- Individual hypersensitivity to any of the components, as well as to plants of the Compositae family.
- Peptic ulcer disease.
- Diseases of the liver and gall bladder.
- Alcoholism.
- Epilepsy.
- Traumatic brain injuries.
The tincture should not be taken during pregnancy or breastfeeding, since there is no information about its harmlessness to the fetus and newborn. The drug is also not prescribed for children under 12 years of age.
Interaction
Diarotocan is not recommended to be combined with other drugs containing ethyl alcohol, drugs that give a disulfiram-like reaction (metronidazole, ketoconazole, chloramphenicol, cefoperazone, gliclazide, chlorpropamide) and have a sedative effect (tranquilizers, sleeping pills). Otherwise, you can expect negative phenomena in the form of vomiting, a feeling of heat in the body, increased heart rate, and depression of the nervous system.
What you need to know before you start taking Eroton
First of all, you should stop taking Eroton if you have an allergic reaction to it. It should also not be taken if you are taking medications to treat pulmonary hypertension (especially Adempas, an antihypertensive drug that stimulates the enzyme guanylate cyclase).
You should also not use Eroton if you are taking nitrate drugs (for example, nitroglycerin, isosorbide dinitrate) to treat heart pain, since the mechanism of action of the latter is also associated with the release of the NO factor. As a result of this combined interaction, vasodilation may increase and this will lead to a sharp drop in blood pressure with possible loss of consciousness.
Before using Eroton, you should consult a doctor to take your medical history to make sure there are no conditions such as:
- problems with the cardiovascular system (arrhythmia, arterial hypo- or hypertension, coronary heart disease);
- problems with blood circulation;
- retinitis pigmentosa (hereditary eye disease);
- visual impairment;
- blood diseases (for example, anemia, leukemia);
- pulmonary veno-occlusive disease (complications of pulmonary hypertension, which affects small pulmonary veins);
- liver and/or kidney diseases;
- physical deformation of the penis (for example, Peyronie's disease).
It is also especially important to consult your doctor before starting this medication if you are pregnant or planning to become pregnant, or if you are breastfeeding a baby.
Eroton is approved for use from 18 years of age.
special instructions
Since the drug contains ethanol, when using it you should not drive vehicles or work with moving mechanisms. Although the concentration of alcohol in a diluted solution is low, you should still remember the risk of decreased attention and speed of psychomotor reactions.
Diarotocan is a drug that is a mixture of plant extracts. It is successfully used to treat inflammatory pathologies of the oral cavity and pharynx, providing a local effect on the mucous membrane. But, as with other medications, you should follow the doctor’s prescriptions and recommendations in everything.
Composition and release form Vazotop R (28 tablets)
Vazotop R contains ramipril as an active ingredient and auxiliary components: hypromellose, pregelatinized starch, microcrystalline cellulose, powdered beef flavor, sodium stearyl fumarate, colloidal silicon anhydride and iron oxide. They are tablets for oral administration, oblong in shape with a groove in the middle. Tablets, depending on the amount of ramipril, have different colors: beige - 1.25 mg, yellow - 2.5 mg and pink - 5.0 mg, respectively. Each half of the tablet is marked with the amount of active substance on one side and the Latin letter “V” on the other. 28 tablets are packaged in plastic jars with a moisture-absorbing membrane and a rotating lid. Pack 3 cans in cardboard boxes.
Lozap plus, 50 mg+12.5 mg, film-coated tablets, 60 pcs.
Losartan
Cases of decreased concentrations of the active metabolite have been described with the combined use of rifampicin and fluconazole. Clinical evidence for such interactions has not been evaluated.
As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt substitutes may result in increased plasma potassium concentrations. The combined use of these drugs is not recommended.
As with other drugs that affect sodium excretion, the drug may slow down the excretion of lithium. Therefore, when prescribing lithium salts and ARBs simultaneously, it is necessary to carefully monitor the concentration of lithium salts in the blood plasma.
With the simultaneous use of ARBs and NSAIDs, for example, selective COX-2 inhibitors, acetylsalicylic acid in doses used for anti-inflammatory effect, and non-selective NSAIDs, a weakening of the hypotensive effect of Lozap® plus may be observed.
The simultaneous use of ARBs or diuretics and NSAIDs may cause an increased risk of deterioration of renal function, incl. acute renal failure and increased plasma potassium levels, especially in patients with underlying renal impairment. Combination treatment should be prescribed with caution, especially in elderly patients. Patients should be adequately hydrated and renal function monitored after initiation of combination treatment and periodically during treatment. In some patients with impaired renal function receiving treatment with NSAIDs, incl. selective COX-2 inhibitors, concomitant use of ARBs may worsen renal dysfunction. These effects are usually reversible. Dual blockade (for example, adding an ACE inhibitor or aliskiren to an ARB) should be carried out only in selected cases, constantly monitoring blood pressure, renal function and plasma electrolytes. There is evidence that dual blockade of the RAAS in patients with diagnosed atherosclerosis, heart failure or diabetes mellitus with target organ damage is associated with an increased incidence of arterial hypotension, syncope, hyperkalemia and renal dysfunction (including acute renal failure), when compared with the use of one a drug that affects the RAAS.
The use of losartan together with aliskiren is contraindicated in patients with diabetes mellitus or impaired renal function (Cl creatinine <60 ml/min).
The drug Lozap® plus, when used simultaneously with other drugs that cause a decrease in blood pressure, such as tricyclic antidepressants, antipsychotic drugs, baclofen, amifostine, may increase the risk of developing arterial hypotension.
Hydrochlorothiazide
When taken concomitantly with thiazide diuretics, interactions with the following substances may occur.
Alcohol, barbiturates, narcotics or antidepressants.
The risk of orthostatic hypotension may increase.
Antidiabetic drugs (insulin and oral drugs).
Treatment with thiazide diuretics may affect glucose tolerance. Dosage adjustment of antidiabetic drugs may be required. Metformin should be used with caution due to the risk of lactic acidosis caused by possible functional renal failure associated with the use of hydrochlorothiazide.
Other antihypertensive drugs.
Additive effect.
Cholestyramine and colestipol
. In the presence of ion exchange resins, the absorption of hydrochlorothiazide is impaired. Taking a single dose of cholestyramine or colestipol leads to the binding of hydrochlorothiazide and a decrease in its absorption from the gastrointestinal tract by 85 and 43%, respectively.
Corticosteroids, adrenocorticotropic hormone (ACTH).
Possible worsening of electrolyte deficiency, especially hypokalemia.
Pressor amines (for example adrenaline).
It is possible that the effect of pressor amines may be reduced, but this does not preclude their use.
Non-depolarizing muscle relaxants (eg tubocurarine chloride).
The effect of muscle relaxants may be enhanced.
Lithium preparations.
Diuretics reduce the renal clearance of lithium and significantly increase the risk of lithium toxicity. It is recommended to avoid the simultaneous use of hydrochlorothiazide with lithium preparations.
Medicines used to treat gout (probenecid, sulfinpyrazone and allopurinol).
Dosage adjustment of anti-gout medications may be required since hydrochlorothiazide can increase plasma uric acid concentrations. Concomitant use with thiazides may increase the incidence of hypersensitivity reactions to allopurinol.
Anticholinergic drugs (eg atropine, biperidine).
It is possible to increase the bioavailability of thiazide diuretics by reducing gastrointestinal motility and the rate of gastric emptying.
Cytotoxic drugs (eg cyclophosphamide, methotrexate).
Thiazide diuretics can inhibit the renal excretion of cytotoxic drugs and enhance their myelosuppressive effect.
Salicylates.
When using high doses of salicylates, hydrochlorothiazide may enhance their toxic effects on the central nervous system.
Methyldopa.
Isolated cases of the development of hemolytic anemia have been described in patients simultaneously receiving hydrochlorothiazide and methyldopa.
Cyclosporine.
Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and complications of gout.
Cardiac glycosides.
Hypokalemia or hypomagnesemia caused by thiazide diuretics may contribute to the development of digitalis-induced arrhythmias.
Medicines whose effect is influenced by changes in the concentration of potassium in the blood plasma.
When prescribing Lozap® plus simultaneously with drugs whose effect is affected by changes in the potassium content in the blood plasma (for example, digitalis glycosides and antiarrhythmic drugs), it is recommended to regularly monitor the concentration of potassium in the blood plasma and ECG monitoring. These measures are also recommended when using the drug Lozap® plus simultaneously with the following drugs that can cause torsade de pointes (ventricular tachycardia) (including antiarrhythmics), since hypokalemia is a factor predisposing to the development of torsade de pointes: class 1A antiarrhythmic drugs (for example quinidine, hydroquinidine, disopyramide); class III antiarrhythmics (eg amiodarone, sotalol, dofetilide, ibutilide); some antipsychotic drugs (eg thioridazine, chlorpromazine, levomepromazine, trifluoperazine, cyamemazine, sulpiride, sultopride, amisulpride, tiapride, pimozide, haloperidol, droperidol); others (eg bepridil, cisapride, difemanil, erythromycin IV, halofantrine, mizolastine, pentamidine, terfenadine, vincamycin IV).
Calcium salts.
Thiazide diuretics may increase plasma calcium levels by decreasing calcium excretion. If the patient is taking calcium supplements, it is necessary to monitor the calcium level in the blood plasma and adjust the dosage of calcium supplements accordingly.
Influence on laboratory test results.
Due to their effect on calcium metabolism, thiazides may interfere with test results to assess parathyroid function.
Carbamazepine.
There is a risk of developing symptomatic hyponatremia. Clinical observation and laboratory monitoring of blood sodium levels are necessary in patients taking carbamazepine.
Iodinated contrast agents.
In case of dehydration caused by the use of diuretics, the risk of developing acute renal failure increases, especially when taking high doses of iodine preparations. Patients should be rehydrated before administration.
Amphotericin B (parenteral), corticosteroids, ACTH, stimulant laxatives, or glycyrrhizin (found in licorice).
Hydrochlorothiazide may cause electrolyte deficiency, especially hypokalemia.
Method of application and dosage of Eroton
Usual Adult Dose for Erectile Dysfunction. Initial dose: 50 mg orally once daily, as needed, 1 hour before sexual activity.
Maintenance: 25 to 100 mg orally once daily, as needed, 1 hour before sexual activity.
Usual geriatric (elderly) dose for erectile dysfunction.
Initial dose: 25 mg orally once daily 1 hour before sexual activity.
Note!
If at the time of sexual intercourse after taking Eroton you experience pain, numbness or tingling in the chest, arms, neck or jaw, you must interrupt the process and immediately consult a doctor. Such symptoms may indicate serious side effects of Eroton with a subsequent risk of complications.
Interaction of Eroton with other drugs and substances
Eroton can interact with various medications and any other substances. It is not recommended to take Eroton with similar erectile dysfunction medications such as avanafil, tadalafil or vardenafil.
Do not take Eroton if you are also taking nitrate medications for chest pain or heart problems. These include nitroglycerin, isosorbide dinitrate and isosorbide mononitrate. This concomitant use may cause a sudden and severe decrease in blood pressure that can be life-threatening.
In addition, there are a number of other medicines that may interact with Eroton, including:
- medicines to treat high blood pressure (antihypertensives) or prostate disorders;
- an antifungal agent (for example, ketoconazole or itraconazole);
- antiviral drugs for the treatment of HIV/AIDS.
These are not all pharmacological drugs that can interact with Eroton. For more information on this drug, please contact your healthcare professional.
Note!
Grapefruit or grapefruit juice together with Eroton can increase the toxic effects of the latter on the body and lead to undesirable effects.
Consequences of an overdose of Eroton
In case of an overdose of Eroton, various symptoms characteristic of this drug, associated with its mechanism of action, may be observed. As a result of such an overdose, the following consequences may occur:
- collapse (acute disruption of the blood supply to vital organs);
- deafness;
- retinal damage or blindness;
- damage to the penis due to prolonged erection;
- heart attack (myocardial infarction).
This is why it is very important to always consult a healthcare professional before taking Eroton. You must always follow all doctor's instructions and read the instructions for the drug.
What should you not do while taking Eroton?
When taking Eroton, it is worth remembering that you should not take it simultaneously with alcoholic beverages, as this increases the incidence of side effects, which can be extremely dangerous for your health.
Also, when taking Eroton, you should avoid eating grapefruits and grapefruit juice, since this fruit significantly enhances the pharmacological effect of Eroton, which can lead to complicated side effects and even an overdose.
If you are taking Eroton, you should not use other concomitant medications to treat impotence without first consulting your doctor. This can only do more harm than produce the expected, effective result.
What are the side effects of Eroton?
Common side effects from using Eroton include:
- dizziness, headache, fog:
- heartburn, nausea, indigestion;
- abnormal vision (blurry vision, changes in color vision)
- runny nose and/or nasal congestion, nosebleeds;
- problems sleeping (insomnia);
- muscle pain, back pain.
If you experience any of the following conditions after taking Eroton, you should immediately seek medical help:
- pressing pain in the heart, which can radiate to the arm, shoulder, jaw;
- hard breath;
- changes in vision or sudden loss of vision;
- painful erection that lasts more than 4 hours (prolonged erection can damage the penis);
- ringing in the ears or sudden hearing loss;
- arrhythmia (pulse changes);
- swelling of the arms, ankles, or feet;
- convulsions;
- feeling like you might lose consciousness.
